Mutant Atp13a2 proteins involved in parkinsonism are degraded by ER-associated degradation and sensitize cells to ER-stress induced cell death

Human Molecular Genetics

Volumn 20, Issue 18, 2011, Pages 3565-3577

  Ugolino, Janet ^a   Fang, Shengyun ^a   Kubisch, Christian ^b,c   Monteiro, Mervyn J ^a  

^a UNIVERSITY OF MARYLAND SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY HOSPITAL OF COLOGNE   (Germany)

^c UNIVERSITY OF ULM   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ATP13A2 PROTEIN; BENZYLOXYCARBONYLLEUCYLLEUCYLLEUCINAL; CHLORMETHINE; MUTANT PROTEIN; PROTEIN P97; SMALL INTERFERING RNA; UNCLASSIFIED DRUG;

ARTICLE; CELL DEATH; CONTROLLED STUDY; CYTOPLASM; CYTOTOXICITY; ENDOPLASMIC RETICULUM; ENDOPLASMIC RETICULUM ASSOCIATED DEGRADATION; ENDOPLASMIC RETICULUM STRESS; FEMALE; GENE DISRUPTION; GENETIC CODE; HUMAN; HUMAN CELL; IMMUNOPRECIPITATION; PARKINSONISM; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN ASSEMBLY; PROTEIN DEGRADATION; PROTEIN DETERMINATION; PROTEIN EXPRESSION; PROTEIN FOLDING; PROTEIN LOCALIZATION; PROTEIN METABOLISM; UBIQUITINATION;

CELL DEATH; CELL LINE; ENDOPLASMIC RETICULUM STRESS; ENDOPLASMIC RETICULUM-ASSOCIATED DEGRADATION; HUMANS; MUTATION; PARKINSONIAN DISORDERS; PROTEASOME ENDOPEPTIDASE COMPLEX; PROTON-TRANSLOCATING ATPASES;

EID: 80052254663     PISSN: 09646906     EISSN: 14602083     Source Type: Journal    
DOI: 10.1093/hmg/ddr274     Document Type: Article

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