The Parkinson's disease protein α-synuclein disrupts cellular Rab homeostasis

Proceedings of the National Academy of Sciences of the United States of America

Volumn 105, Issue 1, 2008, Pages 145-150

  Gitler, Aaron D ^a,f   Bevis, Brooke J ^a   Shorter, James ^a,f   Strathearn, Katherine E ^b   Hamamichi, Shusei ^c   Su, Linhui Julie ^a   Caldwell, Kim A ^c   Caldwell, Guy A ^c   Rochet, Jean Christophe ^b   McCaffery, J Michael ^d   Barlowe, Charles ^e   Lindquist, Susan ^a,g  

^a HOWARD HUGHES MEDICAL INSTITUTE   (United States)

^b PURDUE UNIVERSITY   (United States)

^c UNIVERSITY OF ALABAMA   (United States)

^d JOHNS HOPKINS UNIVERSITY   (United States)

^e DARTMOUTH MEDICAL SCHOOL   (United States)

^f UNIVERSITY OF PENNSYLVANIA   (United States)

^g WHITEHEAD INSTITUTE FOR BIOMEDICAL RESEARCH   (United States)

Author keywords

Endoplasmic reticulum; Golgi; Rab GTPase; Vesicle trafficking; Yeasts

Indexed keywords

ALPHA SYNUCLEIN; RAB PROTEIN;

ARTICLE; CELL FREE SYSTEM; CELL MEMBRANE; CONTROLLED STUDY; DOPAMINERGIC SYSTEM; DOSE RESPONSE; ENDOPLASMIC RETICULUM; GOLGI COMPLEX; HOMEOSTASIS; IMMUNOELECTRON MICROSCOPY; IMMUNOFLUORESCENCE; NERVE ENDING; NONHUMAN; PARKINSON DISEASE; PRIORITY JOURNAL; TRANSPORT VESICLE; ULTRASTRUCTURE;

ALPHA-SYNUCLEIN; ANIMALS; BIOLOGICAL TRANSPORT; CAENORHABDITIS ELEGANS; CELL MEMBRANE; ENDOPLASMIC RETICULUM; GOLGI APPARATUS; HOMEOSTASIS; HUMANS; MICROSCOPY, FLUORESCENCE; MODELS, BIOLOGICAL; NEURONS; RAB GTP-BINDING PROTEINS; RAB3A GTP-BINDING PROTEIN; SACCHAROMYCES CEREVISIAE;

EID: 38349160161     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.0710685105     Document Type: Article

References (32)

1. Lee VM, Trojanowski JQ (2006) Mechanisms of Parkinson's disease linked to pathological alpha-synuclein: New targets for drug discovery. Neuron 52:33-38.
2. Spillantini MG, et al. (1997) Alpha-synuclein in Lewy bodies. Nature 388:839-840.
3. Kontopoulos E, Parvin JD, Feany MB (2006) Alpha-synuclein acts in the nucleus to inhibit histone acetylation and promote neurotoxicity. Hum Mol Genet 15:3012-3023.
4. Lee HJ, Patel S, Lee SJ (2005) Intravesicular localization and exocytosis of alpha-synuclein and its aggregates. J Neurosci 25:6016-6024.
5. Fortin DL, et al. (2004) Lipid rafts mediate the synaptic localization of alpha-synuclein. J Neurosci 24:6715-6723.
6. Kubo S, et al. (2005) A combinatorial code for the interaction of alpha-synuclein with membranes. J Biol Chem 280:31664-31672.
7. Eliezer D, Kutluay E, Bussell R, Jr, Browne G (2001) Conformational properties of alpha-synuclein in its free and lipid-associated states. J Mol Biol 307:1061-1073.
8. Weinreb PH, Zhen W, Poon AW, Conway KA, Lansbury PT, Jr (1996) NACP, a protein implicated in Alzheimer's disease and learning, is natively unfolded. Biochemistry 35:13709-13715.
9. Chandra S, Gallardo G, Fernandez-Chacon R, Schluter OM, Sudhof TC (2005) Alpha-synuclein cooperates with CSPalpha in preventing neurodegeneration. Cell 123:383-396.
10. Outeiro TF, Lindquist S (2003) Yeast cells provide insight into alpha-synuclein biology and pathobiology. Science 302:1772-1775.
11. Volles MJ, Lansbury PT, Jr (2007) Relationships between the sequence of alpha-synuclein and its membrane affinity, fibrillization propensity, and yeast toxicity. J Mol Biol 366:1510-1522.
12. Cabin DE, et al. (2002) Synaptic vesicle depletion correlates with attenuated synaptic responses to prolonged repetitive stimulation in mice lacking alpha-synuclein. J Neurosci 22:8797-8807.
13. Abeliovich A, et al. (2000) Mice lacking alpha-synuclein display functional deficits in the nigrostriatal dopamine system. Neuron 25:239-252.
14. Larsen KE, et al. (2006) Alpha-synuclein overexpression in PC12 and chromaffin cells impairs catecholamine release by interfering with a late step in exocytosis. J Neurosci 26:11915-11922.
15. Gitler AD, Shorter J (2007) Prime time for alpha-synuclein. J Neurosci 27:2433-2434.
16. Cooper AA, et al. (2006) Alpha-synuclein blocks ER-Golgi traffic and Rab1 rescues neuron loss in Parkinson's models. Science 313:324-328.
17. Gurkan C, et al. (2005) Large-scale profiling of Rab GTPase trafficking networks: The membrome. Mol Biol Cell 16:3847-3864.
18. Pfeffer SR (1999) Transport-vesicle targeting: Tethers before SNAREs. Nat Cell Biol 1:E17-E22.
19. Barlowe C (1997) Coupled ER to Golgi transport reconstituted with purified cytosolic proteins. J Cell Biol 139:1097-1108.
20. Conway KA, Harper JD, Lansbury PT (1998) Accelerated in vitro fibril formation by a mutant alpha-synuclein linked to early-onset Parkinson disease. Nat Med 4:1318-1320.
21. Jo E, Fuller N, Rand RP, St George-Hyslop P, Fraser PE (2002) Defective membrane interactions of familial Parkinson's disease mutant A30P alpha-synuclein. J Mol Biol 315:799-807.
22. Novick P, Field C, Schekman R (1980) Identification of 23 complementation groups required for post-translational events in the yeast secretory pathway. Cell 21:205-215.
23. Kaiser CA, Schekman R (1990) Distinct sets of SEC genes govern transport vesicle formation and fusion early in the secretory pathway. Cell 61:723-733.
24. Alberti S, Gitler AD, Lindquist S (2007) A suite of Gateway cloning vectors for high-throughput genetic analysis in Saccharomyces cerevisiae. Yeast 24:913-919.
25. Calero M, et al. (2003) Dual prenylation is required for Rab protein localization and function. Mol Biol Cell 14:1852-1867.
26. Gosavi N, Lee HJ, Lee JS, Patel S, Lee SJ (2002) Golgi fragmentation occurs in the cells with prefibrillar alpha-synuclein aggregates and precedes the formation of fibrillar inclusion. J Biol Chem 277:48984-48992.
27. Hayashida K, Oyanagi S, Mizutani Y, Yokochi M (1993) An early cytoplasmic change before Lewy body maturation: An ultrastructural study of the substantia nigra from an autopsy case of juvenile parkinsonism. Acta Neuropathol (Berlin) 85:445-448.
28. Forno LS, Norville RL (1976) Ultrastructure of Lewy bodies in the stellate ganglion. Acta Neuropathol (Berlin) 34:183-197.
29. Watanabe I, Vachal E, Tomita T (1977) Dense core vesicles around the Lewy body in incidental Parkinson's disease: An electron microscopic study. Acta Neuropathol (Berlin) 39:173-175.
30. Caudle WM, et al. (2007) Reduced vesicular storage of dopamine causes progressive nigrostriatal neurodegeneration. J Neurosci 27:8138-8148.
31. Lotharius J, Brundin P (2002) Pathogenesis of Parkinson's disease: Dopamine, vesicles and alpha-synuclein. Nat Rev Neurosci 3:932-942.
32. Xu J, et al. (2002) Dopamine-dependent neurotoxicity of alpha-synuclein: A mechanism for selective neurodegeneration in Parkinson disease. Nat Med 8:600-606.