Phosphorylation of the Translation Initiation Factor eIF2α Increases BACE1 Levels and Promotes Amyloidogenesis

Neuron

Volumn 60, Issue 6, 2008, Pages 988-1009

  O'Connor, Tracy ^a   Sadleir, Katherine R ^a   Maus, Erika ^a   Velliquette, Rodney A ^a   Zhao, Jie ^a   Cole, Sarah L ^a   Eimer, William A ^a   Hitt, Brian ^a   Bembinster, Leslie A ^a   Lammich, Sven ^b   Lichtenthaler, Stefan F ^b   Hébert, Sébastien S ^c   De Strooper, Bart ^c   Haass, Christian ^b   Bennett, David A ^d   Vassar, Robert ^a  

^a NORTHWESTERN UNIVERSITY   (United States)

^b UNIVERSITY OF MUNICH   (Germany)

^c DEPARTMENT OF PLANT SYSTEMS BIOLOGY   (Belgium)

^d RUSH UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

CELLBIO; HUMDISEASE; MOLNEURO

Indexed keywords

AMYLOID BETA PROTEIN; BETA SECRETASE; INITIATION FACTOR 2ALPHA; PROTEIN BACE1; PROTEIN P58; SALUBRINAL; THIOUREA DERIVATIVE; UNCLASSIFIED DRUG;

ALZHEIMER DISEASE; ANIMAL EXPERIMENT; ARTICLE; BRAIN NERVE CELL; CONTROLLED STUDY; ENERGY; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; TRANSLATION INITIATION;

AGE FACTORS; AGED, 80 AND OVER; ALZHEIMER DISEASE; AMYLOID BETA-PROTEIN; AMYLOID BETA-PROTEIN PRECURSOR; AMYLOID PRECURSOR PROTEIN SECRETASES; ANIMALS; ANTIMETABOLITES; ASPARTIC ENDOPEPTIDASES; CELLS, CULTURED; CEREBRAL CORTEX; CONVULSANTS; DACTINOMYCIN; DEOXYGLUCOSE; DISEASE MODELS, ANIMAL; EIF-2 KINASE; EMBRYO, MAMMALIAN; ENZYME ACTIVATION; GENE EXPRESSION REGULATION; GLUCOSE; HUMANS; MICE; MICE, INBRED C57BL; MICE, TRANSGENIC; NEURONS; NITRO COMPOUNDS; PEPTIDE FRAGMENTS; PHOSPHORYLATION; PROPIONIC ACIDS; PROTEIN SYNTHESIS INHIBITORS; SENILE PLAQUES; TIME FACTORS; TRANSCRIPTION FACTORS; TRANSFECTION;

EID: 57649245230     PISSN: 08966273     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.neuron.2008.10.047     Document Type: Article

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