-
1
-
-
76749098103
-
Parkinson's disease: Mitochondrial damage control
-
Abeliovich A. 2010. Parkinson's disease: Mitochondrial damage control. Nature 463: 744-745.
-
(2010)
Nature
, vol.463
, pp. 744-745
-
-
Abeliovich, A.1
-
2
-
-
60149092294
-
Severely dystrophic axons at amyloid plaques remain continuous and connected to viable cell bodies
-
Adalbert R, Nogradi A, Babetto E, Janeckova L, Walker SA, Kerschensteiner M, Misgeld T, Coleman MP. 2009. Severely dystrophic axons at amyloid plaques remain continuous and connected to viable cell bodies. Brain 132: 402-416.
-
(2009)
Brain
, vol.132
, pp. 402-416
-
-
Adalbert, R.1
Nogradi, A.2
Babetto, E.3
Janeckova, L.4
Walker, S.A.5
Kerschensteiner, M.6
Misgeld, T.7
Coleman, M.P.8
-
3
-
-
77955282380
-
Curcuminoids enhance memory in an amyloid-infused rat model of Alzheimer's disease
-
Ahmed T, Enam SA, Gilani AH. 2010. Curcuminoids enhance memory in an amyloid-infused rat model of Alzheimer's disease. Neuroscience 169: 1296-1306.
-
(2010)
Neuroscience
, vol.169
, pp. 1296-1306
-
-
Ahmed, T.1
Enam, S.A.2
Gilani, A.H.3
-
4
-
-
0031036896
-
Apoptosis and autophagy in nigral neurons of patients with Parkinson's disease
-
Anglade P, Vyas S, Javoy-Agid F, Herrero MT, Michel PP, Marquez J, Mouatt-Prigent A, Ruberg M, Hirsch EC, Agid Y. 1997. Apoptosis and autophagy in nigral neurons of patients with Parkinson's disease. Histol Histopathol 12: 25-31.
-
(1997)
Histol Histopathol
, vol.12
, pp. 25-31
-
-
Anglade, P.1
Vyas, S.2
Javoy-Agid, F.3
Herrero, M.T.4
Michel, P.P.5
Marquez, J.6
Mouatt-Prigent, A.7
Ruberg, M.8
Hirsch, E.C.9
Agid, Y.10
-
5
-
-
7244236320
-
Inclusion body formation reduces levels of mutant huntingtin and the risk of neuronal death
-
Arrasate M, Mitra S, Schweitzer ES, Segal MR, Finkbeiner S. 2004. Inclusion body formation reduces levels of mutant huntingtin and the risk of neuronal death. Nature 431: 805-810.
-
(2004)
Nature
, vol.431
, pp. 805-810
-
-
Arrasate, M.1
Mitra, S.2
Schweitzer, E.S.3
Segal, M.R.4
Finkbeiner, S.5
-
6
-
-
0000730374
-
Cytoplasmic components in hepatic cell lysosomes
-
Ashford TP, Porter KR. 1962. Cytoplasmic components in hepatic cell lysosomes. J Cell Biol 12: 198-202.
-
(1962)
J Cell Biol
, vol.12
, pp. 198-202
-
-
Ashford, T.P.1
Porter, K.R.2
-
7
-
-
20344387475
-
Autophagy: Dual roles in life and death?
-
Baehrecke EH. 2005. Autophagy: Dual roles in life and death? Nat Rev Mol Cell Biol 6: 505-510.
-
(2005)
Nat Rev Mol Cell Biol
, vol.6
, pp. 505-510
-
-
Baehrecke, E.H.1
-
8
-
-
51349130544
-
The chaperone-mediated autophagy receptor organizes in dynamic protein complexes at the lysosomal membrane
-
Bandyopadhyay U, Kaushik S, Varticovski L, Cuervo AM. 2008. The chaperone-mediated autophagy receptor organizes in dynamic protein complexes at the lysosomal membrane. Mol Cell Biol 28: 5747-5763.
-
(2008)
Mol Cell Biol
, vol.28
, pp. 5747-5763
-
-
Bandyopadhyay, U.1
Kaushik, S.2
Varticovski, L.3
Cuervo, A.M.4
-
9
-
-
77955989034
-
Identification of regulators of chaperonemediated autophagy
-
Bandyopadhyay U, Sridhar S, Kaushik S, Kiffin R, Cuerv AM. 2010. Identification of regulators of chaperonemediated autophagy. Mol Cell 39: 535-547.
-
(2010)
Mol Cell
, vol.39
, pp. 535-547
-
-
Bandyopadhyay, U.1
Sridhar, S.2
Kaushik, S.3
Kiffin, R.4
Cuerv, A.M.5
-
10
-
-
0030905260
-
Suppression of cathepsins B and L causes a proliferation of lysosomes and the formation of meganeurites in hippocampus
-
Bednarski E, Ribak CE, Lynch G. 1997. Suppression of cathepsins B and L causes a proliferation of lysosomes and the formation of meganeurites in hippocampus. J Neurosci 17: 4006-4021.
-
(1997)
J Neurosci
, vol.17
, pp. 4006-4021
-
-
Bednarski, E.1
Ribak, C.E.2
Lynch, G.3
-
11
-
-
44649090171
-
Activation of the amyloid cascade in apolipoprotein E4 transgenic mice induces lysosomal activation and neurodegeneration resulting in marked cognitive deficits
-
Belinson H, Lev D, Masliah E, Michaelson DM. 2008. Activation of the amyloid cascade in apolipoprotein E4 transgenic mice induces lysosomal activation and neurodegeneration resulting in marked cognitive deficits. J Neurosci 28: 4690-4701.
-
(2008)
J Neurosci
, vol.28
, pp. 4690-4701
-
-
Belinson, H.1
Lev, D.2
Masliah, E.3
Michaelson, D.M.4
-
12
-
-
79957608284
-
A tale on animal models o Parkinson's disease
-
Bezard E, Przedborski S. 2011. A tale on animal models o Parkinson's disease. Mov Disord 26: 993-1002.
-
(2011)
Mov Disord
, vol.26
, pp. 993-1002
-
-
Bezard, E.1
Przedborski, S.2
-
13
-
-
63849230729
-
The PI3K-Akt-mTOR pathway regulates Ab oligomer induced neuronal cell cycle events
-
Bhaskar K, Miller M, Chludzinski A, Herrup K, Zagorski M, Lamb BT. 2009. The PI3K-Akt-mTOR pathway regulates Ab oligomer induced neuronal cell cycle events. Mol Neurodegener 4: 14.
-
(2009)
Mol Neurodegener
, vol.4
, pp. 14
-
-
Bhaskar, K.1
Miller, M.2
Chludzinski, A.3
Herrup, K.4
Zagorski, M.5
Lamb, B.T.6
-
14
-
-
0043234207
-
Cathepsin D triggers Bax activation, resulting in selective apoptosis-inducing factor (AIF) relocation in T lymphocytes entering the early commitment phase to apoptosis
-
Bidere N, Lorenzo HK, Carmona S, Laforge M, Harper F, Dumont C, Senik A. 2003. Cathepsin D triggers Bax activation, resulting in selective apoptosis-inducing factor (AIF) relocation in T lymphocytes entering the early commitment phase to apoptosis. J Biol Chem 278: 31401-31411.
-
(2003)
J Biol Chem
, vol.278
, pp. 31401-31411
-
-
Bidere, N.1
Lorenzo, H.K.2
Carmona, S.3
Laforge, M.4
Harper, F.5
Dumont, C.6
Senik, A.7
-
15
-
-
49049096562
-
Autophagy induction and autophagosome clearance in neurons: Relationship to autophagic pathology in Alzheimer's disease
-
Boland B, Kumar A, Lee S, Platt FM, Wegiel J, Yu WH, Nixon RA. 2008. Autophagy induction and autophagosome clearance in neurons: Relationship to autophagic pathology in Alzheimer's disease. J Neurosci 28: 6926-6937.
-
(2008)
J Neurosci
, vol.28
, pp. 6926-6937
-
-
Boland, B.1
Kumar, A.2
Lee, S.3
Platt, F.M.4
Wegiel, J.5
Yu, W.H.6
Nixon, R.A.7
-
16
-
-
84863482530
-
Lysosomal function and dysfunction: Mechanism and disease
-
Boya P. 2011. Lysosomal function and dysfunction: Mechanism and disease. Antioxid Redox Signal 17: 766-774.
-
(2011)
Antioxid Redox Signal
, vol.17
, pp. 766-774
-
-
Boya, P.1
-
17
-
-
54949137644
-
Lysosomal membrane permeabilization in cell death
-
Boya P, Kroemer G. 2008. Lysosomal membrane permeabilization in cell death. Oncogene 27: 6434-6451.
-
(2008)
Oncogene
, vol.27
, pp. 6434-6451
-
-
Boya, P.1
Kroemer, G.2
-
18
-
-
0015274335
-
The effect of aging on lysosomal permeability in nerve cells of the central nervous system. An enzyme histochemical study in rat
-
Brunk U, Brun A. 1972. The effect of aging on lysosomal permeability in nerve cells of the central nervous system. An enzyme histochemical study in rat. Histochemie 30: 315-324.
-
(1972)
Histochemie
, vol.30
, pp. 315-324
-
-
Brunk, U.1
Brun, A.2
-
19
-
-
0032988381
-
Oxidative stress, growth factor starvation and Fas activation may all cause apoptosis through lysosomal leak
-
Brunk UT, Svensson I. 1999. Oxidative stress, growth factor starvation and Fas activation may all cause apoptosis through lysosomal leak. Redox Rep 4: 3-11.
-
(1999)
Redox Rep
, vol.4
, pp. 3-11
-
-
Brunk, U.T.1
Svensson, I.2
-
20
-
-
77951227122
-
Molecular interplay between mammalian target of rapamycin (mTOR), amyloid-b, and Tau: Effects on cognitive impairments
-
Caccamo A, Majumder S, Richardson A, Strong R, Oddo S. 2010. Molecular interplay between mammalian target of rapamycin (mTOR), amyloid-b, and Tau: Effects on cognitive impairments. J Biol Chem 285: 13107-13120.
-
(2010)
J Biol Chem
, vol.285
, pp. 13107-13120
-
-
Caccamo, A.1
Majumder, S.2
Richardson, A.3
Strong, R.4
Oddo, S.5
-
21
-
-
14844310312
-
Role of the autophagic-lysosomal system on low potassium-induced apoptosis in cultured cerebellar granule cells
-
Canu N, Tufi R, Serafino AL, Amadoro G, Ciotti MT, Calissano P. 2005. Role of the autophagic-lysosomal system on low potassium-induced apoptosis in cultured cerebellar granule cells. J Neurochem 92: 1228-1242.
-
(2005)
J Neurochem
, vol.92
, pp. 1228-1242
-
-
Canu, N.1
Tufi, R.2
Serafino, A.L.3
Amadoro, G.4
Ciotti, M.T.5
Calissano, P.6
-
22
-
-
0028220243
-
Lysosomal abnormalities in degenerating neurons link neuronal compromise to senile plaque development in Alzheimer disease
-
Cataldo AM, Hamilton DJ, Nixon RA. 1994. Lysosomal abnormalities in degenerating neurons link neuronal compromise to senile plaque development in Alzheimer disease. Brain Res 640: 68-80.
-
(1994)
Brain Res
, vol.640
, pp. 68-80
-
-
Cataldo, A.M.1
Hamilton, D.J.2
Nixon, R.A.3
-
23
-
-
0028947294
-
Gene expression and cellular content of cathepsinDin Alzheimer's disease brain: Evidence for early up-regulation of the endosomal-lysosomal system
-
Cataldo AM, Barnett JL, Berman SA, Li J, Quarless S, Bursztajn S, Lippa C, Nixon RA. 1995. Gene expression and cellular content of cathepsinDin Alzheimer's disease brain: Evidence for early up-regulation of the endosomal-lysosomal system. Neuron 14: 671-680.
-
(1995)
Neuron
, vol.14
, pp. 671-680
-
-
Cataldo, A.M.1
Barnett, J.L.2
Berman, S.A.3
Li, J.4
Quarless, S.5
Bursztajn, S.6
Lippa, C.7
Nixon, R.A.8
-
24
-
-
0030045552
-
Properties of the endosomal-lysosomal system in the human central nervous system: Disturbances mark most neurons in populations at risk to degenerate in Alzheimer's disease
-
Cataldo AM, Hamilton DJ, Barnett JL, Paskevich PA, Nixon RA. 1996. Properties of the endosomal-lysosomal system in the human central nervous system: Disturbances mark most neurons in populations at risk to degenerate in Alzheimer's disease. J Neurosci 16: 186-199.
-
(1996)
J Neurosci
, vol.16
, pp. 186-199
-
-
Cataldo, A.M.1
Hamilton, D.J.2
Barnett, J.L.3
Paskevich, P.A.4
Nixon, R.A.5
-
25
-
-
0030836345
-
Increased neuronal endocytosis and protease delivery to early endosomes in sporadic Alzheimer's disease: Neuropathologic evidence for a mechanism of increased bamyloidogenesis
-
Cataldo AM, Barnett JL, Pieroni C, Nixon RA. 1997. Increased neuronal endocytosis and protease delivery to early endosomes in sporadic Alzheimer's disease: Neuropathologic evidence for a mechanism of increased bamyloidogenesis. J Neurosci 17: 6142-6151.
-
(1997)
J Neurosci
, vol.17
, pp. 6142-6151
-
-
Cataldo, A.M.1
Barnett, J.L.2
Pieroni, C.3
Nixon, R.A.4
-
26
-
-
0033869715
-
Endocytic pathway abnormalities precede amyloid b deposition in sporadic Alzheimer's disease and Down syndrome: Differential effects of APOE genotype and presenilin mutations
-
Cataldo AM, Peterhoff CM, Troncoso JC, Gomez-Isla T, Hyman BT, Nixon RA. 2000. Endocytic pathway abnormalities precede amyloid b deposition in sporadic Alzheimer's disease and Down syndrome: Differential effects of APOE genotype and presenilin mutations. AmJ Pathol 157: 277-286.
-
(2000)
AmJ Pathol
, vol.157
, pp. 277-286
-
-
Cataldo, A.M.1
Peterhoff, C.M.2
Troncoso, J.C.3
Gomez-Isla, T.4
Hyman, B.T.5
Nixon, R.A.6
-
27
-
-
3843114301
-
Presenilin mutations in familial Alzheimer disease and transgenic mouse models accelerate neuronal lysosomal pathology
-
Cataldo AM, Peterhoff CM, Schmidt SD, Terio NB, Duff K, Beard M, Mathews PM, Nixon RA. 2004. Presenilin mutations in familial Alzheimer disease and transgenic mouse models accelerate neuronal lysosomal pathology. J Neuropathol Exp Neurol 63: 821-830.
-
(2004)
J Neuropathol Exp Neurol
, vol.63
, pp. 821-830
-
-
Cataldo, A.M.1
Peterhoff, C.M.2
Schmidt, S.D.3
Terio, N.B.4
Duff, K.5
Beard, M.6
Mathews, P.M.7
Nixon, R.A.8
-
28
-
-
77449098426
-
Towards an understanding of the anti-aging mechanism of caloric restriction
-
Cavallini G, Donati A, Gori Z, Bergamini E. 2008. Towards an understanding of the anti-aging mechanism of caloric restriction. Curr Aging Sci 1: 4-9.
-
(2008)
Curr Aging Sci
, vol.1
, pp. 4-9
-
-
Cavallini, G.1
Donati, A.2
Gori, Z.3
Bergamini, E.4
-
29
-
-
0017928013
-
Cell death of motoneurons in the chick embryo spinal cord. I. A light and electron microscopic study of naturally occurring and induced cell loss during development
-
Chu-Wang IW, Oppenheim RW. 1978. Cell death of motoneurons in the chick embryo spinal cord. I. A light and electron microscopic study of naturally occurring and induced cell loss during development. J Comp Neurol 177: 33-57.
-
(1978)
J Comp Neurol
, vol.177
, pp. 33-57
-
-
Chu-Wang, I.W.1
Oppenheim, R.W.2
-
30
-
-
0000189281
-
Cellular differentiation in the kidneys of newborn mice studies with the electron microscope
-
Clark SL Jr. 1957. Cellular differentiation in the kidneys of newborn mice studies with the electron microscope. J Biophys Biochem Cytol 3: 349-362.
-
(1957)
J Biophys Biochem Cytol
, vol.3
, pp. 349-362
-
-
Clark Jr., S.L.1
-
31
-
-
0025283961
-
Developmental cell death: Morphological diversity and multiple mechanisms
-
Clarke PG. 1990. Developmental cell death: Morphological diversity and multiple mechanisms. Anat Embryol 181: 195-213.
-
(1990)
Anat Embryol
, vol.181
, pp. 195-213
-
-
Clarke, P.G.1
-
32
-
-
27644591304
-
Axon degeneration mechanisms: Commonality amid diversity
-
Coleman M. 2005. Axon degeneration mechanisms: Commonality amid diversity. Nat Rev Neurosci 6: 889-898.
-
(2005)
Nat Rev Neurosci
, vol.6
, pp. 889-898
-
-
Coleman, M.1
-
33
-
-
4344659685
-
Impaired degradation of mutant a-synuclein by chaperone-mediated autophagy
-
Cuervo AM, Stefanis L, Fredenburg R, Lansbury PT, Sulzer D. 2004. Impaired degradation of mutant a-synuclein by chaperone-mediated autophagy. Science 305: 1292-1295.
-
(2004)
Science
, vol.305
, pp. 1292-1295
-
-
Cuervo, A.M.1
Stefanis, L.2
Fredenburg, R.3
Lansbury, P.T.4
Sulzer, D.5
-
34
-
-
33749042331
-
Transcriptional repression of PGC-1a by mutant huntingtin leads to mitochondrial dysfunction and neurodegeneration
-
Cui L, Jeong H, Borovecki F, Parkhurst CN, Tanese N, Krainc D. 2006. Transcriptional repression of PGC-1a by mutant huntingtin leads to mitochondrial dysfunction and neurodegeneration. Cell 127: 59-69.
-
(2006)
Cell
, vol.127
, pp. 59-69
-
-
Cui, L.1
Jeong, H.2
Borovecki, F.3
Parkhurst, C.N.4
Tanese, N.5
Krainc, D.6
-
35
-
-
77149132129
-
Autophagy protects the rotenone-induced cell death in a-synuclein overexpressing SHSY5Y cells
-
Dadakhujaev S, Noh HS, Jung EJ, Cha JY, Baek SM, Ha JH, Kim DR. 2010. Autophagy protects the rotenone-induced cell death in a-synuclein overexpressing SHSY5Y cells. Neurosci Lett 472: 47-52.
-
(2010)
Neurosci Lett
, vol.472
, pp. 47-52
-
-
Dadakhujaev, S.1
Noh, H.S.2
Jung, E.J.3
Cha, J.Y.4
Baek, S.M.5
Ha, J.H.6
Kim, D.R.7
-
36
-
-
67649399288
-
Loss of PINK1 function promotes mitophagy through effects on oxidative stress and mitochondrial fission
-
Dagda RK, Cherra SJ 3rd, Kulich SM, Tandon A, Park D, Chu CT. 2009. Loss of PINK1 function promotes mitophagy through effects on oxidative stress and mitochondrial fission. J Biol Chem 284: 13843-13855.
-
(2009)
J Biol Chem
, vol.284
, pp. 13843-13855
-
-
Dagda, R.K.1
Cherra III, S.J.2
Kulich, S.M.3
Tandon, A.4
Park, D.5
Chu, C.T.6
-
37
-
-
84863954409
-
Regulation and function of autophagy during cell survival and cell death
-
doi: 10.1101/cshperspect. a008813
-
Das G, Shravage BV, Baehrecke EH. 2012. Regulation and function of autophagy during cell survival and cell death. Cold Spring Harb Perspect Biol doi: 10.1101/cshperspect. a008813.
-
(2012)
Cold Spring Harb Perspect Biol
-
-
Das, G.1
Shravage, B.V.2
Baehrecke, E.H.3
-
38
-
-
0002549377
-
The lysosome
-
de Duve C. 1963. The lysosome. Sci Am 208: 64-72.
-
(1963)
Sci Am
, vol.208
, pp. 64-72
-
-
de Duve, C.1
-
40
-
-
77956855813
-
Pathogenic lysosomal depletion i Parkinson's disease
-
Dehay B, Bove J, Rodriguez-Muela N, Perier C, Recasens A, Boya P, Vila M. 2010. Pathogenic lysosomal depletion i Parkinson's disease. J Neurosci 30: 12535-12544.
-
(2010)
J Neurosci
, vol.30
, pp. 12535-12544
-
-
Dehay, B.1
Bove, J.2
Rodriguez-Muela, N.3
Perier, C.4
Recasens, A.5
Boya, P.6
Vila, M.7
-
41
-
-
34248182509
-
ATP13A2 missense mutations in juvenile parkinsonism and young onset Parkinson disease
-
Di Fonzo A, Chien HF, Socal M, Giraudo S, Tassorelli C, Iliceto G, Fabbrini G, Marconi R, Fincati E, Abbruzzes G, et al. 2007. ATP13A2 missense mutations in juvenile parkinsonism and young onset Parkinson disease. Neurology 68: 1557-1562.
-
(2007)
Neurology
, vol.68
, pp. 1557-1562
-
-
Di Fonzo, A.1
Chien, H.F.2
Socal, M.3
Giraudo, S.4
Tassorelli, C.5
Iliceto, G.6
Fabbrini, G.7
Marconi, R.8
Fincati, E.9
Abbruzzes, G.10
-
42
-
-
77951750296
-
Selective autophagy in cancer development and therapy
-
Dikic I, Johansen T, Kirkin V. 2010. Selective autophagy in cancer development and therapy. Cancer Res 70: 3431-3434.
-
(2010)
Cancer Res
, vol.70
, pp. 3431-3434
-
-
Dikic, I.1
Johansen, T.2
Kirkin, V.3
-
43
-
-
0037150687
-
Sp1 and TAFII130 transcriptional activity disrupted in early Huntington's disease
-
Dunah AW, Jeong H, Griffin A, Kim YM, Standaert DG, Hersch SM, Mouradian MM, Young AB, Tanese N, KraincD. 2002. Sp1 and TAFII130 transcriptional activity disrupted in early Huntington's disease. Science 296: 2238-2243.
-
(2002)
Science
, vol.296
, pp. 2238-2243
-
-
Dunah, A.W.1
Jeong, H.2
Griffin, A.3
Kim, Y.M.4
Standaert, D.G.5
Hersch, S.M.6
Mouradian, M.M.7
Young, A.B.8
Tanese, N.9
Krainc, D.10
-
44
-
-
11844294713
-
Induction of lysosomal membrane permeabilization by compounds that activate p53-independent apoptosis
-
Erdal H, Berndtsson M, Castro J, Brunk U, Shoshan MC, Linder S. 2005. Induction of lysosomal membrane permeabilization by compounds that activate p53-independent apoptosis. Proc Natl Acad Sci 102: 192-197.
-
(2005)
Proc Natl Acad Sci
, vol.102
, pp. 192-197
-
-
Erdal, H.1
Berndtsson, M.2
Castro, J.3
Brunk, U.4
Shoshan, M.C.5
Linder, S.6
-
45
-
-
26844531363
-
Maturation of autophagic vacuoles in Mammalian cells
-
Eskelinen EL. 2005. Maturation of autophagic vacuoles in Mammalian cells. Autophagy 1: 1-10.
-
(2005)
Autophagy
, vol.1
, pp. 1-10
-
-
Eskelinen, E.L.1
-
46
-
-
62949091373
-
Autophagy: A lysosomal degradation pathway with a central role in health and disease
-
Eskelinen EL, Saftig P. 2009. Autophagy: A lysosomal degradation pathway with a central role in health and disease. Biochim Biophys Acta 1793: 664-673.
-
(2009)
Biochim Biophys Acta
, vol.1793
, pp. 664-673
-
-
Eskelinen, E.L.1
Saftig, P.2
-
47
-
-
57649195400
-
Autophagy and multivesicular bodies:Twoclosely related partners
-
Fader CM, Colombo MI. 2009. Autophagy and multivesicular bodies:Twoclosely related partners. Cell Death Differ 16: 70-78.
-
(2009)
Cell Death Differ
, vol.16
, pp. 70-78
-
-
Fader, C.M.1
Colombo, M.I.2
-
48
-
-
35948983328
-
Functional multivesicular bodies are required for autophagic clearance of protein aggregates associatedwith neurodegenerative disease
-
Filimonenko M, Stuffers S, Raiborg C, Yamamoto A, Malerod L, Fisher EMC, Isaacs A, Brech A, Stenmark H, Simonsen A. 2007. Functional multivesicular bodies are required for autophagic clearance of protein aggregates associatedwith neurodegenerative disease. J Cell Biol 179: 485-500.
-
(2007)
J Cell Biol
, vol.179
, pp. 485-500
-
-
Filimonenko, M.1
Stuffers, S.2
Raiborg, C.3
Yamamoto, A.4
Malerod, L.5
Fisher, E.M.C.6
Isaacs, A.7
Brech, A.8
Stenmark, H.9
Simonsen, A.10
-
49
-
-
0344874551
-
Emerging role for autophagy in the removal of aggresomes i Schwann cells
-
Fortun J, DunnWA Jr, Joy S, Li J, Notterpek L. 2003. Emerging role for autophagy in the removal of aggresomes i Schwann cells. J Neurosci 23: 10672-10680.
-
(2003)
J Neurosci
, vol.23
, pp. 10672-10680
-
-
Fortun, J.1
Dunn Jr., W.A.2
Joy, S.3
Li, J.4
Notterpek, L.5
-
50
-
-
0037096376
-
Calpain activation in Huntington's disease
-
Gafni J, Ellerby LM. 2002. Calpain activation in Huntington's disease. J Neurosci 22: 4842-4849.
-
(2002)
J Neurosci
, vol.22
, pp. 4842-4849
-
-
Gafni, J.1
Ellerby, L.M.2
-
51
-
-
69149089036
-
Molecular pathogenesis of Parkinson disease: Insights from genetic studies
-
Gasser T. 2009. Molecular pathogenesis of Parkinson disease: Insights from genetic studies. Expert Rev Mol Med 11: e22.
-
(2009)
Expert Rev Mol Med
, vol.11
-
-
Gasser, T.1
-
52
-
-
75949130828
-
PINK1/Parkinmediated mitophagy is dependent on VDAC1 and p62/ SQSTM1
-
Geisler S, Holmstrom KM, Skujat D, Fiesel FC, Rothfus OC, Kahle PJ, Springer W. 2010. PINK1/Parkinmediated mitophagy is dependent on VDAC1 and p62/ SQSTM1. Nat Cell Biol 12: 119-131.
-
(2010)
Nat Cell Biol
, vol.12
, pp. 119-131
-
-
Geisler, S.1
Holmstrom, K.M.2
Skujat, D.3
Fiesel, F.C.4
Rothfus, O.C.5
Kahle, P.J.6
Springer, W.7
-
53
-
-
0036173770
-
Recruitment and activation of caspase-8 by the Huntingtin-interacting protein Hip-1 and a novel partner Hippi
-
Gervais FG, Singaraja R, Xanthoudakis S, Gutekunst CA, Leavitt BR, Metzler M, Hackam AS, Tam J, Vaillancour JP, HoutzagerV, et al. 2002. Recruitment and activation of caspase-8 by the Huntingtin-interacting protein Hip-1 and a novel partner Hippi. Nat Cell Biol 4: 95-105.
-
(2002)
Nat Cell Biol
, vol.4
, pp. 95-105
-
-
Gervais, F.G.1
Singaraja, R.2
Xanthoudakis, S.3
Gutekunst, C.A.4
Leavitt, B.R.5
Metzler, M.6
Hackam, A.S.7
Tam, J.8
Vaillancour, J.P.9
Houtzager, V.10
-
54
-
-
77949897022
-
Amyotrophic lateral sclerosis and frontotemporal lobar degeneration: A spectrum of TDP-43 proteinopathies
-
Geser F, Lee VM, Trojanowski JQ. 2010. Amyotrophic lateral sclerosis and frontotemporal lobar degeneration: A spectrum of TDP-43 proteinopathies. Neuropathology 30: 103-112.
-
(2010)
Neuropathology
, vol.30
, pp. 103-112
-
-
Geser, F.1
Lee, V.M.2
Trojanowski, J.Q.3
-
55
-
-
45149107487
-
Mechanisms of neurodegeneration in Huntington's disease
-
Gil JM, Rego AC. 2008. Mechanisms of neurodegeneration in Huntington's disease. Eur J Neurosci 27: 2803-2820.
-
(2008)
Eur J Neurosci
, vol.27
, pp. 2803-2820
-
-
Gil, J.M.1
Rego, A.C.2
-
56
-
-
78049427173
-
Microarray analysis of hippocampal CA1 neurons implicates early endosomal dysfunction during Alzheimer's disease progression
-
Ginsberg SD, Alldred MJ, Counts SE, Cataldo AM, Neve RL, Jiang Y, Wuu J, Chao MV, Mufson EJ, Nixon RA, et al. 2010. Microarray analysis of hippocampal CA1 neurons implicates early endosomal dysfunction during Alzheimer's disease progression. Biol Psychiatry 68: 885-893.
-
(2010)
Biol Psychiatry
, vol.68
, pp. 885-893
-
-
Ginsberg, S.D.1
Alldred, M.J.2
Counts, S.E.3
Cataldo, A.M.4
Neve, R.L.5
Jiang, Y.6
Wuu, J.7
Chao, M.V.8
Mufson, E.J.9
Nixon, R.A.10
-
57
-
-
0035159785
-
Intracellular mechanisms of amyloid accumulation and pathogenesis in Alzheimer's disease
-
Glabe C. 2001. Intracellular mechanisms of amyloid accumulation and pathogenesis in Alzheimer's disease. J Mol Neurosci 17: 137-145.
-
(2001)
J Mol Neurosci
, vol.17
, pp. 137-145
-
-
Glabe, C.1
-
58
-
-
0024299286
-
Prelysosomal convergence of autophagic and endocytic pathways
-
Gordon PB, Seglen PO. 1988. Prelysosomal convergence of autophagic and endocytic pathways. Biochem Biophys Res Commun 151: 40-47.
-
(1988)
Biochem Biophys Res Commun
, vol.151
, pp. 40-47
-
-
Gordon, P.B.1
Seglen, P.O.2
-
59
-
-
33745003424
-
Cleavage at the caspase-6 site is required for neuronal dysfunction and degeneration due to mutant huntingtin
-
Graham RK, Deng Y, Slow EJ, Haigh B, Bissada N, Lu G, Pearson J, Shehadeh J, Bertram L, Murphy Z, et al. 2006. Cleavage at the caspase-6 site is required for neuronal dysfunction and degeneration due to mutant huntingtin. Cell 125: 1179-1191.
-
(2006)
Cell
, vol.125
, pp. 1179-1191
-
-
Graham, R.K.1
Deng, Y.2
Slow, E.J.3
Haigh, B.4
Bissada, N.5
Lu, G.6
Pearson, J.7
Shehadeh, J.8
Bertram, L.9
Murphy, Z.10
-
60
-
-
77950358315
-
Leptin reduces pathology and improves memory in a transgenic mouse model of Alzheimer's disease
-
Greco SJ, Bryan KJ, Sarkar S, Zhu X, Smith MA, Ashford JW, Johnston JM, Tezapsidis N, Casadesus G. 2010. Leptin reduces pathology and improves memory in a transgenic mouse model of Alzheimer's disease. J Alzheimers Dis 19: 1155-1167.
-
(2010)
J Alzheimers Dis
, vol.19
, pp. 1155-1167
-
-
Greco, S.J.1
Bryan, K.J.2
Sarkar, S.3
Zhu, X.4
Smith, M.A.5
Ashford, J.W.6
Johnston, J.M.7
Tezapsidis, N.8
Casadesus, G.9
-
61
-
-
0033756474
-
Cathepsin B contributes to TNF-a-mediated hepatocyte apoptosis by promoting mitochondrial release of cytochrome c
-
Guicciardi ME, Deussing J, Miyoshi H, Bronk SF, Svingen PA, Peters C, Kaufmann SH, Gores GJ. 2000. Cathepsin B contributes to TNF-a-mediated hepatocyte apoptosis by promoting mitochondrial release of cytochrome c. J Clin Invest 106: 1127-1137.
-
(2000)
J Clin Invest
, vol.106
, pp. 1127-1137
-
-
Guicciardi, M.E.1
Deussing, J.2
Miyoshi, H.3
Bronk, S.F.4
Svingen, P.A.5
Peters, C.6
Kaufmann, S.H.7
Gores, G.J.8
-
62
-
-
33745192802
-
Suppression of basal autophagy in neural cells causes neurodegenerative disease in mice
-
Hara T, Nakamura K, Matsui M, Yamamoto A, Nakahara Y, Suzuki-Migishima R, Yokoyama M, Mishima K, Saito I, Okano H, et al. 2006. Suppression of basal autophagy in neural cells causes neurodegenerative disease in mice. Nature 441: 885-889.
-
(2006)
Nature
, vol.441
, pp. 885-889
-
-
Hara, T.1
Nakamura, K.2
Matsui, M.3
Yamamoto, A.4
Nakahara, Y.5
Suzuki-Migishima, R.6
Yokoyama, M.7
Mishima, K.8
Saito, I.9
Okano, H.10
-
63
-
-
0017646340
-
Anterior horn cell degeneration and Bunina-type inclusions associatedwith dementia
-
Hart MN, Cancilla PA, Frommes S, Hirano A. 1977. Anterior horn cell degeneration and Bunina-type inclusions associatedwith dementia. ActaNeuropathol 38: 225-228.
-
(1977)
ActaNeuropathol
, vol.38
, pp. 225-228
-
-
Hart, M.N.1
Cancilla, P.A.2
Frommes, S.3
Hirano, A.4
-
64
-
-
12944250987
-
Caspase-3: A vulnerability factor and final effector in apoptotic death of dopaminergic neurons in Parkinson's disease
-
Hartmann A, Hunot S, Michel PP, Muriel MP, Vyas S, Faucheux BA, Mouatt-Prigent A, Turmel H, Srinivasan A, Ruberg M, et al. 2000. Caspase-3: A vulnerability factor and final effector in apoptotic death of dopaminergic neurons in Parkinson's disease. Proc Natl Acad Sci 97: 2875-2880.
-
(2000)
Proc Natl Acad Sci
, vol.97
, pp. 2875-2880
-
-
Hartmann, A.1
Hunot, S.2
Michel, P.P.3
Muriel, M.P.4
Vyas, S.5
Faucheux, B.A.6
Mouatt-Prigent, A.7
Turmel, H.8
Srinivasan, A.9
Ruberg, M.10
-
65
-
-
0027538111
-
An early cytoplasmic change before Lewy body maturation: An ultrastructural study of the substantia nigra from an autopsy case of juvenile parkinsonism
-
Hayashida K, Oyanagi S, Mizutani Y, Yokochi M. 1993. An early cytoplasmic change before Lewy body maturation: An ultrastructural study of the substantia nigra from an autopsy case of juvenile parkinsonism. Acta Neuropathol 85: 445-448.
-
(1993)
Acta Neuropathol
, vol.85
, pp. 445-448
-
-
Hayashida, K.1
Oyanagi, S.2
Mizutani, Y.3
Yokochi, M.4
-
66
-
-
72549095406
-
Regulation mechanisms and signaling pathways of autophagy
-
He C, Klionsky DJ. 2009. Regulation mechanisms and signaling pathways of autophagy. Annu Rev Genet 43: 67-93.
-
(2009)
Annu Rev Genet
, vol.43
, pp. 67-93
-
-
He, C.1
Klionsky, D.J.2
-
67
-
-
70349627027
-
XBP-1 deficiency in the nervous system protects against amyotrophic lateral sclerosis by increasing autophagy
-
Hetz C, Thielen P, Matus S, Nassif M, Court F, Kiffin R, Martinez G, Cuervo AM, Brown RH, Glimcher LH. 2009. XBP-1 deficiency in the nervous system protects against amyotrophic lateral sclerosis by increasing autophagy. Genes Dev 23: 2294-2306.
-
(2009)
Genes Dev
, vol.23
, pp. 2294-2306
-
-
Hetz, C.1
Thielen, P.2
Matus, S.3
Nassif, M.4
Court, F.5
Kiffin, R.6
Martinez, G.7
Cuervo, A.M.8
Brown, R.H.9
Glimcher, L.H.10
-
69
-
-
0029838035
-
Neuropathology of ALS: An overview
-
Hirano A. 1996. Neuropathology of ALS: An overview. Neurology 47: S63-S66.
-
(1996)
Neurology
, vol.47
-
-
Hirano, A.1
-
70
-
-
0013832794
-
Lysomes in the rat sciatic nerve following crush
-
Holtzman E, Novikoff AB. 1965. Lysomes in the rat sciatic nerve following crush. J Cell Biol 27: 651-669.
-
(1965)
J Cell Biol
, vol.27
, pp. 651-669
-
-
Holtzman, E.1
Novikoff, A.B.2
-
71
-
-
0014085531
-
Lysosomes and GERL in normal and chromatolytic neurons of the rat ganglion nodosum
-
Holtzman E, Novikoff AB, Villaverde H. 1967. Lysosomes and GERL in normal and chromatolytic neurons of the rat ganglion nodosum. J Cell Biol 33: 419-435.
-
(1967)
J Cell Biol
, vol.33
, pp. 419-435
-
-
Holtzman, E.1
Novikoff, A.B.2
Villaverde, H.3
-
72
-
-
0024370374
-
Endocytosis and autophagy in dying neurons: An ultrastructural study in chick embryos
-
Hornung JP, Koppel H, Clarke PG. 1989. Endocytosis and autophagy in dying neurons: An ultrastructural study in chick embryos. J Comp Neurol 283: 425-437.
-
(1989)
J Comp Neurol
, vol.283
, pp. 425-437
-
-
Hornung, J.P.1
Koppel, H.2
Clarke, P.G.3
-
73
-
-
0021675999
-
Inhibitors of lysosomal enzymes: Accumulation of lipofuscin-like dense bodies in the brain
-
Ivy GO, Schottler F, Wenzel J, Baudry M, Lynch G. 1984. Inhibitors of lysosomal enzymes: Accumulation of lipofuscin-like dense bodies in the brain. Science 226: 985-987.
-
(1984)
Science
, vol.226
, pp. 985-987
-
-
Ivy, G.O.1
Schottler, F.2
Wenzel, J.3
Baudry, M.4
Lynch, G.5
-
74
-
-
77956215864
-
Regulation of amyloid precursor protein processing by the Beclin 1 complex
-
Jaeger PA, Pickford F, Sun CH, Lucin KM, Masliah E, Wyss-Coray T. 2010. Regulation of amyloid precursor protein processing by the Beclin 1 complex. PLoS ONE 5: e11102.
-
(2010)
PLoS ONE
, vol.5
-
-
Jaeger, P.A.1
Pickford, F.2
Sun, C.H.3
Lucin, K.M.4
Masliah, E.5
Wyss-Coray, T.6
-
75
-
-
0035336658
-
Altered proteasomal function due to the expression of polyglutamine-expanded truncated N-terminal huntingtin induces apoptosis by caspase activation through mitochondrial cytochrome c release
-
Jana NR, Zemskov EA, Wang G, Nukina N. 2001. Altered proteasomal function due to the expression of polyglutamine-expanded truncated N-terminal huntingtin induces apoptosis by caspase activation through mitochondrial cytochrome c release. Hum Mol Genet 10: 1049-1059.
-
(2001)
Hum Mol Genet
, vol.10
, pp. 1049-1059
-
-
Jana, N.R.1
Zemskov, E.A.2
Wang, G.3
Nukina, N.4
-
76
-
-
63049132756
-
Acetylation targets mutant huntingtin to autophagosomes for degradation
-
Jeong H, Then F, Melia TJ Jr, Mazzulli JR, Cui L, Savas JN, Voisine C, Paganetti P, Tanese N, Hart AC, et al. 2009. Acetylation targets mutant huntingtin to autophagosomes for degradation. Cell 137: 60-72.
-
(2009)
Cell
, vol.137
, pp. 60-72
-
-
Jeong, H.1
Then, F.2
Melia Jr., T.J.3
Mazzulli, J.R.4
Cui, L.5
Savas, J.N.6
Voisine, C.7
Paganetti, P.8
Tanese, N.9
Hart, A.C.10
-
77
-
-
0037077284
-
Apolipoprotein E4 potentiates amyloid b peptide-induced lysosomal leakage and apoptosis in neuronal cells
-
Ji ZS, Miranda RD, Newhouse YM, Weisgraber KH, Huan Y, Mahley RW. 2002. Apolipoprotein E4 potentiates amyloid b peptide-induced lysosomal leakage and apoptosis in neuronal cells. J Biol Chem 277: 21821-21828.
-
(2002)
J Biol Chem
, vol.277
, pp. 21821-21828
-
-
Ji, Z.S.1
Miranda, R.D.2
Newhouse, Y.M.3
Weisgraber, K.H.4
Huan, Y.5
Mahley, R.W.6
-
78
-
-
33645553416
-
Reactivity of apolipoprotein E4 and amyloid b peptide: Lysosomal stability and neurodegeneration
-
Ji ZS, Mullendorff K, Cheng IH, Miranda RD, Huang Y, Mahley RW. 2006. Reactivity of apolipoprotein E4 and amyloid b peptide: Lysosomal stability and neurodegeneration. J Biol Chem 281: 2683-2692.
-
(2006)
J Biol Chem
, vol.281
, pp. 2683-2692
-
-
Ji, Z.S.1
Mullendorff, K.2
Cheng, I.H.3
Miranda, R.D.4
Huang, Y.5
Mahley, R.W.6
-
79
-
-
77951666702
-
Regulation of apoptosis-associated lysosomal membrane permeabilization
-
Johansson AC, Appelqvist H, Nilsson C, Kagedal K, Rober K, Ollinger K. 2010. Regulation of apoptosis-associated lysosomal membrane permeabilization. Apoptosis 15: 527-540.
-
(2010)
Apoptosis
, vol.15
, pp. 527-540
-
-
Johansson, A.C.1
Appelqvist, H.2
Nilsson, C.3
Kagedal, K.4
Rober, K.5
Ollinger, K.6
-
80
-
-
25844434838
-
Up-regulation of lysosomal cathepsin L and autophagy during neuronal death induced by reduced serum and potassium
-
Kaasik A, Rikk T, Piirsoo A, Zharkovsky T, Zharkovsky A. 2005. Up-regulation of lysosomal cathepsin L and autophagy during neuronal death induced by reduced serum and potassium. Eur J Neurosci 22: 1023-1031.
-
(2005)
Eur J Neurosci
, vol.22
, pp. 1023-1031
-
-
Kaasik, A.1
Rikk, T.2
Piirsoo, A.3
Zharkovsky, T.4
Zharkovsky, A.5
-
81
-
-
60249098801
-
Dietary supplementation with resveratrol reduces plaque pathology in a transgenic model of Alzheimer's disease
-
Karuppagounder SS, Pinto JT, Xu H, Chen HL, Beal MF, Gibson GE. 2009. Dietary supplementation with resveratrol reduces plaque pathology in a transgenic model of Alzheimer's disease. Neurochem Int 54: 111-118.
-
(2009)
Neurochem Int
, vol.54
, pp. 111-118
-
-
Karuppagounder, S.S.1
Pinto, J.T.2
Xu, H.3
Chen, H.L.4
Beal, M.F.5
Gibson, G.E.6
-
82
-
-
53249130741
-
Therapeutic application of histone deacetylase inhibitors for central nervous system disorders
-
Kazantsev AG, Thompson LM. 2008. Therapeutic application of histone deacetylase inhibitors for central nervous system disorders. Nat Rev Drug Discov 7: 854-868.
-
(2008)
Nat Rev Drug Discov
, vol.7
, pp. 854-868
-
-
Kazantsev, A.G.1
Thompson, L.M.2
-
83
-
-
0034307476
-
Huntingtin expression stimulates endosomal-lysosomal activity, endosome tubulation, and autophagy
-
Kegel KB, Kim M, Sapp E, McIntyre C, Castano JG, Aronin N, DiFiglia M. 2000. Huntingtin expression stimulates endosomal-lysosomal activity, endosome tubulation, and autophagy. J Neurosci 20: 7268-7278.
-
(2000)
J Neurosci
, vol.20
, pp. 7268-7278
-
-
Kegel, K.B.1
Kim, M.2
Sapp, E.3
McIntyre, C.4
Castano, J.G.5
Aronin, N.6
DiFiglia, M.7
-
84
-
-
77955845955
-
Lysosomal rupture, necroapoptotic interactions and potential crosstalk between cysteine proteases in neurons shortly after focal ischemia
-
Kilinc M, Gursoy-Ozdemir Y, Gurer G, Erdener SE, Erdemli E, Can A, Dalkara T. 2010. Lysosomal rupture, necroapoptotic interactions and potential crosstalk between cysteine proteases in neurons shortly after focal ischemia. Neurobiol Dis 40: 293-302.
-
(2010)
Neurobiol Dis
, vol.40
, pp. 293-302
-
-
Kilinc, M.1
Gursoy-Ozdemir, Y.2
Gurer, G.3
Erdener, S.E.4
Erdemli, E.5
Can, A.6
Dalkara, T.7
-
85
-
-
77953724901
-
A comprehensive glossary of autophagy-related molecules and processes
-
Klionsky DJ, Codogno P, Cuervo AM, Deretic V, Elazar Z, Fueyo-Margareto J, Gewirtz DA, Kroemer G, Levine B, Mizushima N, et al. 2010. A comprehensive glossary of autophagy-related molecules and processes. Autophagy 6: 438-448.
-
(2010)
Autophagy
, vol.6
, pp. 438-448
-
-
Klionsky, D.J.1
Codogno, P.2
Cuervo, A.M.3
Deretic, V.4
Elazar, Z.5
Fueyo-Margareto, J.6
Gewirtz, D.A.7
Kroemer, G.8
Levine, B.9
Mizushima, N.10
-
86
-
-
36148991943
-
Cell-autonomous death of cerebellar purkinje neurons with autophagy in Niemann-Pick type C disease
-
Ko DC, Milenkovic L, Beier SM, Manuel H, Buchanan J, Scott MP. 2005. Cell-autonomous death of cerebellar purkinje neurons with autophagy in Niemann-Pick type C disease. PLoS Genet 1: 81-95.
-
(2005)
PLoS Genet
, vol.1
, pp. 81-95
-
-
Ko, D.C.1
Milenkovic, L.2
Beier, S.M.3
Manuel, H.4
Buchanan, J.5
Scott, M.P.6
-
87
-
-
0034666116
-
Cathepsin D deficiency induces lysosomal storage with ceroid lipofuscin in mouse CNS neurons
-
Koike M, Nakanishi H, Saftig P, Ezaki J, Isahara K, Ohsawa Y, Schulz-Schaeffer W, Watanabe T, Waguri S, Kametaka S, et al. 2000. Cathepsin D deficiency induces lysosomal storage with ceroid lipofuscin in mouse CNS neurons. J Neurosci 20: 6898-6906.
-
(2000)
J Neurosci
, vol.20
, pp. 6898-6906
-
-
Koike, M.1
Nakanishi, H.2
Saftig, P.3
Ezaki, J.4
Isahara, K.5
Ohsawa, Y.6
Schulz-Schaeffer, W.7
Watanabe, T.8
Waguri, S.9
Kametaka, S.10
-
88
-
-
39549093998
-
Inhibition of autophagy prevents hippocampal pyramidal neuron death after hypoxic-ischemic injury
-
Koike M, Shibata M, Tadakoshi M, Gotoh K, Komatsu M, Waguri S, Kawahara N, Kuida K, Nagata S, Kominami E, et al. 2008. Inhibition of autophagy prevents hippocampal pyramidal neuron death after hypoxic-ischemic injury. Am J Pathol 172: 454-469.
-
(2008)
Am J Pathol
, vol.172
, pp. 454-469
-
-
Koike, M.1
Shibata, M.2
Tadakoshi, M.3
Gotoh, K.4
Komatsu, M.5
Waguri, S.6
Kawahara, N.7
Kuida, K.8
Nagata, S.9
Kominami, E.10
-
89
-
-
33646800306
-
Loss of autophagy in the central nervous system causes neurodegeneration in mice
-
Komatsu M, Waguri S, Chiba T, Murata S, Iwata J, Tanida I, Ueno T, Koike M, Uchiyama Y, Kominami E, et al. 2006. Loss of autophagy in the central nervous system causes neurodegeneration in mice. Nature 441: 880-884.
-
(2006)
Nature
, vol.441
, pp. 880-884
-
-
Komatsu, M.1
Waguri, S.2
Chiba, T.3
Murata, S.4
Iwata, J.5
Tanida, I.6
Ueno, T.7
Koike, M.8
Uchiyama, Y.9
Kominami, E.10
-
90
-
-
35448938087
-
Essential role for autophagy protein Atg7 in the maintenance of axonal homeostasis and the prevention of axonal degeneration
-
Komatsu M, Wang QJ, Holstein GR, Friedrich VL Jr, Iwata J, Kominami E, Chait BT, Tanaka K, Yue Z. 2007. Essential role for autophagy protein Atg7 in the maintenance of axonal homeostasis and the prevention of axonal degeneration. Proc Natl Acad Sci 104: 14489-14494.
-
(2007)
Proc Natl Acad Sci
, vol.104
, pp. 14489-14494
-
-
Komatsu, M.1
Wang, Q.J.2
Holstein, G.R.3
Friedrich Jr., V.L.4
Iwata, J.5
Kominami, E.6
Chait, B.T.7
Tanaka, K.8
Yue, Z.9
-
91
-
-
60549093730
-
Autophagy inhibition compromises degradation of ubiquitin-proteasome pathway substrates
-
Korolchuk VI, Mansilla A, Menzies FM, Rubinsztein DC. 2009. Autophagy inhibition compromises degradation of ubiquitin-proteasome pathway substrates. Mol Cell 33: 517-527.
-
(2009)
Mol Cell
, vol.33
, pp. 517-527
-
-
Korolchuk, V.I.1
Mansilla, A.2
Menzies, F.M.3
Rubinsztein, D.C.4
-
92
-
-
28544435485
-
Lysosomes and autophagy in cell death control
-
Kroemer G, Jaattela M. 2005. Lysosomes and autophagy in cell death control. Nat Rev Cancer 5: 886-897.
-
(2005)
Nat Rev Cancer
, vol.5
, pp. 886-897
-
-
Kroemer, G.1
Jaattela, M.2
-
94
-
-
39849107361
-
Motor neuron disease occurring in a mutant dynactin mouse model is characterized by defects in vesicular trafficking
-
Laird FM, Farah MH, Ackerley S, Hoke A, Maragakis N, Rothstein JD, Griffin J, Price DL, Martin LJ, Wong PC. 2008. Motor neuron disease occurring in a mutant dynactin mouse model is characterized by defects in vesicular trafficking. J Neurosci 28: 1997-2005.
-
(2008)
J Neurosci
, vol.28
, pp. 1997-2005
-
-
Laird, F.M.1
Farah, M.H.2
Ackerley, S.3
Hoke, A.4
Maragakis, N.5
Rothstein, J.D.6
Griffin, J.7
Price, D.L.8
Martin, L.J.9
Wong, P.C.10
-
95
-
-
0034595940
-
Activation of calpain I converts excitotoxic neuron death into a caspase-independent cell death
-
Lankiewicz S, Marc Luetjens C, Truc Bui N, Krohn AJ, Poppe M, Cole GM, Saido TC, Prehn JH. 2000. Activation of calpain I converts excitotoxic neuron death into a caspase-independent cell death. J Biol Chem 275: 17064-17071.
-
(2000)
J Biol Chem
, vol.275
, pp. 17064-17071
-
-
Lankiewicz, S.1
Marc Luetjens, C.2
Truc Bui, N.3
Krohn, A.J.4
Poppe, M.5
Cole, G.M.6
Saido, T.C.7
Prehn, J.H.8
-
96
-
-
77949775195
-
Repeat expansion disease: Progress and puzzles in disease pathogenesis
-
La Spada AR, Taylor JP. 2010. Repeat expansion disease: Progress and puzzles in disease pathogenesis. Nat Rev Genet 11: 247-258.
-
(2010)
Nat Rev Genet
, vol.11
, pp. 247-258
-
-
la Spada, A.R.1
Taylor, J.P.2
-
97
-
-
67649996222
-
Inhibition of autophagy induction delays neuronal cell loss caused by dysfunctional ESCRTIII in frontotemporal dementia
-
Lee JA, Gao FB. 2009. Inhibition of autophagy induction delays neuronal cell loss caused by dysfunctional ESCRTIII in frontotemporal dementia. J Neurosci 29: 8506-8511.
-
(2009)
J Neurosci
, vol.29
, pp. 8506-8511
-
-
Lee, J.A.1
Gao, F.B.2
-
98
-
-
34548492271
-
ESCRT-III dysfunction causes autophagosome accumulation and neurodegeneration
-
Lee JA, Beigneux A, Ahmad ST, Young SG, Gao FB. 2007. ESCRT-III dysfunction causes autophagosome accumulation and neurodegeneration. Curr Biol 17: 1561-1567.
-
(2007)
Curr Biol
, vol.17
, pp. 1561-1567
-
-
Lee, J.A.1
Beigneux, A.2
Ahmad, S.T.3
Young, S.G.4
Gao, F.B.5
-
99
-
-
77953913051
-
Lysosomal proteolysis and autophagy require presenilin 1 and are disrupted by Alzheimer-related PS1 mutations
-
Lee JH, Yu WH, Kumar A, Lee S, Mohan PS, Peterhoff CM, Marinez-Vicente M, Massey AG, Sovak G, Uchiyama Y, et al. 2010. Lysosomal proteolysis and autophagy require presenilin 1 and are disrupted by Alzheimer-related PS1 mutations. Cell 141: 1146-1158.
-
(2010)
Cell
, vol.141
, pp. 1146-1158
-
-
Lee, J.H.1
Yu, W.H.2
Kumar, A.3
Lee, S.4
Mohan, P.S.5
Peterhoff, C.M.6
Marinez-Vicente, M.7
Massey, A.G.8
Sovak, G.9
Uchiyama, Y.10
-
100
-
-
79957663035
-
Lysosomal proteolysis inhibition selectively disrupts axonal transport of degradative organelles and causes an Alzheimer's-like axonal dystrophy
-
Lee S, Sato Y, Nixon RA. 2011. Lysosomal proteolysis inhibition selectively disrupts axonal transport of degradative organelles and causes an Alzheimer's-like axonal dystrophy. J Neurosci 31: 7817-7830.
-
(2011)
J Neurosci
, vol.31
, pp. 7817-7830
-
-
Lee, S.1
Sato, Y.2
Nixon, R.A.3
-
101
-
-
25144506835
-
Autophagy in cell death: An innocent convict?
-
Levine B, Yuan J. 2005. Autophagy in cell death: An innocent convict? J Clin Invest 115: 2679-2688.
-
(2005)
J Clin Invest
, vol.115
, pp. 2679-2688
-
-
Levine, B.1
Yuan, J.2
-
102
-
-
41449113885
-
Altered macroautophagy in the spinal cord of SOD1 mutant mice
-
Li L, Zhang X, Le W. 2008. Altered macroautophagy in the spinal cord of SOD1 mutant mice. Autophagy 4: 290-293.
-
(2008)
Autophagy
, vol.4
, pp. 290-293
-
-
Li, L.1
Zhang, X.2
Le, W.3
-
103
-
-
78650824020
-
Parkinson's disease involves autophagy and abnormal distribution of cathepsin L
-
Li L, Wang X, Fei X, Xia L, Qin Z, Liang Z. 2011. Parkinson's disease involves autophagy and abnormal distribution of cathepsin L. Neurosci Lett 489: 62-67.
-
(2011)
Neurosci Lett
, vol.489
, pp. 62-67
-
-
Li, L.1
Wang, X.2
Fei, X.3
Xia, L.4
Qin, Z.5
Liang, Z.6
-
104
-
-
77449094358
-
Neuralspecific deletion of FIP200 leads to cerebellar degeneration caused by increased neuronal death and axon degeneration
-
Liang CC, Wang C, Peng X, Gan B, Guan JL. 2010. Neuralspecific deletion of FIP200 leads to cerebellar degeneration caused by increased neuronal death and axon degeneration. J Biol Chem 285: 3499-3509.
-
(2010)
J Biol Chem
, vol.285
, pp. 3499-3509
-
-
Liang, C.C.1
Wang, C.2
Peng, X.3
Gan, B.4
Guan, J.L.5
-
105
-
-
0029079332
-
Neuroaxonal dystrophy in experimental Creutzfeldt-Jakob disease: Electron microscopical and immunohistochemical demonstration of neurofilament accumulations within affected neurites
-
Liberski PP, Budka H, Yanagihara R, Gajdusek DC. 1995. Neuroaxonal dystrophy in experimental Creutzfeldt-Jakob disease: Electron microscopical and immunohistochemical demonstration of neurofilament accumulations within affected neurites. J Comp Pathol 112: 243-255.
-
(1995)
J Comp Pathol
, vol.112
, pp. 243-255
-
-
Liberski, P.P.1
Budka, H.2
Yanagihara, R.3
Gajdusek, D.C.4
-
106
-
-
58449101589
-
Ab42-induced neurodegeneration via an age-dependent autophagic-lysosomal injury in Drosophila
-
Ling D, Song HJ, Garza D, Neufeld TP, Salvaterra PM. 2009. Ab42-induced neurodegeneration via an age-dependent autophagic-lysosomal injury in Drosophila. PLoS ONE 4: e4201.
-
(2009)
PLoS ONE
, vol.4
-
-
Ling, D.1
Song, H.J.2
Garza, D.3
Neufeld, T.P.4
Salvaterra, P.M.5
-
107
-
-
0031031041
-
The autophagic and endocytic pathways converge at the nascent autophagic vacuoles
-
LiouW, Geuze HJ, Geelen MJ, Slot JW. 1997. The autophagic and endocytic pathways converge at the nascent autophagic vacuoles. J Cell Biol 136: 61-70.
-
(1997)
J Cell Biol
, vol.136
, pp. 61-70
-
-
Liou, W.1
Geuze, H.J.2
Geelen, M.J.3
Slot, J.W.4
-
108
-
-
77956274584
-
Genome-wide analysis reveals mechanisms modulating autophagy in normal brain aging and in Alzheimer's disease
-
Lipinski MM, Zheng B, Lu T, Yan Z, Py BF, Ng A, Xavier RJ, Li C, Yankner BA, Scherzer CR, et al. 2010. Genome-wide analysis reveals mechanisms modulating autophagy in normal brain aging and in Alzheimer's disease. Pro Natl Acad Sci 107: 14164-14169.
-
(2010)
Pro Natl Acad Sci
, vol.107
, pp. 14164-14169
-
-
Lipinski, M.M.1
Zheng, B.2
Lu, T.3
Yan, Z.4
Py, B.F.5
Ng, A.6
Xavier, R.J.7
Li, C.8
Yankner, B.A.9
Scherzer, C.R.10
-
110
-
-
3242701496
-
Toxicity of familial ALS-linked SOD1 mutants from selective recruitment to spinal mitochondria
-
Liu J, Lillo C, Jonsson PA, Vande Velde C, Ward CM, Miller TM, Subramaniam JR, Rothstein JD, Marklund S, Andersen PM, et al. 2004. Toxicity of familial ALS-linked SOD1 mutants from selective recruitment to spinal mitochondria. Neuron 43: 5-17.
-
(2004)
Neuron
, vol.43
, pp. 5-17
-
-
Liu, J.1
Lillo, C.2
Jonsson, P.A.3
Vande Velde, C.4
Ward, C.M.5
Miller, T.M.6
Subramaniam, J.R.7
Rothstein, J.D.8
Marklund, S.9
Andersen, P.M.10
-
111
-
-
37349063722
-
The neuropathology of FTD associated with ALS
-
Mackenzie IR. 2007. The neuropathology of FTD associated with ALS. Alzheimer Dis Assoc Disord 21: S44-S49.
-
(2007)
Alzheimer Dis Assoc Disord
, vol.21
-
-
McKenzie, I.R.1
-
112
-
-
33745740540
-
Apolipoprotein (apo) E4 and Alzheimer's disease: Unique conformational and biophysical properties of apoE4 can modulate neuropathology
-
Mahley RW, Huang Y. 2006. Apolipoprotein (apo) E4 and Alzheimer's disease: Unique conformational and biophysical properties of apoE4 can modulate neuropathology. Acta Neurol Scand Suppl 185: 8-14.
-
(2006)
Acta Neurol Scand Suppl
, vol.185
, pp. 8-14
-
-
Mahley, R.W.1
Huang, Y.2
-
114
-
-
80053243942
-
Inducing autophagy by rapamycin before, but not after, the formation of plaques and tangles ameliorates cognitive deficits
-
Majumder S, Richardson A, Strong R, Oddo S. 2011. Inducing autophagy by rapamycin before, but not after, the formation of plaques and tangles ameliorates cognitive deficits. PLoS ONE 6: e25416.
-
(2011)
PLoS ONE
, vol.6
-
-
Majumder, S.1
Richardson, A.2
Strong, R.3
Oddo, S.4
-
115
-
-
34247372639
-
Proteomic analysis of steroid-triggered autophagic programmed cell death during Drosophila development
-
Martin DN, Balgley B, Dutta S, Chen J, Rudnick P, Cranford J, Kantartzis S, DeVoe DL, Lee C, Baehrecke EH. 2007. Proteomic analysis of steroid-triggered autophagic programmed cell death during Drosophila development. Cell Death Differ 14: 916-923.
-
(2007)
Cell Death Differ
, vol.14
, pp. 916-923
-
-
Martin, D.N.1
Balgley, B.2
Dutta, S.3
Chen, J.4
Rudnick, P.5
Cranford, J.6
Kantartzis, S.7
DeVoe, D.L.8
Lee, C.9
Baehrecke, E.H.10
-
116
-
-
77951665859
-
Cargo recognition failure is responsible for inefficient autophagy in Huntington's disease
-
Martinez-Vicente M, Talloczy Z, Wong E, Tang G, Koga H, Kaushik S, de Vries R, Arias E, Harris S, Sulzer D, et al. 2010. Cargo recognition failure is responsible for inefficient autophagy in Huntington's disease. Nat Neurosci 13: 567-576.
-
(2010)
Nat Neurosci
, vol.13
, pp. 567-576
-
-
Martinez-Vicente, M.1
Talloczy, Z.2
Wong, E.3
Tang, G.4
Koga, H.5
Kaushik, S.6
de Vries, R.7
Arias, E.8
Harris, S.9
Sulzer, D.10
-
117
-
-
77952242572
-
The Parkinson-associated protein PINK1 interacts with Beclin1 and promotes autophagy
-
Michiorri S, Gelmetti V, Giarda E, Lombardi F, Romano F, Marongiu R, Nerini-Molteni S, Sale P, Vago R, Arena G, et al. 2010. The Parkinson-associated protein PINK1 interacts with Beclin1 and promotes autophagy. Cell Death Differ 17: 962-974.
-
(2010)
Cell Death Differ
, vol.17
, pp. 962-974
-
-
Michiorri, S.1
Gelmetti, V.2
Giarda, E.3
Lombardi, F.4
Romano, F.5
Marongiu, R.6
Nerini-Molteni, S.7
Sale, P.8
Vago, R.9
Arena, G.10
-
118
-
-
1542283812
-
In vivo analysis of autophagy in response to nutrient starvation using transgenic mice expressing a fluorescent autophagosome marker
-
Mizushima N, Yamamoto A, Matsui M, Yoshimori T, Ohsumi Y. 2004. In vivo analysis of autophagy in response to nutrient starvation using transgenic mice expressing a fluorescent autophagosome marker. Mol Bio Cell 15: 1101-1111.
-
(2004)
Mol Bio Cell
, vol.15
, pp. 1101-1111
-
-
Mizushima, N.1
Yamamoto, A.2
Matsui, M.3
Yoshimori, T.4
Ohsumi, Y.5
-
119
-
-
33846612007
-
Analysis of IFT74 as a candidate gene for chromosome 9p-linked ALS-FTD
-
Momeni P, Schymick J, Jain S, Cookson MR, Cairns NJ, Greggio E, Greenway MJ, Berger S, Pickering-Brown S, Chio A, et al. 2006. Analysis of IFT74 as a candidate gene for chromosome 9p-linked ALS-FTD. BMC Neurol 6: 44.
-
(2006)
BMC Neurol
, vol.6
, pp. 44
-
-
Momeni, P.1
Schymick, J.2
Jain, S.3
Cookson, M.R.4
Cairns, N.J.5
Greggio, E.6
Greenway, M.J.7
Berger, S.8
Pickering-Brown, S.9
Chio, A.10
-
120
-
-
34548125010
-
Increased autophagy in transgenic mice with a G93A mutant SOD1 gene
-
Morimoto N, Nagai M, Ohta Y, Miyazaki K, Kurata T, Morimoto M, Murakami T, Takehisa Y, Ikeda Y, Kamiya T, et al. 2007. Increased autophagy in transgenic mice with a G93A mutant SOD1 gene. Brain Res 1167: 112-117.
-
(2007)
Brain Res
, vol.1167
, pp. 112-117
-
-
Morimoto, N.1
Nagai, M.2
Ohta, Y.3
Miyazaki, K.4
Kurata, T.5
Morimoto, M.6
Murakami, T.7
Takehisa, Y.8
Ikeda, Y.9
Kamiya, T.10
-
121
-
-
79953043473
-
Caloric restriction and resveratrol promote longevity through the Sirtuin-1-dependent induction of autophagy
-
Morselli E, Maiuri MC, Markaki M, Megalou E, Pasparaki A, Palikaras K, Criollo A, Galluzzi L, Malik SA, Vitale I, et al. 2010. Caloric restriction and resveratrol promote longevity through the Sirtuin-1-dependent induction of autophagy. Cell Death Dis 1: e10.
-
(2010)
Cell Death Dis
, vol.1
-
-
Morselli, E.1
Maiuri, M.C.2
Markaki, M.3
Megalou, E.4
Pasparaki, A.5
Palikaras, K.6
Criollo, A.7
Galluzzi, L.8
Malik, S.A.9
Vitale, I.10
-
122
-
-
0034030313
-
Frontotemporal dementiawith motor neuron disease (amyotrophic lateral sclerosis with dementia)
-
Nakano I. 2000. Frontotemporal dementiawith motor neuron disease (amyotrophic lateral sclerosis with dementia). Neuropathology 20: 68-75.
-
(2000)
Neuropathology
, vol.20
, pp. 68-75
-
-
Nakano, I.1
-
123
-
-
0027742029
-
On the possibility of autolysosomal processing of skein-like inclusions. Electron microscopic observation in a case of amyotrophic lateral sclerosis
-
Nakano I, Shibata T, Uesaka Y. 1993. On the possibility of autolysosomal processing of skein-like inclusions. Electron microscopic observation in a case of amyotrophic lateral sclerosis. J Neurol Sci 120: 54-59.
-
(1993)
J Neurol Sci
, vol.120
, pp. 54-59
-
-
Nakano, I.1
Shibata, T.2
Uesaka, Y.3
-
124
-
-
58149314211
-
Parkin is recruited selectively to impaired mitochondria and promotes their autophagy
-
Narendra D, Tanaka A, Suen DF, Youle RJ. 2008. Parkin is recruited selectively to impaired mitochondria and promotes their autophagy. J Cell Biol 183: 795-803.
-
(2008)
J Cell Biol
, vol.183
, pp. 795-803
-
-
Narendra, D.1
Tanaka, A.2
Suen, D.F.3
Youle, R.J.4
-
125
-
-
75749156257
-
PINK1 is selectively stabilized on impaired mitochondria to activate Parkin
-
Narendra DP, Jin SM, Tanaka A, Suen DF, Gautier CA, Shen J, Cookson MR, Youle RJ. 2010. PINK1 is selectively stabilized on impaired mitochondria to activate Parkin. PLoS Biol 8: e1000298.
-
(2010)
PLoS Biol
, vol.8
-
-
Narendra, D.P.1
Jin, S.M.2
Tanaka, A.3
Suen, D.F.4
Gautier, C.A.5
Shen, J.6
Cookson, M.R.7
Youle, R.J.8
-
126
-
-
0344953581
-
2+, ATP, mitochondrial membrane potential, and calpain activity on the mechanism of neuron death induced by 3-nitropropionic acid
-
2+, ATP, mitochondrial membrane potential, and calpain activity on the mechanism of neuron death induced by 3-nitropropionic acid. Neurochem Int 43: 89-99.
-
(2003)
Neurochem Int
, vol.43
, pp. 89-99
-
-
Nasr, P.1
Gursahani, H.I.2
Pang, Z.3
Bondada, V.4
Lee, J.5
Hadley, R.W.6
Geddes, J.W.7
-
127
-
-
33747881231
-
Autophagy in neurodegenerative disease: Friend, foe or turncoat?
-
Nixon RA. 2006. Autophagy in neurodegenerative disease: Friend, foe or turncoat? Trends Neurosci 29: 528-535.
-
(2006)
Trends Neurosci
, vol.29
, pp. 528-535
-
-
Nixon, R.A.1
-
128
-
-
0028806557
-
The endosomal-lysosomal system of neurons: New roles
-
Nixon RA, Cataldo AM. 1995. The endosomal-lysosomal system of neurons: New roles. Trends Neurosci 18: 489-496.
-
(1995)
Trends Neurosci
, vol.18
, pp. 489-496
-
-
Nixon, R.A.1
Cataldo, A.M.2
-
129
-
-
33747388358
-
Lysosomal system pathways: Genes to neurodegeneration in Alzheimer's disease
-
Nixon RA, Cataldo AM. 2006. Lysosomal system pathways: Genes to neurodegeneration in Alzheimer's disease. JAlzheimers Dis 9: 277-289.
-
(2006)
JAlzheimers Dis
, vol.9
, pp. 277-289
-
-
Nixon, R.A.1
Cataldo, A.M.2
-
130
-
-
79955969705
-
Autophagy failure in Alzheimer's disease-Locating the primary defect
-
Nixon RA, Yang DS. 2011. Autophagy failure in Alzheimer's disease-Locating the primary defect. Neurobiol Dis 43: 38-45.
-
(2011)
Neurobiol Dis
, vol.43
, pp. 38-45
-
-
Nixon, R.A.1
Yang, D.S.2
-
131
-
-
0034304390
-
The endosomal-lysosomal system of neurons in Alzheimer's disease pathogenesis: A review
-
Nixon RA, Cataldo AM, Mathews PM. 2000. The endosomal-lysosomal system of neurons in Alzheimer's disease pathogenesis: A review. Neurochem Res 25: 1161-1172.
-
(2000)
Neurochem Res
, vol.25
, pp. 1161-1172
-
-
Nixon, R.A.1
Cataldo, A.M.2
Mathews, P.M.3
-
132
-
-
14844303381
-
Extensive involvement of autophagy in Alzheimer disease: An immuno-electron microscopy study
-
Nixon RA, Wegiel J, Kumar A, Yu WH, Peterhoff C, Cataldo A, Cuervo AM. 2005. Extensive involvement of autophagy in Alzheimer disease: An immuno-electron microscopy study. JNeuropathol ExpNeurol 64: 113-122.
-
(2005)
JNeuropathol ExpNeurol
, vol.64
, pp. 113-122
-
-
Nixon, R.A.1
Wegiel, J.2
Kumar, A.3
Yu, W.H.4
Peterhoff, C.5
Cataldo, A.6
Cuervo, A.M.7
-
133
-
-
48249103491
-
Neurodegenerative lysosomal disorders: A continuum from development to late age
-
Nixon RA, Yang DS, Lee JH. 2008. Neurodegenerative lysosomal disorders: A continuum from development to late age. Autophagy 4: 590-599.
-
(2008)
Autophagy
, vol.4
, pp. 590-599
-
-
Nixon, R.A.1
Yang, D.S.2
Lee, J.H.3
-
134
-
-
67549132527
-
The late stages of autophagy: How does the end begin?
-
Noda T, Fujita N, Yoshimori T. 2009. The late stages of autophagy: How does the end begin? Cell Death Differ 16: 984-990.
-
(2009)
Cell Death Differ
, vol.16
, pp. 984-990
-
-
Noda, T.1
Fujita, N.2
Yoshimori, T.3
-
135
-
-
34249037565
-
Crystal structure of the Bcl-XL-Beclin 1 peptide complex: Beclin 1 is a nove BH3-only protein
-
Oberstein A, Jeffrey PD, Shi Y. 2007. Crystal structure of the Bcl-XL-Beclin 1 peptide complex: Beclin 1 is a nove BH3-only protein. J Biol Chem 282: 13123-13132.
-
(2007)
J Biol Chem
, vol.282
, pp. 13123-13132
-
-
Oberstein, A.1
Jeffrey, P.D.2
Shi, Y.3
-
136
-
-
0035286734
-
Molecular dissection of autophagy: Two ubiquitin-like systems
-
Ohsumi Y. 2001. Molecular dissection of autophagy: Two ubiquitin-like systems. Nat RevMol Cell Biol 2: 211-216.
-
(2001)
Nat RevMol Cell Biol
, vol.2
, pp. 211-216
-
-
Ohsumi, Y.1
-
137
-
-
0033587128
-
Inhibition of caspase-1 slows disease progression in a mouse model of Huntington's disease
-
Ona VO, Li M, Vonsattel JP, Andrews LJ, Khan SQ, Chung WM, Frey AS, Menon AS, Li XJ, Stieg PE, et al. 1999. Inhibition of caspase-1 slows disease progression in a mouse model of Huntington's disease. Nature 399: 263-267.
-
(1999)
Nature
, vol.399
, pp. 263-267
-
-
Ona, V.O.1
Li, M.2
Vonsattel, J.P.3
Andrews, L.J.4
Khan, S.Q.5
Chung, W.M.6
Frey, A.S.7
Menon, A.S.8
Li, X.J.9
Stieg, P.E.10
-
138
-
-
80052716148
-
Characterization of the CLEAR network reveals an integrated control of cellular clearance pathways
-
Palmieri M, Impey S, Kang H, di Ronza A, Pelz C, Sardiello M, Ballabio A. 2011. Characterization of the CLEAR network reveals an integrated control of cellular clearance pathways. Hum Mol Genet 20: 3852-3866.
-
(2011)
Hum Mol Genet
, vol.20
, pp. 3852-3866
-
-
Palmieri, M.1
Impey, S.2
Kang, H.3
di Ronza, A.4
Pelz, C.5
Sardiello, M.6
Ballabio, A.7
-
139
-
-
0030946503
-
Mechanisms of cell death induced by the mitochondrial toxin 3-nitropropionic acid: Acute excitotoxic necrosis and delayed apoptosis
-
Pang Z, Geddes JW. 1997. Mechanisms of cell death induced by the mitochondrial toxin 3-nitropropionic acid: Acute excitotoxic necrosis and delayed apoptosis. J Neurosci 17: 3064-3073.
-
(1997)
J Neurosci
, vol.17
, pp. 3064-3073
-
-
Pang, Z.1
Geddes, J.W.2
-
140
-
-
0038279765
-
Calpain facilitates the neuron death induced by 3-nitropropionic acid and contributes to the necrotic morphology
-
Pang Z, Bondada V, Sengoku T, Siman R, Geddes JW. 2003. Calpain facilitates the neuron death induced by 3-nitropropionic acid and contributes to the necrotic morphology. J Neuropathol Exp Neurol 62: 633-643.
-
(2003)
J Neuropathol Exp Neurol
, vol.62
, pp. 633-643
-
-
Pang, Z.1
Bondada, V.2
Sengoku, T.3
Siman, R.4
Geddes, J.W.5
-
141
-
-
33749006845
-
ALS phenotypes with mutations in CHMP2B (charged multivesicular body protein 2B)
-
Parkinson N, Ince PG, Smith MO, Highley R, Skibinski G, Andersen PM, Morrison KE, Pall HS, Hardiman O, Collinge J, et al. 2006. ALS phenotypes with mutations in CHMP2B (charged multivesicular body protein 2B). Neurology 67: 1074-1077.
-
(2006)
Neurology
, vol.67
, pp. 1074-1077
-
-
Parkinson, N.1
Ince, P.G.2
Smith, M.O.3
Highley, R.4
Skibinski, G.5
Andersen, P.M.6
Morrison, K.E.7
Pall, H.S.8
Hardiman, O.9
Collinge, J.10
-
142
-
-
67749106389
-
Autophagy, lithium, and amyotrophic lateral sclerosis
-
Pasquali L, Longone P, Isidoro C, Ruggieri S, Paparelli A, Fornai F. 2009. Autophagy, lithium, and amyotrophic lateral sclerosis. Muscle Nerve 40: 173-194.
-
(2009)
Muscle Nerve
, vol.40
, pp. 173-194
-
-
Pasquali, L.1
Longone, P.2
Isidoro, C.3
Ruggieri, S.4
Paparelli, A.5
Fornai, F.6
-
143
-
-
25144457455
-
Bcl-2 antiapoptotic proteins inhibit Beclin 1-dependent autophagy
-
Pattingre S, Tassa A, Qu X, Garuti R, Liang XH, Mizushim N, Packer M, Schneider MD, Levine B. 2005. Bcl-2 antiapoptotic proteins inhibit Beclin 1-dependent autophagy. Cell 122: 927-939.
-
(2005)
Cell
, vol.122
, pp. 927-939
-
-
Pattingre, S.1
Tassa, A.2
Qu, X.3
Garuti, R.4
Liang, X.H.5
Mizushim, N.6
Packer, M.7
Schneider, M.D.8
Levine, B.9
-
144
-
-
45749114895
-
The autophagy-related protein beclin 1 shows reduced expression in early Alzheimer disease and regulates amyloid b accumulation in mice
-
Pickford F, Masliah E, Britschgi M, Lucin K, Narasimhan R, Jaeger PA, Small S, Spencer B, Rockenstein E, Levine B, et al. 2008. The autophagy-related protein beclin 1 shows reduced expression in early Alzheimer disease and regulates amyloid b accumulation in mice. J Clin Invest 118: 2190-2199.
-
(2008)
J Clin Invest
, vol.118
, pp. 2190-2199
-
-
Pickford, F.1
Masliah, E.2
Britschgi, M.3
Lucin, K.4
Narasimhan, R.5
Jaeger, P.A.6
Small, S.7
Spencer, B.8
Rockenstein, E.9
Levine, B.10
-
145
-
-
79960664223
-
Activation of autophagy in a rat model of retinal ischemia following high intraocular pressure
-
Piras A, Gianetto D, Conte D, Bosone A, Vercelli A. 2011. Activation of autophagy in a rat model of retinal ischemia following high intraocular pressure. PLoS ONE 6: e22514.
-
(2011)
PLoS ONE
, vol.6
-
-
Piras, A.1
Gianetto, D.2
Conte, D.3
Bosone, A.4
Vercelli, A.5
-
146
-
-
70350059677
-
Postischemic treatment of neonatal cerebral ischemia should target autophagy
-
Puyal J, Vaslin A, Mottier V, Clarke PG. 2009. Postischemic treatment of neonatal cerebral ischemia should target autophagy. Ann Neurol 66: 378-389.
-
(2009)
Ann Neurol
, vol.66
, pp. 378-389
-
-
Puyal, J.1
Vaslin, A.2
Mottier, V.3
Clarke, P.G.4
-
147
-
-
20144381544
-
Essential roles of Atg5 and FADD in autophagic cell death: Dissection of autophagic cell death into vacuole formation and cell death
-
Pyo JO, Jang MH, Kwon YK, Lee HJ, Jun JI, Woo HN, Cho DH, Choi B, Lee H, Kim JH, et al. 2005. Essential roles of Atg5 and FADD in autophagic cell death: Dissection of autophagic cell death into vacuole formation and cell death. J Biol Chem 280: 20722-20729.
-
(2005)
J Biol Chem
, vol.280
, pp. 20722-20729
-
-
Pyo, J.O.1
Jang, M.H.2
Kwon, Y.K.3
Lee, H.J.4
Jun, J.I.5
Woo, H.N.6
Cho, D.H.7
Choi, B.8
Lee, H.9
Kim, J.H.10
-
148
-
-
33749133430
-
Hereditary parkinsonism with dementia is caused by mutations in ATP13A2, encoding a lysosomal type 5 P-type ATPase
-
Ramirez A, Heimbach A, Grundemann J, Stiller B, Hampshire D, Cid LP, Goebel I, Mubaidin AF, Wriekat AL, Roeper J, et al. 2006. Hereditary parkinsonism with dementia is caused by mutations in ATP13A2, encoding a lysosomal type 5 P-type ATPase. Nat Genet 38: 1184-1191.
-
(2006)
Nat Genet
, vol.38
, pp. 1184-1191
-
-
Ramirez, A.1
Heimbach, A.2
Grundemann, J.3
Stiller, B.4
Hampshire, D.5
Cid, L.P.6
Goebel, I.7
Mubaidin, A.F.8
Wriekat, A.L.9
Roeper, J.10
-
149
-
-
58149397537
-
Marked calpastatin (CAST) depletion in Alzheimer's disease accelerates cytoskeleton disruption and neurodegeneration: Neuroprotection by CAST overexpression
-
Rao MV, Mohan PS, Peterhoff CM, Yang DS, Schmidt SD, Stavrides PH, Campbell J, Chen Y, Jiang Y, Paskevich PA, et al. 2008. Marked calpastatin (CAST) depletion in Alzheimer's disease accelerates cytoskeleton disruption and neurodegeneration: Neuroprotection by CAST overexpression. J Neurosci 28: 12241-12254.
-
(2008)
J Neurosci
, vol.28
, pp. 12241-12254
-
-
Rao, M.V.1
Mohan, P.S.2
Peterhoff, C.M.3
Yang, D.S.4
Schmidt, S.D.5
Stavrides, P.H.6
Campbell, J.7
Chen, Y.8
Jiang, Y.9
Paskevich, P.A.10
-
150
-
-
2642586352
-
Inhibition of mTOR induces autophagy and reduces toxicity of polyglutamine expansions in fly and mouse models of Huntington disease
-
Ravikumar B, Vacher C, Berger Z, Davies JE, Luo S, Oroz LG, Scaravilli F, Easton DF, Duden R, O'Kane CJ, et al. 2004. Inhibition of mTOR induces autophagy and reduces toxicity of polyglutamine expansions in fly and mouse models of Huntington disease. Nat Genet 36: 585-595.
-
(2004)
Nat Genet
, vol.36
, pp. 585-595
-
-
Ravikumar, B.1
Vacher, C.2
Berger, Z.3
Davies, J.E.4
Luo, S.5
Oroz, L.G.6
Scaravilli, F.7
Easton, D.F.8
Duden, R.9
O'Kane, C.J.10
-
151
-
-
22844436451
-
Dynein mutations impair autophagic clearance of aggregate-prone proteins
-
Ravikumar B, Acevedo-Arozena A, Imarisio S, Berger Z, Vacher C, O'Kane CJ, Brown SD, Rubinsztein DC. 2005. Dynein mutations impair autophagic clearance of aggregate-prone proteins. Nat Genet 37: 771-776.
-
(2005)
Nat Genet
, vol.37
, pp. 771-776
-
-
Ravikumar, B.1
Acevedo-Arozena, A.2
Imarisio, S.3
Berger, Z.4
Vacher, C.5
O'Kane, C.J.6
Brown, S.D.7
Rubinsztein, D.C.8
-
152
-
-
78149475088
-
Regulation of mammalian autophagy in physiology and pathophysiology
-
Ravikumar B, Sarkar S, Davies JE, Futter M, Garcia-Arencibia M, Green-Thompson ZW, Jimenez-Sanchez M, Korolchuk VI, Lichtenberg M, Luo S, et al. 2010. Regulation of mammalian autophagy in physiology and pathophysiology. Physiol Rev 90: 1383-1435.
-
(2010)
Physiol Rev
, vol.90
, pp. 1383-1435
-
-
Ravikumar, B.1
Sarkar, S.2
Davies, J.E.3
Futter, M.4
Garcia-Arencibia, M.5
Green-Thompson, Z.W.6
Jimenez-Sanchez, M.7
Korolchuk, V.I.8
Lichtenberg, M.9
Luo, S.10
-
154
-
-
0022369964
-
Neuronal nuclear membrane indentation and astrocyte/neuron ratio in Huntington's disease. A quantitative electron microscopic study
-
Roos RA, Bots GT, Hermans J. 1985. Neuronal nuclear membrane indentation and astrocyte/neuron ratio in Huntington's disease. A quantitative electron microscopic study. J Hirnforsch 26: 689-693.
-
(1985)
J Hirnforsch
, vol.26
, pp. 689-693
-
-
Roos, R.A.1
Bots, G.T.2
Hermans, J.3
-
155
-
-
26444515364
-
Autophagy and its possible roles in nervous system diseases, damage and repair
-
Rubinsztein DC, DiFiglia M, Heintz N, Nixon RA, Qin ZH, Ravikumar B, Stefanis L, Tolkovsky AM. 2005. Autophagy and its possible roles in nervous system diseases, damage and repair. Autophagy 1: 11-22.
-
(2005)
Autophagy
, vol.1
, pp. 11-22
-
-
Rubinsztein, D.C.1
DiFiglia, M.2
Heintz, N.3
Nixon, R.A.4
Qin, Z.H.5
Ravikumar, B.6
Stefanis, L.7
Tolkovsky, A.M.8
-
157
-
-
41949137715
-
A comparison of huntington disease and huntington disease-like 2 neuropathology
-
Rudnicki DD, Pletnikova O, Vonsattel JP, Ross CA, Margolis RL. 2008. A comparison of huntington disease and huntington disease-like 2 neuropathology. J Neuropathol Exp Neurol 67: 366-374.
-
(2008)
J Neuropathol Exp Neurol
, vol.67
, pp. 366-374
-
-
Rudnicki, D.D.1
Pletnikova, O.2
Vonsattel, J.P.3
Ross, C.A.4
Margolis, R.L.5
-
158
-
-
78651423598
-
Microautophagy of cytosolic proteins by late endosomes
-
Sahu R, Kaushik S, Clement CC, Cannizzo ES, Scharf B, Follenzi A, Potolicchio I, Nieves E, Cuervo AM, Santambrogi L. 2011. Microautophagy of cytosolic proteins by late endosomes. Dev Cell 20: 131-139.
-
(2011)
Dev Cell
, vol.20
, pp. 131-139
-
-
Sahu, R.1
Kaushik, S.2
Clement, C.C.3
Cannizzo, E.S.4
Scharf, B.5
Follenzi, A.6
Potolicchio, I.7
Nieves, E.8
Cuervo, A.M.9
Santambrogi, L.10
-
159
-
-
0033103523
-
Caspase-8 is required for cell death induced by expanded polyglutamine repeats
-
Sanchez I, Xu CJ, Juo P, Kakizaka A, Blenis J, Yuan J. 1999. Caspase-8 is required for cell death induced by expanded polyglutamine repeats. Neuron 22: 623-633.
-
(1999)
Neuron
, vol.22
, pp. 623-633
-
-
Sanchez, I.1
Xu, C.J.2
Juo, P.3
Kakizaka, A.4
Blenis, J.5
Yuan, J.6
-
160
-
-
47049100413
-
Essential role for Nix in autophagic maturation of erythroid cells
-
Sandoval H, Thiagarajan P, Dasgupta SK, Schumacher A, Prchal JT, Chen M, Wang J. 2008. Essential role for Nix in autophagic maturation of erythroid cells. Nature 454: 232-235.
-
(2008)
Nature
, vol.454
, pp. 232-235
-
-
Sandoval, H.1
Thiagarajan, P.2
Dasgupta, S.K.3
Schumacher, A.4
Prchal, J.T.5
Chen, M.6
Wang, J.7
-
161
-
-
79955522014
-
Autophagy in spinal cord motor neurons in sporadic amyotrophic lateral sclerosis
-
Sasaki S. 2011. Autophagy in spinal cord motor neurons in sporadic amyotrophic lateral sclerosis. J Neuropathol Exp Neurol 70: 349-359.
-
(2011)
J Neuropathol Exp Neurol
, vol.70
, pp. 349-359
-
-
Sasaki, S.1
-
162
-
-
0015880897
-
The morphology of various types of cell death in prenatal tissues
-
Schweichel JU, Merker HJ. 1973. The morphology of various types of cell death in prenatal tissues. Teratology 7: 253-266.
-
(1973)
Teratology
, vol.7
, pp. 253-266
-
-
Schweichel, J.U.1
Merker, H.J.2
-
163
-
-
37549066697
-
A block of autophagy in lysosomal storage disorders
-
Settembre C, Fraldi A, Jahreiss L, Spampanato C, Venturi C, Medina D, de Pablo R, Tacchetti C, Rubinsztein DC, Ballabio A. 2008a. A block of autophagy in lysosomal storage disorders. Hum Mol Genet 17: 119-129.
-
(2008)
Hum Mol Genet
, vol.17
, pp. 119-129
-
-
Settembre, C.1
Fraldi, A.2
Jahreiss, L.3
Spampanato, C.4
Venturi, C.5
Medina, D.6
de Pablo, R.7
Tacchetti, C.8
Rubinsztein, D.C.9
Ballabio, A.10
-
165
-
-
80955177196
-
TFEB links autophagy to lysosomal biogenesis
-
Settembre C, Di Malta C, Polito VA, Garcia Arencibia M, Vetrini F, Erdin S, Erdin SU, Huynh T, Medina D, Colella P, et al. 2011. TFEB links autophagy to lysosomal biogenesis. Science 332: 1429-1433.
-
(2011)
Science
, vol.332
, pp. 1429-1433
-
-
Settembre, C.1
Di Malta, C.2
Polito, V.A.3
Garcia Arencibia, M.4
Vetrini, F.5
Erdin, S.6
Erdin, S.U.7
Huynh, T.8
Medina, D.9
Colella, P.10
-
166
-
-
0029004341
-
Cloning of a gene bearing missense mutations in earlyonset familial Alzheimer's disease
-
Sherrington R, Rogaev EI, Liang Y, Rogaeva EA, Levesque G, Ikeda M, Chi H, Lin C, Li G, Holman K, et al. 1995. Cloning of a gene bearing missense mutations in earlyonset familial Alzheimer's disease. Nature 375: 754-760.
-
(1995)
Nature
, vol.375
, pp. 754-760
-
-
Sherrington, R.1
Rogaev, E.I.2
Liang, Y.3
Rogaeva, E.A.4
Levesque, G.5
Ikeda, M.6
Chi, H.7
Lin, C.8
Li, G.9
Holman, K.10
-
167
-
-
77953858790
-
TRAF6 and A20 regulate lysine 63-linked ubiquitination of Beclin-1 to control TLR4-induced autophagy
-
Shi CS, Kehrl JH. 2010. TRAF6 and A20 regulate lysine 63-linked ubiquitination of Beclin-1 to control TLR4-induced autophagy. Sci Signal 3: ra42.
-
(2010)
Sci Signal
, vol.3
-
-
Shi, C.S.1
Kehrl, J.H.2
-
168
-
-
33744916798
-
Regulation of intracellular accumulation of mutantHuntingtin by Beclin 1
-
Shibata M, Lu T, Furuya T, Degterev A, Mizushima N, Yoshimori T, MacDonald M, Yankner B, Yuan J. 2006. Regulation of intracellular accumulation of mutantHuntingtin by Beclin 1. J Biol Chem 281: 14474-14485.
-
(2006)
J Biol Chem
, vol.281
, pp. 14474-14485
-
-
Shibata, M.1
Lu, T.2
Furuya, T.3
Degterev, A.4
Mizushima, N.5
Yoshimori, T.6
McDonald, M.7
Yankner, B.8
Yuan, J.9
-
169
-
-
10344262564
-
Role of Bcl-2 family proteins in a non-apoptotic programmed cell death dependent on autophagy genes
-
Shimizu S, Kanaseki T, Mizushima N, Mizuta T, Arakawa-Kobayashi S, Thompson CB, Tsujimoto Y. 2004. Role of Bcl-2 family proteins in a non-apoptotic programmed cell death dependent on autophagy genes. Nat Cell Biol 6: 1221-1228.
-
(2004)
Nat Cell Biol
, vol.6
, pp. 1221-1228
-
-
Shimizu, S.1
Kanaseki, T.2
Mizushima, N.3
Mizuta, T.4
Arakawa-Kobayashi, S.5
Thompson, C.B.6
Tsujimoto, Y.7
-
170
-
-
70350319531
-
Multicenter analysis of glucocerebrosidase mutations in Parkinson's disease
-
Sidransky E, Nalls MA, Aasly JO, Aharon-Peretz J, Annesi G, Barbosa ER, Bar-Shira A, Berg D, Bras J, Brice A, et al. 2009. Multicenter analysis of glucocerebrosidase mutations in Parkinson's disease. N Engl J Med 361: 1651-1661.
-
(2009)
N Engl J Med
, vol.361
, pp. 1651-1661
-
-
Sidransky, E.1
Nalls, M.A.2
Aasly, J.O.3
Aharon-Peretz, J.4
Annesi, G.5
Barbosa, E.R.6
Bar-Shira, A.7
Berg, D.8
Bras, J.9
Brice, A.10
-
171
-
-
23044471011
-
Mutations in the endosomal ESCRTIII-complex subunit CHMP2B in frontotemporal dementia
-
Skibinski G, Parkinson NJ, Brown JM, Chakrabarti L, Lloyd SL, Hummerich H, Nielsen JE, Hodges JR, Spillantini MG, Thusgaard T, et al. 2005. Mutations in the endosomal ESCRTIII-complex subunit CHMP2B in frontotemporal dementia. Nat Genet 37: 806-808.
-
(2005)
Nat Genet
, vol.37
, pp. 806-808
-
-
Skibinski, G.1
Parkinson, N.J.2
Brown, J.M.3
Chakrabarti, L.4
Lloyd, S.L.5
Hummerich, H.6
Nielsen, J.E.7
Hodges, J.R.8
Spillantini, M.G.9
Thusgaard, T.10
-
172
-
-
70350550208
-
Beclin 1 gene transfer activates autophagy and ameliorates the neurodegenerative pathology in a-synuclein models of Parkinson's and Lewy body diseases
-
Spencer B, Potkar R, Trejo M, Rockenstein E, Patrick C, Gindi R, Adame A, Wyss-Coray T, Masliah E. 2009. Beclin 1 gene transfer activates autophagy and ameliorates the neurodegenerative pathology in a-synuclein models of Parkinson's and Lewy body diseases. J Neurosci 29: 13578-13588.
-
(2009)
J Neurosci
, vol.29
, pp. 13578-13588
-
-
Spencer, B.1
Potkar, R.2
Trejo, M.3
Rockenstein, E.4
Patrick, C.5
Gindi, R.6
Adame, A.7
Wyss-Coray, T.8
Masliah, E.9
-
173
-
-
77956305343
-
Inhibition of mTOR by rapamycin abolishes cognitive deficits and reduces amyloid-b levels in a mouse model of Alzheimer's disease
-
Spilman P, Podlutskaya N, Hart MJ, Debnath J, Gorostiza O, Bredesen D, Richardson A, Strong R, Galvan V. 2010. Inhibition of mTOR by rapamycin abolishes cognitive deficits and reduces amyloid-b levels in a mouse model of Alzheimer's disease. PLoS ONE 5: e9979.
-
(2010)
PLoS ONE
, vol.5
-
-
Spilman, P.1
Podlutskaya, N.2
Hart, M.J.3
Debnath, J.4
Gorostiza, O.5
Bredesen, D.6
Richardson, A.7
Strong, R.8
Galvan, V.9
-
174
-
-
13544273998
-
Caspase-dependent and-independent neuronal death: Twodistinct pathways to neuronal injury
-
Stefanis L. 2005. Caspase-dependent and-independent neuronal death: Twodistinct pathways to neuronal injury. Neuroscientist 11: 50-62.
-
(2005)
Neuroscientist
, vol.11
, pp. 50-62
-
-
Stefanis, L.1
-
175
-
-
54049140363
-
The syndromes of frontotemporal dysfunction in amyotrophic lateral sclerosis
-
Strong MJ. 2008. The syndromes of frontotemporal dysfunction in amyotrophic lateral sclerosis. Amyotroph Lateral Scler 9: 323-338.
-
(2008)
Amyotroph Lateral Scler
, vol.9
, pp. 323-338
-
-
Strong, M.J.1
-
176
-
-
67651160559
-
Consensus criteria for the diagnosis of frontotemporal cognitive and behavioural syndromes in amyotrophic lateral sclerosis
-
Strong MJ, Grace GM, Freedman M, Lomen-Hoerth C, Woolley S, Goldstein LH, Murphy J, Shoesmith C, Rosenfeld J, Leigh PN, et al. 2009. Consensus criteria for the diagnosis of frontotemporal cognitive and behavioural syndromes in amyotrophic lateral sclerosis. Amyotroph Lateral Scler 10: 131-146.
-
(2009)
Amyotroph Lateral Scler
, vol.10
, pp. 131-146
-
-
Strong, M.J.1
Grace, G.M.2
Freedman, M.3
Lomen-Hoerth, C.4
Woolley, S.5
Goldstein, L.H.6
Murphy, J.7
Shoesmith, C.8
Rosenfeld, J.9
Leigh, P.N.10
-
177
-
-
53849106834
-
Cystatin Ccathepsin B axis regulates amyloid b levels and associated neuronal deficits in an animal model of Alzheimer's disease
-
Sun B, Zhou Y, Halabisky B, Lo I, Cho SH, Mueller-Steiner S, Devidze N, Wang X, Grubb A, Gan L. 2008. Cystatin Ccathepsin B axis regulates amyloid b levels and associated neuronal deficits in an animal model of Alzheimer's disease. Neuron 60: 247-257.
-
(2008)
Neuron
, vol.60
, pp. 247-257
-
-
Sun, B.1
Zhou, Y.2
Halabisky, B.3
Lo, I.4
Cho, S.H.5
Mueller-Steiner, S.6
Devidze, N.7
Wang, X.8
Grubb, A.9
Gan, L.10
-
178
-
-
0036023937
-
Death by necrosis. Uncontrollable catastrophe, or is there order behind the chaos?
-
Syntichaki P, Tavernarakis N. 2002. Death by necrosis. Uncontrollable catastrophe, or is there order behind the chaos? EMBO Rep 3: 604-609.
-
(2002)
EMBO Rep
, vol.3
, pp. 604-609
-
-
Syntichaki, P.1
Tavernarakis, N.2
-
179
-
-
77956386515
-
Endogenous HMGB1 regulates autophagy
-
Tang D, Kang R, Livesey KM, Cheh CW, Farkas A, Loughran P, Hoppe G, Bianchi ME, Tracey KJ, Zeh HJ 3rd, et al. 2010. Endogenous HMGB1 regulates autophagy. J Cell Biol 190: 881-892.
-
(2010)
J Cell Biol
, vol.190
, pp. 881-892
-
-
Tang, D.1
Kang, R.2
Livesey, K.M.3
Cheh, C.W.4
Farkas, A.5
Loughran, P.6
Hoppe, G.7
Bianchi, M.E.8
Tracey, K.J.9
Zeh III, H.J.10
-
181
-
-
33644641768
-
Oxidative stress, accumulation of biological "garbage, " and aging
-
Terman A, Brunk UT. 2006. Oxidative stress, accumulation of biological "garbage, " and aging. Antioxid Redox Signal 8: 197-204.
-
(2006)
Antioxid Redox Signal
, vol.8
, pp. 197-204
-
-
Terman, A.1
Brunk, U.T.2
-
182
-
-
79957917512
-
A smallmolecule enhancer of autophagy decreases levels of Ab and APP-CTF via Atg5-dependent autophagy pathway
-
Tian Y, Bustos V, Flajolet M, Greengard P. 2011. A smallmolecule enhancer of autophagy decreases levels of Ab and APP-CTF via Atg5-dependent autophagy pathway. FASEB J 25: 1934-1942.
-
(2011)
FASEB J
, vol.25
, pp. 1934-1942
-
-
Tian, Y.1
Bustos, V.2
Flajolet, M.3
Greengard, P.4
-
183
-
-
77952533111
-
VCP/p97 is essential for maturation of ubiquitin-containing autophagosomes and this function is impaired by mutations that cause IBMPFD
-
Tresse E, Salomons FA, Vesa J, Bott LC, Kimonis V, Yao TP, Dantuma NP, Taylor JP. 2010. VCP/p97 is essential for maturation of ubiquitin-containing autophagosomes and this function is impaired by mutations that cause IBMPFD. Autophagy 6: 217-227.
-
(2010)
Autophagy
, vol.6
, pp. 217-227
-
-
Tresse, E.1
Salomons, F.A.2
Vesa, J.3
Bott, L.C.4
Kimonis, V.5
Yao, T.P.6
Dantuma, N.P.7
Taylor, J.P.8
-
184
-
-
0034659833
-
A mutation in the ovine cathepsin D gene causes a congenital lysosomal storage disease with profound neurodegeneration
-
Tyynela J, Sohar I, Sleat DE, Gin RM, Donnelly RJ, Baumann M, Haltia M, Lobel P. 2000. A mutation in the ovine cathepsin D gene causes a congenital lysosomal storage disease with profound neurodegeneration. Emb J 19: 2786-2792.
-
(2000)
Emb J
, vol.19
, pp. 2786-2792
-
-
Tyynela, J.1
Sohar, I.2
Sleat, D.E.3
Gin, R.M.4
Donnelly, R.J.5
Baumann, M.6
Haltia, M.7
Lobel, P.8
-
185
-
-
0034849783
-
Autophagic cell death and its execution by lysosomal cathepsins
-
Uchiyama Y. 2001. Autophagic cell death and its execution by lysosomal cathepsins. Arch Histol Cytol 64: 233-246.
-
(2001)
Arch Histol Cytol
, vol.64
, pp. 233-246
-
-
Uchiyama, Y.1
-
186
-
-
41649086378
-
Selective association of misfolded ALS-linked mutant SOD1 with the cytoplasmic face of mitochondria
-
Vande Velde C, Miller TM, Cashman NR, Cleveland DW. 2008. Selective association of misfolded ALS-linked mutant SOD1 with the cytoplasmic face of mitochondria. Proc Natl Acad Sci 105: 4022-4027.
-
(2008)
Proc Natl Acad Sci
, vol.105
, pp. 4022-4027
-
-
Vande Velde, C.1
Miller, T.M.2
Cashman, N.R.3
Cleveland, D.W.4
-
187
-
-
56349119573
-
Motor deficit in a Drosophila model of mucolipidosis type IV due to defective clearance of apoptotic cells
-
Venkatachalam K, Long AA, Elsaesser R, Nikolaeva D, Broadie K, Montell C. 2008. Motor deficit in a Drosophila model of mucolipidosis type IV due to defective clearance of apoptotic cells. Cell 135: 838-851.
-
(2008)
Cell
, vol.135
, pp. 838-851
-
-
Venkatachalam, K.1
Long, A.A.2
Elsaesser, R.3
Nikolaeva, D.4
Broadie, K.5
Montell, C.6
-
188
-
-
79953221421
-
Severe global cerebral ischemia-induced programmed necrosis of hippocampal CA1 neurons in rat is prevented by 3-methyladenine: A widely used inhibitor of autophagy
-
Wang JY, Xia Q, Chu KT, Pan J, Sun LN, Zeng B, Zhu YJ, Wang Q, Wang K, Luo BY. 2011. Severe global cerebral ischemia-induced programmed necrosis of hippocampal CA1 neurons in rat is prevented by 3-methyladenine: A widely used inhibitor of autophagy. J Neuropathol Exp Neurol 70: 314-322.
-
(2011)
J Neuropathol Exp Neurol
, vol.70
, pp. 314-322
-
-
Wang, J.Y.1
Xia, Q.2
Chu, K.T.3
Pan, J.4
Sun, L.N.5
Zeng, B.6
Zhu, Y.J.7
Wang, Q.8
Wang, K.9
Luo, B.Y.10
-
189
-
-
0041589248
-
a-Synuclein is degraded by both autophagy and the proteasome
-
Webb JL, Ravikumar B, Atkins J, Skepper JN, Rubinsztei DC. 2003. a-Synuclein is degraded by both autophagy and the proteasome. J Biol Chem 278: 25009-25013.
-
(2003)
J Biol Chem
, vol.278
, pp. 25009-25013
-
-
Webb, J.L.1
Ravikumar, B.2
Atkins, J.3
Skepper, J.N.4
Rubinsztei, D.C.5
-
190
-
-
44949237240
-
JNK1-mediated phosphorylation of Bcl-2 regulates starvationinduced autophagy
-
Wei Y, Pattingre S, Sinha S, Bassik M, Levine B. 2008. JNK1-mediated phosphorylation of Bcl-2 regulates starvationinduced autophagy. Mol Cell 30: 678-688.
-
(2008)
Mol Cell
, vol.30
, pp. 678-688
-
-
Wei, Y.1
Pattingre, S.2
Sinha, S.3
Bassik, M.4
Levine, B.5
-
191
-
-
79959415069
-
Biogenesis and cargo selectivity of autophagosomes
-
Weidberg H, Shvets E, Elazar Z. 2011. Biogenesis and cargo selectivity of autophagosomes. Annu Rev Biochem 80: 125-156.
-
(2011)
Annu Rev Biochem
, vol.80
, pp. 125-156
-
-
Weidberg, H.1
Shvets, E.2
Elazar, Z.3
-
192
-
-
50249189191
-
Neuronal injury in rat model of permanent focal cerebral ischemia is associated with activation of autophagic and lysosomal pathways
-
Wen YD, Sheng R, Zhang LS, Han R, Zhang X, Zhang XD, Han F, Fukunaga K, Qin ZH. 2008. Neuronal injury in rat model of permanent focal cerebral ischemia is associated with activation of autophagic and lysosomal pathways. Autophagy 4: 762-769.
-
(2008)
Autophagy
, vol.4
, pp. 762-769
-
-
Wen, Y.D.1
Sheng, R.2
Zhang, L.S.3
Han, R.4
Zhang, X.5
Zhang, X.D.6
Han, F.7
Fukunaga, K.8
Qin, Z.H.9
-
194
-
-
35348948380
-
Tumor necrosis factor-related apoptosisinducing ligand activates a lysosomal pathway of apoptosis that is regulated by Bcl-2 proteins
-
Werneburg NW, Guicciardi ME, Bronk SF, Kaufmann SH, Gores GJ. 2007. Tumor necrosis factor-related apoptosisinducing ligand activates a lysosomal pathway of apoptosis that is regulated by Bcl-2 proteins. J Biol Chem 282: 28960-28970.
-
(2007)
J Biol Chem
, vol.282
, pp. 28960-28970
-
-
Werneburg, N.W.1
Guicciardi, M.E.2
Bronk, S.F.3
Kaufmann, S.H.4
Gores, G.J.5
-
195
-
-
75949104449
-
Mitochondria get a Parkin' ticket
-
Wild P, Dikic I. 2010. Mitochondria get a Parkin' ticket. Nat Cell Biol 12: 104-106.
-
(2010)
Nat Cell Biol
, vol.12
, pp. 104-106
-
-
Wild, P.1
Dikic, I.2
-
196
-
-
30844436109
-
Mannose 6-phosphate receptors, Niemann-Pick C2 protein, and lysosomal cholesterol accumulation
-
Willenborg M, Schmidt CK, Braun P, Landgrebe J, Vo Figura K, Saftig P, Eskelinen EL. 2005. Mannose 6-phosphate receptors, Niemann-Pick C2 protein, and lysosomal cholesterol accumulation. J Lipid Res 46: 2559-2569.
-
(2005)
J Lipid Res
, vol.46
, pp. 2559-2569
-
-
Willenborg, M.1
Schmidt, C.K.2
Braun, P.3
Landgrebe, J.4
Vo Figura, K.5
Saftig, P.6
Eskelinen, E.L.7
-
197
-
-
84971325184
-
Autophagy failure in Alzheimer's disease and lysosomal storage disorders: A common pathway to neurodegeneration
-
(ed. Yue Z, Chu CT)., World Scientific, Hackensack*N.J
-
Wolfe DM, Nixon RA. 2012. Autophagy failure in Alzheimer's disease and lysosomal storage disorders: A common pathway to neurodegeneration. In Autophagy of the nervous system: Cellular self-digestion in neurons and neurological diseases (ed. Yue Z, Chu CT). World Scientific, Hackensack*N.J.
-
(2012)
Autophagy of the nervous system: Cellular self-digestion in neurons and neurological diseases
-
-
Wolfe, D.M.1
Nixon, R.A.2
-
198
-
-
0029053881
-
An adverse property of a familial ALS-linked SOD1 mutation causes motor neuron disease characterized by vacuolar degeneration of mitochondria
-
World Scientific, Hackensack, NJ. Wong PC, Pardo CA, Borchelt DR, Lee MK, Copeland NG, Jenkins NA, Sisodia SS, Cleveland DW, Price DL. 1995. An adverse property of a familial ALS-linked SOD1 mutation causes motor neuron disease characterized by vacuolar degeneration of mitochondria. Neuron 14: 1105-1116.
-
(1995)
Neuron
, vol.14
, pp. 1105-1116
-
-
Wong, P.C.1
Pardo, C.A.2
Borchelt, D.R.3
Lee, M.K.4
Copeland, N.G.5
Jenkins, N.A.6
Sisodia, S.S.7
Cleveland, D.W.8
Price, D.L.9
-
199
-
-
49349087497
-
PINK1 is necessary for long term survival and mitochondrial function in human dopaminergic neurons
-
Wood-Kaczmar A, Gandhi S, Yao Z, Abramov AY, Miljan EA, Keen G, Stanyer L, Hargreaves I, Klupsch K, Deas E, et al. 2008. PINK1 is necessary for long term survival and mitochondrial function in human dopaminergic neurons. PLoS ONE 3: e2455.
-
(2008)
PLoS ONE
, vol.3
-
-
Wood-Kaczmar, A.1
Gandhi, S.2
Yao, Z.3
Abramov, A.Y.4
Miljan, E.A.5
Keen, G.6
Stanyer, L.7
Hargreaves, I.8
Klupsch, K.9
Deas, E.10
-
200
-
-
65849127844
-
Abberant a-synuclein confers toxicity to neurons in part through inhibition of chaperone-mediated autophagy
-
Xilouri M, Vogiatzi T, Vekrellis K, Park D, Stefanis L. 2009. Abberant a-synuclein confers toxicity to neurons in part through inhibition of chaperone-mediated autophagy. PLoS ONE 4: e5515.
-
(2009)
PLoS ONE
, vol.4
-
-
Xilouri, M.1
Vogiatzi, T.2
Vekrellis, K.3
Park, D.4
Stefanis, L.5
-
201
-
-
80053330248
-
2-Methoxyestradiol attenuates autophagy activation after global ischemia
-
Xin XY, Pan J, Wang XQ, Ma JF, Ding JQ, Yang GY, Chen SD. 2011. 2-Methoxyestradiol attenuates autophagy activation after global ischemia. Can J Neurol Sci 38: 631-638.
-
(2011)
Can J Neurol Sci
, vol.38
, pp. 631-638
-
-
Xin, X.Y.1
Pan, J.2
Wang, X.Q.3
Ma, J.F.4
Ding, J.Q.5
Yang, G.Y.6
Chen, S.D.7
-
202
-
-
70450222302
-
The role of lysosomal rupture in neuronal death
-
Yamashima T, Oikawa S. 2009. The role of lysosomal rupture in neuronal death. Prog Neurobiol 89: 343-358.
-
(2009)
Prog Neurobiol
, vol.89
, pp. 343-358
-
-
Yamashima, T.1
Oikawa, S.2
-
203
-
-
0032526652
-
Loss of endosomal/lysosomal membrane impermeability is an early event in amyloid Ab1-42 pathogenesis
-
Yang AJ, Chandswangbhuvana D, Margol L, Glabe CG. 1998. Loss of endosomal/lysosomal membrane impermeability is an early event in amyloid Ab1-42 pathogenesis. J Neurosci Res 52: 691-698.
-
(1998)
J Neurosci Res
, vol.52
, pp. 691-698
-
-
Yang, A.J.1
Chandswangbhuvana, D.2
Margol, L.3
Glabe, C.G.4
-
204
-
-
51349125291
-
Neuronal apoptosis and autophagy cross talk in aging PS/APP mice, a model of Alzheimer's disease
-
Yang DS, Kumar A, Stavrides P, Peterson J, Peterhoff CM, Pawlik M, Levy E, Cataldo AM, Nixon RA. 2008. Neuronal apoptosis and autophagy cross talk in aging PS/APP mice, a model of Alzheimer's disease. Am J Pathol 173: 665-681.
-
(2008)
Am J Pathol
, vol.173
, pp. 665-681
-
-
Yang, D.S.1
Kumar, A.2
Stavrides, P.3
Peterson, J.4
Peterhoff, C.M.5
Pawlik, M.6
Levy, E.7
Cataldo, A.M.8
Nixon, R.A.9
-
205
-
-
78650716872
-
Reversal of autophagy dysfunction in the TgCRND8 mouse model of Alzheimer's disease ameliorates amyloid pathologies and memory deficits
-
Yang DS, Stavrides P, Mohan PS, Kaushik S, Kumar A, Ohno M, Schmidt SD, Wesson D, Bandyopadhyay U, Jiang Y, et al. 2011. Reversal of autophagy dysfunction in the TgCRND8 mouse model of Alzheimer's disease ameliorates amyloid pathologies and memory deficits. Brain 134: 258-277.
-
(2011)
Brain
, vol.134
, pp. 258-277
-
-
Yang, D.S.1
Stavrides, P.2
Mohan, P.S.3
Kaushik, S.4
Kumar, A.5
Ohno, M.6
Schmidt, S.D.7
Wesson, D.8
Bandyopadhyay, U.9
Jiang, Y.10
-
206
-
-
68949209958
-
Cell death pathways in Parkinson's disease: Role of mitochondria
-
Yao Z, Wood NW. 2009. Cell death pathways in Parkinson's disease: Role of mitochondria. Antioxid Redox Signal 11: 2135-2149.
-
(2009)
Antioxid Redox Signal
, vol.11
, pp. 2135-2149
-
-
Yao, Z.1
Wood, N.W.2
-
207
-
-
55649106830
-
Targeting reactive oxygen species, reactive nitrogen species and inflammation in MPTP neurotoxicity and Parkinson's disease
-
Yokoyama H, Kuroiwa H, Yano R, Araki T. 2008. Targeting reactive oxygen species, reactive nitrogen species and inflammation in MPTP neurotoxicity and Parkinson's disease. Neurol Sci 29: 293-301.
-
(2008)
Neurol Sci
, vol.29
, pp. 293-301
-
-
Yokoyama, H.1
Kuroiwa, H.2
Yano, R.3
Araki, T.4
-
208
-
-
79957472437
-
Parkin mediates proteasome-dependent protein degradation and rupture of the outer mitochondrial membrane
-
Yoshii SR, Kishi C, Ishihara N, Mizushima N. 2011. Parkin mediates proteasome-dependent protein degradation and rupture of the outer mitochondrial membrane. J Biol Chem 286: 19630-19640.
-
(2011)
J Biol Chem
, vol.286
, pp. 19630-19640
-
-
Yoshii, S.R.1
Kishi, C.2
Ishihara, N.3
Mizushima, N.4
-
211
-
-
33749162486
-
Calpain-mediated cleavage of Atg5 switches autophagy to apoptosis
-
Yousefi S. 2006. Calpain-mediated cleavage of Atg5 switches autophagy to apoptosis. Nat Cell Biol 8: 1124-1132.
-
(2006)
Nat Cell Biol
, vol.8
, pp. 1124-1132
-
-
Yousefi, S.1
-
212
-
-
2642553881
-
Regulation of an ATG7-beclin 1 program of autophagic cell death by caspase-8
-
Yu L, Alva A, Su H, Dutt P, Freundt E, Welsh S, Baehreck EH, Lenardo MJ. 2004. Regulation of an ATG7-beclin 1 program of autophagic cell death by caspase-8. Science 304: 1500-1502.
-
(2004)
Science
, vol.304
, pp. 1500-1502
-
-
Yu, L.1
Alva, A.2
Su, H.3
Dutt, P.4
Freundt, E.5
Welsh, S.6
Baehreck, E.H.7
Lenardo, M.J.8
-
213
-
-
68449089023
-
Metabolic activity determines efficacy of macroautophagic clearance of pathological oligomeric a-synuclein
-
Yu WH, Dorado B, Figueroa HY, Wang L, Planel E, Cookson MR, Clark LN, Duff KE. 2009. Metabolic activity determines efficacy of macroautophagic clearance of pathological oligomeric a-synuclein. Am J Pathol 175: 736-747.
-
(2009)
Am J Pathol
, vol.175
, pp. 736-747
-
-
Yu, W.H.1
Dorado, B.2
Figueroa, H.Y.3
Wang, L.4
Planel, E.5
Cookson, M.R.6
Clark, L.N.7
Duff, K.E.8
-
214
-
-
77953699711
-
Termination of autophagy and reformation of lysosomes regulated by mTOR
-
Yu L, McPhee CK, Zheng L, Mardones GA, Rong Y, Peng J, Mi N, Zhao Y, Liu Z, Wan F, et al. 2010. Termination of autophagy and reformation of lysosomes regulated by mTOR. Nature 465: 942-946.
-
(2010)
Nature
, vol.465
, pp. 942-946
-
-
Yu, L.1
McPhee, C.K.2
Zheng, L.3
Mardones, G.A.4
Rong, Y.5
Peng, J.6
Mi, N.7
Zhao, Y.8
Liu, Z.9
Wan, F.10
-
215
-
-
0034641936
-
Apoptosis in the nervous system
-
Yuan J, Yankner BA. 2000. Apoptosis in the nervous system. Nature 407: 802-809.
-
(2000)
Nature
, vol.407
, pp. 802-809
-
-
Yuan, J.1
Yankner, B.A.2
-
216
-
-
0037194894
-
A novel protein complex linking the d2 glutamate receptor and autophagy: Implications for neurodegeneration in lurcher mice
-
Yue Z, Horton A, Bravin M, DeJager PL, Selimi F, Heintz N. 2002. A novel protein complex linking the d2 glutamate receptor and autophagy: Implications for neurodegeneration in lurcher mice. Neuron 35: 921-933.
-
(2002)
Neuron
, vol.35
, pp. 921-933
-
-
Yue, Z.1
Horton, A.2
Bravin, M.3
DeJager, P.L.4
Selimi, F.5
Heintz, N.6
-
217
-
-
61849102389
-
DAP-kinase-mediated phosphorylation on the BH3 domain of beclin 1 promotes dissociation of beclin 1 from Bcl-XL and induction of autophagy
-
Zalckvar E, Berissi H, Mizrachy L, Idelchuk Y, Koren I, Eisenstein M, Sabanay H, Pinkas-Kramarski R, Kimch A. 2009. DAP-kinase-mediated phosphorylation on the BH3 domain of beclin 1 promotes dissociation of beclin 1 from Bcl-XL and induction of autophagy. EMBO Rep 10: 285-292.
-
(2009)
EMBO Rep
, vol.10
, pp. 285-292
-
-
Zalckvar, E.1
Berissi, H.2
Mizrachy, L.3
Idelchuk, Y.4
Koren, I.5
Eisenstein, M.6
Sabanay, H.7
Pinkas-Kramarski, R.8
Kimch, A.9
-
218
-
-
33845720388
-
Huntingtin inhibits caspase-3 activation
-
Zhang Y, Leavitt BR, van Raamsdonk JM, Dragatsis I, Goldowitz D, MacDonald ME, Hayden MR, Friedlande RM. 2006. Huntingtin inhibits caspase-3 activation. EMBO J 25: 5896-5906.
-
(2006)
EMBO J
, vol.25
, pp. 5896-5906
-
-
Zhang, Y.1
Leavitt, B.R.2
van Raamsdonk, J.M.3
Dragatsis, I.4
Goldowitz, D.5
McDonald, M.E.6
Hayden, M.R.7
Friedlande, R.M.8
-
219
-
-
84855937149
-
Autophagosomes accumulation is associated with b-amyloid deposits and secondary damage in the thalamus after focal cortical infarction in hypertensive rats
-
Zhang J, Zhang Y, Li J, Xing S, Li C, Li Y, Dang C, Fan Y, Yu J, Pei Z, et al. 2012. Autophagosomes accumulation is associated with b-amyloid deposits and secondary damage in the thalamus after focal cortical infarction in hypertensive rats. J Neurochem 120: 564-573.
-
(2012)
J Neurochem
, vol.120
, pp. 564-573
-
-
Zhang, J.1
Zhang, Y.2
Li, J.3
Xing, S.4
Li, C.5
Li, Y.6
Dang, C.7
Fan, Y.8
Yu, J.9
Pei, Z.10
-
220
-
-
33847048316
-
Regulation of autophagy by extracellular signal-regulated protein kinases during 1-methyl-4-phenylpyridinium-induced cell death
-
Zhu JH, Horbinski C, Guo F, Watkins S, Uchiyama Y, Chu CT. 2007. Regulation of autophagy by extracellular signal-regulated protein kinases during 1-methyl-4-phenylpyridinium-induced cell death. Am J Pathol 170: 75-86.
-
(2007)
Am J Pathol
, vol.170
, pp. 75-86
-
-
Zhu, J.H.1
Horbinski, C.2
Guo, F.3
Watkins, S.4
Uchiyama, Y.5
Chu, C.T.6
|