Nuclear receptors license phagocytosis by trem2+ myeloid cells in mouse models of Alzheimer’s disease

Journal of Neuroscience

Volumn 35, Issue 16, 2015, Pages 6532-6543

  Savage, Julie C ^a   Jay, Taylor ^a,c   Goduni, Elanda ^a   Quigley, Caitlin ^a   Mariani, Monica M ^a   Malm, Tarja ^b   Ransohoff, Richard M ^c   Lamb, Bruce T ^a,c   Landreth, Gary E ^a  

^a CASE WESTERN RESERVE UNIVERSITY   (United States)

^b UNIVERSITY OF EASTERN FINLAND   (Finland)

^c LERNER RESEARCH INSTITUTE   (United States)

Author keywords

Alzheimer s disease; Microglia; Nuclear receptors; Phagocytosis

Indexed keywords

3 [3 [[2 CHLORO 3 (TRIFLUOROMETHYL) BENZYL] (2 DIPHENYLETHYL) AMINO] PROPOXY] PHENYLACETIC ACID; BEXAROTENE; CD45 ANTIGEN; CELL NUCLEUS RECEPTOR; GROWTH ARREST SPECIFIC PROTEIN 6; PIOGLITAZONE; PROTEIN TYROSINE KINASE; TRIGGERING RECEPTOR EXPRESSED ON MYELOID CELLS 1; TRIGGERING RECEPTOR EXPRESSED ON MYELOID CELLS 2; UNCLASSIFIED DRUG; [4 [2 (3 FLUORO 4 TRIFLUOROMETHYLPHENYL) 4 METHYL 5 THIAZOLYLMETHYLTHIO] 2 METHYLPHENOXY] ACETIC ACID; 2,4 THIAZOLIDINEDIONE DERIVATIVE; 3 [3 [[2 CHLORO 3 (TRIFLUOROMETHYL)BENZYL](2 DIPHENYLETHYL)AMINO]PROPOXY]PHENYLACETIC ACID; AXL RECEPTOR TYROSINE KINASE; BENZOIC ACID DERIVATIVE; BENZYLAMINE DERIVATIVE; CELL RECEPTOR; IMMUNOGLOBULIN RECEPTOR; MEMBRANE PROTEIN; MERTK PROTEIN, MOUSE; ONCOPROTEIN; PTPRC PROTEIN, MOUSE; TETRALIN DERIVATIVE; THIAZOLE DERIVATIVE; TREM2 PROTEIN, MOUSE; [4 [2 (3 FLUORO 4 TRIFLUOROMETHYLPHENYL) 4 METHYL 5 THIAZOLYLMETHYLTHIO] 2 METHYLPHENOXY]ACETIC ACID;

ALZHEIMER DISEASE; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; FLOW CYTOMETRY; GENOTYPE; IMMUNOHISTOCHEMISTRY; MACROPHAGE; MALE; MICROGLIA; MOUSE; MRNA EXPRESSION ASSAY; NONHUMAN; PHAGOCYTOSIS; PRIORITY JOURNAL; PROTEIN EXPRESSION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; RNA EXTRACTION; WESTERN BLOTTING; AGONISTS; AMYLOID PLAQUE; ANIMAL; BIOSYNTHESIS; BONE MARROW CELL; CELL CULTURE; DISEASE MODEL; DRUG EFFECTS; GENE EXPRESSION REGULATION; METABOLISM; PATHOLOGY; PHYSIOLOGY;

ALZHEIMER DISEASE; ANIMALS; ANTIGENS, CD45; BENZOATES; BENZYLAMINES; CELLS, CULTURED; DISEASE MODELS, ANIMAL; GENE EXPRESSION REGULATION; MACROPHAGES; MALE; MEMBRANE GLYCOPROTEINS; MICE; MICROGLIA; MYELOID CELLS; PHAGOCYTOSIS; PLAQUE, AMYLOID; PROTO-ONCOGENE PROTEINS; RECEPTOR PROTEIN-TYROSINE KINASES; RECEPTORS, CYTOPLASMIC AND NUCLEAR; RECEPTORS, IMMUNOLOGIC; TETRAHYDRONAPHTHALENES; THIAZOLES; THIAZOLIDINEDIONES;

EID: 84929326823     PISSN: 02706474     EISSN: 15292401     Source Type: Journal    
DOI: 10.1523/JNEUROSCI.4586-14.2015     Document Type: Article

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