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Acknowledgments: We thank M. Nakamura, B. Seaman, and L. Lanier for their critical review of the data and the manuscript. Antibodies against TREM2 were provided by B. Seaman and M. Nakamura. We thank L. Lanier and M. Orr for providing DAP10-deficient bone marrow and T. Takai for providing antiserum specific for DAP12. Funding: This work was supported by Department of Veteran's Affairs grants to M. B. H., NIH grants to M. B. H. DE019398, P20 RR0201143, W. G. K. HL085580, HL72523, by the Paige Arnold Butterfly Run grant to W. G. K., and by grant U19 AI062629 to K. M. C. Author contributions: M. B. H. initiated the project; J. A. T. performed initial immunoprecipitation studies, Q. P. and S. M. performed all experiments; M. B. H., Q. P., S. M., W. G. K., and K. M. C. designed experiments and analyzed data;
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Acknowledgments: We thank M. Nakamura, B. Seaman, and L. Lanier for their critical review of the data and the manuscript. Antibodies against TREM2 were provided by B. Seaman and M. Nakamura. We thank L. Lanier and M. Orr for providing DAP10-deficient bone marrow and T. Takai for providing antiserum specific for DAP12. Funding: This work was supported by Department of Veteran's Affairs grants to M. B. H., NIH grants to M. B. H. (DE019398, P20 RR0201143), W. G. K. (HL085580, HL72523), by the Paige Arnold Butterfly Run grant to W. G. K., and by grant U19 AI062629 to K. M. C. Author contributions: M. B. H. initiated the project; J. A. T. performed initial immunoprecipitation studies, Q. P. and S. M. performed all experiments; M. B. H., Q. P., S. M., W. G. K., and K. M. C. designed experiments and analyzed data; M. B. H. wrote the paper; Q. P., S. M., W. G. K., and K. M. C. edited the paper. Competing interests: W. G. K. and K. M. C. are advisors to Aquinox Pharmaceuticals. The use of SHIP1 mice requires a materials transfer agreement (MTA).
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