Onset and progression in inherited ALS determined by motor neurons and microglia

Science

Volumn 312, Issue 5778, 2006, Pages 1389-1392

  Boillée, Séverine ^a   Yamanaka, Koji ^a   Lobsiger, Christian S ^a   Copeland, Neal G ^b   Jenkins, Nancy A ^b   Kassiotis, George ^c,d   Kollias, George ^c   Cleveland, Don W ^a  

^a UNIVERSITY OF CALIFORNIA SAN DIEGO   (United States)

^b NATIONAL CANCER INSTITUTE   (United States)

^c BIOMEDICAL SCIENCES RESEARCH CENTER ALEXANDER FLEMING   (Greece)

^d NATIONAL INSTITUTE FOR MEDICAL RESEARCH   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

CELLS; DISEASE CONTROL; GENES;

AMYOTROPHIC LATERAL SCLEROSIS (ALS); DISEASE PROGRESSION; MOTOR NEURONS;

DISEASES;

SUPEROXIDE DISMUTASE;

GENE EXPRESSION; MUTATION; NERVOUS SYSTEM DISORDER;

AMYOTROPHIC LATERAL SCLEROSIS; ARTICLE; CELL TYPE; DEGENERATIVE DISEASE; DISEASE COURSE; GENE EXPRESSION; MICROGLIA; MOTONEURON; NONHUMAN; PRIORITY JOURNAL;

AMYOTROPHIC LATERAL SCLEROSIS; ANIMALS; ANTIGENS, CD11B; DISEASE PROGRESSION; FEMALE; HUMANS; INTEGRASES; MALE; MICE; MICE, INBRED C57BL; MICE, TRANSGENIC; MICROGLIA; MOTOR NEURONS; MUTATION; SUPEROXIDE DISMUTASE;

EID: 33744798774     PISSN: 00368075     EISSN: 10959203     Source Type: Journal    
DOI: 10.1126/science.1123511     Document Type: Article

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30. We gratefully acknowledge D.S. Howland (Molecular Genetics, Wyeth Research, Princeton, NJ 08543-8000) for the QPCR protocol; M. Mallat (U495, IFR70, INSERM UPMC, Paris, France) and V. Zujovic (UMR 546, INSERM UPMC, Paris, France) for advice on microglial cell culture; D. Swing for pronudear injection; J. Folmer for tissue sections; and T. Jessel, G. Martin, and P. Soriano for Islet1-Cre, ZP3-Cre, and Rosa26 reporter mice, respectively. This work was supported by grants from NIH (NS 27036), the Center for ALS Research at Johns Hopkins, the ALS Association, and the European Commission (LSHG-CT-2005-005203). S.B. is a recipient of a Fondation pour la Recherche Medicale fellowship and an INSERM fellowship. K.Y. is a recipient of a Uehara Memorial Foundation fellowship and a Development grant from the Muscular Dystrophy Association.