Parkin and PINK1 Patient iPSC-Derived Midbrain Dopamine Neurons Exhibit Mitochondrial Dysfunction and α-Synuclein Accumulation

Stem Cell Reports

Volumn 7, Issue 4, 2016, Pages 664-677

  Chung, Sun Young ^a   Kishinevsky, Sarah ^a   Mazzulli, Joseph R ^b   Graziotto, John ^b   Mrejeru, Ana ^c   Mosharov, Eugene V ^c   Puspita, Lesly ^d   Valiulahi, Parvin ^d   Sulzer, David ^c   Milner, Teresa A ^e,f   Taldone, Tony ^a   Krainc, Dimitri ^b   Studer, Lorenz ^a   Shim, Jae won ^d  

^a MEMORIAL SLOAN KETTERING CANCER CENTER   (United States)

^b NORTHWESTERN UNIVERSITY   (United States)

^c NewYork Presbyterian Hospital   (United States)

^d Soonchunhyang University   (South Korea)

^e FEIL FAMILY BRAIN AND MIND RESEARCH INSTITUTE   (United States)

^f ROCKEFELLER UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA SYNUCLEIN; BETA TUBULIN; DOPAMINE; HEPATOCYTE NUCLEAR FACTOR 3BETA; MICROTUBULE ASSOCIATED PROTEIN 2; NUCLEAR RECEPTOR RELATED FACTOR 1; PARKIN; PHOSPHATIDYLINOSITOL 3,4,5 TRISPHOSPHATE 3 PHOSPHATASE; PTEN INDUCED PUTATIVE KINASE 1; REACTIVE OXYGEN METABOLITE; SUPEROXIDE DISMUTASE; SYNAPSIN; TYROSINE 3 MONOOXYGENASE; UNCLASSIFIED DRUG; PROTEIN KINASE; PTEN-INDUCED PUTATIVE KINASE; UBIQUITIN PROTEIN LIGASE;

ANIMAL CELL; ARTICLE; CELL MATURATION; CELL SURVIVAL; CONTROLLED STUDY; CYTOSOL; DISORDERS OF MITOCHONDRIAL FUNCTIONS; DOPAMINERGIC NERVE CELL; EMBRYO; HUMAN; HUMAN CELL; INDUCED PLURIPOTENT STEM CELL; MESENCEPHALON; MITOCHONDRIAL VOLUME; MOUSE; NERVE CELL DIFFERENTIATION; NONHUMAN; OXIDATIVE STRESS; PARKINSON DISEASE; PRIORITY JOURNAL; PROTEIN EXPRESSION; UPREGULATION; ANIMAL; ANTIBODY SPECIFICITY; BIOLOGICAL MODEL; CELL DIFFERENTIATION; CELL LINE; CYTOLOGY; GENETICS; METABOLISM; MITOCHONDRION; MUTATION; PHYSIOLOGICAL STRESS; ULTRASTRUCTURE;

ALPHA-SYNUCLEIN; ANIMALS; CELL DIFFERENTIATION; CELL LINE; DOPAMINE; DOPAMINERGIC NEURONS; HUMANS; INDUCED PLURIPOTENT STEM CELLS; MESENCEPHALON; MICE; MITOCHONDRIA; MODELS, BIOLOGICAL; MUTATION; ORGAN SPECIFICITY; PARKINSON DISEASE; PROTEIN KINASES; STRESS, PHYSIOLOGICAL; UBIQUITIN-PROTEIN LIGASES;

EID: 84992183855     PISSN: 22136711     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.stemcr.2016.08.012     Document Type: Article

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