SIRP/CD47 signaling in neurological disorders

Brain Research

Volumn 1623, Issue , 2015, Pages 74-80

  Zhang, Haiyue ^a,c   Li, Fengwu ^b   Yang, Yuanyuan ^a,c   Chen, Jun ^a   Hu, Xiaoming ^a,b  

^a UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

^b CAPITAL MEDICAL UNIVERSITY   (China)

^c CENTRAL SOUTH UNIVERSITY   (China)

Author keywords

CD47; Microglia; Neuroinflammation; Signal regulatory protein(SIRP)

Indexed keywords

ADAPTOR PROTEIN; CD47 ANTIGEN; MEMBRANE PROTEIN; REGULATOR PROTEIN; SIGNAL REGULATORY PROTEIN; SIGNAL REGULATORY PROTEIN ALPHA; SIGNAL REGULATORY PROTEIN BETA; SIGNAL REGULATORY PROTEIN BETA 1; SIGNAL REGULATORY PROTEIN GAMMA; TRANSMEMBRANE ADAPTOR PROTEIN DAP12; UNCLASSIFIED DRUG; IMMUNOGLOBULIN RECEPTOR;

BRAIN LEVEL; CELL ACTIVATION; CELL COMMUNICATION; CELL PHAGOCYTOSIS; CENTRAL NERVOUS SYSTEM; CENTRAL NERVOUS SYSTEM DISEASE; CEREBROVASCULAR ACCIDENT; HUMAN; MICROGLIA; MOLECULAR PATHOLOGY; MULTIPLE SCLEROSIS; NERVE CELL; NERVOUS SYSTEM INFLAMMATION; NEUROLOGIC DISEASE; NEUROPATHOLOGY; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN PROTEIN INTERACTION; PROTEIN TARGETING; REVIEW; SIGNAL TRANSDUCTION; ANIMAL; IMMUNOMODULATION; METABOLISM; PHYSIOLOGY;

ANIMALS; ANTIGENS, CD47; CENTRAL NERVOUS SYSTEM DISEASES; HUMANS; MICROGLIA; NEUROIMMUNOMODULATION; RECEPTORS, IMMUNOLOGIC; SIGNAL TRANSDUCTION;

EID: 84941316111     PISSN: 00068993     EISSN: 18726240     Source Type: Journal    
DOI: 10.1016/j.brainres.2015.03.012     Document Type: Review

References (45)

1. 2-dependent pathways Mol. Cell. Biol. 25 2005 7181 7192
2. M.E. Bamberger, and et al. A cell surface receptor complex for fibrillar beta-amyloid mediates microglial activation J. Neurosci. 23 2003 2665 2674
3. A.N. Barclay, and T.K. Van den Berg The interaction between signal regulatory protein alpha (SIRPalpha) and CD47: structure, function, and therapeutic target Annu. Rev. Immunol. 32 2014 25 50
4. K.D. Barron The microglial cell. A historical review J Neurol Sci 134 Suppl 1995 57 68
5. R.L. Benton, and et al. Transcriptomic screening of microvascular endothelial cells implicates novel molecular regulators of vascular dysfunction after spinal cord injury J. Cereb. Blood Flow Metab. 28 2008 1771 1785
6. H.E. de Vries, and et al. Signal-regulatory protein alpha-CD47 interactions are required for the transmigration of monocytes across cerebral endothelium J. Immunol. 168 2002 5832 5839
7. A.M. Floden, and C.K. Combs Microglia demonstrate age-dependent interaction with amyloid-beta fibrils J. Alzheimers Dis. 25 2011 279 293
8. S. Gaikwad, and et al. Signal regulatory protein-beta1: a microglial modulator of phagocytosis in Alzheimers disease Am. J. Pathol. 175 2009 2528 2539
9. M. Gitik, and et al. Myelin down-regulates myelin phagocytosis by microglia and macrophages through interactions between CD47 on myelin and SIRPalpha (signal regulatory protein-alpha) on phagocytes J. Neuroinflamm. 8 2011 24
10. H.D. Gresham, and et al. Negative regulation of phagocytosis in murine macrophages by the Src kinase family member Fgr. J. Exp. Med. 191 2000 515 528
11. M.H. Han, and et al. Janus-like opposing roles of CD47 in autoimmune brain inflammation in humans and mice J. Exp. Med. 209 2012 1325 1334
12. U.K. Hanisch, and H. Kettenmann Microglia: active sensor and versatile effector cells in the normal and pathologic brain Nat. Neurosci. 10 2007 1387 1394
13. D. Hatherley, and et al. Paired receptor specificity explained by structures of signal regulatory proteins alone and complexed with CD47 Mol. Cell 31 2008 266 277
14. A. Hayashi, and et al. Positive regulation of phagocytosis by SIRPbeta and its signaling mechanism in macrophages J. Biol. Chem. 279 2004 29450 29460
15. X. Hu, and et al. Microglial and macrophage polarization-new prospects for brain repair Nat. Rev. Neurol. 11 2015 56 64
16. X. Hu, and et al. Neurobiology of microglial action in CNS injuries: receptor-mediated signaling mechanisms and functional roles Prog. Neurobiol. 119-120 2014 60 84
17. K. Ide, and et al. Role for CD47-SIRPalpha signaling in xenograft rejection by macrophages Proc. Natl. Acad. Sci. USA 104 2007 5062 5066
18. W.J. Janssen, and et al. Surfactant proteins A and D suppress alveolar macrophage phagocytosis via interaction with SIRP alpha Am. J. Respir. Crit. Care Med. 178 2008 158 167
19. P. Jiang, C.F. Lagenaur, and V. Narayanan Integrin-associated protein is a ligand for the P84 neural adhesion molecule J. Biol. Chem. 274 1999 559 562
20. G. Jin, and et al. CD47 gene knockout protects against transient focal cerebral ischemia in mice Exp. Neurol. 217 2009 165 170
21. A. Kharitonenkov, and et al. A family of proteins that inhibit signalling through tyrosine kinase receptors Nature 386 1997 181 186
22. J. Koenigsknecht, and G. Landreth Microglial phagocytosis of fibrillar beta-amyloid through a beta1 integrin-dependent mechanism J. Neurosci. 24 2004 9838 9846
23. X.N. Kong, and et al. LPS-induced down-regulation of signal regulatory protein {alpha} contributes to innate immune activation in macrophages J. Exp. Med. 204 2007 2719 2731
24. M. Lalancette-Hebert, and et al. Selective ablation of proliferating microglial cells exacerbates ischemic injury in the brain J. Neurosci. 27 2007 2596 2605
25. S. Latour, and et al. Bidirectional negative regulation of human T and dendritic cells by CD47 and its cognate receptor signal-regulator protein-alpha: down-regulation of IL-12 responsiveness and inhibition of dendritic cell activation J. Immunol. 167 2001 2547 2554
26. W.Y. Lee, and et al. The role of cis dimerization of signal regulatory protein alpha (SIRPalpha) in binding to CD47 J. Biol. Chem. 285 2010 37953 37963
27. B. Linnartz, and H. Neumann Microglial activatory (immunoreceptor tyrosine-based activation motif)- and inhibitory (immunoreceptor tyrosine-based inhibition motif)-signaling receptors for recognition of the neuronal glycocalyx Glia 61 2013 37 46
28. S.Q. Liu, and et al. Negative regulation of monocyte adhesion to arterial elastic laminae by signal regulatory protein alpha and Src homology 2 domain-containing protein-tyrosine phosphatase-1 J. Biol. Chem. 280 2005 39294 39301
29. T. Murata, and et al. CD47 promotes neuronal development through Src- and FRG/Vav2-mediated activation of Rac and Cdc42 J. Neurosci. 26 2006 12397 12407
30. S.A. Myers, and et al. CD47 knockout mice exhibit improved recovery from spinal cord injury Neurobiol. Dis. 42 2011 21 34
31. B.G. Neel, H. Gu, and L. Pao The 'Shp'ing news: SH2 domain-containing tyrosine phosphatases in cell signaling Trends Biochem. Sci. 28 2003 284 293
32. H. Ohnishi, and et al. Differential localization of Src homology 2 domain-containing protein tyrosine phosphatase substrate-1 and CD47 and its molecular mechanisms in cultured hippocampal neurons J. Neurosci. 25 2005 2702 2711
33. P.A. Oldenborg, and et al. Role of CD47 as a marker of self on red blood cells Science 288 2000 2051 2054
34. X. Shen, and et al. Recruitment of Pyk2 to SHPS-1 signaling complex is required for IGF-I-dependent mitogenic signaling in vascular smooth muscle cells Cell. Mol. Life Sci. 67 2010 3893 3903
35. R.E. Smith, and et al. A novel MyD-1 (SIRP-1alpha) signaling pathway that inhibits LPS-induced TNFalpha production by monocytes Blood 102 2003 2532 2540
36. P. Thored, and et al. Long-term accumulation of microglia with proneurogenic phenotype concomitant with persistent neurogenesis in adult subventricular zone after stroke Glia 57 2009 835 849
37. J.F. Timms, and et al. SHPS-1 is a scaffold for assembling distinct adhesion-regulated multi-protein complexes in macrophages Curr. Biol. 9 1999 927 930
38. A. Veillette, E. Thibaudeau, and S. Latour High expression of inhibitory receptor SHPS-1 and its association with protein-tyrosine phosphatase SHP-1 in macrophages J. Biol. Chem. 273 1998 22719 22728
39. E.F. Vernon-Wilson, and et al. CD47 is a ligand for rat macrophage membrane signal regulatory protein SIRP (OX41) and human SIRPalpha 1 Eur. J. Immunol. 30 2000 2130 2137
40. L. Wang, and et al. SHPS-1 deficiency induces robust neuroprotection against experimental stroke by attenuating oxidative stress J. Neurochem. 122 2012 834 843
41. X.X. Wang, L.J. Dangott, and K.H. Pfenninger The heterogeneous growth cone glycoprotein gp93 is identical to the signal regulatory protein SIRPalpha/SHPS-1/BIT J. Neurochem. 86 2003 55 60
42. K. Weiskopf, and et al. Engineered SIRPalpha variants as immunotherapeutic adjuvants to anticancer antibodies Science 341 2013 88 91
43. C. Xing, and et al. Induction of vascular endothelial growth factor and matrix metalloproteinase-9 via CD47 signaling in neurovascular cells Neurochem. Res. 35 2010 1092 1097
44. T. Yamao, and et al. Negative regulation of platelet clearance and of the macrophage phagocytic response by the transmembrane glycoprotein SHPS-1 J. Biol. Chem. 277 2002 39833 39839
45. X. Zhou, and et al. Brain CD47 expression in a swine model of intracerebral hemorrhage Brain Res. 1574 2014 70 76