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Volumn 35, Issue , 2017, Pages 441-468

Microglia function in the central nervous system during health and neurodegeneration

Author keywords

Homeostasis; Microglia; Neurodegeneration; Phenotypes; Receptors; Regulation

Indexed keywords

CYTOKINE; MUSCARINIC M1 RECEPTOR; MUSCARINIC M2 RECEPTOR; NEUROTRANSMITTER; PATHOGEN ASSOCIATED MOLECULAR PATTERN; PATTERN RECOGNITION RECEPTOR; TRANSCRIPTOME;

EID: 85018340947     PISSN: 07320582     EISSN: 15453278     Source Type: Book Series    
DOI: 10.1146/annurev-immunol-051116-052358     Document Type: Review
Times cited : (1633)

References (203)
  • 1
    • 78149360132 scopus 로고    scopus 로고
    • Fate mapping analysis reveals that adult microglia derive from primitive macrophages
    • Ginhoux F, Greter M, Leboeuf M, Nandi S, See P, et al. 2010. Fate mapping analysis reveals that adult microglia derive from primitive macrophages. Science 330:841-45
    • (2010) Science , vol.330 , pp. 841-845
    • Ginhoux, F.1    Greter, M.2    Leboeuf, M.3    Nandi, S.4    See, P.5
  • 3
    • 84963841577 scopus 로고    scopus 로고
    • Origin, fate and dynamics of macrophages at central nervous system interfaces
    • Goldmann T, Wieghofer P, Jordao MJ, Prutek F, Hagemeyer N, et al. 2016. Origin, fate and dynamics of macrophages at central nervous system interfaces. Nat. Immunol. 17:797-805
    • (2016) Nat. Immunol. , vol.17 , pp. 797-805
    • Goldmann, T.1    Wieghofer, P.2    Jordao, M.J.3    Prutek, F.4    Hagemeyer, N.5
  • 4
    • 84951284076 scopus 로고    scopus 로고
    • The development and maintenance of resident macrophages
    • Perdiguero EG, Geissmann F. 2016. The development and maintenance of resident macrophages. Nat. Immunol. 17:2-8
    • (2016) Nat. Immunol. , vol.17 , pp. 2-8
    • Perdiguero, E.G.1    Geissmann, F.2
  • 5
    • 0036092801 scopus 로고    scopus 로고
    • Targeted disruption of the mouse colony-stimulating factor 1 receptor gene results in osteopetrosis, mononuclear phagocyte deficiency, increased primitive progenitor cell frequencies, and reproductive defects
    • Dai XM, Ryan GR, Hapel AJ, Dominguez MG, Russell RG, et al. 2002. Targeted disruption of the mouse colony-stimulating factor 1 receptor gene results in osteopetrosis, mononuclear phagocyte deficiency, increased primitive progenitor cell frequencies, and reproductive defects. Blood 99:111-20
    • (2002) Blood , vol.99 , pp. 111-120
    • Dai, X.M.1    Ryan, G.R.2    Hapel, A.J.3    Dominguez, M.G.4    Russell, R.G.5
  • 6
    • 84898676953 scopus 로고    scopus 로고
    • Colony-stimulating factor 1 receptor signaling is necessary for microglia viability, unmasking a microglia progenitor cell in the adult brain
    • Elmore MR, Najafi AR, Koike MA, Dagher NN, Spangenberg EE, et al. 2014. Colony-stimulating factor 1 receptor signaling is necessary for microglia viability, unmasking a microglia progenitor cell in the adult brain. Neuron 82:380-97
    • (2014) Neuron , vol.82 , pp. 380-397
    • Elmore, M.R.1    Najafi, A.R.2    Koike, M.A.3    Dagher, N.N.4    Spangenberg, E.E.5
  • 7
    • 84864152036 scopus 로고    scopus 로고
    • IL-34 is a tissue-restricted ligand of CSF1R required for the development of Langerhans cells and microglia
    • Wang Y, Szretter KJ, Vermi W, Gilfillan S, Rossini C, et al. 2012. IL-34 is a tissue-restricted ligand of CSF1R required for the development of Langerhans cells and microglia. Nat. Immunol. 13:753-60
    • (2012) Nat. Immunol. , vol.13 , pp. 753-760
    • Wang, Y.1    Szretter, K.J.2    Vermi, W.3    Gilfillan, S.4    Rossini, C.5
  • 8
    • 84870907320 scopus 로고    scopus 로고
    • Stroma-derived interleukin-34 controls the development and maintenance of Langerhans cells and the maintenance of microglia
    • Greter M, Lelios I, Pelczar P, Hoeffel G, Price J, et al. 2012. Stroma-derived interleukin-34 controls the development and maintenance of Langerhans cells and the maintenance of microglia. Immunity 37:1050-60
    • (2012) Immunity , vol.37 , pp. 1050-1060
    • Greter, M.1    Lelios, I.2    Pelczar, P.3    Hoeffel, G.4    Price, J.5
  • 9
  • 10
    • 44049092407 scopus 로고    scopus 로고
    • Discovery of a cytokine and its receptor by functional screening of the extracellular proteome
    • Lin H, Lee E, Hestir K, Leo C, Huang M, et al. 2008. Discovery of a cytokine and its receptor by functional screening of the extracellular proteome. Science 320:807-11
    • (2008) Science , vol.320 , pp. 807-811
    • Lin, H.1    Lee, E.2    Hestir, K.3    Leo, C.4    Huang, M.5
  • 11
    • 84859407607 scopus 로고    scopus 로고
    • Structural basis for the dual recognition of helical cytokines IL-34 and CSF-1 by CSF-1R
    • Ma X, Lin WY, Chen Y, Stawicki S, Mukhyala K, et al. 2012. Structural basis for the dual recognition of helical cytokines IL-34 and CSF-1 by CSF-1R. Structure 20:676-87
    • (2012) Structure , vol.20 , pp. 676-687
    • Ma, X.1    Lin, W.Y.2    Chen, Y.3    Stawicki, S.4    Mukhyala, K.5
  • 12
    • 19744380563 scopus 로고    scopus 로고
    • Resting microglial cells are highly dynamic surveillants of brain parenchyma in vivo
    • Nimmerjahn A, Kirchhoff F, Helmchen F. 2005. Resting microglial cells are highly dynamic surveillants of brain parenchyma in vivo. Science 308:1314-18
    • (2005) Science , vol.308 , pp. 1314-1318
    • Nimmerjahn, A.1    Kirchhoff, F.2    Helmchen, F.3
  • 13
    • 22244464662 scopus 로고    scopus 로고
    • ATP mediates rapid microglial response to local brain injury in vivo
    • Davalos D, Grutzendler J, Yang G, Kim JV, Zuo Y, et al. 2005. ATP mediates rapid microglial response to local brain injury in vivo. Nat. Neurosci. 8:752-58
    • (2005) Nat. Neurosci. , vol.8 , pp. 752-758
    • Davalos, D.1    Grutzendler, J.2    Yang, G.3    Kim, J.V.4    Zuo, Y.5
  • 14
    • 65249157852 scopus 로고    scopus 로고
    • Resting microglia directly monitor the functional state of synapses in vivo and determine the fate of ischemic terminals
    • Wake H, Moorhouse AJ, Jinno S, Kohsaka S, Nabekura J. 2009. Resting microglia directly monitor the functional state of synapses in vivo and determine the fate of ischemic terminals. J. Neurosci. 29:3974-80
    • (2009) J. Neurosci. , vol.29 , pp. 3974-3980
    • Wake, H.1    Moorhouse, A.J.2    Jinno, S.3    Kohsaka, S.4    Nabekura, J.5
  • 15
    • 84954051633 scopus 로고    scopus 로고
    • Bipolar/rod-shaped microglia are proliferating microglia with distinct M1/M2 phenotypes
    • TamWY, Ma CH. 2014. Bipolar/rod-shaped microglia are proliferating microglia with distinct M1/M2 phenotypes. Sci. Rep. 4:7279
    • (2014) Sci. Rep. , vol.4 , pp. 7279
    • Tam, W.Y.1    Ma, C.H.2
  • 16
    • 84869191121 scopus 로고    scopus 로고
    • Regulation of microglia activation and deactivation by nuclear receptors
    • Saijo K, Crotti A, Glass CK. 2013. Regulation of microglia activation and deactivation by nuclear receptors. Glia 61:104-11
    • (2013) Glia , vol.61 , pp. 104-111
    • Saijo, K.1    Crotti, A.2    Glass, C.K.3
  • 18
    • 84896958063 scopus 로고    scopus 로고
    • Innate immune sensing and signaling of cytosolic nucleic acids
    • Wu J, Chen ZJ. 2014. Innate immune sensing and signaling of cytosolic nucleic acids. Annu. Rev. Immunol. 32:461-88
    • (2014) Annu. Rev. Immunol. , vol.32 , pp. 461-488
    • Wu, J.1    Chen, Z.J.2
  • 19
    • 84859405717 scopus 로고    scopus 로고
    • Signaling by myeloid C-type lectin receptors in immunity and homeostasis
    • Sancho D, Reis e Sousa C. 2012. Signaling by myeloid C-type lectin receptors in immunity and homeostasis. Annu. Rev. Immunol. 30:491-529
    • (2012) Annu. Rev. Immunol. , vol.30 , pp. 491-529
    • Sancho, D.1    Reis Sousa, E.C.2
  • 20
    • 67650102353 scopus 로고    scopus 로고
    • Scavenger receptors: Role in innate immunity andmicrobial pathogenesis
    • Areschoug T, Gordon S. 2009. Scavenger receptors: role in innate immunity andmicrobial pathogenesis. Cell. Microbiol. 11:1160-69
    • (2009) Cell. Microbiol. , vol.11 , pp. 1160-1169
    • Areschoug, T.1    Gordon, S.2
  • 23
    • 84964355559 scopus 로고    scopus 로고
    • TAM receptors regulatemultiple features of microglial physiology
    • Fourgeaud L, Traves PG, Tufail Y, Leal-Bailey H, Lew ED, et al. 2016.TAM receptors regulatemultiple features of microglial physiology. Nature 532:240-44
    • (2016) Nature , vol.532 , pp. 240-244
    • Fourgeaud, L.1    Traves, P.G.2    Tufail, Y.3    Leal-Bailey, H.4    Lew, E.D.5
  • 24
    • 84855384345 scopus 로고    scopus 로고
    • The fractalkine receptor but not CCR2 is present on microglia from embryonic development throughout adulthood
    • Mizutani M, Pino PA, Saederup N, Charo IF, Ransohoff RM, et al. 2012. The fractalkine receptor but not CCR2 is present on microglia from embryonic development throughout adulthood. J. Immunol. 188:29-36
    • (2012) J. Immunol. , vol.188 , pp. 29-36
    • Mizutani, M.1    Pino, P.A.2    Saederup, N.3    Charo, I.F.4    Ransohoff, R.M.5
  • 25
    • 0034028817 scopus 로고    scopus 로고
    • Analysis of fractalkine receptor CX3CR1 function by targeted deletion and green fluorescent protein reporter gene insertion
    • Jung S, Aliberti J, Graemmel P, Sunshine MJ, Kreutzberg GW, et al. 2000. Analysis of fractalkine receptor CX3CR1 function by targeted deletion and green fluorescent protein reporter gene insertion. Mol. Cell. Biol. 20:4106-14
    • (2000) Mol. Cell. Biol. , vol.20 , pp. 4106-4114
    • Jung, S.1    Aliberti, J.2    Graemmel, P.3    Sunshine, M.J.4    Kreutzberg, G.W.5
  • 26
    • 84959118543 scopus 로고    scopus 로고
    • TREM2 variants: New keys to decipher Alzheimer disease pathogenesis
    • Colonna M, Wang Y. 2016. TREM2 variants: new keys to decipher Alzheimer disease pathogenesis. Nat. Rev. Neurosci. 17:201-7
    • (2016) Nat. Rev. Neurosci. , vol.17 , pp. 201-207
    • Colonna, M.1    Wang, Y.2
  • 27
    • 84903644330 scopus 로고    scopus 로고
    • Sensing the neuronal glycocalyx by glial sialic acid binding immunoglobulin-like lectins
    • Linnartz-Gerlach B, Mathews M, Neumann H. 2014. Sensing the neuronal glycocalyx by glial sialic acid binding immunoglobulin-like lectins. Neuroscience 275:113-24
    • (2014) Neuroscience , vol.275 , pp. 113-124
    • Linnartz-Gerlach, B.1    Mathews, M.2    Neumann, H.3
  • 28
    • 0041832335 scopus 로고    scopus 로고
    • Characterization of the CD200 receptor family in mice and humans and their interactions with CD200
    • Wright GJ, Cherwinski H, Foster-Cuevas M, Brooke G, Puklavec MJ, et al. 2003. Characterization of the CD200 receptor family in mice and humans and their interactions with CD200. J. Immunol. 171:3034-46
    • (2003) J. Immunol. , vol.171 , pp. 3034-3046
    • Wright, G.J.1    Cherwinski, H.2    Foster-Cuevas, M.3    Brooke, G.4    Puklavec, M.J.5
  • 29
    • 84941316111 scopus 로고    scopus 로고
    • SIRP/CD47 signaling in neurological disorders
    • Zhang H, Li F, Yang Y, Chen J, Hu X. 2015. SIRP/CD47 signaling in neurological disorders. Brain Res. 1623:74-80
    • (2015) Brain Res. , vol.1623 , pp. 74-80
    • Zhang, H.1    Li, F.2    Yang, Y.3    Chen, J.4    Hu, X.5
  • 30
    • 84941985434 scopus 로고    scopus 로고
    • Fine-tuning of type i IFN-signaling in microglia-implications for homeostasis, CNS autoimmunity and interferonopathies
    • Goldmann T, Blank T, Prinz M. 2016. Fine-tuning of type I IFN-signaling in microglia-implications for homeostasis, CNS autoimmunity and interferonopathies. Curr. Opin. Neurobiol. 36:38-42
    • (2016) Curr. Opin. Neurobiol. , vol.36 , pp. 38-42
    • Goldmann, T.1    Blank, T.2    Prinz, M.3
  • 31
    • 34848843543 scopus 로고    scopus 로고
    • Neurotransmitter receptors on microglia
    • Pocock JM, Kettenmann H. 2007. Neurotransmitter receptors on microglia. Trends Neurosci. 30:527-35
    • (2007) Trends Neurosci. , vol.30 , pp. 527-535
    • Pocock, J.M.1    Kettenmann, H.2
  • 32
    • 15244350494 scopus 로고    scopus 로고
    • Stimulation of microglial metabotropic glutamate receptor mGlu2 triggers tumor necrosis factor a-induced neurotoxicity in concert with microglialderived Fas ligand
    • Taylor DL, Jones F, Kubota ES, Pocock JM. 2005. Stimulation of microglial metabotropic glutamate receptor mGlu2 triggers tumor necrosis factor a-induced neurotoxicity in concert with microglialderived Fas ligand. J. Neurosci. 25:2952-64
    • (2005) J. Neurosci. , vol.25 , pp. 2952-2964
    • Taylor, D.L.1    Jones, F.2    Kubota, E.S.3    Pocock, J.M.4
  • 33
    • 3042751871 scopus 로고    scopus 로고
    • Heterogeneity and potentiation of AMPA type of glutamate receptors in rat cultured microglia
    • Hagino Y, Kariura Y, Manago Y, Amano T, Wang B, et al. 2004. Heterogeneity and potentiation of AMPA type of glutamate receptors in rat cultured microglia. Glia 47:68-77
    • (2004) Glia , vol.47 , pp. 68-77
    • Hagino, Y.1    Kariura, Y.2    Manago, Y.3    Amano, T.4    Wang, B.5
  • 35
    • 84857883847 scopus 로고    scopus 로고
    • Macrophage plasticity and polarization: In vivo veritas
    • Sica A, Mantovani A. 2012. Macrophage plasticity and polarization: in vivo veritas. J. Clin. Investig. 122:787-95
    • (2012) J. Clin. Investig. , vol.122 , pp. 787-795
    • Sica, A.1    Mantovani, A.2
  • 36
    • 84953840062 scopus 로고    scopus 로고
    • Next generation transcriptomics and genomics elucidate biological complexity of microglia in health and disease
    • Wes PD, Holtman IR, Boddeke EW, Moller T, Eggen BJ. 2016. Next generation transcriptomics and genomics elucidate biological complexity of microglia in health and disease. Glia 64:197-213
    • (2016) Glia , vol.64 , pp. 197-213
    • Wes, P.D.1    Holtman, I.R.2    Boddeke, E.W.3    Moller, T.4    Eggen, B.J.5
  • 37
    • 84893745524 scopus 로고    scopus 로고
    • Identification of a unique TGF-β-dependent molecular and functional signature in microglia
    • Butovsky O, Jedrychowski MP, Moore CS, Cialic R, Lanser AJ, et al. 2014. Identification of a unique TGF-β-dependent molecular and functional signature in microglia. Nat. Neurosci. 17:131-43
    • (2014) Nat. Neurosci. , vol.17 , pp. 131-143
    • Butovsky, O.1    Jedrychowski, M.P.2    Moore, C.S.3    Cialic, R.4    Lanser, A.J.5
  • 38
    • 84920724792 scopus 로고    scopus 로고
    • Environment drives selection and function of enhancers controlling tissue-specific macrophage identities
    • Gosselin D, Link VM, Romanoski CE, Fonseca GJ, Eichenfield DZ, et al. 2014. Environment drives selection and function of enhancers controlling tissue-specific macrophage identities. Cell 159:1327-40
    • (2014) Cell , vol.159 , pp. 1327-1340
    • Gosselin, D.1    Link, V.M.2    Romanoski, C.E.3    Fonseca, G.J.4    Eichenfield, D.Z.5
  • 39
    • 84906901689 scopus 로고    scopus 로고
    • An RNA-sequencing transcriptome and splicing database of glia, neurons, and vascular cells of the cerebral cortex
    • Zhang Y, Chen K, Sloan SA, Bennett ML, Scholze AR, et al. 2014. An RNA-sequencing transcriptome and splicing database of glia, neurons, and vascular cells of the cerebral cortex. J. Neurosci. 34:11929-47
    • (2014) J. Neurosci. , vol.34 , pp. 11929-11947
    • Zhang, Y.1    Chen, K.2    Sloan, S.A.3    Bennett, M.L.4    Scholze, A.R.5
  • 41
    • 84979730436 scopus 로고    scopus 로고
    • A polarizing question: Do M1 and M2 microglia exist?
    • Ransohoff RM. 2016. A polarizing question: Do M1 and M2 microglia exist? Nat. Neurosci. 19:987-91
    • (2016) Nat. Neurosci. , vol.19 , pp. 987-991
    • Ransohoff, R.M.1
  • 42
    • 84880802569 scopus 로고    scopus 로고
    • A neurodegeneration-specific gene-expression signature of acutely isolated microglia from an amyotrophic lateral sclerosis mouse model
    • Chiu IM, Morimoto ET, Goodarzi H, Liao JT, O'Keeffe S, et al. 2013. A neurodegeneration-specific gene-expression signature of acutely isolated microglia from an amyotrophic lateral sclerosis mouse model. Cell Rep. 4:385-401
    • (2013) Cell Rep. , vol.4 , pp. 385-401
    • Chiu, I.M.1    Morimoto, E.T.2    Goodarzi, H.3    Liao, J.T.4    O'Keeffe, S.5
  • 43
    • 84860666662 scopus 로고    scopus 로고
    • TGF-beta signaling through SMAD2/3 induces the quiescent microglial phenotype within the CNS environment
    • Abutbul S, Shapiro J, Szaingurten-Solodkin I, Levy N, Carmy Y, et al. 2012. TGF-beta signaling through SMAD2/3 induces the quiescent microglial phenotype within the CNS environment. Glia 60:1160-71
    • (2012) Glia , vol.60 , pp. 1160-1171
    • Abutbul, S.1    Shapiro, J.2    Szaingurten-Solodkin, I.3    Levy, N.4    Carmy, Y.5
  • 45
    • 84959110290 scopus 로고    scopus 로고
    • Microglial brain regiondependent diversity and selective regional sensitivities to aging
    • Grabert K, Michoel T, Karavolos MH, Clohisey S, Baillie JK, et al. 2016. Microglial brain regiondependent diversity and selective regional sensitivities to aging. Nat. Neurosci. 19:504-16
    • (2016) Nat. Neurosci. , vol.19 , pp. 504-516
    • Grabert, K.1    Michoel, T.2    Karavolos, M.H.3    Clohisey, S.4    Baillie, J.K.5
  • 49
    • 77951702072 scopus 로고    scopus 로고
    • Eight year prognosis of postinfectious irritable bowel syndrome following waterborne bacterial dysentery
    • Marshall JK, Thabane M, Garg AX, Clark WF, Moayyedi P, Collins SM. 2010. Eight year prognosis of postinfectious irritable bowel syndrome following waterborne bacterial dysentery. Gut 59:605-11
    • (2010) Gut , vol.59 , pp. 605-611
    • Marshall, J.K.1    Thabane, M.2    Garg, A.X.3    Clark, W.F.4    Moayyedi, P.5    Collins, S.M.6
  • 50
    • 84927131694 scopus 로고    scopus 로고
    • Indigenous bacteria from the gut microbiota regulate host serotonin biosynthesis
    • Yano JM, Yu K, Donaldson GP, Shastri GG, Ann P, et al. 2015. Indigenous bacteria from the gut microbiota regulate host serotonin biosynthesis. Cell 161:264-76
    • (2015) Cell , vol.161 , pp. 264-276
    • Yano, J.M.1    Yu, K.2    Donaldson, G.P.3    Shastri, G.G.4    Ann, P.5
  • 53
    • 84988812811 scopus 로고    scopus 로고
    • Estrogens, neuroinflammation, and neurodegeneration
    • Villa A, Vegeto E, Poletti A, Maggi A. 2016. Estrogens, neuroinflammation, and neurodegeneration. Endocr. Rev. 37:372-402
    • (2016) Endocr. Rev. , vol.37 , pp. 372-402
    • Villa, A.1    Vegeto, E.2    Poletti, A.3    Maggi, A.4
  • 54
    • 84866747856 scopus 로고    scopus 로고
    • Sex, glia, and development: Interactions in health and disease
    • Schwarz JM, Bilbo SD. 2012. Sex, glia, and development: interactions in health and disease. Horm. Behav. 62:243-53
    • (2012) Horm. Behav. , vol.62 , pp. 243-253
    • Schwarz, J.M.1    Bilbo, S.D.2
  • 55
    • 84862235381 scopus 로고    scopus 로고
    • Sexual differentiation of the rodent brain: Dogma and beyond
    • Lenz KM, Nugent BM, McCarthy MM. 2012. Sexual differentiation of the rodent brain: dogma and beyond. Front. Neurosci. 6:26
    • (2012) Front. Neurosci. , vol.6 , pp. 26
    • Lenz, K.M.1    Nugent, B.M.2    McCarthy, M.M.3
  • 56
    • 84856756074 scopus 로고    scopus 로고
    • Effects of aging and sensory loss on glial cells in mouse visual and auditory cortices
    • Tremblay ME, Zettel ML, Ison JR, Allen PD, Majewska AK. 2012. Effects of aging and sensory loss on glial cells in mouse visual and auditory cortices. Glia 60:541-58
    • (2012) Glia , vol.60 , pp. 541-558
    • Tremblay, M.E.1    Zettel, M.L.2    Ison, J.R.3    Allen, P.D.4    Majewska, A.K.5
  • 57
  • 58
    • 33846980461 scopus 로고    scopus 로고
    • Microglia derived from aging mice exhibit an altered inflammatory profile
    • Sierra A, Gottfried-Blackmore AC, McEwen BS, Bulloch K. 2007. Microglia derived from aging mice exhibit an altered inflammatory profile. Glia 55:412-24
    • (2007) Glia , vol.55 , pp. 412-424
    • Sierra, A.1    Gottfried-Blackmore, A.C.2    McEwen, B.S.3    Bulloch, K.4
  • 60
    • 84979737421 scopus 로고    scopus 로고
    • Age-related myelin degradation burdens the clearance function of microglia during aging
    • Safaiyan S, Kannaiyan N, Snaidero N, Brioschi S, Biber K, et al. 2016. Age-related myelin degradation burdens the clearance function of microglia during aging. Nat. Neurosci. 19:995-98
    • (2016) Nat. Neurosci. , vol.19 , pp. 995-998
    • Safaiyan, S.1    Kannaiyan, N.2    Snaidero, N.3    Brioschi, S.4    Biber, K.5
  • 61
    • 84935061166 scopus 로고    scopus 로고
    • Neuronal and microglial regulators of cortical wiring: Usual and novel guideposts
    • Squarzoni P, Thion MS, Garel S. 2015. Neuronal and microglial regulators of cortical wiring: usual and novel guideposts. Front. Neurosci. 9:248
    • (2015) Front. Neurosci. , vol.9 , pp. 248
    • Squarzoni, P.1    Thion, M.S.2    Garel, S.3
  • 62
    • 84923258878 scopus 로고    scopus 로고
    • Neural progenitor cells orchestrate microglia migration and positioning into the developing cortex
    • Arno B, Grassivaro F, Rossi C, Bergamaschi A, Castiglioni V, et al. 2014. Neural progenitor cells orchestrate microglia migration and positioning into the developing cortex. Nat. Commun. 5:5611
    • (2014) Nat. Commun. , vol.5 , pp. 5611
    • Arno, B.1    Grassivaro, F.2    Rossi, C.3    Bergamaschi, A.4    Castiglioni, V.5
  • 63
    • 84881366985 scopus 로고    scopus 로고
    • Resting microglia respond to and regulate neuronal activity in vivo
    • Li Y, Du XF, Du JL. 2013. Resting microglia respond to and regulate neuronal activity in vivo. Commun. Integr. Biol. 6:e24493
    • (2013) Commun. Integr. Biol. , vol.6 , pp. e24493
    • Li, Y.1    Du, X.F.2    Du, J.L.3
  • 64
    • 84978997878 scopus 로고    scopus 로고
    • Microglia engulf viable newborn cells in the epileptic dentate gyrus
    • Luo C, Koyama R, Ikegaya Y. 2016. Microglia engulf viable newborn cells in the epileptic dentate gyrus. Glia 64:1508-17
    • (2016) Glia , vol.64 , pp. 1508-1517
    • Luo, C.1    Koyama, R.2    Ikegaya, Y.3
  • 65
    • 84962339344 scopus 로고    scopus 로고
    • Neurogenic niche microglia undergo positional remodeling and progressive activation contributing to age-associated reductions in neurogenesis
    • Solano Fonseca R, Mahesula S, Apple DM, Raghunathan R, Dugan A, et al. 2016. Neurogenic niche microglia undergo positional remodeling and progressive activation contributing to age-associated reductions in neurogenesis. Stem Cells Dev. 25:542-55
    • (2016) Stem Cells Dev. , vol.25 , pp. 542-555
    • Solano Fonseca, R.1    Mahesula, S.2    Apple, D.M.3    Raghunathan, R.4    Dugan, A.5
  • 66
    • 84872176512 scopus 로고    scopus 로고
    • Microglia: New roles for the synaptic stripper
    • Kettenmann H, Kirchhoff F, Verkhratsky A. 2013. Microglia: new roles for the synaptic stripper. Neuron 77:10-18
    • (2013) Neuron , vol.77 , pp. 10-18
    • Kettenmann, H.1    Kirchhoff, F.2    Verkhratsky, A.3
  • 68
    • 84861427387 scopus 로고    scopus 로고
    • Microglia sculpt postnatal neural circuits in an activity and complement-dependent manner
    • Schafer DP, Lehrman EK, Kautzman AG, Koyama R, Mardinly AR, et al. 2012. Microglia sculpt postnatal neural circuits in an activity and complement-dependent manner. Neuron 74:691-705
    • (2012) Neuron , vol.74 , pp. 691-705
    • Schafer, D.P.1    Lehrman, E.K.2    Kautzman, A.G.3    Koyama, R.4    Mardinly, A.R.5
  • 70
    • 84888348687 scopus 로고    scopus 로고
    • TGF-beta signaling regulates neuronal C1q expression and developmental synaptic refinement
    • Bialas AR, Stevens B. 2013. TGF-beta signaling regulates neuronal C1q expression and developmental synaptic refinement. Nat. Neurosci. 16:1773-82
    • (2013) Nat. Neurosci. , vol.16 , pp. 1773-1782
    • Bialas, A.R.1    Stevens, B.2
  • 71
    • 80052633284 scopus 로고    scopus 로고
    • Synaptic pruning by microglia is necessary for normal brain development
    • Paolicelli RC, Bolasco G, Pagani F, Maggi L, Scianni M, et al. 2011. Synaptic pruning by microglia is necessary for normal brain development. Science 333:1456-58
    • (2011) Science , vol.333 , pp. 1456-1458
    • Paolicelli, R.C.1    Bolasco, G.2    Pagani, F.3    Maggi, L.4    Scianni, M.5
  • 72
    • 84867796425 scopus 로고    scopus 로고
    • Deficiency of the microglial receptor CX3CR1 impairs postnatal functional development of thalamocortical synapses in the barrel cortex
    • Hoshiko M, Arnoux I, Avignone E, Yamamoto N, Audinat E. 2012. Deficiency of the microglial receptor CX3CR1 impairs postnatal functional development of thalamocortical synapses in the barrel cortex. J. Neurosci. 32:15106-11
    • (2012) J. Neurosci. , vol.32 , pp. 15106-15111
    • Hoshiko, M.1    Arnoux, I.2    Avignone, E.3    Yamamoto, N.4    Audinat, E.5
  • 73
    • 84930929363 scopus 로고    scopus 로고
    • Neuromodulatory properties of inflammatory cytokines and their impact on neuronal excitability
    • Vezzani A, Viviani B. 2015. Neuromodulatory properties of inflammatory cytokines and their impact on neuronal excitability. Neuropharmacology 96:70-82
    • (2015) Neuropharmacology , vol.96 , pp. 70-82
    • Vezzani, A.1    Viviani, B.2
  • 74
    • 0034088617 scopus 로고    scopus 로고
    • Natural patterns of activity and long-term synaptic plasticity
    • Paulsen O, Sejnowski TJ. 2000. Natural patterns of activity and long-term synaptic plasticity. Curr. Opin. Neurobiol. 10:172-79
    • (2000) Curr. Opin. Neurobiol. , vol.10 , pp. 172-179
    • Paulsen, O.1    Sejnowski, T.J.2
  • 75
    • 84897391531 scopus 로고    scopus 로고
    • Strippers reveal their depressing secrets: Removing AMPA receptors
    • Collingridge GL, Peineau S. 2014. Strippers reveal their depressing secrets: removing AMPA receptors. Neuron 82:3-6
    • (2014) Neuron , vol.82 , pp. 3-6
    • Collingridge, G.L.1    Peineau, S.2
  • 76
    • 84897401619 scopus 로고    scopus 로고
    • Microglial CR3 activation triggers long-term synaptic depression in the hippocampus via NADPH oxidase
    • Zhang J, Malik A, Choi HB, Ko RW, Dissing-Olesen L, MacVicar BA. 2014. Microglial CR3 activation triggers long-term synaptic depression in the hippocampus via NADPH oxidase. Neuron 82:195-207
    • (2014) Neuron , vol.82 , pp. 195-207
    • Zhang, J.1    Malik, A.2    Choi, H.B.3    Ko, R.W.4    Dissing-Olesen, L.5    MacVicar, B.A.6
  • 77
    • 84894574217 scopus 로고    scopus 로고
    • Microglia promote learningdependent synapse formation through brain-derived neurotrophic factor
    • Parkhurst CN, Yang G, Ninan I, Savas JN, Yates JR 3rd, et al. 2013. Microglia promote learningdependent synapse formation through brain-derived neurotrophic factor. Cell 155:1596-609
    • (2013) Cell , vol.155 , pp. 1596-1609
    • Parkhurst, C.N.1    Yang, G.2    Ninan, I.3    Savas, J.N.4    Yates, J.R.5
  • 78
    • 84870524516 scopus 로고    scopus 로고
    • Brain-derived neurotrophic factordependent synaptic plasticity is suppressed by interleukin-1βvia p38 mitogen-activated protein kinase
    • Tong L, Prieto GA, Kramar EA, Smith ED, Cribbs DH, et al. 2012. Brain-derived neurotrophic factordependent synaptic plasticity is suppressed by interleukin-1βvia p38 mitogen-activated protein kinase. J. Neurosci. 32:17714-24
    • (2012) J. Neurosci. , vol.32 , pp. 17714-17724
    • Tong, L.1    Prieto, G.A.2    Kramar, E.A.3    Smith, E.D.4    Cribbs, D.H.5
  • 79
    • 84941600256 scopus 로고    scopus 로고
    • Neuroinflammatory changes negatively impact on LTP: A focus on IL-1β
    • Lynch MA. 2015. Neuroinflammatory changes negatively impact on LTP: a focus on IL-1β. Brain Res. 1621:197-204
    • (2015) Brain Res. , vol.1621 , pp. 197-204
    • Lynch, M.A.1
  • 80
    • 30744439794 scopus 로고    scopus 로고
    • BDNF from microglia causes the shift in neuronal anion gradient underlying neuropathic pain
    • Coull JA, Beggs S, Boudreau D, Boivin D, Tsuda M, et al. 2005. BDNF from microglia causes the shift in neuronal anion gradient underlying neuropathic pain. Nature 438:1017-21
    • (2005) Nature , vol.438 , pp. 1017-1021
    • Coull, J.A.1    Beggs, S.2    Boudreau, D.3    Boivin, D.4    Tsuda, M.5
  • 81
    • 33646199097 scopus 로고    scopus 로고
    • Synaptic scaling mediated by glial TNF-alpha
    • Stellwagen D, Malenka RC. 2006. Synaptic scaling mediated by glial TNF-alpha. Nature 440:1054-59
    • (2006) Nature , vol.440 , pp. 1054-1059
    • Stellwagen, D.1    Malenka, R.C.2
  • 82
    • 84856384517 scopus 로고    scopus 로고
    • Microglia activation triggers astrocytemediated modulation of excitatory neurotransmission
    • Pascual O, Ben Achour S, Rostaing P, Triller A, Bessis A. 2012. Microglia activation triggers astrocytemediated modulation of excitatory neurotransmission. PNAS 109:E197-205
    • (2012) PNAS , vol.109 , pp. E197-205
    • Pascual, O.1    Ben Achour, S.2    Rostaing, P.3    Triller, A.4    Bessis, A.5
  • 84
    • 84954287873 scopus 로고    scopus 로고
    • Mechanism of microglia neuroprotection: Involvement of P2X7, TNFa, and valproic acid
    • Masuch A, Shieh CH, van Rooijen N, van Calker D, Biber K. 2016. Mechanism of microglia neuroprotection: involvement of P2X7, TNFa, and valproic acid. Glia 64:76-89
    • (2016) Glia , vol.64 , pp. 76-89
    • Masuch, A.1    Shieh, C.H.2    Van Rooijen, N.3    Van Calker, D.4    Biber, K.5
  • 85
    • 85019538622 scopus 로고    scopus 로고
    • Microglial contact prevents excess depolarization and rescues neurons from excitotoxicity
    • 2016
    • Kato G, Inada H, Wake H, Akiyoshi R, Miyamoto A, et al. 2016. Microglial contact prevents excess depolarization and rescues neurons from excitotoxicity. eNeuro 3:e0004-16.2016
    • (2016) ENeuro , vol.3 , pp. e0004-16
    • Kato, G.1    Inada, H.2    Wake, H.3    Akiyoshi, R.4    Miyamoto, A.5
  • 86
    • 55049084760 scopus 로고    scopus 로고
    • Themystery andmagic of glia: A perspective on their roles in health and disease
    • Barres BA. 2008. Themystery andmagic of glia: a perspective on their roles in health and disease. Neuron 60:430-40
    • (2008) Neuron , vol.60 , pp. 430-440
    • Barres, B.A.1
  • 87
    • 13344286293 scopus 로고    scopus 로고
    • Knockout of glutamate transporters reveals a major role for astroglial transport in excitotoxicity and clearance of glutamate
    • Rothstein JD, Dykes-Hoberg M, Pardo CA, Bristol LA, Jin L, et al. 1996. Knockout of glutamate transporters reveals a major role for astroglial transport in excitotoxicity and clearance of glutamate. Neuron 16:675-86
    • (1996) Neuron , vol.16 , pp. 675-686
    • Rothstein, J.D.1    Dykes-Hoberg, M.2    Pardo, C.A.3    Bristol, L.A.4    Jin, L.5
  • 88
    • 84890285161 scopus 로고    scopus 로고
    • Astrocytes potentiate GABAergic transmission in the thalamic reticular nucleus via endozepine signaling
    • Christian CA, Huguenard JR. 2013. Astrocytes potentiate GABAergic transmission in the thalamic reticular nucleus via endozepine signaling. PNAS 110:20278-83
    • (2013) PNAS , vol.110 , pp. 20278-20283
    • Christian, C.A.1    Huguenard, J.R.2
  • 89
    • 78349279184 scopus 로고    scopus 로고
    • Astrocytes are GABAergic cells that modulate microglial activity
    • Lee M, Schwab C, McGeer PL. 2011. Astrocytes are GABAergic cells that modulate microglial activity. Glia 59:152-65
    • (2011) Glia , vol.59 , pp. 152-165
    • Lee, M.1    Schwab, C.2    McGeer, P.L.3
  • 90
    • 32544455798 scopus 로고    scopus 로고
    • Astrocytes induce hemeoxygenase-1 expression in microglia: A feasible mechanism for preventing excessive brain inflammation
    • Min KJ, Yang MS, Kim SU, Jou I, Joe EH. 2006. Astrocytes induce hemeoxygenase-1 expression in microglia: a feasible mechanism for preventing excessive brain inflammation. J. Neurosci. 26:1880-87
    • (2006) J. Neurosci. , vol.26 , pp. 1880-1887
    • Min, K.J.1    Yang, M.S.2    Kim, S.U.3    Jou, I.4    Joe, E.H.5
  • 91
    • 79957636093 scopus 로고    scopus 로고
    • A dual role for microglia in promoting tissue inhibitor of metalloproteinase (TIMP) expression in glial cells in response to neuroinflammatory stimuli
    • Welser-Alves JV, Crocker SJ, Milner R. 2011. A dual role for microglia in promoting tissue inhibitor of metalloproteinase (TIMP) expression in glial cells in response to neuroinflammatory stimuli. J. Neuroinflammation 8:61
    • (2011) J. Neuroinflammation , vol.8 , pp. 61
    • Welser-Alves, J.V.1    Crocker, S.J.2    Milner, R.3
  • 92
    • 33646438843 scopus 로고    scopus 로고
    • Prostaglandin D2-mediated microglia/astrocyte interaction enhances astrogliosis and demyelination in twitcher
    • Mohri I, Taniike M, Taniguchi H, Kanekiyo T, Aritake K, et al. 2006. Prostaglandin D2-mediated microglia/astrocyte interaction enhances astrogliosis and demyelination in twitcher. J. Neurosci. 26:4383-93
    • (2006) J. Neurosci. , vol.26 , pp. 4383-4393
    • Mohri, I.1    Taniike, M.2    Taniguchi, H.3    Kanekiyo, T.4    Aritake, K.5
  • 93
    • 77957733643 scopus 로고    scopus 로고
    • Engulfment of cerebral apoptotic bodies controls the course of prion disease in a mouse strain-dependent manner
    • Kranich J, Krautler NJ, Falsig J, Ballmer B, Li S, et al. 2010. Engulfment of cerebral apoptotic bodies controls the course of prion disease in a mouse strain-dependent manner. J. Exp. Med. 207:2271-81
    • (2010) J. Exp. Med. , vol.207 , pp. 2271-2281
    • Kranich, J.1    Krautler, N.J.2    Falsig, J.3    Ballmer, B.4    Li, S.5
  • 94
    • 84937392013 scopus 로고    scopus 로고
    • Neurodegenerative diseases: Expanding the prion concept
    • Walker LC, Jucker M. 2015. Neurodegenerative diseases: expanding the prion concept. Annu. Rev. Neurosci. 38:87-103
    • (2015) Annu. Rev. Neurosci. , vol.38 , pp. 87-103
    • Walker, L.C.1    Jucker, M.2
  • 95
    • 84958225958 scopus 로고    scopus 로고
    • The cellular phase of Alzheimer's disease
    • De Strooper B, Karran E. 2016. The cellular phase of Alzheimer's disease. Cell 164:603-15
    • (2016) Cell , vol.164 , pp. 603-615
    • De Strooper, B.1    Karran, E.2
  • 96
    • 84964336988 scopus 로고    scopus 로고
    • Extracellular vesicles and a novel form of communication in the brain
    • Basso M, Bonetto V. 2016. Extracellular vesicles and a novel form of communication in the brain. Front. Neurosci. 10:127
    • (2016) Front. Neurosci. , vol.10 , pp. 127
    • Basso, M.1    Bonetto, V.2
  • 97
    • 84954068135 scopus 로고    scopus 로고
    • Neuroinflammation and depression: Microglia activation, extracellular microvesicles and microRNA dysregulation
    • Brites D, Fernandes A. 2015. Neuroinflammation and depression: microglia activation, extracellular microvesicles and microRNA dysregulation. Front. Cell. Neurosci. 9:476
    • (2015) Front. Cell. Neurosci. , vol.9 , pp. 476
    • Brites, D.1    Fernandes, A.2
  • 99
    • 78649434414 scopus 로고    scopus 로고
    • Microglia in the degenerating brain are capable of phagocytosis of beads and of apoptotic cells, but do not efficiently remove PrPSc, even upon LPS stimulation
    • Hughes MM, Field RH, Perry VH, Murray CL, Cunningham C. 2010. Microglia in the degenerating brain are capable of phagocytosis of beads and of apoptotic cells, but do not efficiently remove PrPSc, even upon LPS stimulation. Glia 58:2017-30
    • (2010) Glia , vol.58 , pp. 2017-2030
    • Hughes, M.M.1    Field, R.H.2    Perry, V.H.3    Murray, C.L.4    Cunningham, C.5
  • 101
    • 84922783473 scopus 로고    scopus 로고
    • Apolipoprotein e levels and Alzheimer risk
    • Hyman BT, Holtzman DM. 2015. Apolipoprotein E levels and Alzheimer risk. Ann. Neurol. 77:204-5
    • (2015) Ann. Neurol. , vol.77 , pp. 204-205
    • Hyman, B.T.1    Holtzman, D.M.2
  • 102
    • 79956311751 scopus 로고    scopus 로고
    • Critical role of astroglial apolipoprotein e and liver X receptor-aexpression formicroglial Aβphagocytosis
    • Terwel D, Steffensen KR, Verghese PB, Kummer MP, Gustafsson JA, et al. 2011. Critical role of astroglial apolipoprotein E and liver X receptor-aexpression formicroglial Aβphagocytosis. J. Neurosci. 31:7049-59
    • (2011) J. Neurosci. , vol.31 , pp. 7049-7059
    • Terwel, D.1    Steffensen, K.R.2    Verghese, P.B.3    Kummer, M.P.4    Gustafsson, J.A.5
  • 103
    • 84862777666 scopus 로고    scopus 로고
    • ApoE-directed therapeutics rapidly clear beta-amyloid and reverse deficits in AD mouse models
    • Cramer PE, Cirrito JR, Wesson DW, Lee CY, Karlo JC, et al. 2012. ApoE-directed therapeutics rapidly clear beta-amyloid and reverse deficits in AD mouse models. Science 335:1503-6
    • (2012) Science , vol.335 , pp. 1503-1506
    • Cramer, P.E.1    Cirrito, J.R.2    Wesson, D.W.3    Lee, C.Y.4    Karlo, J.C.5
  • 104
    • 84864249514 scopus 로고    scopus 로고
    • Mechanisms underlying the rapid peroxisome proliferator-activated receptor-gamma-mediated amyloid clearance and reversal of cognitive deficits in a murine model of Alzheimer's disease
    • Mandrekar-Colucci S, Karlo JC, Landreth GE. 2012. Mechanisms underlying the rapid peroxisome proliferator-activated receptor-gamma-mediated amyloid clearance and reversal of cognitive deficits in a murine model of Alzheimer's disease. J. Neurosci. 32:10117-28
    • (2012) J. Neurosci. , vol.32 , pp. 10117-10128
    • Mandrekar-Colucci, S.1    Karlo, J.C.2    Landreth, G.E.3
  • 106
    • 84873087532 scopus 로고    scopus 로고
    • NLRP3 is activated in Alzheimer's disease and contributes to pathology in APP/PS1 mice
    • Heneka MT, Kummer MP, Stutz A, Delekate A, Schwartz S, et al. 2013. NLRP3 is activated in Alzheimer's disease and contributes to pathology in APP/PS1 mice. Nature 493:674-78
    • (2013) Nature , vol.493 , pp. 674-678
    • Heneka, M.T.1    Kummer, M.P.2    Stutz, A.3    Delekate, A.4    Schwartz, S.5
  • 109
    • 55049142500 scopus 로고    scopus 로고
    • Genome-wide association analysis reveals putativeAlzheimer's disease susceptibility loci in addition toAPOE
    • Bertram L, Lange C, Mullin K, Parkinson M, Hsiao M, et al. 2008. Genome-wide association analysis reveals putativeAlzheimer's disease susceptibility loci in addition toAPOE. Am. J.Hum.Genet. 83:623-32
    • (2008) Am. J.Hum.Genet. , vol.83 , pp. 623-632
    • Bertram, L.1    Lange, C.2    Mullin, K.3    Parkinson, M.4    Hsiao, M.5
  • 110
    • 78549264026 scopus 로고    scopus 로고
    • Genome-wide association study identifies variants at CLU and CR1 associated with Alzheimer's disease
    • Lambert JC, Heath S, Even G, Campion D, Sleegers K, et al. 2009. Genome-wide association study identifies variants at CLU and CR1 associated with Alzheimer's disease. Nat. Genet. 41:1094-99
    • (2009) Nat. Genet. , vol.41 , pp. 1094-1099
    • Lambert, J.C.1    Heath, S.2    Even, G.3    Campion, D.4    Sleegers, K.5
  • 111
    • 64049095240 scopus 로고    scopus 로고
    • TREM and TREM-like receptors in inflammation and disease
    • Ford JW, McVicar DW. 2009. TREM and TREM-like receptors in inflammation and disease. Curr. Opin. Immunol. 21:38-46
    • (2009) Curr. Opin. Immunol. , vol.21 , pp. 38-46
    • Ford, J.W.1    McVicar, D.W.2
  • 112
    • 84968784057 scopus 로고    scopus 로고
    • The TREM2-DAP12 signaling pathway in Nasu-Hakola disease: A molecular genetics perspective
    • Xing J, Titus AR, Humphrey MB. 2015. The TREM2-DAP12 signaling pathway in Nasu-Hakola disease: a molecular genetics perspective. Res. Rep. Biochem. 5:89-100
    • (2015) Res. Rep. Biochem. , vol.5 , pp. 89-100
    • Xing, J.1    Titus, A.R.2    Humphrey, M.B.3
  • 114
    • 84925464993 scopus 로고    scopus 로고
    • TREM2 lipid sensing sustains the microglial response in an Alzheimer's disease model
    • Wang Y, Cella M, Mallinson K, Ulrich JD, Young KL, et al. 2015. TREM2 lipid sensing sustains the microglial response in an Alzheimer's disease model. Cell 160:1061-71
    • (2015) Cell , vol.160 , pp. 1061-1071
    • Wang, Y.1    Cella, M.2    Mallinson, K.3    Ulrich, J.D.4    Young, K.L.5
  • 115
    • 84992038840 scopus 로고    scopus 로고
    • Alzheimer's disease-associatedTREM2variants exhibit either decreased or increased ligand-dependent activation
    • In press
    • Song W, Hooli B, Mullin K, Jin SC, Cella M, et al. 2016. Alzheimer's disease-associatedTREM2variants exhibit either decreased or increased ligand-dependent activation. Alzheimers Dement. In press. https:// doi.org/10.1016/j.jalz.2016.07.004
    • (2016) Alzheimers Dement
    • Song, W.1    Hooli, B.2    Mullin, K.3    Jin, S.C.4    Cella, M.5
  • 116
    • 84992028918 scopus 로고    scopus 로고
    • TREM2 binds to apolipoproteins, including APOE and CLU/APOJ, and thereby facilitates uptake of amyloid-beta by microglia
    • Yeh FL, Wang Y, Tom I, Gonzalez LC, Sheng M. 2016. TREM2 binds to apolipoproteins, including APOE and CLU/APOJ, and thereby facilitates uptake of amyloid-beta by microglia. Neuron 91:328-40
    • (2016) Neuron , vol.91 , pp. 328-340
    • Yeh, F.L.1    Wang, Y.2    Tom, I.3    Gonzalez, L.C.4    Sheng, M.5
  • 117
    • 84944937240 scopus 로고    scopus 로고
    • Apolipoprotein e is a ligand for triggering receptor expressed on myeloid cells 2 (TREM2)
    • Atagi Y, Liu CC, Painter MM, Chen XF, Verbeeck C, et al. 2015. Apolipoprotein E is a ligand for triggering receptor expressed on myeloid cells 2 (TREM2). J. Biol. Chem. 290:26043-50
    • (2015) J. Biol. Chem. , vol.290 , pp. 26043-26050
    • Atagi, Y.1    Liu, C.C.2    Painter, M.M.3    Chen, X.F.4    Verbeeck, C.5
  • 118
    • 84944937159 scopus 로고    scopus 로고
    • The triggering receptor expressed on myeloid cells 2 binds apolipoprotein e
    • Bailey CC, DeVaux LB, Farzan M. 2015. The triggering receptor expressed on myeloid cells 2 binds apolipoprotein E. J. Biol. Chem. 290:26033-42
    • (2015) J. Biol. Chem. , vol.290 , pp. 26033-26042
    • Bailey, C.C.1    DeVaux, L.B.2    Farzan, M.3
  • 119
    • 67649205726 scopus 로고    scopus 로고
    • Macrophage colony-stimulating factor induces the proliferation and survival of macrophages via a pathway involving DAP12 and betacatenin
    • Otero K, Turnbull IR, Poliani PL, Vermi W, Cerutti E, et al. 2009. Macrophage colony-stimulating factor induces the proliferation and survival of macrophages via a pathway involving DAP12 and betacatenin. Nat. Immunol. 10:734-43
    • (2009) Nat. Immunol. , vol.10 , pp. 734-743
    • Otero, K.1    Turnbull, I.R.2    Poliani, P.L.3    Vermi, W.4    Cerutti, E.5
  • 120
    • 65649114773 scopus 로고    scopus 로고
    • A role for TREM2 ligands in the phagocytosis of apoptotic neuronal cells by microglia
    • Hsieh CL, Koike M, Spusta SC, Niemi EC, Yenari M, et al. 2009. A role for TREM2 ligands in the phagocytosis of apoptotic neuronal cells by microglia. J. Neurochem. 109:1144-56
    • (2009) J. Neurochem. , vol.109 , pp. 1144-1156
    • Hsieh, C.L.1    Koike, M.2    Spusta, S.C.3    Niemi, E.C.4    Yenari, M.5
  • 121
    • 34247500821 scopus 로고    scopus 로고
    • TREM2-transduced myeloid precursors mediate nervous tissue debris clearance and facilitate recovery in an animal model of multiple sclerosis
    • Takahashi K, Prinz M, Stagi M, Chechneva O, Neumann H. 2007. TREM2-transduced myeloid precursors mediate nervous tissue debris clearance and facilitate recovery in an animal model of multiple sclerosis. PLOS Med. 4:e124
    • (2007) PLOS Med. , vol.4 , pp. e124
    • Takahashi, K.1    Prinz, M.2    Stagi, M.3    Chechneva, O.4    Neumann, H.5
  • 122
    • 14244268775 scopus 로고    scopus 로고
    • Clearance of apoptotic neurons without inflammation by microglial triggering receptor expressed on myeloid cells-2
    • Takahashi K, Rochford CD, Neumann H. 2005. Clearance of apoptotic neurons without inflammation by microglial triggering receptor expressed on myeloid cells-2. J. Exp. Med. 201:647-57
    • (2005) J. Exp. Med. , vol.201 , pp. 647-657
    • Takahashi, K.1    Rochford, C.D.2    Neumann, H.3
  • 124
    • 33746875981 scopus 로고    scopus 로고
    • Cutting edge: Inhibition of TLR and FcR responses in macrophages by triggering receptor expressed onmyeloid cells (TREM)-2 and DAP12
    • Hamerman JA, Jarjoura JR, Humphrey MB, Nakamura MC, Seaman WE, Lanier LL. 2006. Cutting edge: inhibition of TLR and FcR responses in macrophages by triggering receptor expressed onmyeloid cells (TREM)-2 and DAP12. J. Immunol. 177:2051-55
    • (2006) J. Immunol. , vol.177 , pp. 2051-2055
    • Hamerman, J.A.1    Jarjoura, J.R.2    Humphrey, M.B.3    Nakamura, M.C.4    Seaman, W.E.5    Lanier, L.L.6
  • 125
    • 85006873054 scopus 로고    scopus 로고
    • Neurodegenerative disease mutations in TREM2 reveal a functional surface and distinct loss-of-function mechanisms
    • Kober DL, Alexander-Brett JM, Karch CM, Cruchaga C, Colonna M, et al. 2016. Neurodegenerative disease mutations in TREM2 reveal a functional surface and distinct loss-of-function mechanisms. eLife 5:e20391
    • (2016) ELife , vol.5 , pp. e20391
    • Kober, D.L.1    Alexander-Brett, J.M.2    Karch, C.M.3    Cruchaga, C.4    Colonna, M.5
  • 126
    • 18544390923 scopus 로고    scopus 로고
    • Mutations in two genes encoding different subunits of a receptor signaling complex result in an identical disease phenotype
    • Paloneva J, Manninen T, Christman G, Hovanes K, Mandelin J, et al. 2002. Mutations in two genes encoding different subunits of a receptor signaling complex result in an identical disease phenotype. Am. J. Hum. Genet. 71:656-62
    • (2002) Am. J. Hum. Genet. , vol.71 , pp. 656-662
    • Paloneva, J.1    Manninen, T.2    Christman, G.3    Hovanes, K.4    Mandelin, J.5
  • 127
    • 84939910739 scopus 로고    scopus 로고
    • Polycystic lipomembranous osteodysplasia with sclerosing leukoencephalopathy (PLOSL)
    • updated Mar. 12, 2015, Univ. Wash., Seattle
    • Paloneva J, Autti T, Hakola P, Haltia MJ. 2002. Polycystic lipomembranous osteodysplasia with sclerosing leukoencephalopathy (PLOSL). GeneReviews, updated Mar. 12, 2015, Univ. Wash., Seattle. https:// www.ncbi.nlm.nih.gov/books/NBK1197/
    • (2002) GeneReviews
    • Paloneva, J.1    Autti, T.2    Hakola, P.3    Haltia, M.J.4
  • 128
    • 84902243410 scopus 로고    scopus 로고
    • Alteredmicroglial response to Aβplaques in APPPS1-21 mice heterozygous for TREM2
    • Ulrich JD, Finn MB, Wang Y, Shen A, Mahan TE, et al. 2014. Alteredmicroglial response to Aβplaques in APPPS1-21 mice heterozygous for TREM2. Mol. Neurodegener. 9:20
    • (2014) Mol. Neurodegener. , vol.9 , pp. 20
    • Ulrich, J.D.1    Finn, M.B.2    Wang, Y.3    Shen, A.4    Mahan, T.E.5
  • 129
    • 84924737031 scopus 로고    scopus 로고
    • TREM2 deficiency eliminates TREM2+ inflammatory macrophages and ameliorates pathology in Alzheimer's disease mouse models
    • Jay TR, Miller CM, Cheng PJ, Graham LC, Bemiller S, et al. 2015. TREM2 deficiency eliminates TREM2+ inflammatory macrophages and ameliorates pathology in Alzheimer's disease mouse models. J. Exp. Med. 212:287-95
    • (2015) J. Exp. Med. , vol.212 , pp. 287-295
    • Jay, T.R.1    Miller, C.M.2    Cheng, P.J.3    Graham, L.C.4    Bemiller, S.5
  • 130
    • 84969286765 scopus 로고    scopus 로고
    • TREM2-mediated early microglial response limits diffusion and toxicity of amyloid plaques
    • Wang Y, Ulland TK, Ulrich JD, Song W, Tzaferis JA, et al. 2016. TREM2-mediated early microglial response limits diffusion and toxicity of amyloid plaques. J. Exp. Med. 213:667-75
    • (2016) J. Exp. Med. , vol.213 , pp. 667-675
    • Wang, Y.1    Ulland, T.K.2    Ulrich, J.D.3    Song, W.4    Tzaferis, J.A.5
  • 131
    • 84968764145 scopus 로고    scopus 로고
    • TREM2 haplodeficiency in mice and humans impairs the microglia barrier function leading to decreased amyloid compaction and severe axonal dystrophy
    • Yuan P, Condello C, Keene CD, Wang Y, Bird TD, et al. 2016. TREM2 haplodeficiency in mice and humans impairs the microglia barrier function leading to decreased amyloid compaction and severe axonal dystrophy. Neuron 90:724-39
    • (2016) Neuron , vol.90 , pp. 724-739
    • Yuan, P.1    Condello, C.2    Keene, C.D.3    Wang, Y.4    Bird, T.D.5
  • 132
    • 85010369316 scopus 로고    scopus 로고
    • Disease progression-dependent effects of TREM2 deficiency in a mouse model of Alzheimer's disease
    • Jay TR, Hirsch AM, Broihier ML, Miller CM, Neilson LE, et al. 2017. Disease progression-dependent effects of TREM2 deficiency in a mouse model of Alzheimer's disease. J. Neurosci. 37:637-47
    • (2017) J. Neurosci. , vol.37 , pp. 637-647
    • Jay, T.R.1    Hirsch, A.M.2    Broihier, M.L.3    Miller, C.M.4    Neilson, L.E.5
  • 133
    • 84904479732 scopus 로고    scopus 로고
    • TREM2mutations implicated in neurodegeneration impair cell surface transport and phagocytosis
    • Kleinberger G, Yamanishi Y, Suarez-Calvet M, Czirr E, Lohmann E, et al. 2014. TREM2mutations implicated in neurodegeneration impair cell surface transport and phagocytosis. Sci. Transl.Med. 6:243ra86
    • (2014) Sci. Transl.Med. , vol.6 , pp. 243ra86
    • Kleinberger, G.1    Yamanishi, Y.2    Suarez-Calvet, M.3    Czirr, E.4    Lohmann, E.5
  • 134
    • 84887853222 scopus 로고    scopus 로고
    • Sequential proteolytic processing of the triggering receptor expressed on myeloid cells-2 (TREM2) protein by ectodomain shedding and gamma-secretase-dependent intramembranous cleavage
    • Wunderlich P, Glebov K, Kemmerling N, Tien NT, Neumann H, Walter J. 2013. Sequential proteolytic processing of the triggering receptor expressed on myeloid cells-2 (TREM2) protein by ectodomain shedding and gamma-secretase-dependent intramembranous cleavage. J. Biol. Chem. 288:33027-36
    • (2013) J. Biol. Chem. , vol.288 , pp. 33027-33036
    • Wunderlich, P.1    Glebov, K.2    Kemmerling, N.3    Tien, N.T.4    Neumann, H.5    Walter, J.6
  • 135
    • 84960155154 scopus 로고    scopus 로고
    • STREM2 cerebrospinal fluid levels are a potential biomarker for microglia activity in early-stage Alzheimer's disease and associate with neuronal injury markers
    • Suarez-Calvet M, Kleinberger G, Araque Caballero MA, Brendel M, Rominger A, et al. 2016. sTREM2 cerebrospinal fluid levels are a potential biomarker for microglia activity in early-stage Alzheimer's disease and associate with neuronal injury markers. EMBO Mol. Med. 8:466-76
    • (2016) EMBO Mol. Med. , vol.8 , pp. 466-476
    • Suarez-Calvet, M.1    Kleinberger, G.2    Araque Caballero, M.A.3    Brendel, M.4    Rominger, A.5
  • 136
    • 84954193258 scopus 로고    scopus 로고
    • Cerebrospinal fluid soluble TREM2is higher in Alzheimer disease and associated with mutation status
    • Piccio L, Deming Y, Del-Aguila JL, Ghezzi L, Holtzman DM, et al. 2016. Cerebrospinal fluid soluble TREM2is higher in Alzheimer disease and associated with mutation status. Acta Neuropathol. 131:925-33
    • (2016) Acta Neuropathol. , vol.131 , pp. 925-933
    • Piccio, L.1    Deming, Y.2    Del-Aguila, J.L.3    Ghezzi, L.4    Holtzman, D.M.5
  • 137
    • 84891706947 scopus 로고    scopus 로고
    • CD33 Alzheimer's disease locus: Altered monocyte function and amyloid biology
    • Bradshaw EM, Chibnik LB, Keenan BT, Ottoboni L, Raj T, et al. 2013. CD33 Alzheimer's disease locus: altered monocyte function and amyloid biology. Nat. Neurosci. 16:848-50
    • (2013) Nat. Neurosci. , vol.16 , pp. 848-850
    • Bradshaw, E.M.1    Chibnik, L.B.2    Keenan, B.T.3    Ottoboni, L.4    Raj, T.5
  • 138
    • 84878433339 scopus 로고    scopus 로고
    • Alzheimer's disease risk gene CD33 inhibits microglial uptake of amyloid beta
    • Griciuc A, Serrano-Pozo A, Parrado AR, Lesinski AN, Asselin CN, et al. 2013. Alzheimer's disease risk gene CD33 inhibits microglial uptake of amyloid beta. Neuron 78:631-43
    • (2013) Neuron , vol.78 , pp. 631-643
    • Griciuc, A.1    Serrano-Pozo, A.2    Parrado, A.R.3    Lesinski, A.N.4    Asselin, C.N.5
  • 139
    • 84962418507 scopus 로고    scopus 로고
    • Complement andmicroglia mediate early synapse loss in Alzheimer mouse models
    • Hong S, Beja-Glasser VF, Nfonoyim BM, Frouin A, Li S, et al. 2016. Complement andmicroglia mediate early synapse loss in Alzheimer mouse models. Science 352:712-16
    • (2016) Science , vol.352 , pp. 712-716
    • Hong, S.1    Beja-Glasser, V.F.2    Nfonoyim, B.M.3    Frouin, A.4    Li, S.5
  • 141
    • 84871680169 scopus 로고    scopus 로고
    • Deletion of Crry, the murine ortholog of the sporadic Alzheimer's disease risk gene CR1, impacts Tau phosphorylation and brain CFH
    • Killick R, Hughes TR, Morgan BP, Lovestone S. 2013. Deletion of Crry, the murine ortholog of the sporadic Alzheimer's disease risk gene CR1, impacts Tau phosphorylation and brain CFH. Neurosci. Lett. 533:96-99
    • (2013) Neurosci. Lett. , vol.533 , pp. 96-99
    • Killick, R.1    Hughes, T.R.2    Morgan, B.P.3    Lovestone, S.4
  • 142
    • 84978946831 scopus 로고    scopus 로고
    • Analysis of the putative role of CR1 in Alzheimer's disease: Genetic association, expression and function
    • Fonseca MI, Chu S, Pierce AL, Brubaker WD, Hauhart RE, et al. 2016. Analysis of the putative role of CR1 in Alzheimer's disease: genetic association, expression and function. PLOS One 11:e0149792
    • (2016) PLOS One , vol.11 , pp. e0149792
    • Fonseca, M.I.1    Chu, S.2    Pierce, A.L.3    Brubaker, W.D.4    Hauhart, R.E.5
  • 143
    • 32344440522 scopus 로고    scopus 로고
    • Bone marrow-derived microglia play a critical role in restricting senile plaque formation in Alzheimer's disease
    • Simard AR, Soulet D, Gowing G, Julien JP, Rivest S. 2006. Bone marrow-derived microglia play a critical role in restricting senile plaque formation in Alzheimer's disease. Neuron 49:489-502
    • (2006) Neuron , vol.49 , pp. 489-502
    • Simard, A.R.1    Soulet, D.2    Gowing, G.3    Julien, J.P.4    Rivest, S.5
  • 144
    • 34147115541 scopus 로고    scopus 로고
    • Ccr2 deficiency impairsmicroglial accumulation and accelerates progression of Alzheimer-like disease
    • El Khoury J, Toft M, Hickman SE, Means TK, Terada K, et al. 2007. Ccr2 deficiency impairsmicroglial accumulation and accelerates progression of Alzheimer-like disease. Nat. Med. 13:432-38
    • (2007) Nat. Med. , vol.13 , pp. 432-438
    • El Khoury, J.1    Toft, M.2    Hickman, S.E.3    Means, T.K.4    Terada, K.5
  • 145
    • 59049104731 scopus 로고    scopus 로고
    • Selective targeting of perivascular macrophages for clearance of betaamyloid in cerebral amyloid angiopathy
    • Hawkes CA, McLaurin J. 2009. Selective targeting of perivascular macrophages for clearance of betaamyloid in cerebral amyloid angiopathy. PNAS 106:1261-66
    • (2009) PNAS , vol.106 , pp. 1261-1266
    • Hawkes, C.A.1    McLaurin, J.2
  • 146
    • 36448955070 scopus 로고    scopus 로고
    • Microglia in the adult brain arise from Ly-6ChiCCR2+ monocytes only under defined host conditions
    • Mildner A, Schmidt H, Nitsche M, Merkler D, Hanisch UK, et al. 2007. Microglia in the adult brain arise from Ly-6ChiCCR2+ monocytes only under defined host conditions. Nat. Neurosci. 10:1544-53
    • (2007) Nat. Neurosci. , vol.10 , pp. 1544-1553
    • Mildner, A.1    Schmidt, H.2    Nitsche, M.3    Merkler, D.4    Hanisch, U.K.5
  • 147
    • 36448994709 scopus 로고    scopus 로고
    • Local self-renewal can sustain CNS microglia maintenance and function throughout adult life
    • Ajami B, Bennett JL, Krieger C, Tetzlaff W, Rossi FM. 2007. Local self-renewal can sustain CNS microglia maintenance and function throughout adult life. Nat. Neurosci. 10:1538-43
    • (2007) Nat. Neurosci. , vol.10 , pp. 1538-1543
    • Ajami, B.1    Bennett, J.L.2    Krieger, C.3    Tetzlaff, W.4    Rossi, F.M.5
  • 148
    • 84893649256 scopus 로고    scopus 로고
    • State of play in amyotrophic lateral sclerosis genetics
    • Renton AE, Chio A, Traynor BJ. 2014. State of play in amyotrophic lateral sclerosis genetics. Nat. Neurosci. 17:17-23
    • (2014) Nat. Neurosci. , vol.17 , pp. 17-23
    • Renton, A.E.1    Chio, A.2    Traynor, B.J.3
  • 149
    • 33750478657 scopus 로고    scopus 로고
    • Wild-type microglia extend survival in PU.1 knockout mice with familial amyotrophic lateral sclerosis
    • Beers DR, Henkel JS, Xiao Q, Zhao W, Wang J, et al. 2006. Wild-type microglia extend survival in PU.1 knockout mice with familial amyotrophic lateral sclerosis. PNAS 103:16021-26
    • (2006) PNAS , vol.103 , pp. 16021-16026
    • Beers, D.R.1    Henkel, J.S.2    Xiao, Q.3    Zhao, W.4    Wang, J.5
  • 150
    • 33744798774 scopus 로고    scopus 로고
    • Onset and progression in inherited ALS determined by motor neurons and microglia
    • Boillee S, Yamanaka K, Lobsiger CS, Copeland NG, Jenkins NA, et al. 2006. Onset and progression in inherited ALS determined by motor neurons and microglia. Science 312:1389-92
    • (2006) Science , vol.312 , pp. 1389-1392
    • Boillee, S.1    Yamanaka, K.2    Lobsiger, C.S.3    Copeland, N.G.4    Jenkins, N.A.5
  • 151
    • 84895422067 scopus 로고    scopus 로고
    • Microglia inducemotor neuron death via the classical NF-κB pathway in amyotrophic lateral sclerosis
    • Frakes AE, Ferraiuolo L, Haidet-Phillips AM, Schmelzer L, Braun L, et al. 2014. Microglia inducemotor neuron death via the classical NF-κB pathway in amyotrophic lateral sclerosis. Neuron 81:1009-23
    • (2014) Neuron , vol.81 , pp. 1009-1023
    • Frakes, A.E.1    Ferraiuolo, L.2    Haidet-Phillips, A.M.3    Schmelzer, L.4    Braun, L.5
  • 152
    • 84865987121 scopus 로고    scopus 로고
    • Modulating inflammatory monocytes with a unique microRNA gene signature ameliorates murine ALS
    • Butovsky O, Siddiqui S, Gabriely G, Lanser AJ, Dake B, et al. 2012. Modulating inflammatory monocytes with a unique microRNA gene signature ameliorates murine ALS. J. Clin. Investig. 122:3063-87
    • (2012) J. Clin. Investig. , vol.122 , pp. 3063-3087
    • Butovsky, O.1    Siddiqui, S.2    Gabriely, G.3    Lanser, A.J.4    Dake, B.5
  • 153
    • 84962494933 scopus 로고    scopus 로고
    • C9orf72 is required for proper macrophage and microglial function in mice
    • O'Rourke JG, Bogdanik L, Yanez A, Lall D, Wolf AJ, et al. 2016. C9orf72 is required for proper macrophage and microglial function in mice. Science 351:1324-29
    • (2016) Science , vol.351 , pp. 1324-1329
    • O'Rourke, J.G.1    Bogdanik, L.2    Yanez, A.3    Lall, D.4    Wolf, A.J.5
  • 154
    • 84866175097 scopus 로고    scopus 로고
    • The neuroinflammatory response in ALS: The roles of microglia and T cells
    • Lewis CA, Manning J, Rossi F, Krieger C. 2012. The neuroinflammatory response in ALS: the roles of microglia and T cells. Neurol. Res. Int. 2012:803701
    • (2012) Neurol. Res. Int. , vol.2012 , pp. 803701
    • Lewis, C.A.1    Manning, J.2    Rossi, F.3    Krieger, C.4
  • 155
    • 84897398469 scopus 로고    scopus 로고
    • TREM2 variant p.R47H as a risk factor for sporadic amyotrophic lateral sclerosis
    • Cady J, Koval ED, Benitez BA, Zaidman C, Jockel-Balsarotti J, et al. 2014. TREM2 variant p.R47H as a risk factor for sporadic amyotrophic lateral sclerosis. JAMA Neurol. 71:449-53
    • (2014) JAMA Neurol. , vol.71 , pp. 449-453
    • Cady, J.1    Koval, E.D.2    Benitez, B.A.3    Zaidman, C.4    Jockel-Balsarotti, J.5
  • 156
    • 84945749129 scopus 로고    scopus 로고
    • Exome sequencing in amyotrophic lateral sclerosis identifies risk genes and pathways
    • Cirulli ET, Lasseigne BN, Petrovski S, Sapp PC, Dion PA, et al. 2015. Exome sequencing in amyotrophic lateral sclerosis identifies risk genes and pathways. Science 347:1436-41
    • (2015) Science , vol.347 , pp. 1436-1441
    • Cirulli, E.T.1    Lasseigne, B.N.2    Petrovski, S.3    Sapp, P.C.4    Dion, P.A.5
  • 158
    • 84929619164 scopus 로고    scopus 로고
    • Activation of MyD88-dependent TLR1/2 signaling by misfolded alpha-synuclein, a protein linked to neurodegenerative disorders
    • Daniele SG, Beraud D, Davenport C, Cheng K, Yin H, Maguire-Zeiss KA. 2015. Activation of MyD88-dependent TLR1/2 signaling by misfolded alpha-synuclein, a protein linked to neurodegenerative disorders. Sci. Signal. 8:ra45
    • (2015) Sci. Signal. , vol.8 , pp. ra45
    • Daniele, S.G.1    Beraud, D.2    Davenport, C.3    Cheng, K.4    Yin, H.5    Maguire-Zeiss, K.A.6
  • 159
    • 84943806397 scopus 로고    scopus 로고
    • Pathways to Parkinsonism Redux: Convergent pathobiological mechanisms in genetics of Parkinson's disease
    • Kumaran R, Cookson MR. 2015. Pathways to Parkinsonism Redux: convergent pathobiological mechanisms in genetics of Parkinson's disease. Hum. Mol. Genet. 24:R32-44
    • (2015) Hum. Mol. Genet. , vol.24 , pp. R32-44
    • Kumaran, R.1    Cookson, M.R.2
  • 160
    • 84903435402 scopus 로고    scopus 로고
    • Abrogation of alphasynuclein-mediated dopaminergic neurodegeneration in LRRK2-deficient rats
    • Daher JP, Volpicelli-Daley LA, Blackburn JP, Moehle MS, West AB. 2014. Abrogation of alphasynuclein-mediated dopaminergic neurodegeneration in LRRK2-deficient rats. PNAS 111:9289-94
    • (2014) PNAS , vol.111 , pp. 9289-9294
    • Daher, J.P.1    Volpicelli-Daley, L.A.2    Blackburn, J.P.3    Moehle, M.S.4    West, A.B.5
  • 161
    • 84879113935 scopus 로고    scopus 로고
    • TREM2 in neurodegeneration: Evidence for association of the p.R47H variant with frontotemporal dementia and Parkinson's disease
    • Rayaprolu S, Mullen B, Baker M, Lynch T, Finger E, et al. 2013. TREM2 in neurodegeneration: evidence for association of the p.R47H variant with frontotemporal dementia and Parkinson's disease. Mol. Neurodegener. 8:19
    • (2013) Mol. Neurodegener. , vol.8 , pp. 19
    • Rayaprolu, S.1    Mullen, B.2    Baker, M.3    Lynch, T.4    Finger, E.5
  • 164
    • 34447636065 scopus 로고    scopus 로고
    • Microglial activation in presymptomatic Huntington's disease gene carriers
    • Tai YF, Pavese N, Gerhard A, Tabrizi SJ, Barker RA, et al. 2007. Microglial activation in presymptomatic Huntington's disease gene carriers. Brain 130:1759-66
    • (2007) Brain , vol.130 , pp. 1759-1766
    • Tai, Y.F.1    Pavese, N.2    Gerhard, A.3    Tabrizi, S.J.4    Barker, R.A.5
  • 165
    • 85014011092 scopus 로고    scopus 로고
    • RNA-Seq of Huntington's disease patient myeloid cells reveals innate transcriptional dysregulation associated with proinflammatory pathway activation
    • Miller JR, Lo KK, Andre R, Hensman Moss DJ, Trager U, et al. 2016. RNA-Seq of Huntington's disease patient myeloid cells reveals innate transcriptional dysregulation associated with proinflammatory pathway activation. Hum. Mol. Genet. 25:2893-904
    • (2016) Hum. Mol. Genet. , vol.25 , pp. 2893-2904
    • Miller, J.R.1    Lo, K.K.2    Andre, R.3    Hensman Moss, D.J.4    Trager, U.5
  • 166
    • 84962166692 scopus 로고    scopus 로고
    • Enhanced immune response to MMP3 stimulation in microglia expressing mutant huntingtin
    • Connolly C, Magnusson-Lind A, Lu G, Wagner PK, Southwell AL, et al. 2016. Enhanced immune response to MMP3 stimulation in microglia expressing mutant huntingtin. Neuroscience 325:74-88
    • (2016) Neuroscience , vol.325 , pp. 74-88
    • Connolly, C.1    Magnusson-Lind, A.2    Lu, G.3    Wagner, P.K.4    Southwell, A.L.5
  • 167
    • 77955500335 scopus 로고    scopus 로고
    • Matrix metalloproteinases are modifiers of huntingtin proteolysis and toxicity in Huntington's disease
    • Miller JP, Holcomb J, Al-Ramahi I, de Haro M, Gafni J, et al. 2010. Matrix metalloproteinases are modifiers of huntingtin proteolysis and toxicity in Huntington's disease. Neuron 67:199-212
    • (2010) Neuron , vol.67 , pp. 199-212
    • Miller, J.P.1    Holcomb, J.2    Al-Ramahi, I.3    De Haro, M.4    Gafni, J.5
  • 168
    • 79954621581 scopus 로고    scopus 로고
    • Glaucoma
    • Quigley HA. 2011. Glaucoma. Lancet 377:1367-77
    • (2011) Lancet , vol.377 , pp. 1367-1377
    • Quigley, H.A.1
  • 169
    • 67649386575 scopus 로고    scopus 로고
    • Age-related macular degeneration: An immunologically driven disease
    • Nussenblatt RB, Liu B, Li Z. 2009. Age-related macular degeneration: an immunologically driven disease. Curr. Opin. Investig. Drugs 10:434-42
    • (2009) Curr. Opin. Investig. Drugs , vol.10 , pp. 434-442
    • Nussenblatt, R.B.1    Liu, B.2    Li, Z.3
  • 170
    • 84879185182 scopus 로고    scopus 로고
    • The role of inflammation in the pathogenesis of glaucoma
    • Vohra R, Tsai JC, Kolko M. 2013. The role of inflammation in the pathogenesis of glaucoma. Surv. Ophthalmol. 58:311-20
    • (2013) Surv. Ophthalmol. , vol.58 , pp. 311-320
    • Vohra, R.1    Tsai, J.C.2    Kolko, M.3
  • 171
    • 79960671469 scopus 로고    scopus 로고
    • Age related macular degeneration and drusen: Neuroinflammation in the retina
    • Buschini E, Piras A, Nuzzi R, Vercelli A. 2011. Age related macular degeneration and drusen: neuroinflammation in the retina. Prog. Neurobiol. 95:14-25
    • (2011) Prog. Neurobiol. , vol.95 , pp. 14-25
    • Buschini, E.1    Piras, A.2    Nuzzi, R.3    Vercelli, A.4
  • 172
    • 77955421449 scopus 로고    scopus 로고
    • Microglia in the healthy and degenerating retina: Insights from novel mouse models
    • Karlstetter M, Ebert S, Langmann T. 2010. Microglia in the healthy and degenerating retina: insights from novel mouse models. Immunobiology 215:685-91
    • (2010) Immunobiology , vol.215 , pp. 685-691
    • Karlstetter, M.1    Ebert, S.2    Langmann, T.3
  • 173
    • 84155163254 scopus 로고    scopus 로고
    • Muller glial cells in retinal disease
    • Bringmann A, Wiedemann P. 2012. Muller glial cells in retinal disease. Ophthalmologica 227:1-19
    • (2012) Ophthalmologica , vol.227 , pp. 1-19
    • Bringmann, A.1    Wiedemann, P.2
  • 174
    • 84959333621 scopus 로고    scopus 로고
    • Selective A2A receptor antagonist prevents microglia-mediated neuroinflammation and protects retinal ganglion cells from high intraocular pressure-induced transient ischemic injury
    • Madeira MH, Boia R, Elvas F, Martins T, Cunha RA, et al. 2016. Selective A2A receptor antagonist prevents microglia-mediated neuroinflammation and protects retinal ganglion cells from high intraocular pressure-induced transient ischemic injury. Transl. Res. 169:112-28
    • (2016) Transl. Res. , vol.169 , pp. 112-128
    • Madeira, M.H.1    Boia, R.2    Elvas, F.3    Martins, T.4    Cunha, R.A.5
  • 175
    • 77953282828 scopus 로고    scopus 로고
    • Hematopoietic origin of pathological grooming in Hoxb8 mutant mice
    • Chen SK, Tvrdik P, Peden E, Cho S, Wu S, et al. 2010. Hematopoietic origin of pathological grooming in Hoxb8 mutant mice. Cell 141:775-85
    • (2010) Cell , vol.141 , pp. 775-785
    • Chen, S.K.1    Tvrdik, P.2    Peden, E.3    Cho, S.4    Wu, S.5
  • 177
    • 84928175766 scopus 로고    scopus 로고
    • Methyl-CpG binding protein 2 regulates microglia and macrophage gene expression in response to inflammatory stimuli
    • Cronk JC, Derecki NC, Ji E, Xu Y, Lampano AE, et al. 2015. Methyl-CpG binding protein 2 regulates microglia and macrophage gene expression in response to inflammatory stimuli. Immunity 42:679-91
    • (2015) Immunity , vol.42 , pp. 679-691
    • Cronk, J.C.1    Derecki, N.C.2    Ji, E.3    Xu, Y.4    Lampano, A.E.5
  • 178
    • 84859454582 scopus 로고    scopus 로고
    • Wild-type microglia arrest pathology in a mouse model of Rett syndrome
    • Derecki NC, Cronk JC, Lu Z, Xu E, Abbott SB, et al. 2012. Wild-type microglia arrest pathology in a mouse model of Rett syndrome. Nature 484:105-9
    • (2012) Nature , vol.484 , pp. 105-109
    • Derecki, N.C.1    Cronk, J.C.2    Lu, Z.3    Xu, E.4    Abbott, S.B.5
  • 179
    • 84930203800 scopus 로고    scopus 로고
    • Wild-type microglia do not reverse pathology in mouse models of Rett syndrome
    • Wang J, Wegener JE, Huang TW, Sripathy S, De Jesus-Cortes H, et al. 2015. Wild-type microglia do not reverse pathology in mouse models of Rett syndrome. Nature 521:E1-4
    • (2015) Nature , vol.521 , pp. E1-4
    • Wang, J.1    Wegener, J.E.2    Huang, T.W.3    Sripathy, S.4    De Jesus-Cortes, H.5
  • 180
    • 84979528624 scopus 로고    scopus 로고
    • Microglia contribute to circuit defects in Mecp2 null mice independent of microglia-specific loss of Mecp2 expression
    • Schafer DP, Heller CT, Gunner G, Heller M, Gordon C, et al. 2016. Microglia contribute to circuit defects in Mecp2 null mice independent of microglia-specific loss of Mecp2 expression. eLife 5:e15224
    • (2016) ELife , vol.5 , pp. e15224
    • Schafer, D.P.1    Heller, C.T.2    Gunner, G.3    Heller, M.4    Gordon, C.5
  • 181
    • 35848950202 scopus 로고    scopus 로고
    • Immunological aspects in the neurobiology of suicide: Elevated microglial density in schizophrenia and depression is associated with suicide
    • Steiner J, Bielau H, Brisch R, Danos P, Ullrich O, et al. 2008. Immunological aspects in the neurobiology of suicide: elevated microglial density in schizophrenia and depression is associated with suicide. J. Psychiatr. Res. 42:151-57
    • (2008) J. Psychiatr. Res. , vol.42 , pp. 151-157
    • Steiner, J.1    Bielau, H.2    Brisch, R.3    Danos, P.4    Ullrich, O.5
  • 182
    • 81155157520 scopus 로고    scopus 로고
    • Severe depression is associated with increased microglial quinolinic acid in subregions of the anterior cingulate gyrus: Evidence for an immune-modulated glutamatergic neurotransmission?
    • Steiner J, Walter M, Gos T, Guillemin GJ, Bernstein HG, et al. 2011. Severe depression is associated with increased microglial quinolinic acid in subregions of the anterior cingulate gyrus: evidence for an immune-modulated glutamatergic neurotransmission? J. Neuroinflammation 8:94
    • (2011) J. Neuroinflammation , vol.8 , pp. 94
    • Steiner, J.1    Walter, M.2    Gos, T.3    Guillemin, G.J.4    Bernstein, H.G.5
  • 183
    • 84908617290 scopus 로고    scopus 로고
    • Evidence for increased microglial priming and macrophage recruitment in the dorsal anterior cingulatewhite matter of depressed suicides
    • Torres-Platas SG, Cruceanu C, Chen GG, Turecki G, Mechawar N. 2014. Evidence for increased microglial priming and macrophage recruitment in the dorsal anterior cingulatewhite matter of depressed suicides. Brain Behav. Immun. 42:50-59
    • (2014) Brain Behav. Immun. , vol.42 , pp. 50-59
    • Torres-Platas, S.G.1    Cruceanu, C.2    Chen, G.G.3    Turecki, G.4    Mechawar, N.5
  • 186
    • 84905253467 scopus 로고    scopus 로고
    • Keratan sulfate expression is associated with activation of a subpopulation of microglia/macrophages in Wallerian degeneration
    • Shinjo R, Imagama S, Ito Z, Ando K, Nishida Y, et al. 2014. Keratan sulfate expression is associated with activation of a subpopulation of microglia/macrophages in Wallerian degeneration. Neurosci. Lett. 579:80-85
    • (2014) Neurosci. Lett. , vol.579 , pp. 80-85
    • Shinjo, R.1    Imagama, S.2    Ito, Z.3    Ando, K.4    Nishida, Y.5
  • 187
    • 84937634728 scopus 로고    scopus 로고
    • The role of the immune system in neurodegenerative disorders: Adaptive or maladaptive?
    • Doty KR, Guillot-Sestier MV, Town T. 2015. The role of the immune system in neurodegenerative disorders: Adaptive or maladaptive? Brain Res. 1617:155-73
    • (2015) Brain Res. , vol.1617 , pp. 155-173
    • Doty, K.R.1    Guillot-Sestier, M.V.2    Town, T.3
  • 188
    • 84925279976 scopus 로고    scopus 로고
    • Immunotherapeutic approaches for Alzheimer's disease
    • Wisniewski T, Goni F. 2015. Immunotherapeutic approaches for Alzheimer's disease. Neuron 85:1162-76
    • (2015) Neuron , vol.85 , pp. 1162-1176
    • Wisniewski, T.1    Goni, F.2
  • 189
    • 84985896386 scopus 로고    scopus 로고
    • The antibody aducanumab reduces Aβplaques in Alzheimer's disease
    • Sevigny J, Chiao P, Bussiere T, Weinreb PH, Williams L, et al. 2016.The antibody aducanumab reduces Aβplaques in Alzheimer's disease. Nature 537:50-56
    • (2016) Nature , vol.537 , pp. 50-56
    • Sevigny, J.1    Chiao, P.2    Bussiere, T.3    Weinreb, P.H.4    Williams, L.5
  • 190
    • 84984804748 scopus 로고    scopus 로고
    • TREM2 deficiency reduces the efficacy of immunotherapeutic amyloid clearance
    • Xiang X, Werner G, Bohrmann B, Liesz A, Mazaheri F, et al. 2016. TREM2 deficiency reduces the efficacy of immunotherapeutic amyloid clearance. EMBO Mol. Med. 8:992-1004
    • (2016) EMBO Mol. Med. , vol.8 , pp. 992-1004
    • Xiang, X.1    Werner, G.2    Bohrmann, B.3    Liesz, A.4    Mazaheri, F.5
  • 191
    • 85002881692 scopus 로고    scopus 로고
    • Inflammation in Alzheimer's disease: Lessons learned frommicrogliadepletion models
    • Spangenberg EE, Green KN. 2017. Inflammation in Alzheimer's disease: lessons learned frommicrogliadepletion models. Brain Behav. Immun. 61:1-11
    • (2017) Brain Behav. Immun. , vol.61 , pp. 1-11
    • Spangenberg, E.E.1    Green, K.N.2
  • 192
    • 84964632197 scopus 로고    scopus 로고
    • Pharmacological targeting of CSF1R inhibits microglial proliferation and prevents the progression of Alzheimer's-like pathology
    • Olmos-Alonso A, Schetters ST, Sri S, Askew K, Mancuso R, et al. 2016. Pharmacological targeting of CSF1R inhibits microglial proliferation and prevents the progression of Alzheimer's-like pathology. Brain 139:891-907
    • (2016) Brain , vol.139 , pp. 891-907
    • Olmos-Alonso, A.1    Schetters, S.T.2    Sri, S.3    Askew, K.4    Mancuso, R.5
  • 193
    • 84919832455 scopus 로고    scopus 로고
    • Phenotypic characterization of a Csf1r haploinsufficient mouse model of adult-onset leukodystrophy with axonal spheroids and pigmented glia (ALSP)
    • Chitu V, Gokhan S, Gulinello M, Branch CA, Patil M, et al. 2015. Phenotypic characterization of a Csf1r haploinsufficient mouse model of adult-onset leukodystrophy with axonal spheroids and pigmented glia (ALSP). Neurobiol. Dis. 74:219-28
    • (2015) Neurobiol. Dis. , vol.74 , pp. 219-228
    • Chitu, V.1    Gokhan, S.2    Gulinello, M.3    Branch, C.A.4    Patil, M.5
  • 194
    • 84874539371 scopus 로고    scopus 로고
    • Colony-stimulating factor 1 receptor (CSF1R) signaling in injured neurons facilitates protection and survival
    • Luo J, Elwood F, Britschgi M, Villeda S, Zhang H, et al. 2013. Colony-stimulating factor 1 receptor (CSF1R) signaling in injured neurons facilitates protection and survival. J. Exp. Med. 210:157-72
    • (2013) J. Exp. Med. , vol.210 , pp. 157-172
    • Luo, J.1    Elwood, F.2    Britschgi, M.3    Villeda, S.4    Zhang, H.5
  • 196
    • 84979643006 scopus 로고    scopus 로고
    • Silibinin rescues learning and memory deficits by attenuating microglia activation and preventing neuroinflammatory reactions in SAMP8 mice
    • Jin G, Bai D, Yin S, Yang Z, Zou D, et al. 2016. Silibinin rescues learning and memory deficits by attenuating microglia activation and preventing neuroinflammatory reactions in SAMP8 mice. Neurosci. Lett. 629:256-61
    • (2016) Neurosci. Lett. , vol.629 , pp. 256-261
    • Jin, G.1    Bai, D.2    Yin, S.3    Yang, Z.4    Zou, D.5
  • 197
    • 84929326823 scopus 로고    scopus 로고
    • Nuclear receptors license phagocytosis by TREM2+ myeloid cells in mouse models of Alzheimer's disease
    • Savage JC, Jay T, Goduni E, Quigley C, Mariani MM, et al. 2015. Nuclear receptors license phagocytosis by TREM2+ myeloid cells in mouse models of Alzheimer's disease. J. Neurosci. 35:6532-43
    • (2015) J. Neurosci. , vol.35 , pp. 6532-6543
    • Savage, J.C.1    Jay, T.2    Goduni, E.3    Quigley, C.4    Mariani, M.M.5
  • 198
    • 84975747555 scopus 로고    scopus 로고
    • An anti-apoE4 specific monoclonal antibody counteracts the pathological effects of apoE4 in vivo
    • Luz I, Liraz O, Michaelson DM. 2016. An anti-apoE4 specific monoclonal antibody counteracts the pathological effects of apoE4 in vivo. Curr. Alzheimer Res. 13:918-29
    • (2016) Curr. Alzheimer Res. , vol.13 , pp. 918-929
    • Luz, I.1    Liraz, O.2    Michaelson, D.M.3
  • 199
    • 84863890450 scopus 로고    scopus 로고
    • Autophagy and neuronal cell death in neurological disorders
    • Nixon RA, Yang DS. 2012. Autophagy and neuronal cell death in neurological disorders. Cold Spring Harb. Perspect. Biol. 4:a008839
    • (2012) Cold Spring Harb. Perspect. Biol. , vol.4 , pp. a008839
    • Nixon, R.A.1    Yang, D.S.2
  • 200
    • 84907898151 scopus 로고    scopus 로고
    • Autophagy inmicroglia degrades extracellular beta-amyloid fibrils and regulates the NLRP3 inflammasome
    • Cho MH, Cho K, Kang HJ, Jeon EY, Kim HS, et al. 2014. Autophagy inmicroglia degrades extracellular beta-amyloid fibrils and regulates the NLRP3 inflammasome. Autophagy 10:1761-75
    • (2014) Autophagy , vol.10 , pp. 1761-1775
    • Cho, M.H.1    Cho, K.2    Kang, H.J.3    Jeon, E.Y.4    Kim, H.S.5
  • 201
    • 84978168223 scopus 로고    scopus 로고
    • Deficient autophagy in microglia impairs synaptic pruning and causes social behavioral defects
    • In press
    • Kim HJ, Cho MH, Shim WH, Kim JK, Jeon EY, et al. 2016. Deficient autophagy in microglia impairs synaptic pruning and causes social behavioral defects. Mol. Psychiatry. In press. https://doi.org/ 10.1038/mp.2016.103
    • (2016) Mol. Psychiatry
    • Kim, H.J.1    Cho, M.H.2    Shim, W.H.3    Kim, J.K.4    Jeon, E.Y.5
  • 202
    • 84950241312 scopus 로고    scopus 로고
    • Replacement of brain-resident myeloid cells does not alter cerebral amyloid-beta deposition in mouse models of Alzheimer's disease
    • Varvel NH, Grathwohl SA, Degenhardt K, Resch C, Bosch A, et al. 2015. Replacement of brain-resident myeloid cells does not alter cerebral amyloid-beta deposition in mouse models of Alzheimer's disease. J. Exp. Med. 212:1803-9
    • (2015) J. Exp. Med. , vol.212 , pp. 1803-1809
    • Varvel, N.H.1    Grathwohl, S.A.2    Degenhardt, K.3    Resch, C.4    Bosch, A.5
  • 203
    • 84950248998 scopus 로고    scopus 로고
    • Impact of peripheral myeloid cells on amyloid-beta pathology in Alzheimer's disease-like mice
    • Prokop S, Miller KR, Drost N, Handrick S, Mathur V, et al. 2015. Impact of peripheral myeloid cells on amyloid-beta pathology in Alzheimer's disease-like mice. J. Exp. Med. 212:1811-18
    • (2015) J. Exp. Med. , vol.212 , pp. 1811-1818
    • Prokop, S.1    Miller, K.R.2    Drost, N.3    Handrick, S.4    Mathur, V.5


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