-
1
-
-
0033562966
-
Stress signaling from the lumen of the endoplasmic reticulum: coordination of gene transcriptional and translational controls
-
Kaufman R.J. Stress signaling from the lumen of the endoplasmic reticulum: coordination of gene transcriptional and translational controls. Genes Dev. 1999, 13:1211-1233.
-
(1999)
Genes Dev.
, vol.13
, pp. 1211-1233
-
-
Kaufman, R.J.1
-
2
-
-
34250899722
-
Signal integration in the endoplasmic reticulum unfolded protein response
-
Ron D., Walter P. Signal integration in the endoplasmic reticulum unfolded protein response. Nat. Rev. Mol. Cell Biol. 2007, 8:519-529.
-
(2007)
Nat. Rev. Mol. Cell Biol.
, vol.8
, pp. 519-529
-
-
Ron, D.1
Walter, P.2
-
3
-
-
0034698878
-
Cross-talk between two cysteine protease families. Activation of caspase-12 by calpain in apoptosis
-
Nakagawa T., Yuan J. Cross-talk between two cysteine protease families. Activation of caspase-12 by calpain in apoptosis. J. Cell Biol. 2000, 150:887-894.
-
(2000)
J. Cell Biol.
, vol.150
, pp. 887-894
-
-
Nakagawa, T.1
Yuan, J.2
-
4
-
-
0034610743
-
Caspase-12 mediates endoplasmic-reticulum-specific apoptosis and cytotoxicity by amyloid-beta
-
Nakagawa T., Zhu H., Morishima N., Li E., Xu J., Yankner B.A., Yuan J. Caspase-12 mediates endoplasmic-reticulum-specific apoptosis and cytotoxicity by amyloid-beta. Nature 2000, 403:98-103.
-
(2000)
Nature
, vol.403
, pp. 98-103
-
-
Nakagawa, T.1
Zhu, H.2
Morishima, N.3
Li, E.4
Xu, J.5
Yankner, B.A.6
Yuan, J.7
-
5
-
-
3943092621
-
Pathways towards and away from Alzheimer's disease
-
Mattson M.P. Pathways towards and away from Alzheimer's disease. Nature 2004, 430:631-639.
-
(2004)
Nature
, vol.430
, pp. 631-639
-
-
Mattson, M.P.1
-
6
-
-
33847662852
-
Soluble protein oligomers in neurodegeneration: lessons from the Alzheimer's amyloid beta-peptide
-
Haass C., Selkoe D.J. Soluble protein oligomers in neurodegeneration: lessons from the Alzheimer's amyloid beta-peptide. Nat. Rev. Mol. Cell Biol. 2007, 8:101-112.
-
(2007)
Nat. Rev. Mol. Cell Biol.
, vol.8
, pp. 101-112
-
-
Haass, C.1
Selkoe, D.J.2
-
7
-
-
49149124343
-
Amyloid-beta protein dimers isolated directly from Alzheimer's brains impair synaptic plasticity and memory
-
Shankar G.M., Li S., Mehta T.H., Garcia-Munoz A., Shepardson N.E., Smith I., Brett F.M., Farrell M.A., Rowan M.J., Lemere C.A., Regan C.M., Walsh D.M., Sabatini B.L., Selkoe D.J. Amyloid-beta protein dimers isolated directly from Alzheimer's brains impair synaptic plasticity and memory. Nat. Med. 2008, 14:837-842.
-
(2008)
Nat. Med.
, vol.14
, pp. 837-842
-
-
Shankar, G.M.1
Li, S.2
Mehta, T.H.3
Garcia-Munoz, A.4
Shepardson, N.E.5
Smith, I.6
Brett, F.M.7
Farrell, M.A.8
Rowan, M.J.9
Lemere, C.A.10
Regan, C.M.11
Walsh, D.M.12
Sabatini, B.L.13
Selkoe, D.J.14
-
8
-
-
79955484857
-
Abeta(1-42) inhibition of LTP is mediated by a signaling pathway involving caspase-3, Akt1 and GSK-3beta
-
Jo J., Whitcomb D.J., Olsen K.M., Kerrigan T.L., Lo S.C., Bru-Mercier G., Dickinson B., Scullion S., Sheng M., Collingridge G., Cho K. Abeta(1-42) inhibition of LTP is mediated by a signaling pathway involving caspase-3, Akt1 and GSK-3beta. Nat. Neurosci. 2011, 14:545-547.
-
(2011)
Nat. Neurosci.
, vol.14
, pp. 545-547
-
-
Jo, J.1
Whitcomb, D.J.2
Olsen, K.M.3
Kerrigan, T.L.4
Lo, S.C.5
Bru-Mercier, G.6
Dickinson, B.7
Scullion, S.8
Sheng, M.9
Collingridge, G.10
Cho, K.11
-
9
-
-
0033535553
-
Two transmembrane aspartates in presenilin-1 required for presenilin endoproteolysis and gamma-secretase activity
-
Wolfe M.S., Xia W., Ostaszewski B.L., Diehl T.S., Kimberly W.T., Selkoe D.J. Two transmembrane aspartates in presenilin-1 required for presenilin endoproteolysis and gamma-secretase activity. Nature 1999, 398:513-517.
-
(1999)
Nature
, vol.398
, pp. 513-517
-
-
Wolfe, M.S.1
Xia, W.2
Ostaszewski, B.L.3
Diehl, T.S.4
Kimberly, W.T.5
Selkoe, D.J.6
-
12
-
-
78650122129
-
Metabolic-cognitive syndrome: a cross-talk between metabolic syndrome and Alzheimer's disease
-
Frisardi V., Solfrizzi V., Seripa D., Capurso C., Santamato A., Sancarlo D., Vendemiale G., Pilotto A., Panza F. Metabolic-cognitive syndrome: a cross-talk between metabolic syndrome and Alzheimer's disease. Ageing Res. Rev. 2010, 9:399-417.
-
(2010)
Ageing Res. Rev.
, vol.9
, pp. 399-417
-
-
Frisardi, V.1
Solfrizzi, V.2
Seripa, D.3
Capurso, C.4
Santamato, A.5
Sancarlo, D.6
Vendemiale, G.7
Pilotto, A.8
Panza, F.9
-
13
-
-
77957898888
-
How does diabetes accelerate Alzheimer disease pathology?
-
Sims-Robinson C., Kim B., Rosko A., Feldman E.L. How does diabetes accelerate Alzheimer disease pathology?. Nat. Rev. Neurol. 2010, 6:551-559.
-
(2010)
Nat. Rev. Neurol.
, vol.6
, pp. 551-559
-
-
Sims-Robinson, C.1
Kim, B.2
Rosko, A.3
Feldman, E.L.4
-
14
-
-
77951028451
-
Diabetes-accelerated memory dysfunction via cerebrovascular inflammation and Abeta deposition in an Alzheimer mouse model with diabetes
-
Takeda S., Sato N., Uchio-Yamada K., Sawada K., Kunieda T., Takeuchi D., Kurinami H., Shinohara M., Rakugi H., Morishita R. Diabetes-accelerated memory dysfunction via cerebrovascular inflammation and Abeta deposition in an Alzheimer mouse model with diabetes. Proc. Natl. Acad. Sci. USA 2010, 107:7036-7041.
-
(2010)
Proc. Natl. Acad. Sci. USA
, vol.107
, pp. 7036-7041
-
-
Takeda, S.1
Sato, N.2
Uchio-Yamada, K.3
Sawada, K.4
Kunieda, T.5
Takeuchi, D.6
Kurinami, H.7
Shinohara, M.8
Rakugi, H.9
Morishita, R.10
-
15
-
-
77950343252
-
Endoplasmic reticulum stress and the inflammatory basis of metabolic disease
-
Hotamisligil G.S. Endoplasmic reticulum stress and the inflammatory basis of metabolic disease. Cell 2010, 140:900-917.
-
(2010)
Cell
, vol.140
, pp. 900-917
-
-
Hotamisligil, G.S.1
-
16
-
-
0036895383
-
Endoplasmic reticulum stress and the development of diabetes: a review
-
Harding H.P., Ron D. Endoplasmic reticulum stress and the development of diabetes: a review. Diabetes 2002, 51(Suppl. 3):S455-S461.
-
(2002)
Diabetes
, vol.51
, Issue.SUPPL. 3
-
-
Harding, H.P.1
Ron, D.2
-
17
-
-
0034968330
-
Diabetes mellitus and exocrine pancreatic dysfunction in perk-/- mice reveals a role for translational control in secretory cell survival
-
Harding H.P., Zeng H., Zhang Y., Jungries R., Chung P., Plesken H., Sabatini D.D., Ron D. Diabetes mellitus and exocrine pancreatic dysfunction in perk-/- mice reveals a role for translational control in secretory cell survival. Mol. Cell 2001, 7:1153-1163.
-
(2001)
Mol. Cell
, vol.7
, pp. 1153-1163
-
-
Harding, H.P.1
Zeng, H.2
Zhang, Y.3
Jungries, R.4
Chung, P.5
Plesken, H.6
Sabatini, D.D.7
Ron, D.8
-
18
-
-
5644231992
-
Endoplasmic reticulum stress links obesity, insulin action, and type 2 diabetes
-
Ozcan U., Cao Q., Yilmaz E., Lee A.H., Iwakoshi N.N., Ozdelen E., Tuncman G., Gorgun C., Glimcher L.H., Hotamisligil G.S. Endoplasmic reticulum stress links obesity, insulin action, and type 2 diabetes. Science 2004, 306:457-461.
-
(2004)
Science
, vol.306
, pp. 457-461
-
-
Ozcan, U.1
Cao, Q.2
Yilmaz, E.3
Lee, A.H.4
Iwakoshi, N.N.5
Ozdelen, E.6
Tuncman, G.7
Gorgun, C.8
Glimcher, L.H.9
Hotamisligil, G.S.10
-
19
-
-
77950523710
-
The regulatory subunits of PI3K, p85alpha and p85beta, interact with XBP-1 and increase its nuclear translocation
-
Park S.W., Zhou Y., Lee J., Lu A., Sun C., Chung J., Ueki K., Ozcan U. The regulatory subunits of PI3K, p85alpha and p85beta, interact with XBP-1 and increase its nuclear translocation. Nat. Med. 2010, 16:429-437.
-
(2010)
Nat. Med.
, vol.16
, pp. 429-437
-
-
Park, S.W.1
Zhou, Y.2
Lee, J.3
Lu, A.4
Sun, C.5
Chung, J.6
Ueki, K.7
Ozcan, U.8
-
20
-
-
77950537400
-
A regulatory subunit of phosphoinositide 3-kinase increases the nuclear accumulation of X-box-binding protein-1 to modulate the unfolded protein response
-
Winnay J.N., Boucher J., Mori M.A., Ueki K., Kahn C.R. A regulatory subunit of phosphoinositide 3-kinase increases the nuclear accumulation of X-box-binding protein-1 to modulate the unfolded protein response. Nat. Med. 2010, 16:438-445.
-
(2010)
Nat. Med.
, vol.16
, pp. 438-445
-
-
Winnay, J.N.1
Boucher, J.2
Mori, M.A.3
Ueki, K.4
Kahn, C.R.5
-
21
-
-
79952381078
-
Regulation of glucose homeostasis through a XBP-1-FoxO1 interaction
-
Zhou Y., Lee J., Reno C.M., Sun C., Park S.W., Chung J., Fisher S.J., White M.F., Biddinger S.B., Ozcan U. Regulation of glucose homeostasis through a XBP-1-FoxO1 interaction. Nat. Med. 2011, 17:356-365.
-
(2011)
Nat. Med.
, vol.17
, pp. 356-365
-
-
Zhou, Y.1
Lee, J.2
Reno, C.M.3
Sun, C.4
Park, S.W.5
Chung, J.6
Fisher, S.J.7
White, M.F.8
Biddinger, S.B.9
Ozcan, U.10
-
22
-
-
33748069813
-
Chemical chaperones reduce ER stress and restore glucose homeostasis in a mouse model of type 2 diabetes
-
Ozcan U., Yilmaz E., Ozcan L., Furuhashi M., Vaillancourt E., Smith R.O., Gorgun C.Z., Hotamisligil G.S. Chemical chaperones reduce ER stress and restore glucose homeostasis in a mouse model of type 2 diabetes. Science 2006, 313:1137-1140.
-
(2006)
Science
, vol.313
, pp. 1137-1140
-
-
Ozcan, U.1
Yilmaz, E.2
Ozcan, L.3
Furuhashi, M.4
Vaillancourt, E.5
Smith, R.O.6
Gorgun, C.Z.7
Hotamisligil, G.S.8
-
23
-
-
67749135249
-
The CREB coactivator CRTC2 links hepatic ER stress and fasting gluconeogenesis
-
Wang Y., Vera L., Fischer W.H., Montminy M. The CREB coactivator CRTC2 links hepatic ER stress and fasting gluconeogenesis. Nature 2009, 460:534-537.
-
(2009)
Nature
, vol.460
, pp. 534-537
-
-
Wang, Y.1
Vera, L.2
Fischer, W.H.3
Montminy, M.4
-
24
-
-
33845311194
-
ATF4 regulates gamma-secretase activity during amino acid imbalance
-
Mitsuda T., Hayakawa Y., Itoh M., Ohta K., Nakagawa T. ATF4 regulates gamma-secretase activity during amino acid imbalance. Biochem. Biophys. Res. Commun. 2007, 352:722-727.
-
(2007)
Biochem. Biophys. Res. Commun.
, vol.352
, pp. 722-727
-
-
Mitsuda, T.1
Hayakawa, Y.2
Itoh, M.3
Ohta, K.4
Nakagawa, T.5
-
25
-
-
77953726485
-
Autophagy impairment stimulates PS1 expression and gamma-secretase activity
-
Ohta K., Mizuno A., Ueda M., Li S., Suzuki Y., Hida Y., Hayakawa-Yano Y., Itoh M., Ohta E., Kobori M., Nakagawa T. Autophagy impairment stimulates PS1 expression and gamma-secretase activity. Autophagy 2010, 6:345-352.
-
(2010)
Autophagy
, vol.6
, pp. 345-352
-
-
Ohta, K.1
Mizuno, A.2
Ueda, M.3
Li, S.4
Suzuki, Y.5
Hida, Y.6
Hayakawa-Yano, Y.7
Itoh, M.8
Ohta, E.9
Kobori, M.10
Nakagawa, T.11
-
26
-
-
67349212612
-
An alternative spliced mouse presenilin-2 mRNA encodes a novel gamma-secretase inhibitor
-
Suzuki Y., Ohta K., Itoh M., Sakoh-Sumitomo Y., Mitsuda T., Ueda M., Hayakawa-Yano Y., Li S., Hida Y., Inuzuka T., Jung Y.K., Nakagawa T. An alternative spliced mouse presenilin-2 mRNA encodes a novel gamma-secretase inhibitor. FEBS Lett. 2009, 583:1403-1408.
-
(2009)
FEBS Lett.
, vol.583
, pp. 1403-1408
-
-
Suzuki, Y.1
Ohta, K.2
Itoh, M.3
Sakoh-Sumitomo, Y.4
Mitsuda, T.5
Ueda, M.6
Hayakawa-Yano, Y.7
Li, S.8
Hida, Y.9
Inuzuka, T.10
Jung, Y.K.11
Nakagawa, T.12
-
27
-
-
0033535504
-
A presenilin-1-dependent gamma-secretase-like protease mediates release of Notch intracellular domain
-
De Strooper B., Annaert W., Cupers P., Saftig P., Craessaerts K., Mumm J.S., Schroeter E.H., Schrijvers V., Wolfe M.S., Ray W.J., Goate A., Kopan R. A presenilin-1-dependent gamma-secretase-like protease mediates release of Notch intracellular domain. Nature 1999, 398:518-522.
-
(1999)
Nature
, vol.398
, pp. 518-522
-
-
De Strooper, B.1
Annaert, W.2
Cupers, P.3
Saftig, P.4
Craessaerts, K.5
Mumm, J.S.6
Schroeter, E.H.7
Schrijvers, V.8
Wolfe, M.S.9
Ray, W.J.10
Goate, A.11
Kopan, R.12
-
28
-
-
0020974133
-
Effect of tunicamycin, an inhibitor of protein glycosylation, on division of tumor cells in vitro
-
Savage K.E., Baur P.S. Effect of tunicamycin, an inhibitor of protein glycosylation, on division of tumor cells in vitro. J. Cell Sci. 1983, 64:295-306.
-
(1983)
J. Cell Sci.
, vol.64
, pp. 295-306
-
-
Savage, K.E.1
Baur, P.S.2
-
29
-
-
0030003538
-
Signal transduction by activated mNotch: importance of proteolytic processing and its regulation by the extracellular domain
-
Kopan R., Schroeter E.H., Weintraub H., Nye J.S. Signal transduction by activated mNotch: importance of proteolytic processing and its regulation by the extracellular domain. Proc. Natl. Acad. Sci. USA 1996, 93:1683-1688.
-
(1996)
Proc. Natl. Acad. Sci. USA
, vol.93
, pp. 1683-1688
-
-
Kopan, R.1
Schroeter, E.H.2
Weintraub, H.3
Nye, J.S.4
-
30
-
-
80052166441
-
Quercetin. Monograph
-
Kelly G.S. Quercetin. Monograph. Altern. Med. Rev. 2011, 16:172-194.
-
(2011)
Altern. Med. Rev.
, vol.16
, pp. 172-194
-
-
Kelly, G.S.1
-
32
-
-
77950887221
-
Flavonol activation defines an unanticipated ligand-binding site in the kinase-RNase domain of IRE1
-
Wiseman R.L., Zhang Y., Lee K.P., Harding H.P., Haynes C.M., Price J., Sicheri F., Ron D. Flavonol activation defines an unanticipated ligand-binding site in the kinase-RNase domain of IRE1. Mol. Cell 2010, 38:291-304.
-
(2010)
Mol. Cell
, vol.38
, pp. 291-304
-
-
Wiseman, R.L.1
Zhang, Y.2
Lee, K.P.3
Harding, H.P.4
Haynes, C.M.5
Price, J.6
Sicheri, F.7
Ron, D.8
-
33
-
-
0035947778
-
Feedback inhibition of the unfolded protein response by GADD34-mediated dephosphorylation of eIF2alpha
-
Novoa I., Zeng H., Harding H.P., Ron D. Feedback inhibition of the unfolded protein response by GADD34-mediated dephosphorylation of eIF2alpha. J. Cell Biol. 2001, 153:1011-1022.
-
(2001)
J. Cell Biol.
, vol.153
, pp. 1011-1022
-
-
Novoa, I.1
Zeng, H.2
Harding, H.P.3
Ron, D.4
-
34
-
-
70350539531
-
Atf4 regulates obesity, glucose homeostasis, and energy expenditure
-
Seo J., Fortuno E.S., Suh J.M., Stenesen D., Tang W., Parks E.J., Adams C.M., Townes T., Graff J.M. Atf4 regulates obesity, glucose homeostasis, and energy expenditure. Diabetes 2009, 58:2565-2573.
-
(2009)
Diabetes
, vol.58
, pp. 2565-2573
-
-
Seo, J.1
Fortuno, E.S.2
Suh, J.M.3
Stenesen, D.4
Tang, W.5
Parks, E.J.6
Adams, C.M.7
Townes, T.8
Graff, J.M.9
|