TNF-α mediates PKR-dependent memory impairment and brain IRS-1 inhibition induced by Alzheimer's β-amyloid oligomers in mice and monkeys

Cell Metabolism

Volumn 18, Issue 6, 2013, Pages 831-843

  Lourenco, Mychael V ^a   Clarke, Julia R ^a   Frozza, Rudimar L ^a   Bomfim, Theresa R ^a   Forny Germano, Letícia ^a   Batista, André F ^a   Sathler, Luciana B ^a   Brito Moreira, Jordano ^a   Amaral, Olavo B ^a   Silva, Cesar A ^a   Freitas Correa, Léo ^a   Espírito Santo, Sheila ^b   Campello Costa, Paula ^b   Houzel, Jean Christophe ^a   Klein, William L ^c   Holscher, Christian ^d   Carvalheira, José B ^e   Silva, Aristobolo M ^f,g   Velloso, Lício A ^e   Munoz, Douglas P ^h   Ferreira, Sergio T ^a   De Felice, Fernanda G ^a   more..

^a FEDERAL UNIVERSITY OF RIO DE JANEIRO   (Brazil)

^b FLUMINENSE FEDERAL UNIVERSITY   (Brazil)

^c NORTHWESTERN UNIVERSITY   (United States)

^d LANCASTER UNIVERSITY   (United Kingdom)

^e UNIVERSITY OF CAMPINAS   (Brazil)

^f FEDERAL UNIVERSITY OF MINAS GERAIS   (Brazil)

^g INSTITUTO OSWALDO CRUZ   (Brazil)

^h QUEEN S UNIVERSITY   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

AMYLOID BETA PROTEIN; ANTHRA[1,9 CD]PYRAZOL 6(2H) ONE; GLUCAGON LIKE PEPTIDE 1; INFLIXIMAB; INITIATION FACTOR 2ALPHA; INSULIN RECEPTOR SUBSTRATE 1; OLIGOMER; POSTSYNAPTIC DENSITY PROTEIN 95; PROTEIN KINASE R; SALUBRINAL; SYNAPTOPHYSIN; THAPSIGARGIN; TUMOR NECROSIS FACTOR ALPHA; TUMOR NECROSIS FACTOR ALPHA RECEPTOR;

ALZHEIMER DISEASE; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CELL LOSS; COGNITIVE DEFECT; CONTROLLED STUDY; DIABETES MELLITUS; ENDOPLASMIC RETICULUM STRESS; HAPLORHINI; HIPPOCAMPAL NEURONAL CULTURE; INSULIN RESISTANCE; MACACA FASCICULARIS; MEMORY DISORDER; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION; SYNAPSE; UNFOLDED PROTEIN RESPONSE;

ALZHEIMER DISEASE; AMYLOID BETA-PEPTIDES; ANIMALS; BRAIN; DISEASE MODELS, ANIMAL; EIF-2 KINASE; HAPLORHINI; HYPOGLYCEMIC AGENTS; INSULIN RECEPTOR SUBSTRATE PROTEINS; MEMORY DISORDERS; MICE; MICE, KNOCKOUT; NEURONS; PHOSPHORYLATION; POLYMERS; RECEPTORS, TUMOR NECROSIS FACTOR, TYPE I; SIGNAL TRANSDUCTION; SYNAPSES; TUMOR NECROSIS FACTOR-ALPHA;

EID: 84889656503     PISSN: 15504131     EISSN: 19327420     Source Type: Journal    
DOI: 10.1016/j.cmet.2013.11.002     Document Type: Article

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