TREM2 Haplodeficiency in Mice and Humans Impairs the Microglia Barrier Function Leading to Decreased Amyloid Compaction and Severe Axonal Dystrophy

Neuron

Volumn 90, Issue 4, 2016, Pages 724-739

  Yuan, Peng ^a   Condello, Carlo ^a,f   Keene, C Dirk ^b   Wang, Yaming ^c   Bird, Thomas D ^b   Paul, Steven M ^d   Luo, Wenjie ^d   Colonna, Marco ^c   Baddeley, David ^a,e   Grutzendler, Jaime ^a  

^a YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF WASHINGTON   (United States)

^c WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^d FEIL FAMILY BRAIN AND MIND RESEARCH INSTITUTE   (United States)

^e YALE UNIVERSITY   (United States)

^f UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMYLOID; AMYLOID BETA PROTEIN; KILLER CELL ACTIVATING RECEPTOR ASSOCIATED PROTEIN; PROTEIN TYROSINE KINASE; TAU PROTEIN; TRIGGERING RECEPTOR EXPRESSED ON MYELOID CELLS 2; IMMUNOGLOBULIN RECEPTOR; MEMBRANE PROTEIN; TREM2 PROTEIN, HUMAN; TREM2 PROTEIN, MOUSE;

ALZHEIMER DISEASE; AMYLOID PLAQUE; AMYLOIDOSIS; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONFOCAL MICROSCOPY; CONTROLLED STUDY; ENZYME ACTIVATION; HAPLOINSUFFICIENCY; HUMAN; HUMAN TISSUE; MICROGLIA; MICROSCOPY; MOUSE; NEURITE; NEUROAXONAL DYSTROPHY; NEUROPROTECTION; NONHUMAN; PHAGOCYTOSIS; PHAGOSOME; PRIORITY JOURNAL; PROTEIN DEFICIENCY; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION; STOCHASTIC OPTICAL RECONSTRUCTION MICROSCOPY; SUPER RESOLUTION MICROSCOPY; ANIMAL; AXON; DEFICIENCY; DISEASE MODEL; GENETICS; METABOLISM; MUTATION; PATHOLOGY;

ALZHEIMER DISEASE; AMYLOID; AMYLOID BETA-PEPTIDES; ANIMALS; AXONS; DISEASE MODELS, ANIMAL; HUMANS; MEMBRANE GLYCOPROTEINS; MICE; MICROGLIA; MUTATION; NEURITES; PLAQUE, AMYLOID; RECEPTORS, IMMUNOLOGIC;

EID: 84968764145     PISSN: 08966273     EISSN: 10974199     Source Type: Journal    
DOI: 10.1016/j.neuron.2016.05.003     Document Type: Article

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