Microglia induce motor neuron death via the classical NF-κB pathway in amyotrophic lateral sclerosis

Neuron

Volumn 81, Issue 5, 2014, Pages 1009-1023

  Frakes, Ashley E ^a,b   Ferraiuolo, Laura ^a   Haidet Phillips, Amanda M ^a,d   Schmelzer, Leah ^a   Braun, Lyndsey ^a   Miranda, Carlos J ^a   Ladner, Katherine J ^c   Bevan, Adam K ^a,b   Foust, Kevin D ^c   Godbout, Jonathan P ^c   Popovich, Phillip G ^c   Guttridge, Denis C ^c   Kaspar, Brian K ^a,b,c  

^a THE RESEARCH INSTITUTE AT NATIONWIDE CHILDREN S HOSPITAL   (United States)

^b THE OHIO STATE UNIVERSITY COLLEGE OF MEDICINE   (United States)

^c OHIO STATE UNIVERSITY   (United States)

^d JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; COPPER ZINC SUPEROXIDE DISMUTASE; LUCIFERASE; SYNAPTOTAGMIN I;

ADULT; AMYOTROPHIC LATERAL SCLEROSIS; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL ACTIVATION; CELL DEATH; CONTROLLED STUDY; DISEASE COURSE; FEMALE; GLIOSIS; IN VITRO STUDY; IN VIVO STUDY; LATENT PERIOD; MICROGLIA; MOTOR NERVE; MOUSE; NEUROMODULATION; NEUROPROTECTION; NEUROTOXICITY; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; SIGNAL TRANSDUCTION; SURVIVAL RATE; WILD TYPE; ASTROCYTE; CELL SURVIVAL; ENZYME ACTIVATION; ENZYME INHIBITION; ENZYME REGULATION; GRIP STRENGTH; MOLECULAR MECHANICS; MOTONEURON; NEWBORN; PROTEIN ANALYSIS; PROTEIN DEGRADATION; PROTEIN FUNCTION; PROTEIN PHOSPHORYLATION; UBIQUITINATION;

AGE FACTORS; AMYOTROPHIC LATERAL SCLEROSIS; ANIMALS; ANIMALS, NEWBORN; ASTROCYTES; CELL COMMUNICATION; CELL DEATH; COCULTURE TECHNIQUES; DISEASE MODELS, ANIMAL; FEMALE; MICE; MICE, INBRED STRAINS; MICE, TRANSGENIC; MICROGLIA; MOTOR NEURONS; NF-KAPPA B; PRIMARY CELL CULTURE; SIGNAL TRANSDUCTION; SUPEROXIDE DISMUTASE;

EID: 84895422067     PISSN: 08966273     EISSN: 10974199     Source Type: Journal    
DOI: 10.1016/j.neuron.2014.01.013     Document Type: Article

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