Discovery of a cytokine and its receptor by functional screening of the extracellular proteome

Science

Volumn 320, Issue 5877, 2008, Pages 807-811

  Lin, Haishan ^a   Lee, Ernestine ^a   Hestir, Kevin ^a   Leo, Cindy ^a   Huang, Minmei ^a   Bosch, Elizabeth ^a   Halenbeck, Robert ^a   Wu, Ge ^a   Zhou, Aileen ^a   Behrens, Dirk ^a   Hollenbaugh, Diane ^a,c   Linnemann, Thomas ^a   Qin, Minmin ^a   Wong, Justin ^a   Chu, Keting ^a,d   Doberstein, Stephen K ^a   Williams, Lewis T ^a,b  

^a FIVE PRIME THERAPEUTICS INC   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c MERCK RESEARCH LABORATORIES   (United States)

^d DigitAB Inc   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

COLONY STIMULATING FACTOR 1; CYTOKINE; CYTOKINE RECEPTOR; FIBROBLAST GROWTH FACTOR 3; INTERLEUKIN 15; INTERLEUKIN 34; MEMBRANE PROTEIN; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; PROTEOME; SOMATOMEDIN B; COMPLEMENTARY DNA; INTERLEUKIN 34 RECEPTOR, HUMAN; INTERLEUKIN 34, HUMAN; INTERLEUKIN DERIVATIVE; INTERLEUKIN RECEPTOR; INTERLEUKIN-34 RECEPTOR, HUMAN; INTERLEUKIN-34, HUMAN;

ASSAY; CYTOLOGY; METABOLISM; PROTEOMICS; RECOMBINATION; SECRETION;

AMINO ACID SEQUENCE; ARTICLE; CELL GROWTH; CELL VIABILITY; ENZYME LINKED IMMUNOSORBENT ASSAY; HUMAN; MONOCYTE; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN SECRETION; WESTERN BLOTTING; ANIMAL; CHEMISTRY; EXTRACELLULAR SPACE; ISOLATION AND PURIFICATION; MOLECULAR CLONING; PHYSIOLOGY; PROTEIN TERTIARY STRUCTURE; SECRETION;

ANIMALS; CLONING, MOLECULAR; DNA, COMPLEMENTARY; EXTRACELLULAR SPACE; HUMANS; INTERLEUKINS; MEMBRANE PROTEINS; PROTEIN STRUCTURE, TERTIARY; PROTEOME; RECEPTORS, INTERLEUKIN;

EID: 44049092407     PISSN: 00368075     EISSN: 10959203     Source Type: Journal    
DOI: 10.1126/science.1154370     Document Type: Article

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16. We thank T. Chang, A. Farsad, S. Giese, S. Gomes, M. Ji, K. Justin, D. McDonough, A. Pham, S. Ramirez, A. Sadra, S. Shi, T. Wang, and R. Zhang for technical support and discussions, and other colleagues at Five Prime Therapeutics, Inc. for providing screening assay data in the functional selectivity analysis. We thank J. Damen and C. Pereira of StemCell Technologies, Inc. for performing the colony-formation assays. H.L., E.L., K.H., C.L., M.H., E.B., R.H., G.W., A.Z., D.B., T.L., J.W., S.K.D., and L.T.W. of Five Prime Therapeutics, Inc. have filed a U.S. patent application (#20070264277) based on the work in this paper.