ALS-associated TDP-43 induces endoplasmic reticulum stress, which drives cytoplasmic TDP-43 accumulation and stress granule formation

PLoS ONE

Volumn 8, Issue 11, 2013, Pages

  Walker, Adam K ^a,b,f   Soo, Kai Y ^a   Sundaramoorthy, Vinod ^a   Parakh, Sonam ^a   Ma, Yi ^b   Farg, Manal A ^a   Wallace, Robyn H ^c   Crouch, Peter J ^b   Turner, Bradley J ^b   Horne, Malcolm K ^b,d,e   Atkin, Julie D ^a,b  

^a LA TROBE UNIVERSITY   (Australia)

^b UNIVERSITY OF MELBOURNE   (Australia)

^c UNIVERSITY OF QUEENSLAND   (Australia)

^d UNIVERSITY OF MELBOURNE   (Australia)

^e ST VINCENT S HOSPITAL   (Australia)

^f UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

INITIATION FACTOR 2ALPHA; PROTEIN DISULFIDE ISOMERASE; SALUBRINAL; TAR DNA BINDING PROTEIN; CINNAMIC ACID DERIVATIVE; DNA BINDING PROTEIN; PROTEIN TDP-43; THIOUREA;

AMYOTROPHIC LATERAL SCLEROSIS; ANIMAL CELL; ARTICLE; CARBOXY TERMINAL SEQUENCE; CELL GRANULE; CELL LYSATE; CONTROLLED STUDY; CYTOPATHOLOGY; EMBRYO; ENDOPLASMIC RETICULUM DYSFUNCTION; ENDOPLASMIC RETICULUM STRESS; GENETIC TRANSFECTION; GOLGI COMPLEX; HUMAN; HUMAN CELL; MOUSE; NEUROBLASTOMA CELL; NONHUMAN; PROTEIN ANALYSIS; PROTEIN ASSEMBLY; PROTEIN DEPHOSPHORYLATION; PROTEIN EXPRESSION; PROTEIN PROTEIN INTERACTION; SIGNAL TRANSDUCTION; SPINAL CORD; STRESS GRANULE; TRANSGENIC MOUSE; WILD TYPE; ACTIVE TRANSPORT; ANALOGS AND DERIVATIVES; ANIMAL; CELL LINE; CELL NUCLEUS; CYTOPLASM; DRUG EFFECTS; GENETICS; METABOLISM; MUTATION; PATHOLOGY;

ACTIVE TRANSPORT, CELL NUCLEUS; AMYOTROPHIC LATERAL SCLEROSIS; ANIMALS; CELL LINE; CELL NUCLEUS; CINNAMATES; CYTOPLASM; DNA-BINDING PROTEINS; ENDOPLASMIC RETICULUM STRESS; GOLGI APPARATUS; HUMANS; MICE; MUTATION; PROTEIN DISULFIDE-ISOMERASES; SPINAL CORD; THIOUREA;

EID: 84896710448     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0081170     Document Type: Article

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