Guanabenz treatment accelerates disease in a mutant SOD1 mouse model of ALS

PLoS ONE

Volumn 10, Issue 8, 2015, Pages

  Vieira, Fernando G ^a   Ping, Qinggong ^a   Moreno, Andy J ^a   Kidd, Joshua D ^a   Thompson, Kenneth ^a   Jiang, Bingbing ^a   Lincecum, John M ^a   Wang, Monica Z ^a   De Zutter, Gerard S ^a   Tassinari, Valerie R ^a   Levine, Beth ^a   Hatzipetros, Theo ^a   Gill, Alan ^a   Perrin, Steven ^a  

^a ALS Therapy Development Institute   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

COPPER ZINC SUPEROXIDE DISMUTASE; GADD34 PROTEIN; GUANABENZ; INITIATION FACTOR; INITIATION FACTOR 2ALPHA; PERK PROTEIN; PHOSPHOPROTEIN PHOSPHATASE; TUNICAMYCIN; UNCLASSIFIED DRUG; ALPHA 2 ADRENERGIC RECEPTOR STIMULATING AGENT; ANTIHYPERTENSIVE AGENT; INITIATION FACTOR 2; PERK KINASE; PHOSPHOPROTEIN PHOSPHATASE 1; PPP1R15A PROTEIN, MOUSE; PROTEIN KINASE R; SOD1 G93A PROTEIN; SUPEROXIDE DISMUTASE;

ADVERSE OUTCOME; AMYOTROPHIC LATERAL SCLEROSIS; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CELL VIABILITY; CONTROLLED STUDY; DISEASE EXACERBATION; DRUG BLOOD LEVEL; DRUG DOSE COMPARISON; DRUG EFFECT; DRUG HALF LIFE; ENDOPLASMIC RETICULUM STRESS; FIBROBLAST; MAXIMUM PLASMA CONCENTRATION; MOLECULAR INTERACTION; MOUSE; NONHUMAN; PROTEIN DEPHOSPHORYLATION; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; TIME TO MAXIMUM PLASMA CONCENTRATION; UNFOLDED PROTEIN RESPONSE; ANIMAL; C57BL MOUSE; DISEASE COURSE; DISEASE MODEL; DRUG EFFECTS; GENETICS; METABOLISM; NERVE DEGENERATION; PATHOLOGY; PHOSPHORYLATION; TRANSGENIC MOUSE;

ADRENERGIC ALPHA-2 RECEPTOR AGONISTS; AMYOTROPHIC LATERAL SCLEROSIS; ANIMALS; ANTIHYPERTENSIVE AGENTS; DISEASE MODELS, ANIMAL; DISEASE PROGRESSION; EIF-2 KINASE; ENDOPLASMIC RETICULUM STRESS; EUKARYOTIC INITIATION FACTOR-2; FIBROBLASTS; GUANABENZ; MICE; MICE, INBRED C57BL; MICE, TRANSGENIC; NERVE DEGENERATION; PHOSPHORYLATION; PROTEIN PHOSPHATASE 1; SUPEROXIDE DISMUTASE; TUNICAMYCIN; UNFOLDED PROTEIN RESPONSE;

EID: 84942615942     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0135570     Document Type: Article

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