ENC1 Modulates the Aggregation and Neurotoxicity of Mutant Huntingtin Through p62 Under ER Stress

Molecular Neurobiology

Volumn 53, Issue 10, 2016, Pages 6620-6634

  Lee, Huikyong ^a   Ahn, Hye Hyun ^a   Lee, Won Jae ^a   Oh, Yumin ^a,c   Choi, Hyunwoo ^a   Shim, Sang Mi ^a   Shin, Jaekyoon ^b   Jung, Yong Keun ^a  

^a Seoul National University   (South Korea)

^b Sungkyunkwan University School of Medicine   (South Korea)

^c JOHNS HOPKINS UNIVERSITY   (United States)

Author keywords

Aggregation; Autophagy; ENC1; ER stress; Huntington s disease; p62 SQSTM1

Indexed keywords

BINDING PROTEIN; ECTODERMAL NEURAL CORTEX 1 PROTEIN; HUNTINGTIN; MUTANT PROTEIN; PROTEIN IRE1; PROTEIN P62; REGULATOR PROTEIN; SERINE; STRESS ACTIVATED PROTEIN KINASE; TUMOR NECROSIS FACTOR RECEPTOR ASSOCIATED FACTOR 2; UNCLASSIFIED DRUG; ACTIN BINDING PROTEIN; ECTODERMAL-NEURAL CORTEX 1 PROTEIN; ERN1 PROTEIN, HUMAN; NEUROPEPTIDE; NEUROTOXIN; NUCLEAR PROTEIN; PROTEASOME; PROTEIN AGGREGATE; PROTEIN BINDING; PROTEIN SERINE THREONINE KINASE; RIBONUCLEASE; SEQUESTOSOME 1; SQSTM1 PROTEIN, HUMAN; SQSTM1 PROTEIN, MOUSE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; AUTOPHAGY; CARBOXY TERMINAL SEQUENCE; CONTROLLED STUDY; DOWN REGULATION; EMBRYO; ENDOPLASMIC RETICULUM STRESS; HUMAN; HUMAN CELL; IMMUNOCYTOCHEMISTRY; IMMUNOPRECIPITATION; MOUSE; NERVE CELL NECROSIS; NEUROTOXICITY; NONHUMAN; PROTEIN AGGREGATION; PROTEIN BINDING; PROTEIN DEGRADATION; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN LOCALIZATION; PROTEIN PHOSPHORYLATION; PROTEIN PROTEIN INTERACTION; UBIQUITINATION; ANIMAL; DRUG EFFECTS; HEK293 CELL LINE; METABOLISM; NERVE CELL; PATHOLOGY; PHOSPHORYLATION; TUMOR CELL LINE;

ANIMALS; AUTOPHAGY; CELL LINE, TUMOR; ENDOPLASMIC RETICULUM STRESS; ENDORIBONUCLEASES; HEK293 CELLS; HUMANS; HUNTINGTIN PROTEIN; JNK MITOGEN-ACTIVATED PROTEIN KINASES; MICE; MICROFILAMENT PROTEINS; MUTANT PROTEINS; NEURONS; NEUROPEPTIDES; NEUROTOXINS; NUCLEAR PROTEINS; PHOSPHORYLATION; PROTEASOME ENDOPEPTIDASE COMPLEX; PROTEIN AGGREGATES; PROTEIN BINDING; PROTEIN-SERINE-THREONINE KINASES; PROTEOLYSIS; SEQUESTOSOME-1 PROTEIN; TNF RECEPTOR-ASSOCIATED FACTOR 2;

EID: 84949512969     PISSN: 08937648     EISSN: 15591182     Source Type: Journal    
DOI: 10.1007/s12035-015-9557-8     Document Type: Article

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