Complement and microglia mediate early synapse loss in Alzheimer mouse models

Science

Volumn 352, Issue 6286, 2016, Pages 712-716

  Hong, Soyon ^a   Beja Glasser, Victoria F ^a   Nfonoyim, Bianca M ^a   Frouin, Arnaud ^a   Li, Shaomin ^b   Ramakrishnan, Saranya ^a   Merry, Katherine M ^a   Shi, Qiaoqiao ^b   Rosenthal, Arnon ^c,d,e   Barres, Ben A ^f   Lemere, Cynthia A ^b   Selkoe, Dennis J ^b,g   Stevens, Beth ^a,h  

^a BOSTON CHILDREN S HOSPITAL   (United States)

^b HARVARD MEDICAL SCHOOL   (United States)

^c Alector Inc   (United States)

^d Annexon Bioscience   (United States)

^e UNIVERSITY OF CALIFORNIA   (United States)

^f STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

^g Prothena Biosciences Inc   (Ireland)

^h BROAD INSTITUTE OF MIT AND HARVARD   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMYLOID BETA PROTEIN; COMPLEMENT; COMPLEMENT COMPONENT C1Q; COMPLEMENT RECEPTOR; COMPLEMENT RECEPTOR CR3; UNCLASSIFIED DRUG; CD11B ANTIGEN; DLGH4 PROTEIN, MOUSE; GUANYLATE KINASE; MEMBRANE PROTEIN; SYNAPTOPHYSIN;

BRAIN; CELLS AND CELL COMPONENTS; NERVOUS SYSTEM DISORDER; NEUROLOGY; PROTEIN; RODENT;

ADULT; ALZHEIMER DISEASE; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BRAIN; CONTROLLED STUDY; HIPPOCAMPUS; LONG TERM POTENTIATION; MICROGLIA; MOUSE; NONHUMAN; PHAGOCYTOSIS; PRIORITY JOURNAL; PROTEIN LOCALIZATION; PROTEIN PROCESSING; SYNAPSE; UPREGULATION; AMYLOID PLAQUE; ANIMAL; COGNITIVE DEFECT; COMPLEMENT CLASSICAL PATHWAY; DISEASE MODEL; GENETICS; HIPPOCAMPAL CA1 REGION; IMMUNOLOGY; KNOCKOUT MOUSE; PATHOLOGY; PATHOPHYSIOLOGY;

ALZHEIMER DISEASE; AMYLOID BETA-PEPTIDES; ANIMALS; CA1 REGION, HIPPOCAMPAL; COGNITION DISORDERS; COMPLEMENT C1Q; COMPLEMENT PATHWAY, CLASSICAL; DISEASE MODELS, ANIMAL; GUANYLATE KINASE; LONG-TERM POTENTIATION; MACROPHAGE-1 ANTIGEN; MEMBRANE PROTEINS; MICE; MICE, KNOCKOUT; MICROGLIA; PHAGOCYTOSIS; PLAQUE, AMYLOID; SYNAPSES; SYNAPTOPHYSIN; UP-REGULATION;

EID: 84962418507     PISSN: 00368075     EISSN: 10959203     Source Type: Journal    
DOI: 10.1126/science.aad8373     Document Type: Article

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