CD36 mediates the innate host response to β-amyloid

Journal of Experimental Medicine

Volumn 197, Issue 12, 2003, Pages 1657-1666

  El Khoury, Joseph B ^a   Moore, Kathryn J ^a   Means, Terry K ^a   Leung, Josephine ^a   Terada, Kinya ^a   Toft, Michelle ^a   Freeman, Mason W ^a   Luster, Andrew D ^a  

^a MASSACHUSETTS GENERAL HOSPITAL   (United States)

Author keywords

Alzheimer's disease; Chemokine; Microglia; Reactive oxygen species; Scavenger receptor

Indexed keywords

AMYLOID; AMYLOID BETA PROTEIN; CD36 ANTIGEN; CELL RECEPTOR; CHEMOKINE; CYTOKINE; PATTERN RECOGNITION RECEPTOR; REACTIVE OXYGEN METABOLITE; UNCLASSIFIED DRUG;

ALZHEIMER DISEASE; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; CYTOKINE RELEASE; IMMUNE RESPONSE; INFLAMMATION; MACROPHAGE; MICROGLIA; MOLECULAR MECHANICS; MOUSE; NERVE DEGENERATION; NONHUMAN; PATTERN RECOGNITION; PRIORITY JOURNAL; SENILE PLAQUE;

ALZHEIMER DISEASE; AMYLOID BETA-PROTEIN; ANIMALS; ANTIGENS, CD36; CELL ADHESION; CELLS, CULTURED; CHEMOKINE CCL2; CHEMOKINES; CHEMOTAXIS; HUMANS; IMMUNOHISTOCHEMISTRY; INTERLEUKIN-1; MACROPHAGES, PERITONEAL; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; MICROGLIA; REACTIVE OXYGEN SPECIES; SENILE PLAQUES; TUMOR NECROSIS FACTOR-ALPHA;

EID: 0038204838     PISSN: 00221007     EISSN: None     Source Type: Journal    
DOI: 10.1084/jem.20021546     Document Type: Article

References (33)

1. Itagaki, S., P.L. McGeer, H. Akiyama, S. Zhu, and D. Selkoe. 1989. Relationship of microglia and astrocytes to amyloid deposits of Alzheimer disease. J. Neuroimmunol. 24:173-182.
2. McGeer, P.L., S. Itagaki, H. Tago, and E.G. McGeer. 1987. Reactive microglia in patients with senile dementia of the Alzheimer type are positive for the histocompatibility glycoprotein HLA-DK. Neurosci. Lett. 79:195-200.
3. Giulian, D., L.J. Haverkamp, J.H. Yu, W. Karshin, D. Tom, J. Li, J. Kirkpatrick, L.M. Kuo, and A.E. Roher. 1996. Specific domains of beta-amyloid from Alzheimer plaque elicit neuron killing in human microglia. J. Neurosci. 16:6021-6037.
4. Frautschy, S.A., F. Yang, M. Irrizarry, B. Hyman, T.C. Saido, K. Hsiao, and G.M. Cole. 1998. Microglial response to amyloid plaques in APPsw transgenic mice. Am. J. Pathol. 152:307-317.
5. Geula, C., C.K. Wu, D. Saroff, A. Lorenzo, M. Yuan, and B.A. Yankner. 1998. Aging renders the brain vulnerable to amyloid beta-protein neurotoxicity. Nat. Med. 4:827-831.
6. Weldon, D.T., S.D. Rogers, J.R. Ghilardi, M.P. Finke, J.P. Cleary, E. O'Hare, W.P. Esler, J.E. Maggio, and P.W. Mantyh. 1998. Fibrillar beta-amyloid induces microglial phagocytosis, expression of inducible nitric oxide synthase, and loss of a select population of neurons in the rat CNS in vivo. J. Neurosci. 18:2161-2173.
7. Bornemann, K.D., K.H. Wiederhold, C. Pauli, F. Ermini, M. Stalder, L. Schnell, B. Sommer, M. Jucker, and M. Staufenbiel. 2001. Abeta-induced inflammatory processes in microglia cells of APP23 transgenic mice. Am. J. Pathol. 158:63-73.
8. Selkoe, D.J. 1991. The molecular pathology of Alzheimer's disease. Neuron. 6:487-498.
9. El Khoury, J., S.E. Hickman, C.A. Thomas, L. Cao, S.C. Silverstein, and J.D. Loike. 1996. Scavenger receptor-mediated adhesion of microglia to beta-amyloid fibrils. Nature. 382:716-719.
10. Paresce, D.M., R.N. Ghosh, and F.R. Maxfield. 1996. Microglial cells internalize aggregates of the Alzheimer's disease amyloid beta-protein via a scavenger receptor. Neuron. 17:553-565.
11. Christie, R.H., M. Freeman, and B.T. Hyman. 1996. Expression of the macrophage scavenger receptor, a multifunctional lipoprotein receptor, in microglia associated with senile plaques in Alzheimer's disease. Am. J. Pathol. 148:399-403.
12. Honda, M., H. Akiyama, Y. Yamada, H. Kondo, Y. Kawabe, M. Takeya, K. Takahashi, H. Suzuki, T. Doi, A. Sakamoto, et al. 1998. Immunohistochemical evidence for a macrophage scavenger receptor in Mato cells and reactive microglia of ischemia and Alzheimer's disease. Biochem. Biophys. Res. Commun. 245:734-740.
13. Coraci, I.S., J. Husemann, J.W. Berman, C. Hulette, J.H. Dufour, G.K. Campanella, A.D. Luster, S.C. Silverstein, and J.B. El-Khoury. 2002. CD36, a class B scavenger receptor, is expressed on microglia in Alzheimer's disease brains and can mediate production of reactive oxygen species in response to beta-amyloid fibrils. Am. J. Pathol. 160:101-112.
14. Antic, A., K.A. Dzenko, and J.S. Pachter. 2000. Engagement of the scavenger receptor is not responsible for beta-amyloid stimulation of monocytes to a neurocytopathic state. Exp. Neurol. 161:96-101.
15. Moore, K.J., J. El Khoury, L.A. Medeiros, K. Terada, C. Geula, A.D. Luster, and M.W. Freeman. 2002. A CD36-initiated signaling cascade mediates inflammatory effects of beta-amyloid. J. Biol. Chem. 277:47373-47379.
16. Thomas, C.A., Y. Li, T. Kodama, H. Suzuki, S.C. Silverstein, and J. El Khoury. 2000. Protection from lethal grampositive infection by macrophage scavenger receptor-dependent phagocytosis. J. Exp. Med. 191:147-156.
17. Basu, A., J.K. Krady, M. O'Malley, S.D. Styren, S.T. DeKosky, and S.W. Levison. 2002. The type 1 interleukin-1 receptor is essential for the efficient activation of microglia and the induction of multiple proinflammatory mediators in response to brain injury. J. Neurosci. 22:6071-6082.
18. El Khoury, J., C.A. Thomas, J.D. Loike, S.E. Hickman, L. Cao, and S.C. Silverstein. 1994. Macrophages adhere to glucose-modified basement membrane collagen IV via their scavenger receptors. J. Biol. Chem. 269:10197-10200.
19. Ishizuka, K., T. Kimura, R. Igata-yi, S. Katsuragi, J. Takamatsu, and T. Miyakawa. 1997. Identification of monocyte chemoattractant protein-1 in senile plaques and reactive microglia of Alzheimer's disease. Psychiatry Clin. Neurosci. 51:135-138.
20. Meda, L., P. Baron, E. Prat, E. Scarpini, G. Scarlato, M.A. Cassatella, and F. Rossi. 1999. Proinflammatory profile of cytokine production by human monocytes and murine microglia stimulated with beta-amyloid. J. Neuroimmunol. 93:45-52.
21. Sheng, J.G., W.S. Griffin, M.C. Royston, and R.E. Mrak. 1998. Distribution of interleukin-1-immunoreactive microglia in cerebral cortical layers: implications for neuritic plaque formation in Alzheimer's disease. Neuropathol. Appl. Neurobiol. 24:278-283.
22. Grammas, P., and R. Ovase. 2001. Inflammatory factors are elevated in brain microvessels in Alzheimer's disease. Neurobiol. Aging. 22:837-842.
23. Sly, L.M., R.F. Krzesicki, J.R. Brashler, A.E. Buhl, D.D. McKinley, D.B. Carter, and J.E. Chin. 2001. Endogenous brain cytokine mRNA and inflammatory responses to lipopolysaccharide are elevated in the Tg2576 transgenic mouse model of Alzheimer's disease. Brain Res. Bull. 56:581-588.
24. Meda, L., M.A. Cassatella, G.I. Szendrei, L. Otvos, Jr., P. Baron, M. Villalba, D. Ferrari, and F. Rossi. 1995. Activation of microglial cells by beta-amyloid protein and interferon-gamma. Nature. 374:647-650.
25. Combs, C.K., J.C. Karlo, S.C. Kao, and G.E. Landreth. 2001. beta-Amyloid stimulation of microglia and monocytes results in TNFalpha-dependent expression of inducible nitric oxide synthase and neuronal apoptosis. J. Neurosci. 21:1179-1188.
26. Luster, A.D. 1998. Chemokines-chemotactic cytokines that mediate inflammation. N. Engl. J. Med. 338:436-445.
27. Dickson, D.W., J. Farlo, P. Davies, H. Crystal, P. Fuld, and S.H. Yen. 1988. Alzheimer's disease. A double-labeling immunohistochemical study of senile plaques. Am. J. Pathol. 132:86-101.
28. El Khoury, J., S.E. Hickman, C.A. Thomas, J.D. Loike, and S.C. Silverstein. 1998. Microglia, scavenger receptors, and the pathogenesis of Alzheimer's disease. Neurobiol. Aging. 19: S81-S84.
29. Maxeiner, H., J. Husemann, C.A. Thomas, J.D. Loike, J. El Khoury, and S.C. Silverstein. 1998. Complementary roles for scavenger receptor A and CD36 of human monocyte-derived macrophages in adhesion to surfaces coated with oxidized low-density lipoproteins and in secretion of H2O2. J. Exp. Med. 188:2257-2265.
30. Lue, L.F., D.G. Walker, L. Brachova, T.G. Beach, J. Rogers, A.M. Schmidt, D.M. Stern, and S.D. Yan. 2001. Involvement of microglial receptor for advanced glycation endproducts (RAGE) in Alzheimer's disease: identification of a cellular activation mechanism. Exp. Neurol. 171:29-45.
31. Medzhitov, R., and C. Janeway, Jr. 2000. The Toll receptor family and microbial recognition. Trends Microbiol. 8:452-456.
32. Ohashi, K., V. Burkart, S. Flohe, and H. Kolb. 2000. Cutting edge: heat shock protein 60 is a putative endogenous ligand of the toll-like receptor-4 complex. J. Immunol. 164:558-561.
33. Leadbetter, E.A., I.R. Rifkin, A.M. Hohlbaum, B.C. Beaudette, M.J. Shlomchik, and A. Marshak-Rothstein. 2002. Chromatin-IgG complexes activate B cells by dual engagement of IgM and Toll-like receptors. Nature. 416:603-607.