Sequential proteolytic processing of the triggering receptor expressed on myeloid cells-2 (TREM2) protein by ectodomain shedding and γ-secretase- dependent intramembranous cleavage

Journal of Biological Chemistry

Volumn 288, Issue 46, 2013, Pages 33027-33036

  Wunderlich, Patrick ^a   Glebov, Konstantin ^a   Kemmerling, Nadja ^a   Tien, Nguyen T ^a   Neumann, Harald ^a   Walter, Jochen ^a  

^a UNIVERSITY OF BONN   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

C-TERMINAL FRAGMENTS; DISEASE-ASSOCIATED PROTEINS; ECTODOMAIN SHEDDING; INTRAMEMBRANE PROTEOLYSIS; PHOSPHATIDYLINOSITOL 4 ,5-BISPHOSPHATE; PROTEOLYTIC PROCESSING; SIGNALING PATHWAYS; TISSUE MACROPHAGES;

CELL MEMBRANES; NEURODEGENERATIVE DISEASES; PROTEINS; PROTEOLYSIS; SIGNAL TRANSDUCTION;

CELL SIGNALING;

GAMMA SECRETASE; KILLER CELL ACTIVATING RECEPTOR ASSOCIATED PROTEIN; MEMBRANE RECEPTOR; PHOSPHATIDYLINOSITOL 4,5 BISPHOSPHATE; TRIGGERING RECEPTOR EXPRESSED ON MYELOID CELLS 2; UNCLASSIFIED DRUG;

ARTICLE; CARBOXY TERMINAL SEQUENCE; CELLULAR DISTRIBUTION; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME INHIBITION; LIPID METABOLISM; PRIORITY JOURNAL; PROTEIN CLEAVAGE; PROTEIN DEGRADATION; PROTEIN DOMAIN; PROTEIN PHOSPHORYLATION; PROTEIN PROCESSING; PROTEIN PROTEIN INTERACTION; SIGNAL TRANSDUCTION;

ALZHEIMER DISEASE; INTRAMEMBRANE PROTEOLYSIS; MEMBRANE; PRESENILIN; PROTEIN PHOSPHORYLATION; SECRETASES; SIGNALING;

ADAPTOR PROTEINS, SIGNAL TRANSDUCING; ALZHEIMER DISEASE; AMYLOID PRECURSOR PROTEIN SECRETASES; ANIMALS; CELL MEMBRANE; CERCOPITHECUS AETHIOPS; COS CELLS; HEK293 CELLS; HUMANS; MALE; MEMBRANE GLYCOPROTEINS; MEMBRANE PROTEINS; PHOSPHATIDYLINOSITOL 4,5-DIPHOSPHATE; PHOSPHORYLATION; PROTEIN STRUCTURE, TERTIARY; PROTEOLYSIS; RECEPTORS, IMMUNOLOGIC; SIGNAL TRANSDUCTION;

EID: 84887853222     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M113.517540     Document Type: Article

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