Silibinin rescues learning and memory deficits by attenuating microglia activation and preventing neuroinflammatory reactions in SAMP8 mice

Neuroscience Letters

Volumn 629, Issue , 2016, Pages 256-261

  Jin, Ge ^a   Bai, Dafeng ^b   Yin, Shiliang ^a   Yang, Zhihang ^a   Zou, Dan ^a   Zhang, Zhong ^a   Li, Xiaoxiu ^a   Sun, Yan ^a   Zhu, Qiwen ^a  

^a Department of Pharmacology Shenyang Medical Colleges ^*  (China)

^b The Eleventh People s Hospital of Shenyang   (China)

Author keywords

Alzheimer's disease; Microglia; Neuroinflammatory; SAMP8 mice; Silibinin

Indexed keywords

CYCLOOXYGENASE 2; CYTOKINE; INDUCIBLE NITRIC OXIDE SYNTHASE; INTERLEUKIN 4; INTERLEUKIN 6; MEMANTINE; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE P38; SILIBININ; STRESS ACTIVATED PROTEIN KINASE; MAPK8IP PROTEIN, MOUSE; NEUROPROTECTIVE AGENT; NOS2 PROTEIN, MOUSE; PTGS2 PROTEIN, MOUSE; SIGNAL TRANSDUCING ADAPTOR PROTEIN; SILYMARIN;

ALZHEIMER DISEASE; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIINFLAMMATORY ACTIVITY; ARTICLE; BEHAVIOR; BRAIN CORTEX; CELL ACTIVATION; CONTROLLED STUDY; DRUG EFFECT; DRUG MECHANISM; HIPPOCAMPUS; IN VIVO STUDY; LEARNING DISORDER; MALE; MEMORY DISORDER; MICROGLIA; MORRIS WATER MAZE TEST; MOUSE; NERVE CELL; NERVOUS SYSTEM INFLAMMATION; NEUROPROTECTION; NONHUMAN; NOVEL OBJECT RECOGNITION TEST; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; SPATIAL MEMORY; ANIMAL; COMPLICATION; DRUG EFFECTS; ENCEPHALITIS; LEARNING; MAZE TEST; MEMORY; MEMORY DISORDERS; METABOLISM;

ADAPTOR PROTEINS, SIGNAL TRANSDUCING; ANIMALS; CEREBRAL CORTEX; CYCLOOXYGENASE 2; ENCEPHALITIS; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; HIPPOCAMPUS; INTERLEUKIN-4; INTERLEUKIN-6; JNK MITOGEN-ACTIVATED PROTEIN KINASES; LEARNING; MALE; MAZE LEARNING; MEMORY; MEMORY DISORDERS; MICE; MICROGLIA; NEUROPROTECTIVE AGENTS; NITRIC OXIDE SYNTHASE TYPE II; P38 MITOGEN-ACTIVATED PROTEIN KINASES; SILYMARIN; SPATIAL MEMORY;

EID: 84979643006     PISSN: 03043940     EISSN: 18727972     Source Type: Journal    
DOI: 10.1016/j.neulet.2016.06.008     Document Type: Article

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