Repression of the eIF2α kinase PERK alleviates mGluR-LTD impairments in a mouse model of Alzheimer's disease

Neurobiology of Aging

Volumn 41, Issue , 2016, Pages 19-24

  Yang, Wenzhong ^a   Zhou, Xueyan ^a   Zimmermann, Helena R ^a   Cavener, Douglas R ^b   Klann, Eric ^c   Ma, Tao ^a  

^a WAKE FOREST SCHOOL OF MEDICINE   (United States)

^b PENNSYLVANIA STATE UNIVERSITY   (United States)

^c NEW YORK UNIVERSITY   (United States)

Author keywords

Alzheimer's disease; EIF2 ; MGluR LTD; PERK; Protein synthesis; Synaptic plasticity

Indexed keywords

METABOTROPIC RECEPTOR 5; PROTEIN KINASE R; AMYLOID BETA PROTEIN; EIF2ALPHA KINASE, MOUSE; PERK KINASE; PROTEIN SERINE THREONINE KINASE;

ALZHEIMER DISEASE; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME PHOSPHORYLATION; ENZYME REPRESSION; GENE DELETION; GENE EXPRESSION; HIPPOCAMPAL CA1 REGION; HIPPOCAMPAL CA3 REGION; LONG TERM DEPRESSION; MOUSE; NERVE CELL EXCITABILITY; NEUROPATHOLOGY; NONHUMAN; PERK GENE; PRIORITY JOURNAL; PROTEIN SYNTHESIS; ANIMAL; ANTAGONISTS AND INHIBITORS; COGNITION; DISEASE MODEL; FEMALE; GENETICS; HIPPOCAMPUS; LONG TERM POTENTIATION; MALE; METABOLISM; NERVE CELL PLASTICITY; PATHOPHYSIOLOGY; PHOSPHORYLATION; PHYSIOLOGY; TRANSGENIC MOUSE;

ALZHEIMER DISEASE; AMYLOID BETA-PEPTIDES; ANIMALS; COGNITION; DISEASE MODELS, ANIMAL; EIF-2 KINASE; FEMALE; HIPPOCAMPUS; LONG-TERM POTENTIATION; LONG-TERM SYNAPTIC DEPRESSION; MALE; MICE, TRANSGENIC; NEURONAL PLASTICITY; PHOSPHORYLATION; PROTEIN-SERINE-THREONINE KINASES; RECEPTOR, METABOTROPIC GLUTAMATE 5;

EID: 84963680128     PISSN: 01974580     EISSN: 15581497     Source Type: Journal    
DOI: 10.1016/j.neurobiolaging.2016.02.005     Document Type: Article

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