-
1
-
-
13644256191
-
A selective inhibitor of eIF2alpha dephosphorylation protects cells from ER stress
-
Boyce M, Bryant KF, Jousse C, Long K, Harding HP, Scheuner D, Kaufman RJ, Ma D, Coen DM, Ron D, Yuan J (2005) A selective inhibitor of eIF2alpha dephosphorylation protects cells from ER stress. Science 307:935-939.
-
(2005)
Science
, vol.307
, pp. 935-939
-
-
Boyce, M.1
Bryant, K.F.2
Jousse, C.3
Long, K.4
Harding, H.P.5
Scheuner, D.6
Kaufman, R.J.7
Ma, D.8
Coen, D.M.9
Ron, D.10
Yuan, J.11
-
2
-
-
84863230467
-
Endoplasmic reticulum stress is important for the manifestations of α-synucleinopathy in vivo
-
Colla E, Coune P, Liu Y, Pletnikova O, Troncoso JC, Iwatsubo T, Schneider BL, Lee MK (2012) Endoplasmic reticulum stress is important for the manifestations of α-synucleinopathy in vivo. J Neurosci 32:3306-3320.
-
(2012)
J Neurosci
, vol.32
, pp. 3306-3320
-
-
Colla, E.1
Coune, P.2
Liu, Y.3
Pletnikova, O.4
Troncoso, J.C.5
Iwatsubo, T.6
Schneider, B.L.7
Lee, M.K.8
-
3
-
-
33746533924
-
Alpha-synuclein blocks ER-Golgi traffic and Rab1 rescues neuron loss in Parkinson's models
-
Cooper AA, Gitler AD, Cashikar A, Haynes CM, Hill KJ, Bhullar B, Liu K, Xu K, Strathearn KE, Liu F, Cao S, Caldwell KA, Caldwell GA, Marsischky G, Kolodner RD, Labaer J, Rochet JC, Bonini NM, Lindquist S (2006) Alpha-synuclein blocks ER-Golgi traffic and Rab1 rescues neuron loss in Parkinson's models. Science 313:324-328.
-
(2006)
Science
, vol.313
, pp. 324-328
-
-
Cooper, A.A.1
Gitler, A.D.2
Cashikar, A.3
Haynes, C.M.4
Hill, K.J.5
Bhullar, B.6
Liu, K.7
Xu, K.8
Strathearn, K.E.9
Liu, F.10
Cao, S.11
Caldwell, K.A.12
Caldwell, G.A.13
Marsischky, G.14
Kolodner, R.D.15
Labaer, J.16
Rochet, J.C.17
Bonini, N.M.18
Lindquist, S.19
-
4
-
-
34249053821
-
Tissue subcellular fractionation and protein extraction for use in mass-spectrometry-based proteomics
-
Cox B, Emili A (2006) Tissue subcellular fractionation and protein extraction for use in mass-spectrometry-based proteomics. Nat Protoc 1:1872-1878.
-
(2006)
Nat Protoc
, vol.1
, pp. 1872-1878
-
-
Cox, B.1
Emili, A.2
-
5
-
-
0021340291
-
Isolation of plasma membrane, golgi apparatus, and endoplasmic reticulum fractions from single homogenates of mouse liver
-
Croze EM, Morré DJ (1984) Isolation of plasma membrane, golgi apparatus, and endoplasmic reticulum fractions from single homogenates of mouse liver. J Cell Physiol 119:46-57.
-
(1984)
J Cell Physiol
, vol.119
, pp. 46-57
-
-
Croze, E.M.1
Morré, D.J.2
-
6
-
-
69149089854
-
Inclusion formation and neuronal cell death through neuron-to-neuron transmission of alpha-synuclein
-
Desplats P, Lee HJ, Bae EJ, Patrick C, Rockenstein E, Crews L, Spencer B, Masliah E, Lee SJ (2009) Inclusion formation and neuronal cell death through neuron-to-neuron transmission of alpha-synuclein. Proc Natl Acad Sci U S A 106:13010-13015.
-
(2009)
Proc Natl Acad Sci U S A
, vol.106
, pp. 13010-13015
-
-
Desplats, P.1
Lee, H.J.2
Bae, E.J.3
Patrick, C.4
Rockenstein, E.5
Crews, L.6
Spencer, B.7
Masliah, E.8
Lee, S.J.9
-
7
-
-
0033678217
-
Widespread nitration of pathological inclusions in neurodegenerative synucleinopathies
-
Duda JE, Giasson BI, Chen Q, Gur TL, Hurtig HI, Stern MB, Gollomp SM, Ischiropoulos H, Lee VM, Trojanowski JQ (2000) Widespread nitration of pathological inclusions in neurodegenerative synucleinopathies. Am J Pathol 157:1439-1445.
-
(2000)
Am J Pathol
, vol.157
, pp. 1439-1445
-
-
Duda, J.E.1
Giasson, B.I.2
Chen, Q.3
Gur, T.L.4
Hurtig, H.I.5
Stern, M.B.6
Gollomp, S.M.7
Ischiropoulos, H.8
Lee, V.M.9
Trojanowski, J.Q.10
-
8
-
-
0036174010
-
alpha-Synuclein is phosphorylated in synucleinopathy lesions
-
Fujiwara H, Hasegawa M, Dohmae N, Kawashima A, Masliah E, Goldberg MS, Shen J, Takio K, Iwatsubo T (2002) alpha-Synuclein is phosphorylated in synucleinopathy lesions. Nat Cell Biol 4:160-164.
-
(2002)
Nat Cell Biol
, vol.4
, pp. 160-164
-
-
Fujiwara, H.1
Hasegawa, M.2
Dohmae, N.3
Kawashima, A.4
Masliah, E.5
Goldberg, M.S.6
Shen, J.7
Takio, K.8
Iwatsubo, T.9
-
9
-
-
0037073748
-
Golgi fragmentation occurs in the cells with prefibrillar alpha-synuclein aggregates and precedes the formation of fibrillar inclusion
-
Gosavi N, Lee HJ, Lee JS, Patel S, Lee SJ (2002) Golgi fragmentation occurs in the cells with prefibrillar alpha-synuclein aggregates and precedes the formation of fibrillar inclusion. J Biol Chem 277:48984-48992.
-
(2002)
J Biol Chem
, vol.277
, pp. 48984-48992
-
-
Gosavi, N.1
Lee, H.J.2
Lee, J.S.3
Patel, S.4
Lee, S.J.5
-
10
-
-
0242668337
-
Common structure of soluble amyloid oligomers implies common mechanism of pathogenesis
-
Kayed R, Head E, Thompson JL, McIntire TM, Milton SC, Cotman CW, Glabe CG (2003) Common structure of soluble amyloid oligomers implies common mechanism of pathogenesis. Science 300:486-489.
-
(2003)
Science
, vol.300
, pp. 486-489
-
-
Kayed, R.1
Head, E.2
Thompson, J.L.3
McIntire, T.M.4
Milton, S.C.5
Cotman, C.W.6
Glabe, C.G.7
-
11
-
-
33750361540
-
A century-old debate on protein aggregation and neurodegeneration enters the clinic
-
Lansbury PT, Lashuel HA (2006) A century-old debate on protein aggregation and neurodegeneration enters the clinic. Nature 443:774-779.
-
(2006)
Nature
, vol.443
, pp. 774-779
-
-
Lansbury, P.T.1
Lashuel, H.A.2
-
12
-
-
0037173006
-
Human alpha-synuclein-harboring familial Parkinson's disease-linked Ala-53 → Thr mutation causes neurodegenerative disease with alpha-synuclein aggregation in transgenic mice
-
Lee MK, Stirling W, Xu Y, Xu X, Qui D, Mandir AS, Dawson TM, Copeland NG, Jenkins NA, Price DL (2002) Human alpha-synuclein-harboring familial Parkinson's disease-linked Ala-53 → Thr mutation causes neurodegenerative disease with alpha-synuclein aggregation in transgenic mice. Proc Natl Acad Sci U S A 99:8968-8973.
-
(2002)
Proc Natl Acad Sci U S A
, vol.99
, pp. 8968-8973
-
-
Lee, M.K.1
Stirling, W.2
Xu, Y.3
Xu, X.4
Qui, D.5
Mandir, A.S.6
Dawson, T.M.7
Copeland, N.G.8
Jenkins, N.A.9
Price, D.L.10
-
13
-
-
7244243876
-
Stabilization of α-synuclein protein with aging and familial Parkinson's disease-linked A53T mutation
-
Li W, Lesuisse C, Xu Y, Troncoso JC, Price DL, Lee MK (2004) Stabilization of α-synuclein protein with aging and familial Parkinson's disease-linked A53T mutation. J Neurosci 24:7400-7409.
-
(2004)
J Neurosci
, vol.24
, pp. 7400-7409
-
-
Li, W.1
Lesuisse, C.2
Xu, Y.3
Troncoso, J.C.4
Price, D.L.5
Lee, M.K.6
-
14
-
-
13844320376
-
Aggregation promoting C-terminal truncation of alpha-synuclein is a normal cellular process and is enhanced by the familial Parkinson's disease-linked mutations
-
Li W, West N, Colla E, Pletnikova O, Troncoso JC, Marsh L, Dawson TM, Jäkälä P, Hartmann T, Price DL, Lee MK (2005) Aggregation promoting C-terminal truncation of alpha-synuclein is a normal cellular process and is enhanced by the familial Parkinson's disease-linked mutations. Proc Natl Acad Sci U S A 102:2162-2167.
-
(2005)
Proc Natl Acad Sci U S A
, vol.102
, pp. 2162-2167
-
-
Li, W.1
West, N.2
Colla, E.3
Pletnikova, O.4
Troncoso, J.C.5
Marsh, L.6
Dawson, T.M.7
Jäkälä, P.8
Hartmann, T.9
Price, D.L.10
Lee, M.K.11
-
15
-
-
1842424791
-
Proteasomal inhibition by alpha-synuclein filaments and oligomers
-
Lindersson E, Beedholm R, Højrup P, Moos T, Gai W, Hendil KB, Jensen PH (2004) Proteasomal inhibition by alpha-synuclein filaments and oligomers. J Biol Chem 279:12924-12934.
-
(2004)
J Biol Chem
, vol.279
, pp. 12924-12934
-
-
Lindersson, E.1
Beedholm, R.2
Højrup, P.3
Moos, T.4
Gai, W.5
Hendil, K.B.6
Jensen, P.H.7
-
16
-
-
30644471051
-
Parkinson's disease α-synuclein transgenic mice develop neuronal mitochondrial degeneration and cell death
-
Martin LJ, Pan Y, Price AC, Sterling W, Copeland NG, Jenkins NA, Price DL, Lee MK (2006) Parkinson's disease α-synuclein transgenic mice develop neuronal mitochondrial degeneration and cell death. J Neurosci 26:41-50.
-
(2006)
J Neurosci
, vol.26
, pp. 41-50
-
-
Martin, L.J.1
Pan, Y.2
Price, A.C.3
Sterling, W.4
Copeland, N.G.5
Jenkins, N.A.6
Price, D.L.7
Lee, M.K.8
-
17
-
-
38849174979
-
Dopamine-modified alpha-synuclein blocks chaperone-mediated autophagy
-
Martinez-Vicente M, Talloczy Z, Kaushik S, Massey AC, Mazzulli J, Mosharov EV, Hodara R, Fredenburg R, Wu DC, Follenzi A, Dauer W, Przedborski S, Ischiropoulos H, Lansbury PT, Sulzer D, Cuervo AM (2008) Dopamine-modified alpha-synuclein blocks chaperone-mediated autophagy. J Clin Invest 118:777-788.
-
(2008)
J Clin Invest
, vol.118
, pp. 777-788
-
-
Martinez-Vicente, M.1
Talloczy, Z.2
Kaushik, S.3
Massey, A.C.4
Mazzulli, J.5
Mosharov, E.V.6
Hodara, R.7
Fredenburg, R.8
Wu, D.C.9
Follenzi, A.10
Dauer, W.11
Przedborski, S.12
Ischiropoulos, H.13
Lansbury, P.T.14
Sulzer, D.15
Cuervo, A.M.16
-
18
-
-
77953229747
-
Missing pieces in the Parkinson's disease puzzle
-
Obeso JA, Rodriguez-Oroz MC, Goetz CG, Marin C, Kordower JH, Rodriguez M, Hirsch EC, Farrer M, Schapira AH, Halliday G (2010) Missing pieces in the Parkinson's disease puzzle. Nat Med 16:653-661.
-
(2010)
Nat Med
, vol.16
, pp. 653-661
-
-
Obeso, J.A.1
Rodriguez-Oroz, M.C.2
Goetz, C.G.3
Marin, C.4
Kordower, J.H.5
Rodriguez, M.6
Hirsch, E.C.7
Farrer, M.8
Schapira, A.H.9
Halliday, G.10
-
19
-
-
65249162241
-
Detection of elevated levels of soluble alpha-synuclein oligomers in postmortem brain extracts from patients with dementia with Lewy bodies
-
Paleologou KE, Kragh CL, Mann DM, Salem SA, Al-Shami R, Allsop D, Hassan AH, Jensen PH, El-Agnaf OM (2009) Detection of elevated levels of soluble alpha-synuclein oligomers in postmortem brain extracts from patients with dementia with Lewy bodies. Brain 132:1093-1101.
-
(2009)
Brain
, vol.132
, pp. 1093-1101
-
-
Paleologou, K.E.1
Kragh, C.L.2
Mann, D.M.3
Salem, S.A.4
Al-Shami, R.5
Allsop, D.6
Hassan, A.H.7
Jensen, P.H.8
El-Agnaf, O.M.9
-
20
-
-
29644434199
-
Endoplasmic reticulum stress and mitochondrial cell death pathways mediate A53T mutant alpha-synuclein-induced toxicity
-
Smith WW, Jiang H, Pei Z, Tanaka Y, Morita H, Sawa A, Dawson VL, Dawson TM, Ross CA (2005) Endoplasmic reticulum stress and mitochondrial cell death pathways mediate A53T mutant alpha-synuclein-induced toxicity. Hum Mol Genet 14:3801-3811.
-
(2005)
Hum Mol Genet
, vol.14
, pp. 3801-3811
-
-
Smith, W.W.1
Jiang, H.2
Pei, Z.3
Tanaka, Y.4
Morita, H.5
Sawa, A.6
Dawson, V.L.7
Dawson, T.M.8
Ross, C.A.9
-
21
-
-
77749341440
-
Distinct region-specific α-synuclein oligomers in A53T transgenic mice: Implications for neurodegeneration
-
Tsika E, Moysidou M, Guo J, Cushman M, Gannon P, Sandaltzopoulos R, Giasson BI, Krainc D, Ischiropoulos H, Mazzulli JR (2010) Distinct region-specific α-synuclein oligomers in A53T transgenic mice: implications for neurodegeneration. J Neurosci 30:3409-3418.
-
(2010)
J Neurosci
, vol.30
, pp. 3409-3418
-
-
Tsika, E.1
Moysidou, M.2
Guo, J.3
Cushman, M.4
Gannon, P.5
Sandaltzopoulos, R.6
Giasson, B.I.7
Krainc, D.8
Ischiropoulos, H.9
Mazzulli, J.R.10
-
22
-
-
14944385595
-
Mutant superoxide dismutase 1 forms aggregates in the brain mitochondrial matrix of amyotrophic lateral sclerosis mice
-
Vijayvergiya C, Beal MF, Buck J, Manfredi G (2005) Mutant superoxide dismutase 1 forms aggregates in the brain mitochondrial matrix of amyotrophic lateral sclerosis mice. J Neurosci 25:2463-2470.
-
(2005)
J Neurosci
, vol.25
, pp. 2463-2470
-
-
Vijayvergiya, C.1
Beal, M.F.2
Buck, J.3
Manfredi, G.4
-
23
-
-
3142523288
-
Genetic clues to the pathogenesis of Parkinson's disease
-
Vila M, Przedborski S (2004) Genetic clues to the pathogenesis of Parkinson's disease. Nat Med [10 Suppl]:S58-S62.
-
(2004)
Nat Med
, Issue.10 SUPPL.
-
-
Vila, M.1
Przedborski, S.2
-
24
-
-
0038386274
-
Zeroing in on the pathogenic form of alpha-synuclein and its mechanism of neurotoxicity in Parkinson's disease
-
Volles MJ, Lansbury PT Jr (2003) Zeroing in on the pathogenic form of alpha-synuclein and its mechanism of neurotoxicity in Parkinson's disease. Biochemistry 42:7871-7878.
-
(2003)
Biochemistry
, vol.42
, pp. 7871-7878
-
-
Volles, M.J.1
Lansbury Jr., P.T.2
-
25
-
-
39749113234
-
Differential regulation of small heat shock proteins in transgenic mouse models of neurodegenerative diseases
-
Wang J, Martin E, Gonzales V, Borchelt DR, Lee MK (2008) Differential regulation of small heat shock proteins in transgenic mouse models of neurodegenerative diseases. Neurobiol Aging 29:586-597.
-
(2008)
Neurobiol Aging
, vol.29
, pp. 586-597
-
-
Wang, J.1
Martin, E.2
Gonzales, V.3
Borchelt, D.R.4
Lee, M.K.5
-
26
-
-
77957189194
-
alpha-Synuclein impairs macroautophagy: Implications for Parkinson's disease
-
Winslow AR, Chen CW, Corrochano S, Acevedo-Arozena A, Gordon DE, Peden AA, Lichtenberg M, Menzies FM, Ravikumar B, Imarisio S, Brown S, O'Kane CJ, Rubinsztein DC (2010) alpha-Synuclein impairs macroautophagy: implications for Parkinson's disease. J Cell Biol 190:1023-1037.
-
(2010)
J Cell Biol
, vol.190
, pp. 1023-1037
-
-
Winslow, A.R.1
Chen, C.W.2
Corrochano, S.3
Acevedo-Arozena, A.4
Gordon, D.E.5
Peden, A.A.6
Lichtenberg, M.7
Menzies, F.M.8
Ravikumar, B.9
Imarisio, S.10
Brown, S.11
O'Kane, C.J.12
Rubinsztein, D.C.13
|