The endoplasmic reticulum unfolded protein response in neurodegenerative disorders and its potential therapeutic significance

Frontiers in Molecular Neuroscience

Volumn 10, Issue , 2017, Pages

  Remondelli, Paolo ^a   Renna, Maurizio ^b  

^a UNIVERSITY OF SALERNO   (Italy)

^b UNIVERSITY OF CAMBRIDGE   (United Kingdom)

Author keywords

ER stress; Neurodegenerative diseases; Protein misfolding disorders; Therapeutic targets; Unfolded protein response

Indexed keywords

ACTIVATING TRANSCRIPTION FACTOR 4; ACTIVATING TRANSCRIPTION FACTOR 6; ALPHA SYNUCLEIN; AMYLOID PRECURSOR PROTEIN; AUTOPHAGY RELATED PROTEIN 12; AUTOPHAGY RELATED PROTEIN 5; BECLIN 1; CALCIUM ION; CALRETICULIN; COPPER ZINC SUPEROXIDE DISMUTASE; CYCLIN DEPENDENT KINASE 5; DIBENZOYLMETHANE DERIVATIVE; GLUCOSE REGULATED PROTEIN 78; GLUCOSYLCERAMIDASE; GLUCOSYLCERAMIDE; GUANABENZ; MESSENGER RNA; OPTINEURIN; RAB PROTEIN; REACTIVE OXYGEN METABOLITE; RNA 28S; SALUBRINAL; SECRETORY PROTEIN; SEQUESTOSOME 1; THIOREDOXIN; TRANSCRIPTION FACTOR FKHR; TRAZODONE; TUMOR NECROSIS FACTOR RECEPTOR ASSOCIATED FACTOR 2; UNINDEXED DRUG; X BOX BINDING PROTEIN 1;

ALZHEIMER DISEASE; AMYOTROPHIC LATERAL SCLEROSIS; APOPTOSIS; AUTOPHAGY; BRAIN MITOCHONDRION; CALCIUM HOMEOSTASIS; CLINICAL TRIAL (TOPIC); DEGENERATIVE DISEASE; ENDOPLASMIC RETICULUM; ENDOPLASMIC RETICULUM STRESS; EUKARYOTIC CELL; HUMAN; HUNTINGTON CHOREA; INTRACELLULAR SIGNALING; NONHUMAN; PARKINSON DISEASE; PROTEIN AGGREGATION; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; PROTEIN MISFOLDING; PROTEIN PHOSPHORYLATION; REVIEW; UNFOLDED PROTEIN RESPONSE;

EID: 85021447128     PISSN: 16625099     EISSN: None     Source Type: Journal    
DOI: 10.3389/fnmol.2017.00187     Document Type: Review

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