-
1
-
-
84928770388
-
Neoantigens in cancer immunotherapy
-
Schumacher, T. N. & Schreiber, R. D. Neoantigens in cancer immunotherapy. Science 348, 69-74 (2015).
-
(2015)
Science
, vol.348
, pp. 69-74
-
-
Schumacher, T.N.1
Schreiber, R.D.2
-
2
-
-
84908233609
-
Getting personal with neoantigen-based therapeutic cancer vaccines
-
Hacohen, N., Fritsch, E. F., Carter, T. A., Lander, E. S. & Wu, C. J. Getting personal with neoantigen-based therapeutic cancer vaccines. Cancer Immunol. Res. 1, 11-15 (2013).
-
(2013)
Cancer Immunol. Res
, vol.1
, pp. 11-15
-
-
Hacohen, N.1
Fritsch, E.F.2
Carter, T.A.3
Lander, E.S.4
Wu, C.J.5
-
3
-
-
70350772293
-
Vaccination against HPV-16 oncoproteins for vulvar intraepithelial neoplasia
-
Kenter, G. G. et al. Vaccination against HPV-16 oncoproteins for vulvar intraepithelial neoplasia. N. Engl. J. Med. 361, 1838-1847 (2009).
-
(2009)
N. Engl. J. Med
, vol.361
, pp. 1838-1847
-
-
Kenter, G.G.1
-
4
-
-
84855486511
-
Synthetic double-stranded RNA induces innate immune responses similar to a live viral vaccine in humans
-
Caskey, M. et al. Synthetic double-stranded RNA induces innate immune responses similar to a live viral vaccine in humans. J. Exp. Med. 208, 2357-2366 (2011).
-
(2011)
J. Exp. Med
, vol.208
, pp. 2357-2366
-
-
Caskey, M.1
-
5
-
-
84929481481
-
Pembrolizumab versus ipilimumab in advanced melanoma
-
Robert, C. et al. Pembrolizumab versus ipilimumab in advanced melanoma. N. Engl. J. Med. 372, 2521-2532 (2015).
-
(2015)
N. Engl. J. Med
, vol.372
, pp. 2521-2532
-
-
Robert, C.1
-
6
-
-
0030176270
-
Evidence that a single peptide-MHC complex on a target cell can elicit a cytolytic T cell response
-
Sykulev, Y., Joo, M., Vturina, I., Tsomides, T. J. & Eisen, H. N. Evidence that a single peptide-MHC complex on a target cell can elicit a cytolytic T cell response. Immunity 4, 565-571 (1996).
-
(1996)
Immunity
, vol.4
, pp. 565-571
-
-
Sykulev, Y.1
Joo, M.2
Vturina, I.3
Tsomides, T.J.4
Eisen, H.N.5
-
7
-
-
85009517413
-
SATB1 expression governs epigenetic repression of PD-1 in tumor-reactive T cells
-
Stephen, T. L. et al. SATB1 expression governs epigenetic repression of PD-1 in tumor-reactive T cells. Immunity 46, 51-64 (2017).
-
(2017)
Immunity
, vol.46
, pp. 51-64
-
-
Stephen, T.L.1
-
8
-
-
84900301377
-
Cancer immunotherapy based on mutation-specific CD4+ T cells in a patient with epithelial cancer
-
Tran, E. et al. Cancer immunotherapy based on mutation-specific CD4+ T cells in a patient with epithelial cancer. Science 344, 641-645 (2014).
-
(2014)
Science
, vol.344
, pp. 641-645
-
-
Tran, E.1
-
9
-
-
84906557615
-
A vaccine targeting mutant IDH1 induces antitumour immunity
-
Schumacher, T. et al. A vaccine targeting mutant IDH1 induces antitumour immunity. Nature 512, 324-327 (2014).
-
(2014)
Nature
, vol.512
, pp. 324-327
-
-
Schumacher, T.1
-
10
-
-
84872841412
-
Tumor exome analysis reveals neoantigen-specific T-cell reactivity in an ipilimumab-responsive melanoma
-
van Rooij, N. et al. Tumor exome analysis reveals neoantigen-specific T-cell reactivity in an ipilimumab-responsive melanoma. J. Clin. Oncol. 31, e439-e442 (2013).
-
(2013)
J. Clin. Oncol
, vol.31
, pp. e439-e442
-
-
Van Rooij, N.1
-
11
-
-
84928761118
-
Mutational landscape determines sensitivity to PD-1 blockade in non-small cell lung cancer
-
Rizvi, N. A. et al. Mutational landscape determines sensitivity to PD-1 blockade in non-small cell lung cancer. Science 348, 124-128 (2015).
-
(2015)
Science
, vol.348
, pp. 124-128
-
-
Rizvi, N.A.1
-
12
-
-
84961323160
-
High-Throughput epitope discovery reveals frequent recognition of neo-Antigens by CD4+ T cells in human melanoma
-
Linnemann, C. et al. High-Throughput epitope discovery reveals frequent recognition of neo-Antigens by CD4+ T cells in human melanoma. Nat. Med. 21, 81-85 (2015).
-
(2015)
Nat. Med
, vol.21
, pp. 81-85
-
-
Linnemann, C.1
-
13
-
-
84985995114
-
Durable complete response from metastatic melanoma after transfer of autologous T cells recognizing 10 mutated tumor antigens
-
Prickett, T. D. et al. Durable complete response from metastatic melanoma after transfer of autologous T cells recognizing 10 mutated tumor antigens. Cancer Immunol. Res. 4, 669-678 (2016).
-
(2016)
Cancer Immunol. Res
, vol.4
, pp. 669-678
-
-
Prickett, T.D.1
-
14
-
-
84928195112
-
A dendritic cell vaccine increases the breadth and diversity of melanoma neoantigen-specific T cells
-
Carreno, B. M. et al. A dendritic cell vaccine increases the breadth and diversity of melanoma neoantigen-specific T cells. Science 348, 803-808 (2015).
-
(2015)
Science
, vol.348
, pp. 803-808
-
-
Carreno, B.M.1
-
15
-
-
84928811341
-
Mutant MHC class II epitopes drive therapeutic immune responses to cancer
-
Kreiter, S. et al. Mutant MHC class II epitopes drive therapeutic immune responses to cancer. Nature 520, 692-696 (2015).
-
(2015)
Nature
, vol.520
, pp. 692-696
-
-
Kreiter, S.1
-
16
-
-
84971233983
-
Low mutation burden in ovarian cancer may limit the utility of neoantigen-Targeted vaccines
-
Martin, S. D. et al. Low mutation burden in ovarian cancer may limit the utility of neoantigen-Targeted vaccines. PLoS ONE 11, e0155189 (2016).
-
(2016)
PLoS ONE
, vol.11
, pp. e0155189
-
-
Martin, S.D.1
-
17
-
-
0028348369
-
Crystal structure of the human class II MHC protein HLA-DR1 complexed with an influenza virus peptide
-
Stern, L. J. et al. Crystal structure of the human class II MHC protein HLA-DR1 complexed with an influenza virus peptide. Nature 368, 215-221 (1994).
-
(1994)
Nature
, vol.368
, pp. 215-221
-
-
Stern, L.J.1
-
18
-
-
84927661328
-
T cell antigen receptor recognition of antigen-presenting molecules
-
Rossjohn, J. et al. T cell antigen receptor recognition of antigen-presenting molecules. Annu. Rev. Immunol. 33, 169-200 (2015).
-
(2015)
Annu. Rev. Immunol
, vol.33
, pp. 169-200
-
-
Rossjohn, J.1
-
19
-
-
0025855156
-
Allelespecific motifs revealed by sequencing of self-peptides eluted from MHC molecules
-
Falk, K., Rötzschke, O., Stevanović, S., Jung, G. & Rammensee, H. G. Allelespecific motifs revealed by sequencing of self-peptides eluted from MHC molecules. Nature 351, 290-296 (1991).
-
(1991)
Nature
, vol.351
, pp. 290-296
-
-
Falk, K.1
Rötzschke, O.2
Stevanović, S.3
Jung, G.4
Rammensee, H.G.5
-
20
-
-
84900461408
-
Development and function of dendritic cell subsets
-
Mildner, A. & Jung, S. Development and function of dendritic cell subsets. Immunity 40, 642-656 (2014).
-
(2014)
Immunity
, vol.40
, pp. 642-656
-
-
Mildner, A.1
Jung, S.2
-
21
-
-
85009756462
-
Systemic immunity is required for effective cancer immunotherapy
-
Spitzer, M. H. et al. Systemic immunity is required for effective cancer immunotherapy. Cell 168, 487-502 (2017).
-
(2017)
Cell
, vol.168
, pp. 487-502
-
-
Spitzer, M.H.1
-
22
-
-
84946761882
-
Idiotype-specific CD4+ T cells eradicate disseminated myeloma
-
Haabeth, O. A. et al. Idiotype-specific CD4+ T cells eradicate disseminated myeloma. Leukemia 30, 1216-1220 (2016).
-
(2016)
Leukemia
, vol.30
, pp. 1216-1220
-
-
Haabeth, O.A.1
-
23
-
-
84870277765
-
Induction of tumoricidal function in CD4+ T cells is associated with concomitant memory and terminally differentiated phenotype
-
Hirschhorn-Cymerman, D. et al. Induction of tumoricidal function in CD4+ T cells is associated with concomitant memory and terminally differentiated phenotype. J. Exp. Med. 209, 2113-2126 (2012).
-
(2012)
J. Exp. Med
, vol.209
, pp. 2113-2126
-
-
Hirschhorn-Cymerman, D.1
-
24
-
-
85013878753
-
Mass spectrometry profiling of HLA-Associated peptidomes in mono-Allelic cells enables more accurate epitope prediction
-
Abelin, J. G. et al. Mass spectrometry profiling of HLA-Associated peptidomes in mono-Allelic cells enables more accurate epitope prediction. Immunity 46, 315-326 (2017).
-
Immunity
, vol.46
, Issue.315-326
, pp. 2017
-
-
Abelin, J.G.1
-
25
-
-
78650762588
-
A scalable, fully automated process for construction of sequence-ready human exome targeted capture libraries
-
Fisher, S. et al. A scalable, fully automated process for construction of sequence-ready human exome targeted capture libraries. Genome Biol. 12, R1 (2011).
-
(2011)
Genome Biol
, vol.12
, pp. R1
-
-
Fisher, S.1
-
26
-
-
59849113821
-
Solution hybrid selection with ultra-long oligonucleotides for massively parallel targeted sequencing
-
Gnirke, A. et al. Solution hybrid selection with ultra-long oligonucleotides for massively parallel targeted sequencing. Nat. Biotechnol. 27, 182-189 (2009).
-
(2009)
Nat. Biotechnol
, vol.27
, pp. 182-189
-
-
Gnirke, A.1
-
27
-
-
79951494668
-
Initial genome sequencing and analysis of multiple myeloma
-
Chapman, M. A. et al. Initial genome sequencing and analysis of multiple myeloma. Nature 471, 467-472 (2011).
-
(2011)
Nature
, vol.471
, pp. 467-472
-
-
Chapman, M.A.1
-
28
-
-
79951497419
-
The genomic complexity of primary human prostate cancer
-
Berger, M. F. et al. The genomic complexity of primary human prostate cancer. Nature 470, 214-220 (2011).
-
(2011)
Nature
, vol.470
, pp. 214-220
-
-
Berger, M.F.1
-
29
-
-
80052707308
-
ContEst: Estimating cross-contamination of human samples in next-generation sequencing data
-
Cibulskis, K. et al. ContEst: estimating cross-contamination of human samples in next-generation sequencing data. Bioinformatics 27, 2601-2602 (2011).
-
(2011)
Bioinformatics
, vol.27
, pp. 2601-2602
-
-
Cibulskis, K.1
-
30
-
-
79955483667
-
A framework for variation discovery and genotyping using next-generation DNA sequencing data
-
DePristo, M. A. et al. A framework for variation discovery and genotyping using next-generation DNA sequencing data. Nat. Genet. 43, 491-498 (2011).
-
(2011)
Nat. Genet
, vol.43
, pp. 491-498
-
-
DePristo, M.A.1
-
31
-
-
84864153492
-
Strelka: Accurate somatic small-variant calling from sequenced tumor-normal sample pairs
-
Saunders, C. T. et al. Strelka: Accurate somatic small-variant calling from sequenced tumor-normal sample pairs. Bioinformatics 28, 1811-1817 (2012).
-
(2012)
Bioinformatics
, vol.28
, pp. 1811-1817
-
-
Saunders, C.T.1
-
32
-
-
78651271733
-
Integrative genomics viewer
-
Robinson, J. T. et al. Integrative genomics viewer. Nat. Biotechnol. 29, 24-26 (2011).
-
(2011)
Nat. Biotechnol
, vol.29
, pp. 24-26
-
-
Robinson, J.T.1
-
33
-
-
84925965197
-
Oncotator: Cancer variant annotation tool
-
Ramos, A. H. et al. Oncotator: cancer variant annotation tool. Hum. Mutat. 36, E2423-E2429 (2015).
-
(2015)
Hum. Mutat
, vol.36
, pp. E2423-E2429
-
-
Ramos, A.H.1
-
34
-
-
84904994551
-
PRADA: Pipeline for RNA sequencing data analysis
-
Torres-García, W. et al. PRADA: pipeline for RNA sequencing data analysis. Bioinformatics 30, 2224-2226 (2014).
-
(2014)
Bioinformatics
, vol.30
, pp. 2224-2226
-
-
Torres-García, W.1
-
35
-
-
59449094834
-
NetMHCpan, a method for MHC class i binding prediction beyond humans
-
Hoof, I. et al. NetMHCpan, a method for MHC class I binding prediction beyond humans. Immunogenetics 61, 1-13 (2009).
-
(2009)
Immunogenetics
, vol.61
, pp. 1-13
-
-
Hoof, I.1
-
36
-
-
81255198783
-
Prediction of epitopes using neural network based methods
-
Lundegaard, C., Lund, O. & Nielsen, M. Prediction of epitopes using neural network based methods. J. Immunol. Methods 374, 26-34 (2011).
-
(2011)
J. Immunol. Methods
, vol.374
, pp. 26-34
-
-
Lundegaard, C.1
Lund, O.2
Nielsen, M.3
-
37
-
-
85016164544
-
Classical hodgkin lymphoma with reduced β 2M/MHC Class i expression is associated with inferior outcome independent of 9p24.1 status
-
Roemer, M. G. et al. Classical hodgkin lymphoma with reduced β 2M/MHC Class i expression is associated with inferior outcome independent of 9p24.1 status. Cancer Immunol. Res. 4, 910-916 (2016).
-
(2016)
Cancer Immunol. Res
, vol.4
, pp. 910-916
-
-
Roemer, M.G.1
-
38
-
-
84867530182
-
Mutated BCR-ABL generates immunogenic T-cell epitopes in CML patients
-
Cai, A. et al. Mutated BCR-ABL generates immunogenic T-cell epitopes in CML patients. Clin. Cancer Res. 18, 5761-5772 (2012).
-
(2012)
Clin. Cancer Res
, vol.18
, pp. 5761-5772
-
-
Cai, A.1
-
39
-
-
84903846565
-
Efficient identification of mutated cancer antigens recognized by T cells associated with durable tumor regressions
-
Lu, Y. C. et al. Efficient identification of mutated cancer antigens recognized by T cells associated with durable tumor regressions. Clinical Cancer Res. 20, 3401-3410 (2014).
-
(2014)
Clinical Cancer Res
, vol.20
, pp. 3401-3410
-
-
Lu, Y.C.1
-
40
-
-
0142155578
-
Ex vivo analysis of human memory CD4 T cells specific for hepatitis C virus using MHC class II tetramers
-
Day, C. L. et al. Ex vivo analysis of human memory CD4 T cells specific for hepatitis C virus using MHC class II tetramers. J. Clin. Invest. 112, 831-842 (2003).
-
(2003)
J. Clin. Invest
, vol.112
, pp. 831-842
-
-
Day, C.L.1
-
41
-
-
70349119901
-
In vivo enhancement of peptide display by MHC class II molecules with small molecule catalysts of peptide exchange
-
Call, M. J. et al. In vivo enhancement of peptide display by MHC class II molecules with small molecule catalysts of peptide exchange. J. Immunol. 182, 6342-6352 (2009).
-
(2009)
J. Immunol
, vol.182
, pp. 6342-6352
-
-
Call, M.J.1
-
42
-
-
84964452502
-
CEL-seq2: Sensitive highly-multiplexed single-cell RNA-seq
-
Hashimshony, T. et al. CEL-seq2: sensitive highly-multiplexed single-cell RNA-seq. Genome Biol. 17, 77 (2016).
-
(2016)
Genome Biol
, vol.17
, pp. 77
-
-
Hashimshony, T.1
-
43
-
-
84929151009
-
Spatial reconstruction of single-cell gene expression data
-
Satija, R., Farrell, J. A., Gennert, D., Schier, A. F. & Regev, A. Spatial reconstruction of single-cell gene expression data. Nat. Biotechnol. 33, 495-502 (2015).
-
(2015)
Nat. Biotechnol
, vol.33
, pp. 495-502
-
-
Satija, R.1
Farrell, J.A.2
Gennert, D.3
Schier, A.F.4
Regev, A.5
-
44
-
-
84903574951
-
Bayesian approach to single-cell differential expression analysis
-
Kharchenko, P. V., Silberstein, L. & Scadden, D. T. Bayesian approach to single-cell differential expression analysis. Nat. Methods 11, 740-742 (2014).
-
(2014)
Nat. Methods
, vol.11
, pp. 740-742
-
-
Kharchenko, P.V.1
Silberstein, L.2
Scadden, D.T.3
-
45
-
-
48449106045
-
NetMHC-3.0: Accurate web accessible predictions of human, mouse and monkey MHC class i affinities for peptides of length 8-11
-
Lundegaard, C. et al. NetMHC-3.0: Accurate web accessible predictions of human, mouse and monkey MHC class I affinities for peptides of length 8-11. Nucleic Acids Res. 36, W509-12 (2008).
-
(2008)
Nucleic Acids Res
, vol.36
, pp. W509-W512
-
-
Lundegaard, C.1
|