Stimulation of microglial metabotropic glutamate receptor mGlu2 triggers tumor necrosis factor α-induced neurotoxicity in concert with microglial-derived Fas ligand

Journal of Neuroscience

Volumn 25, Issue 11, 2005, Pages 2952-2964

  Taylor, Deanna L ^a   Jones, Fleur ^a   Chen Seho Kubota, Eva S F ^a   Pocock, Jennifer M ^a  

^a UNIVERSITY COLLEGE LONDON   (United Kingdom)

Author keywords

FasL; Metabotropic glutamate receptor; Microglia; Neurodegenerative disease; Neuroprotection; TNF

Indexed keywords

2 AMINO 4 PHOSPHONOBUTYRIC ACID; 2',3' DICARBOXY CYCLOPROPYLGLYCINE; CASPASE 3; FAS LIGAND; GLYCINE DERIVATIVE; METABOTROPIC RECEPTOR 2; METABOTROPIC RECEPTOR 3; N ACETYLASPARTYLGLUTAMIC ACID; TUMOR NECROSIS FACTOR ALPHA; TUMOR NECROSIS FACTOR RECEPTOR 1; UNCLASSIFIED DRUG;

ALZHEIMER DISEASE; ANIMAL CELL; ANIMAL EXPERIMENT; APOPTOSIS; ARTICLE; CELL ACTIVATION; CONTROLLED STUDY; DEPOLARIZATION; ENZYME ACTIVATION; IN VITRO STUDY; MICROGLIA; MULTIPLE SCLEROSIS; NEUROTOXICITY; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; PROTEIN SECRETION; RAT; RECEPTOR UPREGULATION;

ANIMALS; ANIMALS, NEWBORN; APOPTOSIS; BLOTTING, WESTERN; CASPASE 3; CASPASES; CELL COUNT; CELLS, CULTURED; CEREBELLUM; COCULTURE TECHNIQUES; CULTURE MEDIA, CONDITIONED; DISEASE MODELS, ANIMAL; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG INTERACTIONS; ECTODYSPLASINS; EXCITATORY AMINO ACID ANTAGONISTS; FAS LIGAND PROTEIN; GENE EXPRESSION; LIPOPOLYSACCHARIDES; MEMBRANE GLYCOPROTEINS; MEMBRANE PROTEINS; MICE; MICROGLIA; MITOCHONDRIA; NEURONS; NEUROTOXICITY SYNDROMES; NITRIC OXIDE SYNTHASE TYPE II; RATS; RATS, WISTAR; RECEPTORS, METABOTROPIC GLUTAMATE; RECEPTORS, TUMOR NECROSIS FACTOR, TYPE I; RECEPTORS, TUMOR NECROSIS FACTOR, TYPE II; TIME FACTORS; TUMOR NECROSIS FACTOR-ALPHA; TUMOR NECROSIS FACTORS;

EID: 15244350494     PISSN: 02706474     EISSN: None     Source Type: Journal    
DOI: 10.1523/JNEUROSCI.4456-04.2005     Document Type: Article

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