Phenotypic characterization of a Csf1r haploinsufficient mouse model of adult-onset leukodystrophy with axonal spheroids and pigmented glia (ALSP)

Neurobiology of Disease

Volumn 74, Issue , 2015, Pages 219-228

  Chitu, Violeta ^a   Gokhan, Solen ^a   Gulinello, Maria ^a   Branch, Craig A ^a   Patil, Madhuvati ^a   Basu, Ranu ^a   Stoddart, Corrina ^a   Mehler, Mark F ^a   Richard Stanley, E ^a  

^a ALBERT EINSTEIN COLLEGE OF MEDICINE   (United States)

Author keywords

ALSP; CSF 1R; Dysmyelination; GM CSF; HDLS; Leukodystrophy; Microglia

Indexed keywords

COLONY STIMULATING FACTOR 1 RECEPTOR; COLONY STIMULATING FACTOR RECEPTOR; GRANULOCYTE COLONY STIMULATING FACTOR; GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR; INTERLEUKIN 27; INTERLEUKIN 6; MESSENGER RNA; MYELIN; MYELIN BASIC PROTEIN; UNCLASSIFIED DRUG; CSF1R PROTEIN, MOUSE; CYTOKINE; GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR RECEPTOR;

ADULT; ADULT ONSET LEUKOENCEPHALOPATHY WITH AXONAL SPHEROID AND PIGMENTED GLIA; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANXIETY; ARTICLE; ASTROCYTE; AXONAL SPHEROID; BRAIN CELL CULTURE; BRAIN CORTEX; CELL DENSITY; COGNITIVE DEFECT; COMPARATIVE STUDY; CONTROLLED STUDY; CORPUS CALLOSUM AGENESIS; CORTICAL LAYER II; CORTICAL LAYER III; CORTICAL LAYER V; CSF1R GENE; CSF2 GENE; CSF3 GENE; DEMYELINATION; DEPRESSION; EMOTIONAL DISORDER; FEMALE; GENE; GENE EXPRESSION; HAPLOINSUFFICIENCY; HETEROZYGOTE; HISTOPATHOLOGY; IL27 GENE; IL6 GENE; JUVENILE ANIMAL; LATERAL BRAIN VENTRICLE; LEUKODYSTROPHY; MALE; MICROGLIA; MOUSE; NERVE DEGENERATION; NEUROIMAGING; NEUROPATHOLOGY; NONHUMAN; NUCLEAR MAGNETIC RESONANCE IMAGING; OLIGODENDROCYTE PRECURSOR CELL; PHENOTYPE; PROTEIN EXPRESSION; SENSORIMOTOR NEUROPATHY; SMELLING DISORDER; ULTRASTRUCTURE; VALIDITY; WHITE MATTER; ANIMAL; BRAIN; C57BL MOUSE; DEFICIENCY; DISEASE COURSE; DISEASE MODEL; GENETICS; GLIA; IMMUNOLOGY; KNOCKOUT MOUSE; LEUKOENCEPHALOPATHY; METABOLISM; MOTOR ACTIVITY; NERVE CELL; NEURAL STEM CELL; PATHOLOGY; PATHOPHYSIOLOGY; PHYSIOLOGY; PSYCHOLOGY; SMELLING; VALIDATION STUDY;

ANIMALS; ANXIETY; BRAIN; COGNITION DISORDERS; CYTOKINES; DEPRESSION; DISEASE MODELS, ANIMAL; DISEASE PROGRESSION; FEMALE; LEUKOENCEPHALOPATHIES; MALE; MICE, INBRED C57BL; MICE, KNOCKOUT; MOTOR ACTIVITY; NEURAL STEM CELLS; NEUROGLIA; NEURONS; OLFACTORY PERCEPTION; PHENOTYPE; RECEPTORS, GRANULOCYTE-MACROPHAGE COLONY-STIMULATING FACTOR; WHITE MATTER;

EID: 84919832455     PISSN: 09699961     EISSN: 1095953X     Source Type: Journal    
DOI: 10.1016/j.nbd.2014.12.001     Document Type: Article

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