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Volumn 3, Issue 122, 2010, Pages

TREM2- and DAP12-dependent activation of PI3K requires DAP10 and is inhibited by SHIP1

Author keywords

[No Author keywords available]

Indexed keywords

ACTIN; CALCIUM; GUANINE NUCLEOTIDE EXCHANGE FACTOR; KILLER CELL ACTIVATING RECEPTOR ASSOCIATED PROTEIN; MEMBRANE PROTEIN; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; PHOSPHATASE; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN DAP10; PROTEIN TREM 2; RECEPTOR PROTEIN; SHIP1; UNCLASSIFIED DRUG;

EID: 77953819536     PISSN: 19450877     EISSN: 19379145     Source Type: Journal    
DOI: 10.1126/scisignal.2000500     Document Type: Article
Times cited : (277)

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    • Acknowledgments: We thank M. Nakamura, B. Seaman, and L. Lanier for their critical review of the data and the manuscript. Antibodies against TREM2 were provided by B. Seaman and M. Nakamura. We thank L. Lanier and M. Orr for providing DAP10-deficient bone marrow and T. Takai for providing antiserum specific for DAP12. Funding: This work was supported by Department of Veteran's Affairs grants to M. B. H., NIH grants to M. B. H. DE019398, P20 RR0201143, W. G. K. HL085580, HL72523, by the Paige Arnold Butterfly Run grant to W. G. K., and by grant U19 AI062629 to K. M. C. Author contributions: M. B. H. initiated the project; J. A. T. performed initial immunoprecipitation studies, Q. P. and S. M. performed all experiments; M. B. H., Q. P., S. M., W. G. K., and K. M. C. designed experiments and analyzed data;
    • Acknowledgments: We thank M. Nakamura, B. Seaman, and L. Lanier for their critical review of the data and the manuscript. Antibodies against TREM2 were provided by B. Seaman and M. Nakamura. We thank L. Lanier and M. Orr for providing DAP10-deficient bone marrow and T. Takai for providing antiserum specific for DAP12. Funding: This work was supported by Department of Veteran's Affairs grants to M. B. H., NIH grants to M. B. H. (DE019398, P20 RR0201143), W. G. K. (HL085580, HL72523), by the Paige Arnold Butterfly Run grant to W. G. K., and by grant U19 AI062629 to K. M. C. Author contributions: M. B. H. initiated the project; J. A. T. performed initial immunoprecipitation studies, Q. P. and S. M. performed all experiments; M. B. H., Q. P., S. M., W. G. K., and K. M. C. designed experiments and analyzed data; M. B. H. wrote the paper; Q. P., S. M., W. G. K., and K. M. C. edited the paper. Competing interests: W. G. K. and K. M. C. are advisors to Aquinox Pharmaceuticals. The use of SHIP1 mice requires a materials transfer agreement (MTA).


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