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Volumn 353, Issue 6301, 2016, Pages

Microglia development follows a stepwise program to regulate brain homeostasis

Author keywords

[No Author keywords available]

Indexed keywords

CD14 ANTIGEN; CHEMOKINE RECEPTOR CXCR2; EARLY GROWTH RESPONSE FACTOR 1; MESSENGER RNA; MINICHROMOSOME MAINTENANCE PROTEIN 5; PROTEIN C JUN; PROTEIN FOS; TRANSCRIPTION FACTOR MAFB; CHROMATIN; MAFB PROTEIN, MOUSE;

EID: 84976883162     PISSN: 00368075     EISSN: 10959203     Source Type: Journal    
DOI: 10.1126/science.aad8670     Document Type: Article
Times cited : (831)

References (83)
  • 1
    • 35548986304 scopus 로고    scopus 로고
    • Microglia: Active sensor and versatile effector cells in the normal and pathologic brain
    • pmid: 17965659
    • U.-K. Hanisch, H. Kettenmann, Microglia: Active sensor and versatile effector cells in the normal and pathologic brain. Nat. Neurosci. 10, 1387-1394 (2007). doi: 10.1038/nn1997; pmid: 17965659.
    • (2007) Nat. Neurosci , vol.10 , pp. 1387-1394
    • Hanisch, U.-K.1    Kettenmann, H.2
  • 2
    • 19744380563 scopus 로고    scopus 로고
    • Resting microglial cells are highly dynamic surveillants of brain parenchyma in vivo
    • pmid: 15831717
    • A. Nimmerjahn, F. Kirchhoff, F. Helmchen, Resting microglial cells are highly dynamic surveillants of brain parenchyma in vivo. Science 308, 1314-1318 (2005). doi: 10.1126/science.1110647; pmid: 15831717.
    • (2005) Science , vol.308 , pp. 1314-1318
    • Nimmerjahn, A.1    Kirchhoff, F.2    Helmchen, F.3
  • 3
    • 80053233055 scopus 로고    scopus 로고
    • Heterogeneity of CNS myeloid cells and their roles in neurodegeneration
    • pmid: 21952260
    • M. Prinz, J. Priller, S. S. Sisodia, R. M. Ransohoff, Heterogeneity of CNS myeloid cells and their roles in neurodegeneration. Nat. Neurosci. 14, 1227-1235 (2011). doi: 10.1038/nn.2923; pmid: 21952260.
    • (2011) Nat. Neurosci , vol.14 , pp. 1227-1235
    • Prinz, M.1    Priller, J.2    Sisodia, S.S.3    Ransohoff, R.M.4
  • 4
    • 84925465211 scopus 로고    scopus 로고
    • Tissue-resident macrophages originate from yolk-sac-derived erythro-myeloid progenitors
    • pmid: 25470051
    • E. Gomez Perdiguero et al., Tissue-resident macrophages originate from yolk-sac-derived erythro-myeloid progenitors. Nature 518, 547-551 (2015). doi: 10.1038/nature13989; pmid: 25470051.
    • (2015) Nature , vol.518 , pp. 547-551
    • Perdiguero, E.G.1
  • 5
    • 78149360132 scopus 로고    scopus 로고
    • Fate mapping analysis reveals that adult microglia derive from primitive macrophages
    • pmid: 20966214
    • F. Ginhoux et al., Fate mapping analysis reveals that adult microglia derive from primitive macrophages. Science 330, 841-845 (2010). doi: 10.1126/science.1194637; pmid: 20966214.
    • (2010) Science , vol.330 , pp. 841-845
    • Ginhoux, F.1
  • 6
    • 84859508307 scopus 로고    scopus 로고
    • A lineage of myeloid cells independent of Myb and hematopoietic stem cells
    • pmid: 22442384
    • C. Schulz et al., A lineage of myeloid cells independent of Myb and hematopoietic stem cells. Science 336, 86-90 (2012). doi: 10.1126/science.1219179; pmid: 22442384.
    • (2012) Science , vol.336 , pp. 86-90
    • Schulz, C.1
  • 7
    • 84875892857 scopus 로고    scopus 로고
    • Microglia emerge from erythromyeloid precursors via pu.1- and irf8-dependent pathways
    • pmid: 23334579
    • K. Kierdorf et al., Microglia emerge from erythromyeloid precursors via Pu.1- And Irf8-dependent pathways. Nat. Neurosci. 16, 273-280 (2013). pmid: 23334579.
    • (2013) Nat. Neurosci , vol.16 , pp. 273-280
    • Kierdorf, K.1
  • 8
    • 84937738858 scopus 로고    scopus 로고
    • Genetic cell ablation reveals clusters of local self-renewing microglia in the mammalian central nervous system
    • pmid: 26163371
    • J. Bruttger et al., Genetic cell ablation reveals clusters of local self-renewing microglia in the mammalian central nervous system. Immunity 43, 92-106 (2015). doi: 10.1016/j.immuni.2015.06.012; pmid: 26163371.
    • (2015) Immunity , vol.43 , pp. 92-106
    • Bruttger, J.1
  • 9
    • 36448994709 scopus 로고    scopus 로고
    • Local self-renewal can sustain CNS microglia maintenance and function throughout adult life
    • pmid: 18026097
    • B. Ajami, J. L. Bennett, C. Krieger, W. Tetzlaff, F. M. V. Rossi, Local self-renewal can sustain CNS microglia maintenance and function throughout adult life. Nat. Neurosci. 10, 1538-1543 (2007). doi: 10.1038/nn2014; pmid: 18026097.
    • (2007) Nat. Neurosci , vol.10 , pp. 1538-1543
    • Ajami, B.1    Bennett, J.L.2    Krieger, C.3    Tetzlaff, W.4    Rossi, F.M.V.5
  • 10
    • 84876775203 scopus 로고    scopus 로고
    • Tissue-resident macrophages self-maintain locally throughout adult life with minimal contribution from circulating monocytes
    • pmid: 23601688
    • D. Hashimoto et al., Tissue-resident macrophages self-maintain locally throughout adult life with minimal contribution from circulating monocytes. Immunity 38, 792-804 (2013). doi: 10.1016/j.immuni.2013.04.004; pmid: 23601688.
    • (2013) Immunity , vol.38 , pp. 792-804
    • Hashimoto, D.1
  • 11
    • 84940984138 scopus 로고    scopus 로고
    • Most tissue-resident macrophages except microglia are derived from fetal hematopoietic stem cells
    • pmid: 26287683
    • J. Sheng, C. Ruedl, K. Karjalainen, Most tissue-resident macrophages except microglia are derived from fetal hematopoietic stem cells. Immunity 43, 382-393 (2015). doi: 10.1016/j.immuni.2015.07.016; pmid: 26287683.
    • (2015) Immunity , vol.43 , pp. 382-393
    • Sheng, J.1    Ruedl, C.2    Karjalainen, K.3
  • 12
    • 36448955070 scopus 로고    scopus 로고
    • Microglia in the adult brain arise from ly-6chiccr2+ monocytes only under defined host conditions
    • pmid: 18026096
    • A. Mildner et al., Microglia in the adult brain arise from Ly-6ChiCCR2+ monocytes only under defined host conditions. Nat. Neurosci. 10, 1544-1553 (2007). doi: 10.1038/nn2015; pmid: 18026096.
    • (2007) Nat. Neurosci , vol.10 , pp. 1544-1553
    • Mildner, A.1
  • 13
    • 68049143269 scopus 로고    scopus 로고
    • Infiltrating blood-derived macrophages are vital cells playing an anti-inflammatory role in recovery from spinal cord injury in mice
    • pmid: 19636355
    • R. Shechter et al., Infiltrating blood-derived macrophages are vital cells playing an anti-inflammatory role in recovery from spinal cord injury in mice. PLOS Med. 6, e1000113 (2009). doi: 10.1371/journal.pmed.1000113; pmid: 19636355.
    • (2009) PLOS Med , vol.6 , pp. e1000113
    • Shechter, R.1
  • 14
    • 84875553508 scopus 로고    scopus 로고
    • Recruitment of beneficial M2 macrophages to injured spinal cord is orchestrated by remote brain choroid plexus
    • pmid: 23477737
    • R. Shechter et al., Recruitment of beneficial M2 macrophages to injured spinal cord is orchestrated by remote brain choroid plexus. Immunity 38, 555-569 (2013). pmid: 23477737.
    • (2013) Immunity , vol.38 , pp. 555-569
    • Shechter, R.1
  • 15
    • 84920724792 scopus 로고    scopus 로고
    • Environment drives selection and function of enhancers controlling tissue-specific macrophage identities
    • pmid: 25480297
    • D. Gosselin et al., Environment drives selection and function of enhancers controlling tissue-specific macrophage identities. Cell 159, 1327-1340 (2014). doi: 10.1016/j.cell.2014.11.023; pmid: 25480297.
    • (2014) Cell , vol.159 , pp. 1327-1340
    • Gosselin, D.1
  • 16
    • 84920724791 scopus 로고    scopus 로고
    • Tissue-resident macrophage enhancer landscapes are shaped by the local microenvironment
    • pmid: 25480296
    • Y. Lavin et al., Tissue-resident macrophage enhancer landscapes are shaped by the local microenvironment. Cell 159, 1312-1326 (2014). doi: 10.1016/j.cell.2014.11.018; pmid: 25480296.
    • (2014) Cell , vol.159 , pp. 1312-1326
    • Lavin, Y.1
  • 17
    • 84870907320 scopus 로고    scopus 로고
    • Stroma-derived interleukin-34 controls the development and maintenance of langerhans cells and the maintenance of microglia
    • pmid: 23177320
    • M. Greter et al., Stroma-derived interleukin-34 controls the development and maintenance of Langerhans cells and the maintenance of microglia. Immunity 37, 1050-1060 (2012). doi: 10.1016/j.immuni.2012.11.001; pmid: 23177320.
    • (2012) Immunity , vol.37 , pp. 1050-1060
    • Greter, M.1
  • 18
    • 84864152036 scopus 로고    scopus 로고
    • Il-34 is a tissue-restricted ligand of CSF1R required for the development of langerhans cells and microglia
    • pmid: 22729249
    • Y. Wang et al., IL-34 is a tissue-restricted ligand of CSF1R required for the development of Langerhans cells and microglia. Nat. Immunol. 13, 753-760 (2012). doi: 10.1038/ni.2360; pmid: 22729249.
    • (2012) Nat. Immunol , vol.13 , pp. 753-760
    • Wang, Y.1
  • 19
    • 84893745524 scopus 로고    scopus 로고
    • Identification of a unique TGF-b-dependent molecular and functional signature in microglia
    • pmid: 24316888
    • O. Butovsky et al., Identification of a unique TGF-b-dependent molecular and functional signature in microglia. Nat. Neurosci. 17, 131-143 (2014). doi: 10.1038/nn.3599; pmid: 24316888.
    • (2014) Nat. Neurosci , vol.17 , pp. 131-143
    • Butovsky, O.1
  • 20
    • 84918825145 scopus 로고    scopus 로고
    • Chronic exposure to TGFB1 regulates myeloid cell inflammatory response in an irf7-dependent manner
    • pmid: 25385836
    • M. Cohen et al., Chronic exposure to TGFb1 regulates myeloid cell inflammatory response in an IRF7-dependent manner. EMBO J. 33, 2906-2921 (2014). doi: 10.15252/embj.201489293; pmid: 25385836.
    • (2014) EMBO J , vol.33 , pp. 2906-2921
    • Cohen, M.1
  • 21
    • 84933043202 scopus 로고    scopus 로고
    • Host micro biota constantly control maturation and function of microglia in the CNS
    • pmid: 26030851
    • D. Erny et al., Host micro biota constantly control maturation and function of microglia in the CNS. Nat. Neurosci. 18, 965-977 (2015). doi: 10.1038/nn.4030; pmid: 26030851.
    • (2015) Nat. Neurosci , vol.18 , pp. 965-977
    • Erny, D.1
  • 22
    • 79952986650 scopus 로고    scopus 로고
    • Rorgt+ innate lymphoid cells regulate intestinal homeostasis by integrating negative signals from the symbiotic micro biota
    • pmid: 21336274
    • S. Sawa et al., RORgt+ innate lymphoid cells regulate intestinal homeostasis by integrating negative signals from the symbiotic microbiota. Nat. Immunol. 12, 320-326 (2011). doi: 10.1038/ni.2002; pmid: 21336274.
    • (2011) Nat. Immunol , vol.12 , pp. 320-326
    • Sawa, S.1
  • 23
    • 67749114055 scopus 로고    scopus 로고
    • Immune involvement in schizophrenia and autism: Etiology, pathology and animal models
    • pmid: 19136031
    • P. H. Patterson, Immune involvement in schizophrenia and autism: Etiology, pathology and animal models. Behav. Brain Res. 204, 313-321 (2009). doi: 10.1016/j.bbr.2008.12.016; pmid: 19136031.
    • (2009) Behav. Brain Res , vol.204 , pp. 313-321
    • Patterson, P.H.1
  • 24
    • 84928189502 scopus 로고    scopus 로고
    • C-myb+ erythro-myeloid progenitor-derived fetal monocytes give rise to adult tissue-resident macrophages
    • pmid: 25902481
    • G. Hoeffel et al., C-Myb+ erythro-myeloid progenitor-derived fetal monocytes give rise to adult tissue-resident macrophages. Immunity 42, 665-678 (2015). doi: 10.1016/j.immuni.2015.03.011; pmid: 25902481.
    • (2015) Immunity , vol.42 , pp. 665-678
    • Hoeffel, G.1
  • 25
    • 51149091666 scopus 로고    scopus 로고
    • Developmental neuronal death in hippocampus requires the microglial cd11b integrin and dap12 immunoreceptor
    • pmid: 18685038
    • S. Wakselman et al., Developmental neuronal death in hippocampus requires the microglial CD11b integrin and DAP12 immunoreceptor. J. Neurosci. 28, 8138-8143 (2008). doi: 10.1523/JNEUROSCI.1006-08.2008; pmid: 18685038.
    • (2008) J. Neurosci , vol.28 , pp. 8138-8143
    • Wakselman, S.1
  • 26
    • 77957328867 scopus 로고    scopus 로고
    • Microglia shape adult hippocampal neurogenesis through apoptosis-coupled phagocytosis
    • pmid: 20887954
    • A. Sierra et al., Microglia shape adult hippocampal neurogenesis through apoptosis-coupled phagocytosis. Cell Stem Cell 7, 483-495 (2010). doi: 10.1016/j.stem.2010.08.014; pmid: 20887954.
    • (2010) Cell Stem Cell , vol.7 , pp. 483-495
    • Sierra, A.1
  • 27
    • 80052633284 scopus 로고    scopus 로고
    • Synaptic pruning by microglia is necessary for normal brain development
    • pmid: 21778362
    • R. C. Paolicelli et al., Synaptic pruning by microglia is necessary for normal brain development. Science 333, 1456-1458 (2011). doi: 10.1126/science.1202529; pmid: 21778362.
    • (2011) Science , vol.333 , pp. 1456-1458
    • Paolicelli, R.C.1
  • 28
    • 84861427387 scopus 로고    scopus 로고
    • Microglia sculpt postnatal neural circuits in an activity and complement-dependent manner
    • pmid: 22632727
    • D. P. Schafer et al., Microglia sculpt postnatal neural circuits in an activity and complement-dependent manner. Neuron 74, 691-705 (2012). doi: 10.1016/j.neuron.2012.03.026; pmid: 22632727.
    • (2012) Neuron , vol.74 , pp. 691-705
    • Schafer, D.P.1
  • 29
    • 84869157553 scopus 로고    scopus 로고
    • The quad-partite synapse: Microglia-synapse interactions in the developing and mature CNS
    • pmid: 22829357
    • D. P. Schafer, E. K. Lehrman, B. Stevens, The "quad-partite" synapse: Microglia-synapse interactions in the developing and mature CNS. Glia 61, 24-36 (2013). doi: 10.1002/glia.22389; pmid: 22829357.
    • (2013) Glia , vol.61 , pp. 24-36
    • Schafer, D.P.1    Lehrman, E.K.2    Stevens, B.3
  • 30
    • 84872176512 scopus 로고    scopus 로고
    • Microglia: New roles for the synaptic stripper
    • pmid: 23312512
    • H. Kettenmann, F. Kirchhoff, A. Verkhratsky, Microglia: New roles for the synaptic stripper. Neuron 77, 10-18 (2013). doi: 10.1016/j.neuron.2012.12.023; pmid: 23312512.
    • (2013) Neuron , vol.77 , pp. 10-18
    • Kettenmann, H.1    Kirchhoff, F.2    Verkhratsky, A.3
  • 31
    • 84896692474 scopus 로고    scopus 로고
    • Deficient neuron-microglia signaling results in impaired functional brain connectivity and social behavior
    • pmid: 24487234
    • Y. Zhan et al., Deficient neuron-microglia signaling results in impaired functional brain connectivity and social behavior. Nat. Neurosci. 17, 400-406 (2014). doi: 10.1038/nn.3641; pmid: 24487234.
    • (2014) Nat. Neurosci , vol.17 , pp. 400-406
    • Zhan, Y.1
  • 32
    • 77649167678 scopus 로고    scopus 로고
    • Prenatal infection and schizophrenia: A review of epidemiologic and translational studies
    • pmid: 20123911
    • A. S. Brown, E. J. Derkits, Prenatal infection and schizophrenia: A review of epidemiologic and translational studies. Am. J. Psychiatry 167, 261-280 (2010). doi: 10.1176/appi.ajp.2009.09030361; pmid: 20123911.
    • (2010) Am. J. Psychiatry , vol.167 , pp. 261-280
    • Brown, A.S.1    Derkits, E.J.2
  • 33
    • 84859624500 scopus 로고    scopus 로고
    • Effects of maternal immune activation on gene expression patterns in the fetal brain
    • pmid: 22832908
    • K. A. Garbett, E. Y. Hsiao, S. Kálmán, P. H. Patterson, K. Mirnics, Effects of maternal immune activation on gene expression patterns in the fetal brain. Transl. Psychiatry 2, e98 (2012). doi: 10.1038/tp.2012.24; pmid: 22832908.
    • (2012) Transl. Psychiatry , vol.2 , pp. e98
    • Garbett, K.A.1    Hsiao, E.Y.2    Kálmán, S.3    Patterson, P.H.4    Mirnics, K.5
  • 34
    • 33646831799 scopus 로고    scopus 로고
    • Immunological stress at the maternal-foetal interface: A link between neurodevelopment and adult psychopathology
    • pmid: 16378711
    • U. Meyer, J. Feldon, M. Schedlowski, B. K. Yee, Immunological stress at the maternal-foetal interface: A link between neurodevelopment and adult psychopathology. Brain Behav. Immun. 20, 378-388 (2006). doi: 10.1016/j.bbi.2005.11.003; pmid: 16378711.
    • (2006) Brain Behav. Immun , vol.20 , pp. 378-388
    • Meyer, U.1    Feldon, J.2    Schedlowski, M.3    Yee, B.K.4
  • 35
    • 33646926705 scopus 로고    scopus 로고
    • The time of prenatal immune challenge determines the specificity of inflammation-mediated brain and behavioral pathology
    • pmid: 16672647
    • U. Meyer et al., The time of prenatal immune challenge determines the specificity of inflammation-mediated brain and behavioral pathology. J. Neurosci. 26, 4752-4762 (2006). doi: 10.1523/JNEUROSCI.0099-06.2006; pmid: 16672647.
    • (2006) J. Neurosci , vol.26 , pp. 4752-4762
    • Meyer, U.1
  • 36
    • 77956954550 scopus 로고    scopus 로고
    • Macrophages in Alzheimer's disease: The blood-borne identity
    • pmid: 20517700
    • D. Gate, K. Rezai-Zadeh, D. Jodry, A. Rentsendorj, T. Town, Macrophages in Alzheimer's disease: The blood-borne identity. J Neural Transm. 117, 961-970 (2010). doi: 10.1007/s00702-010-0422-7; pmid: 20517700.
    • (2010) J Neural Transm , vol.117 , pp. 961-970
    • Gate, D.1    Rezai-Zadeh, K.2    Jodry, D.3    Rentsendorj, A.4    Town, T.5
  • 37
    • 20444445870 scopus 로고    scopus 로고
    • Disabled-2 (dab2) is required for transforming growth factor b-induced epithelial to mesenchymal transition (EMT)
    • pmid: 15734730
    • C. Prunier, P. H. Howe, Disabled-2 (Dab2) is required for transforming growth factor b-induced epithelial to mesenchymal transition (EMT). J. Biol. Chem. 280, 17540-17548 (2005). doi: 10.1074/jbc.M500974200; pmid: 15734730.
    • (2005) J. Biol. Chem , vol.280 , pp. 17540-17548
    • Prunier, C.1    Howe, P.H.2
  • 38
    • 84984578085 scopus 로고    scopus 로고
    • Materials and methods are available as supplementary materials on Science Online. 39
    • Materials and methods are available as supplementary materials on Science Online. 39.
  • 39
    • 0029346879 scopus 로고
    • Analysis of gene expression in a complex differentiation hierarchy by global amplification of cDNA from single cells
    • pmid: 7583149
    • G. Brady et al., Analysis of gene expression in a complex differentiation hierarchy by global amplification of cDNA from single cells. Curr. Biol. 5, 909-922 (1995). doi: 10.1016/S0960- 9822(95)00181-3; pmid: 7583149.
    • (1995) Curr. Biol , vol.5 , pp. 909-922
    • Brady, G.1
  • 40
    • 84871642430 scopus 로고    scopus 로고
    • Lineage tracing of pf4-cre marks hematopoietic stem cells and their progeny
    • pmid: 23300543
    • S. D. J. Calaminus et al., Lineage tracing of Pf4-Cre marks hematopoietic stem cells and their progeny. PLOS ONE 7, e51361 (2012). doi: 10.1371/journal.pone.0051361; pmid: 23300543.
    • (2012) PLOS ONE , vol.7 , pp. e51361
    • Calaminus, S.D.J.1
  • 41
    • 84951304572 scopus 로고    scopus 로고
    • The role of the local environment and epigenetics in shaping macrophage identity and their effect on tissue homeostasis
    • pmid: 26681458
    • I. Amit, D. R. Winter, S. Jung, The role of the local environment and epigenetics in shaping macrophage identity and their effect on tissue homeostasis. Nat. Immunol. 17, 18-25 (2016). doi: 10.1038/ni.3325; pmid: 26681458.
    • (2016) Nat. Immunol , vol.17 , pp. 18-25
    • Amit, I.1    Winter, D.R.2    Jung, S.3
  • 42
    • 0033592606 scopus 로고    scopus 로고
    • Learning the parts of objects by nonnegative matrix factorization
    • pmid: 10548103
    • D. D. Lee, H. S. Seung, Learning the parts of objects by nonnegative matrix factorization. Nature 401, 788-791 (1999). doi: 10.1038/44565; pmid: 10548103.
    • (1999) Nature , vol.401 , pp. 788-791
    • Lee, D.D.1    Seung, H.S.2
  • 43
    • 0023899769 scopus 로고
    • Nuclease hypersensitive sites in chromatin
    • pmid: 3052270
    • D. S. Gross, W. T. Garrard, Nuclease hypersensitive sites in chromatin. Annu. Rev. Biochem. 57, 159-197 (1988). doi: 10.1146/annurev.bi.57.070188.001111; pmid: 3052270.
    • (1988) Annu. Rev. Biochem , vol.57 , pp. 159-197
    • Gross, D.S.1    Garrard, W.T.2
  • 44
    • 85015069067 scopus 로고    scopus 로고
    • Controlling the double helix
    • pmid: 12540921
    • G. Felsenfeld, M. Groudine, Controlling the double helix. Nature 421, 448-453 (2003). doi: 10.1038/nature01411; pmid: 12540921.
    • (2003) Nature , vol.421 , pp. 448-453
    • Felsenfeld, G.1    Groudine, M.2
  • 45
    • 84905989433 scopus 로고    scopus 로고
    • The role of chromatin dynamics in immune cell development
    • pmid: 25123274
    • D. R. Winter, I. Amit, The role of chromatin dynamics in immune cell development. Immunol. Rev. 261, 9-22 (2014). doi: 10.1111/imr.12200; pmid: 25123274.
    • (2014) Immunol. Rev , vol.261 , pp. 9-22
    • Winter, D.R.1    Amit, I.2
  • 46
    • 84888877924 scopus 로고    scopus 로고
    • Transposition of native chromatin for fast and sensitive epigenomic profiling of open chromatin, DNA binding proteins and nucleosome position
    • pmid: 24097267
    • J. D. Buenrostro, P. G. Giresi, L. C. Zaba, H. Y. Chang, W. J. Greenleaf, Transposition of native chromatin for fast and sensitive epigenomic profiling of open chromatin, DNA binding proteins and nucleosome position. Nat. Methods 10, 1213-1218 (2013). doi: 10.1038/nmeth.2688; pmid: 24097267.
    • (2013) Nat. Methods , vol.10 , pp. 1213-1218
    • Buenrostro, J.D.1    Giresi, P.G.2    Zaba, L.C.3    Chang, H.Y.4    Greenleaf, W.J.5
  • 47
    • 84907419194 scopus 로고    scopus 로고
    • Chromatin state dynamics during blood formation
    • pmid: 25103404
    • D. Lara-Astiaso et al., Chromatin state dynamics during blood formation. Science 345, 943-949 (2014). doi: 10.1126/science.1256271; pmid: 25103404.
    • (2014) Science , vol.345 , pp. 943-949
    • Lara-Astiaso, D.1
  • 48
    • 34249026300 scopus 로고    scopus 로고
    • High-resolution profiling of histone methylations in the human genome
    • pmid: 17512414
    • A. Barski et al., High-resolution profiling of histone methylations in the human genome. Cell 129, 823-837 (2007). doi: 10.1016/j.cell.2007.05.009; pmid: 17512414.
    • (2007) Cell , vol.129 , pp. 823-837
    • Barski, A.1
  • 49
    • 33847334699 scopus 로고    scopus 로고
    • Distinct and predictive chromatin signatures of transcriptional promoters and enhancers in the human genome
    • pmid: 17277777
    • N. D. Heintzman et al., Distinct and predictive chromatin signatures of transcriptional promoters and enhancers in the human genome. Nat. Genet. 39, 311-318 (2007). doi: 10.1038/ng1966; pmid: 17277777.
    • (2007) Nat. Genet , vol.39 , pp. 311-318
    • Heintzman, N.D.1
  • 50
    • 84893905629 scopus 로고    scopus 로고
    • Massively parallel single-cell RNA-seq for marker-free decomposition of tissues into cell types
    • pmid: 24531970
    • D. A. Jaitin et al., Massively parallel single-cell RNA-seq for marker-free decomposition of tissues into cell types. Science 343, 776-779 (2014). doi: 10.1126/science.1247651; pmid: 24531970.
    • (2014) Science , vol.343 , pp. 776-779
    • Jaitin, D.A.1
  • 51
    • 84950290139 scopus 로고    scopus 로고
    • Transcriptional heterogeneity and lineage commitment in myeloid progenitors
    • pmid: 26627738
    • F. Paul et al., Transcriptional heterogeneity and lineage commitment in myeloid progenitors. Cell 163, 1663-1677 (2015). doi: 10.1016/j.cell.2015.11.013; pmid: 26627738.
    • (2015) Cell , vol.163 , pp. 1663-1677
    • Paul, F.1
  • 52
    • 84926178081 scopus 로고    scopus 로고
    • Bursty gene expression in the intact mammalian liver
    • pmid: 25728770
    • K. Bahar Halpern et al., Bursty gene expression in the intact mammalian liver. Mol. Cell 58, 147-156 (2015). doi: 10.1016/j.molcel.2015.01.027; pmid: 25728770.
    • (2015) Mol. Cell , vol.58 , pp. 147-156
    • Halpern, K.B.1
  • 53
    • 84856762359 scopus 로고    scopus 로고
    • Optimality in the development of intestinal crypts
    • pmid: 22304925
    • S. Itzkovitz, I. C. Blat, T. Jacks, H. Clevers, A. van Oudenaarden, Optimality in the development of intestinal crypts. Cell 148, 608-619 (2012). doi: 10.1016/j.cell.2011.12.025; pmid: 22304925.
    • (2012) Cell , vol.148 , pp. 608-619
    • Itzkovitz, S.1    Blat, I.C.2    Jacks, T.3    Clevers, H.4    Van Oudenaarden, A.5
  • 54
    • 84883434699 scopus 로고    scopus 로고
    • Single-molecule mRNA detection and counting in mammalian tissue
    • pmid: 23949380
    • A. Lyubimova et al., Single-molecule mRNA detection and counting in mammalian tissue. Nat. Protoc. 8, 1743-1758 (2013). doi: 10.1038/nprot.2013.109; pmid: 23949380.
    • (2013) Nat. Protoc , vol.8 , pp. 1743-1758
    • Lyubimova, A.1
  • 55
    • 33846252240 scopus 로고    scopus 로고
    • Genome-wide atlas of gene expression in the adult mouse brain
    • pmid: 17151600
    • E. S. Lein et al., Genome-wide atlas of gene expression in the adult mouse brain. Nature 445, 168-176 (2007). doi: 10.1038/nature05453; pmid: 17151600.
    • (2007) Nature , vol.445 , pp. 168-176
    • Lein, E.S.1
  • 56
    • 0033388099 scopus 로고    scopus 로고
    • An early developmental transcription factor complex that is more stable on nucleosome core particles than on free DNA
    • pmid: 10635321
    • L. A. Cirillo, K. S. Zaret, An early developmental transcription factor complex that is more stable on nucleosome core particles than on free DNA. Mol. Cell 4, 961-969 (1999). doi: 10.1016/S1097-2765(00)80225-7; pmid: 10635321.
    • (1999) Mol. Cell , vol.4 , pp. 961-969
    • Cirillo, L.A.1    Zaret, K.S.2
  • 57
    • 84866303839 scopus 로고    scopus 로고
    • A high- Throughput chromatin immuno precipitation approach reveals principles of dynamic gene regulation in mammals
    • pmid: 22940246
    • M. Garber et al., A high- Throughput chromatin immuno precipitation approach reveals principles of dynamic gene regulation in mammals. Mol. Cell 47, 810-822 (2012). doi: 10.1016/j.molcel.2012.07.030; pmid: 22940246.
    • (2012) Mol. Cell , vol.47 , pp. 810-822
    • Garber, M.1
  • 58
    • 70449393651 scopus 로고    scopus 로고
    • Mafb/c-maf deficiency enables self-renewal of differentiated functional macrophages
    • pmid: 19892988
    • A. Aziz, E. Soucie, S. Sarrazin, M. H. Sieweke, MafB/c-Maf deficiency enables self-renewal of differentiated functional macrophages. Science 326, 867-871 (2009). doi: 10.1126/science.1176056; pmid: 19892988.
    • (2009) Science , vol.326 , pp. 867-871
    • Aziz, A.1    Soucie, E.2    Sarrazin, S.3    Sieweke, M.H.4
  • 59
    • 0034595223 scopus 로고    scopus 로고
    • Mafb is an inducer of monocytic differentiation
    • pmid: 10790365
    • L. M. Kelly, U. Englmeier, I. Lafon, M. H. Sieweke, T. Graf, MafB is an inducer of monocytic differentiation. EMBO J. 19, 1987-1997 (2000). doi: 10.1093/emboj/19.9.1987; pmid: 10790365.
    • (2000) EMBO J , vol.19 , pp. 1987-1997
    • Kelly, L.M.1    Englmeier, U.2    Lafon, I.3    Sieweke, M.H.4    Graf, T.5
  • 60
    • 84958191207 scopus 로고    scopus 로고
    • Lineage-specific enhancers activate self renewal genes in macrophages and embryonic stem cells
    • pmid: 26797145
    • E. L. Soucie et al., Lineage-specific enhancers activate selfrenewal genes in macrophages and embryonic stem cells. Science 351, aad5510 (2016). doi: 10.1126/science.aad5510; pmid: 26797145.
    • (2016) Science , vol.351 , pp. aad5510
    • Soucie, E.L.1
  • 61
    • 84894118144 scopus 로고    scopus 로고
    • Micro biota modulate behavioral and physiological abnormalities associated with neurodevelopmental disorders
    • pmid: 24315484
    • E. Y. Hsiao et al., Micro biota modulate behavioral and physiological abnormalities associated with neurodevelopmental disorders. Cell 155, 1451-1463 (2013). doi: 10.1016/j.cell.2013.11.024; pmid: 24315484.
    • (2013) Cell , vol.155 , pp. 1451-1463
    • Hsiao, E.Y.1
  • 62
    • 84861980130 scopus 로고    scopus 로고
    • Interactions between the micro biota and the immune system
    • pmid: 22674334
    • L. V. Hooper, D. R. Littman, A. J. Macpherson, Interactions between the micro biota and the immune system. Science 336, 1268-1273 (2012). doi: 10.1126/science.1223490; pmid: 22674334.
    • (2012) Science , vol.336 , pp. 1268-1273
    • Hooper, L.V.1    Littman, D.R.2    Macpherson, A.J.3
  • 63
    • 79952763661 scopus 로고    scopus 로고
    • Succession of microbial consortia in the developing infant gut micro biome
    • pmid: 20668239
    • J. E. Koenig et al., Succession of microbial consortia in the developing infant gut microbiome. Proc. Natl. Acad. Sci. U.S.A. 108, 4578-4585 (2011). doi: 10.1073/pnas.1000081107; pmid: 20668239.
    • (2011) Proc. Natl. Acad. Sci. U.S.A , vol.108 , pp. 4578-4585
    • Koenig, J.E.1
  • 65
    • 79959964671 scopus 로고    scopus 로고
    • Maternal infection and immune involvement in autism
    • pmid: 21482187
    • P. H. Patterson, Maternal infection and immune involvement in autism. Trends Mol. Med. 17, 389-394 (2011). doi: 10.1016/j.molmed.2011.03.001; pmid: 21482187.
    • (2011) Trends Mol. Med , vol.17 , pp. 389-394
    • Patterson, P.H.1
  • 66
    • 84948845532 scopus 로고    scopus 로고
    • Prenatal immune activation causes hippocampal synaptic deficits in the absence of overt microglia anomalies
    • pmid: 26408796
    • S. Giovanoli, U. Weber-Stadlbauer, M. Schedlowski, U. Meyer, H. Engler, Prenatal immune activation causes hippocampal synaptic deficits in the absence of overt microglia anomalies. Brain Behav. Immun. 55, 25-38 (2015). doi: 10.1016/jbbi.2015.09015; pmid: 26408796.
    • (2015) Brain Behav. Immun , vol.55 , pp. 25-38
    • Giovanoli, S.1    Weber-Stadlbauer, U.2    Schedlowski, M.3    Meyer, U.4    Engler, H.5
  • 67
    • 84872765982 scopus 로고    scopus 로고
    • Fate mapping reveals origins and dynamics of monocytes and tissue macrophages under homeostasis
    • pmid: 23273845
    • S. Yona et al., Fate mapping reveals origins and dynamics of monocytes and tissue macrophages under homeostasis. Immunity 38, 79-91 (2013). doi: 10.1016/j.immuni.2012.12.001; pmid: 23273845.
    • (2013) Immunity , vol.38 , pp. 79-91
    • Yona, S.1
  • 68
    • 84878340548 scopus 로고    scopus 로고
    • Biphasic assembly of the murine intestinal micro biota during early development
    • pmid: 23535917
    • I. G. Pantoja-Feliciano et al., Biphasic assembly of the murine intestinal micro biota during early development. ISME J. 7, 1112-1115 (2013). doi: 10.1038/ismej.2013.15; pmid: 23535917.
    • (2013) ISME J , vol.7 , pp. 1112-1115
    • Pantoja-Feliciano, I.G.1
  • 69
    • 84907659600 scopus 로고    scopus 로고
    • Aging-induced type i interferon response at the choroid plexus negatively affects brain function
    • pmid: 25147279
    • K. Baruch et al., Aging-induced type I interferon response at the choroid plexus negatively affects brain function. Science 346, 89-93 (2014). doi: 10.1126/science.1252945; pmid: 25147279.
    • (2014) Science , vol.346 , pp. 89-93
    • Baruch, K.1
  • 70
    • 31544460682 scopus 로고    scopus 로고
    • Immune cells contribute to the maintenance of neurogenesis and spatial learning abilities in adulthood
    • pmid: 16415867
    • Y. Ziv et al., Immune cells contribute to the maintenance of neurogenesis and spatial learning abilities in adulthood. Nat. Neurosci. 9, 268-275 (2006). doi: 10.1038/nn1629; pmid: 16415867.
    • (2006) Nat. Neurosci , vol.9 , pp. 268-275
    • Ziv, Y.1
  • 71
    • 77952311924 scopus 로고    scopus 로고
    • Regulation of learning and memory by meningeal immunity: A key role for il-4
    • pmid: 20439540
    • N. C. Derecki et al., Regulation of learning and memory by meningeal immunity: A key role for IL-4. J. Exp. Med. 207, 1067-1080 (2010). doi: 10.1084/jem.20091419; pmid: 20439540.
    • (2010) J. Exp. Med , vol.207 , pp. 1067-1080
    • Derecki, N.C.1
  • 72
    • 77954947887 scopus 로고    scopus 로고
    • The transcription factor Mafb antagonizes antiviral responses by blocking recruitment of coactivators to the transcription factor irf3
    • pmid: 20581830
    • H. Kim, B. Seed, The transcription factor MafB antagonizes antiviral responses by blocking recruitment of coactivators to the transcription factor IRF3. Nat. Immunol. 11, 743-750 (2010). doi: 10.1038/ni.1897; pmid: 20581830.
    • (2010) Nat. Immunol , vol.11 , pp. 743-750
    • Kim, H.1    Seed, B.2
  • 73
    • 84884561907 scopus 로고    scopus 로고
    • Molecular pathways: Co expression of immune checkpoint molecules: Signaling pathways and implications for cancer immunotherapy
    • pmid: 23868869
    • C. J. Nirschl, C. G. Drake, Molecular pathways: Co expression of immune checkpoint molecules: Signaling pathways and implications for cancer immunotherapy. Clin. Cancer Res. 19, 4917-4924 (2013). doi: 10.1158/1078-0432.CCR-12-1972; pmid: 23868869.
    • (2013) Clin. Cancer Res , vol.19 , pp. 4917-4924
    • Nirschl, C.J.1    Drake, C.G.2
  • 74
    • 0034028817 scopus 로고    scopus 로고
    • Analysis of fractalkine receptor cx3cr1 function by targeted deletion and green fluorescent protein reporter gene insertion
    • pmid: 10805752
    • S. Jung et al., Analysis of fractalkine receptor CX3CR1 function by targeted deletion and green fluorescent protein reporter gene insertion. Mol. Cell. Biol. 20, 4106-4114 (2000). doi: 10.1128/MCB.20.11.4106-4114.2000; pmid: 10805752.
    • (2000) Mol. Cell. Biol , vol.20 , pp. 4106-4114
    • Jung, S.1
  • 75
    • 84908302963 scopus 로고    scopus 로고
    • Trans kingdom control of micro biota diurnal oscillations promotes metabolic homeostasis
    • pmid: 25417104
    • C. A. Thaiss et al., Transkingdom control of microbiota diurnal oscillations promotes metabolic homeostasis. Cell 159, 514-529 (2014). doi: 10.1016/j.cell.2014.09.048; pmid: 25417104.
    • (2014) Cell , vol.159 , pp. 514-529
    • Thaiss, C.A.1
  • 76
    • 36949028725 scopus 로고    scopus 로고
    • Relative prenatal and postnatal maternal contributions to schizophrenia-related neurochemical dysfunction after in utero immune challenge
    • pmid: 17443130
    • U. Meyer et al., Relative prenatal and postnatal maternal contributions to schizophrenia-related neurochemical dysfunction after in utero immune challenge. Neuropsychopharmacology 33, 441-456 (2008). doi: 10.1038/sj.npp.1301413; pmid: 17443130.
    • (2008) Neuropsychopharmacology , vol.33 , pp. 441-456
    • Meyer, U.1
  • 77
    • 84972545970 scopus 로고
    • A survey of exact inference for contingency tables
    • A. Agresti, A survey of exact inference for contingency tables. Stat. Sci. 7, 131-153 (1992). doi: 10.1214/ss/1177011454.
    • (1992) Stat. Sci , vol.7 , pp. 131-153
    • Agresti, A.1
  • 78
    • 65449136284 scopus 로고    scopus 로고
    • Top hat: Discovering splice junctions with RNA-seq
    • pmid: 19289445
    • C. Trapnell, L. Pachter, S. L. Salzberg, Top Hat: Discovering splice junctions with RNA-seq. Bioinformatics 25, 1105-1111 (2009). doi: 10.1093/bioinformatics/btp120; pmid: 19289445.
    • (2009) Bioinformatics , vol.25 , pp. 1105-1111
    • Trapnell, C.1    Pachter, L.2    Salzberg, S.L.3
  • 79
    • 77952567987 scopus 로고    scopus 로고
    • Simple combinations of lineage-determining transcription factors prime cis-regulatory elements required for macrophage and b cell identities
    • pmid: 20513432
    • S. Heinz et al., Simple combinations of lineage-determining transcription factors prime cis-regulatory elements required for macrophage and B cell identities. Mol. Cell 38, 576-589 (2010). doi: 10.1016/j.molcel.2010.05.004; pmid: 20513432.
    • (2010) Mol. Cell , vol.38 , pp. 576-589
    • Heinz, S.1
  • 80
    • 34047230770 scopus 로고    scopus 로고
    • Discovering motifs in ranked lists of DNA sequences
    • pmid: 17381235
    • E. Eden, D. Lipson, S. Yogev, Z. Yakhini, Discovering motifs in ranked lists of DNA sequences. PLOS Comput. Biol. 3, e39 (2007). doi: 10.1371/journal.pcbi.0030039; pmid: 17381235.
    • (2007) PLOS Comput. Biol , vol.3 , pp. e39
    • Eden, E.1    Lipson, D.2    Yogev, S.3    Yakhini, Z.4
  • 81
    • 60849139395 scopus 로고    scopus 로고
    • Gorilla: A tool for discovery and visualization of enriched go terms in ranked gene lists
    • pmid: 19192299
    • E. Eden, R. Navon, I. Steinfeld, D. Lipson, Z. Yakhini, GOrilla: A tool for discovery and visualization of enriched GO terms in ranked gene lists. BMC Bioinformatics 10, 48 (2009). doi: 10.1186/1471-2105-10-48; pmid: 19192299.
    • (2009) BMC Bioinformatics , vol.10 , pp. 48
    • Eden, E.1    Navon, R.2    Steinfeld, I.3    Lipson, D.4    Yakhini, Z.5
  • 82
    • 84913593681 scopus 로고    scopus 로고
    • Tn5 transposase and tagmentation procedures for massively scaled sequencing projects
    • pmid: 25079858
    • S. Picelli et al., Tn5 transposase and tagmentation procedures for massively scaled sequencing projects. Genome Res. 24, 2033-2040 (2014). doi: 10.1101/gr.177881.114; pmid: 25079858.
    • (2014) Genome Res , vol.24 , pp. 2033-2040
    • Picelli, S.1
  • 83
    • 62349130698 scopus 로고    scopus 로고
    • Ultrafast and memory-efficient alignment of short DNA sequences to the human genome
    • pmid: 19261174
    • B. Langmead, C. Trapnell, M. Pop, S. L. Salzberg, Ultrafast and memory-efficient alignment of short DNA sequences to the human genome. Genome Biol. 10, R25 (2009). doi: 10.1186/gb-2009-10-3-r25; pmid: 19261174.
    • (2009) Genome Biol , vol.10 , pp. R25
    • Langmead, B.1    Trapnell, C.2    Pop, M.3    Salzberg, S.L.4


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