Up-regulation of activating transcription factor 4 induces severe loss of dopamine nigral neurons in a rat model of Parkinson's disease

Neuroscience Letters

Volumn 627, Issue , 2016, Pages 36-41

  Gully, Joseph C ^a   Sergeyev, Valeriy G ^a,b   Bhootada, Yogesh ^a   Mendez Gomez, Hector ^c   Meyers, Craig A ^a   Zolotukhin, Sergey ^c   Gorbatyuk, Marina S ^a   Gorbatyuk, Oleg S ^a,d  

^a UNIVERSITY OF ALABAMA AT BIRMINGHAM   (United States)

^b UDMURT STATE UNIVERSITY   (Russian Federation)

^c UNIVERSITY OF FLORIDA COLLEGE OF MEDICINE   (United States)

^d The University of Alabama at Birmingham   (United States)

Author keywords

AAV; Alpha synuclein; ATF4; ER stress response; Parkinson's disease

Indexed keywords

ACTIVATING TRANSCRIPTION FACTOR 4; ADENOVIRUS VECTOR; CASPASE 3; CASPASE 7; DOPAMINE; GREEN FLUORESCENT PROTEIN; ALPHA SYNUCLEIN; ATF4 PROTEIN, RAT; CASP3 PROTEIN, RAT; TYROSINE 3 MONOOXYGENASE;

ADENO ASSOCIATED VIRUS; ADULT; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CELL LOSS; CELL SURVIVAL; CONTROLLED STUDY; ENZYME ACTIVATION; FEMALE; GENE OVEREXPRESSION; GENE TRANSFER; NERVE CELL NECROSIS; NERVE DEGENERATION; NEUROPROTECTION; NONHUMAN; PARKINSON DISEASE; PRIORITY JOURNAL; PROMOTER REGION; RAT; STOP CODON; SUBSTANTIA NIGRA PARS COMPACTA; UPREGULATION; WILD TYPE; ANIMAL; DISEASE MODEL; DOPAMINERGIC NERVE CELL; GENETICS; HUMAN; METABOLISM; PATHOLOGY; SPRAGUE DAWLEY RAT;

ACTIVATING TRANSCRIPTION FACTOR 4; ALPHA-SYNUCLEIN; ANIMALS; APOPTOSIS; CASPASE 3; CASPASE 7; DISEASE MODELS, ANIMAL; DOPAMINERGIC NEURONS; FEMALE; HUMANS; PARKINSON DISEASE; PARS COMPACTA; RATS; RATS, SPRAGUE-DAWLEY; TYROSINE 3-MONOOXYGENASE; UP-REGULATION;

EID: 84973164070     PISSN: 03043940     EISSN: 18727972     Source Type: Journal    
DOI: 10.1016/j.neulet.2016.05.039     Document Type: Article

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