Immunological aspects in the neurobiology of suicide: Elevated microglial density in schizophrenia and depression is associated with suicide

Journal of Psychiatric Research

Volumn 42, Issue 2, 2008, Pages 151-157

  Steiner, Johann ^a   Bielau, Hendrik ^a   Brisch, Ralf ^a   Danos, Peter ^b   Ullrich, Oliver ^a   Mawrin, Christian ^c   Bernstein, Hans Gert ^a   Bogerts, Bernhard ^a  

^a OTTO VON GUERICKE UNIVERSITY   (Germany)

^b UNIVERSITY HOSPITAL GIESSEN   (Germany)

^c FRIEDRICH SCHILLER UNIVERSITY JENA   (Germany)

Author keywords

Depression; HLA DR; Microglia; Schizophrenia; Suicide

Indexed keywords

ACUTE PSYCHOSIS; ADULT; AGED; ANALYSIS OF VARIANCE; ARTICLE; AUTOPSY; CINGULATE GYRUS; DEPRESSION; FEMALE; HEMISPHERIC DOMINANCE; HIPPOCAMPUS; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; IMMUNOPATHOLOGY; MALE; MICROGLIA; MOOD DISORDER; NEUROBIOLOGY; NEUROPATHOLOGY; PREFRONTAL CORTEX; PREVALENCE; PRIORITY JOURNAL; SCHIZOPHRENIA; STATISTICAL SIGNIFICANCE; SUICIDE;

ADULT; AGED; BIPOLAR DISORDER; BRAIN; CELL COUNT; DEPRESSIVE DISORDER, MAJOR; FEMALE; GLIOSIS; GYRUS CINGULI; HIPPOCAMPUS; HLA-DR ANTIGENS; HUMANS; IMMUNOENZYME TECHNIQUES; MALE; MEDIODORSAL THALAMIC NUCLEUS; MICROGLIA; MIDDLE AGED; PREFRONTAL CORTEX; REFERENCE VALUES; SCHIZOPHRENIA; SUICIDE;

EID: 35848950202     PISSN: 00223956     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jpsychires.2006.10.013     Document Type: Article

References (42)

1. Alonso R., Chaudieu I., Diorio J., Krishnamurthy A., Quirion R., and Boksa P. Interleukin-2 modulates evoked release of [3H]dopamine in rat cultured mesencephalic cells. Journal of Neurochemistry 61 (1993) 1284-1290
2. Arnold S.E., Trojanowski J.Q., Gur R.E., Blackwell P., Han L.Y., and Choi C. Absence of neurodegeneration and neural injury in the cerebral cortex in a sample of elderly patients with schizophrenia. Archives of General Psychiatry 55 (1998) 225-232
3. Arolt V., and Rothermundt M. The immunology of psychiatric disorders. Psychotherapie Psychosomatik Medizinische Psychologie 55 (2005) 36-48
4. Baron D.A., Hardie T., and Baron S.H. Possible association of interleukin-2 treatment with depression and suicide. Journal of the American Osteopathic Association 93 (1993) 799-800
5. Bayer T.A., Buslei R., Havas L., and Falkai P. Evidence for activation of microglia in patients with psychiatric illnesses. Neuroscience Letter 271 (1999) 126-128
6. Bernstein H.G., Bogerts B., and Keilhoff G. The many faces of nitric oxide in schizophrenia. A review. Schizophrenzia Research 78 (2005) 69-86
7. Bernstein H.G., Heinemann A., Krell D., Dobrowolny H., Bielau H., Keilhoff G., and Bogerts B. Hypothalamic nitric oxide synthase in affective disorder: focus on the suprachiasmatic nucleus. Cellular and Molecular Biology (Noisy-le-grand) 51 (2005) 279-284
8. Bielau H., Mawrin C., Krell D., Agelink M.W., Trubner K., Davis R., Gos T., Bogerts B., Bernstein H.G., and Baumann B. Differences in activation of the dorsal raphe nucleus depending on performance of suicide. Brain Research 1039 (2005) 43-52
9. Charles K.J., Deuchars J., Davies C.H., and Pangalos M.N. GABA B receptor subunit expression in glia. Molecular and Cellular Neuroscience 24 (2003) 214-223
10. Falke E., Han L.Y., and Arnold S.E. Absence of neurodegeneration in the thalamus and caudate of elderly patients with schizophrenia. Psychiatry Research 93 (2000) 103-110
11. Färber K., Pannasch U., and Kettenmann H. Dopamine and noradrenaline control distinct functions in rodent microglial cells. Molecular and Cellular Neuroscience 29 (2005) 128-138
12. Frank M.G., Baratta M.V., Sprunger D.B., Watkins L.R., and Maier S.F. Microglia serve as a neuroimmune substrate for stress-induced potentiation of CNS pro-inflammatory cytokine responses. Brain Behavior and Immunity (2006) Epub ahead of print
13. Graeber M.B., and Streit W.J. Perivascular microglia defined. Trends Neuroscience 13 (1990) 366
14. Gruneberg U., Rich T., Roucard C., Marieke van Ham S., Charron D., and Trowsdale J. Two widely used anti-DR alpha monoclonal antibodies bind to an intracellular C-terminal epitope. Human Immunology 53 (1997) 34-38
15. Jollant F., Bellivier F., Leboyer M., Astruc B., Torres S., Verdier R., Castelnau D., Malafosse A., and Courtet P. Impaired decision making in suicide attempters. American Journal of Psychiatry 162 (2005) 304-310
16. Kim Y.K., Paik J.W., Lee S.W., Yoon D., Han C., and Lee B.H. Increased plasma nitric oxide level associated with suicide attempt in depressive patients. Progress in Neuro-psychopharmacology & Biology Psychiatry 30 (2006) 1091-1096
17. Kurumaji A., Wakai T., and Toru M. Decreases in peripheral-type benzodiazepine receptors in postmortem brains of chronic schizophrenics. Journal of Neural Transmission 104 (1997) 1361-1370
18. Labuzek K., Kowalski J., Gabryel B., and Herman Z.S. Chlorpromazine and loxapine reduce interleukin-1beta and interleukin-2 release by rat mixed glial and microglial cell cultures. European Neuropsychopharmacology 15 (2005) 23-30
19. Lee B.H., Lee S.W., Yoon D., Lee H.J., Yang J.C., Shim S.H., Kim D.H., Ryu S.H., Han C., and Kim Y.K. Increased plasma nitric oxide metabolites in suicide attempters. Neuropsychobiology 53 (2006) 127-132
20. Linden D.R., and El-Fakahany E.E. Microglial derived nitric oxide decreases serotonin content in rat basophilic leukemia (RBL-2H3) cells. European Journal of Pharmacology 436 (2002) 53-56
21. Mittelbronn M., Dietz K., Schluesener H.J., and Meyermann R. Local distribution of microglia in the normal adult human central nervous system differs by up to one order of magnitude. Acta Neuropathologica (Berl) 101 (2001) 249-255
22. Mori K., Ozaki E., Zhang B., Yang L., Yokoyama A., Takeda I., Maeda N., Sakanaka M., and Tanaka J. Effects of norepinephrine on rat cultured microglial cells that express alpha1, alpha2, beta1 and beta2 adrenergic receptors. Neuropharmacology 43 (2002) 1026-1034
23. Müller N., and Ackenheil M. Psychoneuroimmunology and the cytokine action in the CNS: implications for psychiatric disorders. Progress Neuro-psychopharmacology & Biology Psychiatry 22 (1998) 1-33
24. Nikkila H.V., Muller K., Ahokas A., Miettinen K., Rimon R., and Andersson L.C. Accumulation of macrophages in the CSF of schizophrenic patients during acute psychotic episodes. American Journal of Psychiatry 156 (1999) 1725-1729
25. Noda M., Nakanishi H., Nabekura J., and Akaike N. AMPA-kainate subtypes of glutamate receptor in rat cerebral microglia. Journal of Neuroscience 20 (2000) 251-258
26. Nowak G., Ordway G.A., and Paul I.A. Alterations in the N-methyl-d-aspartate (NMDA) receptor complex in the frontal cortex of suicide victims. Brain Research 675 (1995) 157-164
27. Radewicz K., Garey L.J., Gentleman S.M., and Reynolds R. Increase in HLA-DR immunoreactive microglia in frontal and temporal cortex of chronic schizophrenics. Journal of Neuropathology and Experimental Neurology 59 (2000) 137-150
28. Rogers J., Luber-Narod J., Styren S.D., and Civin W.H. Expression of immune system-associated antigens by cells of the human central nervous system: relationship to the pathology of Alzheimer's disease. Neurobiology of Aging 9 (1988) 339-349
29. Schmitt A.B., Brook G.A., Buss A., Nacimiento W., Noth J., and Kreutzberg G.W. Dynamics of microglial activation in the spinal cord after cerebral infarction are revealed by expression of MHC class II antigen. Neuropathology and Applied Neurobiology 24 (1998) 167-176
30. Schuld A., Hinze-Selch D., and Pollmaecher T. Cytokine network in patients with schizophrenia and its significance for the pathophysiology of the illness. Nervenarzt 75 (2004) 215-226
31. Sperner-Unterweger B. Immunological aetiology of major psychiatric disorders: evidence and therapeutic implications. Drugs 65 (2005) 1493-1520
32. Sperner-Unterweger B., Whitworth A., Kemmler G., Hilbe W., Thaler J., Weiss G., and Fleischhacker W.W. T-cell subsets in schizophrenia: a comparison between drug-naive first episode patients and chronic schizophrenic patients. Schizophrenia Research 38 (1999) 61-70
33. Steiner J., Mawrin C., Ziegeler A., Bielau H., Ullrich O., Bernstein H.G., and Bogerts B. Distribution of HLA-DR-positive microglia in schizophrenia reflects impaired cerebral lateralization. Acta Neuropathologica (Berl) 112 (2006) 305-316
34. Togo T., Akiyama H., Kondo H., Ikeda K., Kato M., Iseki E., and Kosaka K. Expression of CD40 in the brain of Alzheimer's disease and other neurological diseases. Brain Research 885 (2000) 117-121
35. van Heeringen K. The neurobiology of suicide and suicidality. Canadian Journal of Psychiatry 48 (2003) 292-300
36. Wagner-Jauregg J. Über die Einwirkung fieberhafter Erkrankungen auf Psychosen. Allgemeine Zeitschrift für Psychiatrie 27 (1887) 93-131
37. Walker L.G., Walker M.B., Heys S.D., Lolley J., Wesnes K., and Eremin O. The psychological and psychiatric effects of rIL-2 therapy: a controlled clinical trial. Psychooncology 6 (1997) 290-301
38. Wang W., Ji P., Riopelle R.J., and Dow K.E. Functional expression of corticotropin-releasing hormone (CRH) receptor 1 in cultured rat microglia. Journal of Neurochemistry 80 (2002) 287-294
39. Wierzba-Bobrowicz T., Lewandowska E., Kosno-Kruszewska E., Lechowicz W., Pasennik E., and Schmidt-Sidor B. Degeneration of microglial cells in frontal and temporal lobes of chronic schizophrenics. Folia Neuropathologica 42 (2004) 157-165
40. Wierzba-Bobrowicz T., Lewandowska E., Lechowicz W., Stepien T., and Pasennik E. Quantitative analysis of activated microglia, ramified and damage of processes in the frontal and temporal lobes of chronic schizophrenics. Folia Neuropathologica 43 (2005) 81-89
41. Yamada K., Noda Y., Nakayama S., Komori Y., Sugihara H., Hasegawa T., and Nabeshima T. Role of nitric oxide in learning and memory and in monoamine metabolism in the rat brain. British Journal of Pharmacology 115 (1995) 852-858
42. Zalcman S., Green-Johnson J.M., Murray L., Nance D.M., Dyck D., Anisman H., and Greenberg A.H. Cytokine-specific central monoamine alterations induced by interleukin-1, -2 and -6. Brain Research 643 (1994) 40-49