TREM2 sustains microglial expansion during aging and response to demyelination

Journal of Clinical Investigation

Volumn 125, Issue 5, 2015, Pages 2161-2170

  Poliani, Pietro Luigi ^a   Wang, Yaming ^b   Fontana, Elena ^a   Robinette, Michelle L ^b   Yamanishi, Yoshinori ^b   Gilfillan, Susan ^b   Colonna, Marco ^b  

^a UNIVERSITY OF BRESCIA   (Italy)

^b WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CUPRIZONE; MEMBRANE RECEPTOR; MYELIN; MYELIN BASIC PROTEIN; TRIGGERING RECEPTOR EXPRESSED ON MYELOID CELLS 2; UNCLASSIFIED DRUG; IMMUNOGLOBULIN RECEPTOR; MEMBRANE PROTEIN; NERVE PROTEIN; TREM2 PROTEIN, HUMAN; TREM2 PROTEIN, MOUSE;

ANIMAL CELL; ANIMAL EXPERIMENT; APOPTOSIS; ARTICLE; ASTROCYTE; BLOOD BRAIN BARRIER; BRAIN CORTEX; CELL ACTIVATION; CELL AGING; CELL COUNT; CELL EXPANSION; CELL STRUCTURE; CEREBELLUM; CONTROLLED STUDY; CORPUS CALLOSUM; DEMYELINATION; GENETIC ASSOCIATION; HIPPOCAMPUS; IN VITRO STUDY; LIPOLYSIS; MICROGLIA; MOUSE; NERVE CELL DEGENERATION; NERVE FIBER DEGENERATION; NONHUMAN; OLIGODENDROGLIA; PHAGOCYTOSIS; PRIORITY JOURNAL; PROTEIN DEPLETION; REMYELINIZATION; SIGNAL TRANSDUCTION; TRANSMISSION ELECTRON MICROSCOPY; AGING; ANIMAL; BIOSYNTHESIS; BRAIN; CHEMICALLY INDUCED; CHONDRODYSPLASIA; DEFICIENCY; DEMYELINATING DISEASE; DISEASE MODEL; GENE EXPRESSION PROFILING; GENETIC TRANSCRIPTION; GENETICS; HUMAN; IMMUNOLOGY; KNOCKOUT MOUSE; LIPODYSTROPHY; METABOLISM; MYELIN SHEATH; NERVE FIBER; PATHOLOGY; PHYSIOLOGY; REGENERATION; REPORTER GENE; SUBACUTE SCLEROSING PANENCEPHALITIS;

AGING; ANIMALS; AXONS; BRAIN; CELL COUNT; CUPRIZONE; DEMYELINATING DISEASES; DISEASE MODELS, ANIMAL; GENE EXPRESSION PROFILING; GENES, REPORTER; HUMANS; LIPODYSTROPHY; MEMBRANE GLYCOPROTEINS; MICE; MICE, KNOCKOUT; MICROGLIA; MYELIN SHEATH; NERVE TISSUE PROTEINS; OSTEOCHONDRODYSPLASIAS; PHAGOCYTOSIS; RECEPTORS, IMMUNOLOGIC; REGENERATION; SUBACUTE SCLEROSING PANENCEPHALITIS; TRANSCRIPTION, GENETIC;

EID: 84929012585     PISSN: 00219738     EISSN: 15588238     Source Type: Journal    
DOI: 10.1172/JCI77983     Document Type: Article

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