Partial restoration of protein synthesis rates by the small molecule ISRIB prevents neurodegeneration without pancreatic toxicity

Cell Death and Disease

Volumn 6, Issue 3, 2015, Pages

  Halliday, M ^a   Radford, H ^a   Sekine, Y ^b   Moreno, J ^a   Verity, N ^a   Le Quesne, J ^a,c   Ortori, C A ^d   Barrett, D A ^d   Fromont, C ^d   Fischer, P M ^d   Harding, H P ^b   Ron, D ^a,e   Mallucci, G R ^a,f  

^a UNIVERSITY OF LEICESTER   (United Kingdom)

^b UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^c UNIVERSITY HOSPITALS OF LEICESTER NHS TRUST   (United Kingdom)

^d UNIVERSITY OF NOTTINGHAM   (United Kingdom)

^e INSTITUTE OF METABOLIC SCIENCE   (United Kingdom)

^f UNIVERSITY OF CAMBRIDGE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIVATING TRANSCRIPTION FACTOR 4; GSK 2606414; INITIATION FACTOR 2; N,N' (CYCLOHEXANE 1,4 DIYL) BIS 2 (4 CHLOROPHENOXY)ACETAMIDE; NEUROPROTECTIVE AGENT; PHOSPHOTRANSFERASE INHIBITOR; UNCLASSIFIED DRUG; 2-(4-CHLOROPHENOXY)-N-(4-(2-(4-CHLOROPHENOXY)ACETAMIDO)CYCLOHEXYL)ACETAMIDE; ACETAMIDE DERIVATIVE; CYCLOHEXYLAMINE DERIVATIVE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BLOOD BRAIN BARRIER; CELL SURVIVAL; CONTROLLED STUDY; DRUG TOXICITY; MOUSE; NERVE CELL; NERVE DEGENERATION; NONHUMAN; PANCREATIC TOXICITY; PRION DISEASE; PRIORITY JOURNAL; PROTEIN SYNTHESIS; STRESS; UNFOLDED PROTEIN RESPONSE; ANIMAL; CELL LINE; DRUG EFFECTS; IMMUNOBLOTTING; LIQUID CHROMATOGRAPHY; METABOLISM; NEURODEGENERATIVE DISEASES; PANCREAS; RAT; TANDEM MASS SPECTROMETRY;

ACETAMIDES; ACTIVATING TRANSCRIPTION FACTOR 4; ANIMALS; CELL LINE; CHROMATOGRAPHY, LIQUID; CYCLOHEXYLAMINES; IMMUNOBLOTTING; MICE; NEURODEGENERATIVE DISEASES; PANCREAS; PROTEIN BIOSYNTHESIS; RATS; TANDEM MASS SPECTROMETRY;

EID: 84988811921     PISSN: None     EISSN: 20414889     Source Type: Journal    
DOI: 10.1038/cddis.2015.49     Document Type: Article

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