ER Stress and Autophagic Perturbations Lead to Elevated Extracellular α-Synuclein in GBA-N370S Parkinson's iPSC-Derived Dopamine Neurons

Stem Cell Reports

Volumn 6, Issue 3, 2016, Pages 342-356

  Fernandes, Hugo J R ^a   Hartfield, Elizabeth M ^a   Christian, Helen C ^a   Emmanoulidou, Evangelia ^b   Zheng, Ying ^a   Booth, Heather ^a   Bogetofte, Helle ^a,c   Lang, Charmaine ^a   Ryan, Brent J ^a   Sardi, S Pablo ^d   Badger, Jennifer ^a   Vowles, Jane ^a,e   Evetts, Samuel ^a   Tofaris, George K ^a   Vekrellis, Kostas ^b   Talbot, Kevin ^a   Hu, Michele T ^a   James, William ^a,e   Cowley, Sally A ^a,e   Wade Martins, Richard ^a  

^a UNIVERSITY OF OXFORD   (United Kingdom)

^b BIOMEDICAL RESEARCH FOUNDATION   (Greece)

^c UNIVERSITY OF SOUTHERN DENMARK   (Denmark)

^d SANOFI   (France)

^e UNIVERSITY OF OXFORD   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA SYNUCLEIN; GLUCOSYLCERAMIDASE;

ARTICLE; AUTOPHAGY; CONTROLLED STUDY; DOPAMINERGIC NERVE CELL; ENDOPLASMIC RETICULUM STRESS; HUMAN; HUMAN CELL; LYSOSOME; MUTATION; NERVE CELL CULTURE; NERVE CELL DIFFERENTIATION; PARKINSON DISEASE; PLURIPOTENT STEM CELL; PRIORITY JOURNAL; PROTEIN HOMEOSTASIS; ANIMAL; CELL CULTURE; CELL LINE; CYTOLOGY; EXOSOME; GENETICS; INDUCED PLURIPOTENT STEM CELL; METABOLISM; MISSENSE MUTATION; MOUSE; NERVOUS SYSTEM DEVELOPMENT; PATHOLOGY;

ALPHA-SYNUCLEIN; ANIMALS; AUTOPHAGY; CELL LINE; CELLS, CULTURED; DOPAMINERGIC NEURONS; ENDOPLASMIC RETICULUM STRESS; EXOSOMES; GLUCOSYLCERAMIDASE; HUMANS; INDUCED PLURIPOTENT STEM CELLS; LYSOSOMES; MICE; MUTATION, MISSENSE; NEUROGENESIS; PARKINSON DISEASE;

EID: 84960803232     PISSN: 22136711     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.stemcr.2016.01.013     Document Type: Article

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