메뉴 건너뛰기




Volumn 22, Issue 11, 2017, Pages 1576-1584

Deficient autophagy in microglia impairs synaptic pruning and causes social behavioral defects

Author keywords

[No Author keywords available]

Indexed keywords

AUTOPHAGY RELATED PROTEIN 7; LYSOZYME;

EID: 84978168223     PISSN: 13594184     EISSN: 14765578     Source Type: Journal    
DOI: 10.1038/mp.2016.103     Document Type: Article
Times cited : (326)

References (74)
  • 2
    • 67650750977 scopus 로고    scopus 로고
    • A synaptic trek to autism
    • Bourgeron T. A synaptic trek to autism. Curr Opin Neurobiol 2009; 19: 231-234.
    • (2009) Curr Opin Neurobiol , vol.19 , pp. 231-234
    • Bourgeron, T.1
  • 3
    • 84867426528 scopus 로고    scopus 로고
    • Cellular and synaptic network defects in autism
    • Peca J, Feng G. Cellular and synaptic network defects in autism. Curr Opin Neurobiol 2012; 22: 866-872.
    • (2012) Curr Opin Neurobiol , vol.22 , pp. 866-872
    • Peca, J.1    Feng, G.2
  • 4
    • 72049108920 scopus 로고    scopus 로고
    • Increased dendritic spine densities on cortical projection neurons in autism spectrum disorders
    • Hutsler JJ, Zhang H. Increased dendritic spine densities on cortical projection neurons in autism spectrum disorders. Brain Res 2010; 1309: 83-94.
    • (2010) Brain Res , vol.1309 , pp. 83-94
    • Hutsler, J.J.1    Zhang, H.2
  • 5
    • 84862659562 scopus 로고    scopus 로고
    • Synaptic dysfunction in neurodevelopmental disorders associated with autism and intellectual disabilities
    • Zoghbi HY, Bear MF. Synaptic dysfunction in neurodevelopmental disorders associated with autism and intellectual disabilities. Cold Spring Harb Perspect Biol 2012; 4: a009886.
    • (2012) Cold Spring Harb Perspect Biol , vol.4 , pp. a009886
    • Zoghbi, H.Y.1    Bear, M.F.2
  • 6
    • 0019321644 scopus 로고
    • Elimination of synapses in the developing nervous system
    • Purves D, Lichtman JW. Elimination of synapses in the developing nervous system. Science 1980; 210: 153-157.
    • (1980) Science , vol.210 , pp. 153-157
    • Purves, D.1    Lichtman, J.W.2
  • 7
    • 0022450104 scopus 로고
    • Concurrent overproduction of synapses in diverse regions of the primate cerebral cortex
    • Rakic P, Bourgeois JP, Eckenhoff MF, Zecevic N, Goldman-Rakic PS. Concurrent overproduction of synapses in diverse regions of the primate cerebral cortex. Science 1986; 232: 232-235.
    • (1986) Science , vol.232 , pp. 232-235
    • Rakic, P.1    Bourgeois, J.P.2    Eckenhoff, M.F.3    Zecevic, N.4    Goldman-Rakic, P.S.5
  • 8
    • 1842455828 scopus 로고    scopus 로고
    • Neural activity and the dynamics of central nervous system development
    • Hua JY, Smith SJ. Neural activity and the dynamics of central nervous system development. Nat Neurosci 2004; 7: 327-332.
    • (2004) Nat Neurosci , vol.7 , pp. 327-332
    • Hua, J.Y.1    Smith, S.J.2
  • 9
    • 0029963657 scopus 로고    scopus 로고
    • Synaptic activity and the construction of cortical circuits
    • Katz LC, Shatz CJ. Synaptic activity and the construction of cortical circuits. Science 1996; 274: 1133-1138.
    • (1996) Science , vol.274 , pp. 1133-1138
    • Katz, L.C.1    Shatz, C.J.2
  • 10
    • 84896692474 scopus 로고    scopus 로고
    • Deficient neuron-microglia signaling results in impaired functional brain connectivity and social behavior
    • Zhan Y, Paolicelli RC, Sforazzini F, Weinhard L, Bolasco G, Pagani F et al. Deficient neuron-microglia signaling results in impaired functional brain connectivity and social behavior. Nat Neurosci 2014; 17: 400-406.
    • (2014) Nat Neurosci , vol.17 , pp. 400-406
    • Zhan, Y.1    Paolicelli, R.C.2    Sforazzini, F.3    Weinhard, L.4    Bolasco, G.5    Pagani, F.6
  • 11
    • 84907987626 scopus 로고    scopus 로고
    • Loss of mTOR-dependent macroautophagy causes autistic-like synaptic pruning deficits
    • Tang G, Gudsnuk K, Kuo SH, Cotrina ML, Rosoklija G, Sosunov A et al. Loss of mTOR-dependent macroautophagy causes autistic-like synaptic pruning deficits. Neuron 2014; 83: 1131-1143.
    • (2014) Neuron , vol.83 , pp. 1131-1143
    • Tang, G.1    Gudsnuk, K.2    Kuo, S.H.3    Cotrina, M.L.4    Rosoklija, G.5    Sosunov, A.6
  • 12
    • 84937558111 scopus 로고    scopus 로고
    • Immune mediators in the brain and peripheral tissues in autism spectrum disorder
    • Estes ML, McAllister AK. Immune mediators in the brain and peripheral tissues in autism spectrum disorder. Nat Rev Neurosci 2015; 16: 469-486.
    • (2015) Nat Rev Neurosci , vol.16 , pp. 469-486
    • Estes, M.L.1    McAllister, A.K.2
  • 13
    • 84861427387 scopus 로고    scopus 로고
    • Microglia sculpt postnatal neural circuits in an activity and complementdependent manner
    • Schafer DP, Lehrman EK, Kautzman AG, Koyama R, Mardinly AR, Yamasaki R et al. Microglia sculpt postnatal neural circuits in an activity and complementdependent manner. Neuron 2012; 74: 691-705.
    • (2012) Neuron , vol.74 , pp. 691-705
    • Schafer, D.P.1    Lehrman, E.K.2    Kautzman, A.G.3    Koyama, R.4    Mardinly, A.R.5    Yamasaki, R.6
  • 14
    • 84946471921 scopus 로고    scopus 로고
    • Microglia in the pathogenesis of autism spectrum disorders
    • Koyama R, Ikegaya Y. Microglia in the pathogenesis of autism spectrum disorders. Neurosci Res 2015; 100: 1-5.
    • (2015) Neurosci Res , vol.100 , pp. 1-5
    • Koyama, R.1    Ikegaya, Y.2
  • 16
    • 84871280445 scopus 로고    scopus 로고
    • Evidence of microglial activation in autism and its possible role in brain underconnectivity
    • Rodriguez JI, Kern JK. Evidence of microglial activation in autism and its possible role in brain underconnectivity. Neuron Glia Biol 2011; 7: 205-213.
    • (2011) Neuron Glia Biol , vol.7 , pp. 205-213
    • Rodriguez, J.I.1    Kern, J.K.2
  • 17
    • 77955684004 scopus 로고    scopus 로고
    • Microglial activation and increased microglial density observed in the dorsolateral prefrontal cortex in autism
    • Morgan JT, Chana G, Pardo CA, Achim C, Semendeferi K, Buckwalter J et al. Microglial activation and increased microglial density observed in the dorsolateral prefrontal cortex in autism. Biol Psychiatry 2010; 68: 368-376.
    • (2010) Biol Psychiatry , vol.68 , pp. 368-376
    • Morgan, J.T.1    Chana, G.2    Pardo, C.A.3    Achim, C.4    Semendeferi, K.5    Buckwalter, J.6
  • 19
  • 20
    • 84923384915 scopus 로고    scopus 로고
    • Transcriptome analysis reveals dysregulation of innate immune response genes and neuronal activitydependent genes in autism
    • Gupta S, Ellis SE, Ashar FN, Moes A, Bader JS, Zhan J et al. Transcriptome analysis reveals dysregulation of innate immune response genes and neuronal activitydependent genes in autism. Nat Commun 2014; 5: 5748.
    • (2014) Nat Commun , vol.5 , pp. 5748
    • Gupta, S.1    Ellis, S.E.2    Ashar, F.N.3    Moes, A.4    Bader, J.S.5    Zhan, J.6
  • 22
    • 84896465806 scopus 로고    scopus 로고
    • Neuronal autophagy and neurodevelopmental disorders
    • Lee KM, Hwang SK, Lee JA. Neuronal autophagy and neurodevelopmental disorders. Exp Neurobiol 2013; 22: 133-142.
    • (2013) Exp Neurobiol , vol.22 , pp. 133-142
    • Lee, K.M.1    Hwang, S.K.2    Lee, J.A.3
  • 23
    • 84885222459 scopus 로고    scopus 로고
    • Identification of small exonic CNV from whole-exome sequence data and application to autism spectrum disorder
    • Poultney CS, Goldberg AP, Drapeau E, Kou Y, Harony-Nicolas H, Kajiwara Y et al. Identification of small exonic CNV from whole-exome sequence data and application to autism spectrum disorder. Am J Hum Genet 2013; 93: 607-619.
    • (2013) Am J Hum Genet , vol.93 , pp. 607-619
    • Poultney, C.S.1    Goldberg, A.P.2    Drapeau, E.3    Kou, Y.4    Harony-Nicolas, H.5    Kajiwara, Y.6
  • 24
    • 77954116814 scopus 로고    scopus 로고
    • Autophagy gone awry in neurodegenerative diseases
    • Wong E, Cuervo AM. Autophagy gone awry in neurodegenerative diseases. Nat Neurosci 2010; 13: 805-811.
    • (2010) Nat Neurosci , vol.13 , pp. 805-811
    • Wong, E.1    Cuervo, A.M.2
  • 26
    • 57049094384 scopus 로고    scopus 로고
    • Okadaic acid increases autophagosomes in rat neurons: Implications for Alzheimer's disease
    • Yoon SY, Choi JE, Kweon HS, Choe H, Kim SW, Hwang O et al. Okadaic acid increases autophagosomes in rat neurons: implications for Alzheimer's disease. J Neurosci Res 2008; 86: 3230-3239.
    • (2008) J Neurosci Res , vol.86 , pp. 3230-3239
    • Yoon, S.Y.1    Choi, J.E.2    Kweon, H.S.3    Choe, H.4    Kim, S.W.5    Hwang, O.6
  • 28
    • 84901380438 scopus 로고    scopus 로고
    • Heterozygous ambra1 deficiency in mice: A genetic trait with autism-like behavior restricted to the female gender
    • Dere E, Dahm L, Lu D, Hammerschmidt K, Ju A, Tantra M et al. Heterozygous ambra1 deficiency in mice: a genetic trait with autism-like behavior restricted to the female gender. Front Behav Neurosci 2014; 8: 181.
    • (2014) Front Behav Neurosci , vol.8 , pp. 181
    • Dere, E.1    Dahm, L.2    Lu, D.3    Hammerschmidt, K.4    Ju, A.5    Tantra, M.6
  • 29
    • 60849109211 scopus 로고    scopus 로고
    • Pharmacological inhibition of mTORC1 suppresses anatomical, cellular, and behavioral abnormalities in neural-specific Pten knock-out mice
    • Zhou J, Blundell J, Ogawa S, Kwon CH, Zhang W, Sinton C et al. Pharmacological inhibition of mTORC1 suppresses anatomical, cellular, and behavioral abnormalities in neural-specific Pten knock-out mice. J Neurosci 2009; 29: 1773-1783.
    • (2009) J Neurosci , vol.29 , pp. 1773-1783
    • Zhou, J.1    Blundell, J.2    Ogawa, S.3    Kwon, C.H.4    Zhang, W.5    Sinton, C.6
  • 30
    • 0242268407 scopus 로고    scopus 로고
    • MTor is required for hypertrophy of Ptendeficient neuronal soma in vivo
    • Kwon CH, Zhu X, Zhang J, Baker SJ. mTor is required for hypertrophy of Ptendeficient neuronal soma in vivo. Proc Natl Acad Sci USA 2003; 100: 12923-12928.
    • (2003) Proc Natl Acad Sci USA , vol.100 , pp. 12923-12928
    • Kwon, C.H.1    Zhu, X.2    Zhang, J.3    Baker, S.J.4
  • 31
    • 84907898151 scopus 로고    scopus 로고
    • Autophagy in microglia degrades extracellular beta-amyloid fibrils and regulates the NLRP3 inflammasome
    • Cho MH, Cho K, Kang HJ, Jeon EY, Kim HS, Kwon HJ et al. Autophagy in microglia degrades extracellular beta-amyloid fibrils and regulates the NLRP3 inflammasome. Autophagy 2014; 10: 1761-1775.
    • (2014) Autophagy , vol.10 , pp. 1761-1775
    • Cho, M.H.1    Cho, K.2    Kang, H.J.3    Jeon, E.Y.4    Kim, H.S.5    Kwon, H.J.6
  • 32
    • 84894073488 scopus 로고    scopus 로고
    • Beta-Amyloid is transmitted via neuronal connections along axonal membranes
    • Song HL, Shim S, Kim DH, Won SH, Joo S, Kim S et al. beta-Amyloid is transmitted via neuronal connections along axonal membranes. Ann Neurol 2014; 75: 88-97.
    • (2014) Ann Neurol , vol.75 , pp. 88-97
    • Song, H.L.1    Shim, S.2    Kim, D.H.3    Won, S.H.4    Joo, S.5    Kim, S.6
  • 33
    • 84928181637 scopus 로고    scopus 로고
    • Disease-associated mutations of TREM2 alter the processing of N-linked oligosaccharides in the Golgi apparatus
    • Park JS, Ji IJ, An HJ, Kang MJ, Kang SW, Kim DH et al. Disease-associated mutations of TREM2 alter the processing of N-linked oligosaccharides in the Golgi apparatus. Traffic 2015; 16: 510-518.
    • (2015) Traffic , vol.16 , pp. 510-518
    • Park, J.S.1    Ji, I.J.2    An, H.J.3    Kang, M.J.4    Kang, S.W.5    Kim, D.H.6
  • 34
    • 33646800306 scopus 로고    scopus 로고
    • Loss of autophagy in the central nervous system causes neurodegeneration in mice
    • Komatsu M, Waguri S, Chiba T, Murata S, Iwata J, Tanida I et al. Loss of autophagy in the central nervous system causes neurodegeneration in mice. Nature 2006; 441: 880-884.
    • (2006) Nature , vol.441 , pp. 880-884
    • Komatsu, M.1    Waguri, S.2    Chiba, T.3    Murata, S.4    Iwata, J.5    Tanida, I.6
  • 36
    • 84921980319 scopus 로고    scopus 로고
    • NMDA receptor dysfunction in autism spectrum disorders
    • Lee EJ, Choi SY, Kim E. NMDA receptor dysfunction in autism spectrum disorders. Curr Opin Pharmacol 2015; 20: 8-13.
    • (2015) Curr Opin Pharmacol , vol.20 , pp. 8-13
    • Lee, E.J.1    Choi, S.Y.2    Kim, E.3
  • 37
  • 38
    • 84901253775 scopus 로고    scopus 로고
    • Dynamic microglial alterations underlie stress-induced depressive-like behavior and suppressed neurogenesis
    • Kreisel T, Frank MG, Licht T, Reshef R, Ben-Menachem-Zidon O, Baratta MV et al. Dynamic microglial alterations underlie stress-induced depressive-like behavior and suppressed neurogenesis. Mol Psychiatry 2014; 19: 699-709.
    • (2014) Mol Psychiatry , vol.19 , pp. 699-709
    • Kreisel, T.1    Frank, M.G.2    Licht, T.3    Reshef, R.4    Ben-Menachem-Zidon, O.5    Baratta, M.V.6
  • 39
    • 7744224673 scopus 로고    scopus 로고
    • Microglia and neuroinflammation: A pathological perspective
    • Streit WJ, Mrak RE, Griffin WS. Microglia and neuroinflammation: a pathological perspective. J Neuroinflam 2004; 1: 14.
    • (2004) J Neuroinflam , vol.1 , pp. 14
    • Streit, W.J.1    Mrak, R.E.2    Griffin, W.S.3
  • 41
    • 30044434850 scopus 로고    scopus 로고
    • Microglia activated by IL-4 or IFN-gamma differentially induce neurogenesis and oligodendrogenesis from adult stem/progenitor cells
    • Butovsky O, Ziv Y, Schwartz A, Landa G, Talpalar AE, Pluchino S et al. Microglia activated by IL-4 or IFN-gamma differentially induce neurogenesis and oligodendrogenesis from adult stem/progenitor cells. Mol Cell Neurosci 2006; 31: 149-160.
    • (2006) Mol Cell Neurosci , vol.31 , pp. 149-160
    • Butovsky, O.1    Ziv, Y.2    Schwartz, A.3    Landa, G.4    Talpalar, A.E.5    Pluchino, S.6
  • 42
    • 84876939061 scopus 로고    scopus 로고
    • Layer v cortical neurons require microglial support for survival during postnatal development
    • Ueno M, Fujita Y, Tanaka T, Nakamura Y, Kikuta J, Ishii M et al. Layer V cortical neurons require microglial support for survival during postnatal development. Nat Neurosci 2013; 16: 543-551.
    • (2013) Nat Neurosci , vol.16 , pp. 543-551
    • Ueno, M.1    Fujita, Y.2    Tanaka, T.3    Nakamura, Y.4    Kikuta, J.5    Ishii, M.6
  • 43
    • 84855341900 scopus 로고    scopus 로고
    • SHANK3 mutations identified in autism lead to modification of dendritic spine morphology via an actin-dependent mechanism
    • Durand CM, Perroy J, Loll F, Perrais D, Fagni L, Bourgeron T et al. SHANK3 mutations identified in autism lead to modification of dendritic spine morphology via an actin-dependent mechanism. Mol Psychiatry 2012; 17: 71-84.
    • (2012) Mol Psychiatry , vol.17 , pp. 71-84
    • Durand, C.M.1    Perroy, J.2    Loll, F.3    Perrais, D.4    Fagni, L.5    Bourgeron, T.6
  • 44
    • 78751672975 scopus 로고    scopus 로고
    • Autophagy in immunity and inflammation
    • Levine B, Mizushima N, Virgin HW. Autophagy in immunity and inflammation. Nature 2011; 469: 323-335.
    • (2011) Nature , vol.469 , pp. 323-335
    • Levine, B.1    Mizushima, N.2    Virgin, H.W.3
  • 45
    • 84886797274 scopus 로고    scopus 로고
    • Autophagy in infection, inflammation and immunity
    • Deretic V, Saitoh T, Akira S. Autophagy in infection, inflammation and immunity. Nat Rev Immunol 2013; 13: 722-737.
    • (2013) Nat Rev Immunol , vol.13 , pp. 722-737
    • Deretic, V.1    Saitoh, T.2    Akira, S.3
  • 46
    • 84958106930 scopus 로고    scopus 로고
    • Differential roles of M1 and M2 microglia in neurodegenerative diseases
    • Tang Y, Le W. Differential roles of M1 and M2 microglia in neurodegenerative diseases. Mol Neurobiol 2015; 53: 1181-1194.
    • (2015) Mol Neurobiol , vol.53 , pp. 1181-1194
    • Tang, Y.1    Le, W.2
  • 47
    • 84957436714 scopus 로고    scopus 로고
    • Microglial M1/M2 polarization and metabolic states
    • Orihuela R, McPherson CA, Harry GJ. Microglial M1/M2 polarization and metabolic states. Br J Pharmacol 2015; 173: 649-665.
    • (2015) Br J Pharmacol , vol.173 , pp. 649-665
    • Orihuela, R.1    McPherson, C.A.2    Harry, G.J.3
  • 48
    • 84899723367 scopus 로고    scopus 로고
    • The AMPK-PPARGC1A pathway is required for antimicrobial host defense through activation of autophagy
    • Yang CS, Kim JJ, Lee HM, Jin HS, Lee SH, Park JH et al. The AMPK-PPARGC1A pathway is required for antimicrobial host defense through activation of autophagy. Autophagy 2014; 10: 785-802.
    • (2014) Autophagy , vol.10 , pp. 785-802
    • Yang, C.S.1    Kim, J.J.2    Lee, H.M.3    Jin, H.S.4    Lee, S.H.5    Park, J.H.6
  • 49
    • 84876891097 scopus 로고    scopus 로고
    • Autophagy in obesity and atherosclerosis: Interrelationships between cholesterol homeostasis, lipoprotein metabolism and autophagy in macrophages and other systems
    • Ouimet M. Autophagy in obesity and atherosclerosis: interrelationships between cholesterol homeostasis, lipoprotein metabolism and autophagy in macrophages and other systems. Biochim Biophys Acta 2013; 1831: 1124-1133.
    • (2013) Biochim Biophys Acta , vol.1831 , pp. 1124-1133
    • Ouimet, M.1
  • 51
    • 84927641793 scopus 로고    scopus 로고
    • Impaired macrophage autophagy increases the immune response in obese mice by promoting proinflammatory macrophage polarization
    • Liu K, Zhao E, Ilyas G, Lalazar G, Lin Y, Haseeb M et al. Impaired macrophage autophagy increases the immune response in obese mice by promoting proinflammatory macrophage polarization. Autophagy 2015; 11: 271-284.
    • (2015) Autophagy , vol.11 , pp. 271-284
    • Liu, K.1    Zhao, E.2    Ilyas, G.3    Lalazar, G.4    Lin, Y.5    Haseeb, M.6
  • 52
    • 84927170323 scopus 로고    scopus 로고
    • Dysregulated brain immunity and neurotrophin signaling in Rett syndrome and autism spectrum disorders
    • Theoharides TC, Athanassiou M, Panagiotidou S, Doyle R. Dysregulated brain immunity and neurotrophin signaling in Rett syndrome and autism spectrum disorders. J Neuroimmunol 2015; 279: 33-38.
    • (2015) J Neuroimmunol , vol.279 , pp. 33-38
    • Theoharides, T.C.1    Athanassiou, M.2    Panagiotidou, S.3    Doyle, R.4
  • 53
    • 84901050518 scopus 로고    scopus 로고
    • Evidence linking oxidative stress, mitochondrial dysfunction, and inflammation in the brain of individuals with autism
    • Rossignol DA, Frye RE. Evidence linking oxidative stress, mitochondrial dysfunction, and inflammation in the brain of individuals with autism. Front Physiol 2014; 5: 150.
    • (2014) Front Physiol , vol.5 , pp. 150
    • Rossignol, D.A.1    Frye, R.E.2
  • 54
    • 84930197296 scopus 로고    scopus 로고
    • The role of inflammation and microglial activation in the pathophysiology of psychiatric disorders
    • Reus GZ, Fries GR, Stertz L, Badawy M, Passos IC, Barichello T et al. The role of inflammation and microglial activation in the pathophysiology of psychiatric disorders. Neuroscience 2015; 300: 141-154.
    • (2015) Neuroscience , vol.300 , pp. 141-154
    • Reus, G.Z.1    Fries, G.R.2    Stertz, L.3    Badawy, M.4    Passos, I.C.5    Barichello, T.6
  • 55
    • 84937977607 scopus 로고    scopus 로고
    • Prenatal factors associated with autism spectrum disorder (ASD)
    • Ornoy A, Weinstein-Fudim L, Ergaz Z. Prenatal factors associated with autism spectrum disorder (ASD). Reprod Toxicol 2015; 56: 155-169.
    • (2015) Reprod Toxicol , vol.56 , pp. 155-169
    • Ornoy, A.1    Weinstein-Fudim, L.2    Ergaz, Z.3
  • 56
    • 84922616643 scopus 로고    scopus 로고
    • Maternal inflammation contributes to brain overgrowth and autism-associated behaviors through altered redox signaling in stem and progenitor cells
    • Le Belle JE, Sperry J, Ngo A, Ghochani Y, Laks DR, Lopez-Aranda M et al. Maternal inflammation contributes to brain overgrowth and autism-associated behaviors through altered redox signaling in stem and progenitor cells. Stem Cell Rep 2014; 3: 725-734.
    • (2014) Stem Cell Rep , vol.3 , pp. 725-734
    • Le Belle, J.E.1    Sperry, J.2    Ngo, A.3    Ghochani, Y.4    Laks, D.R.5    Lopez-Aranda, M.6
  • 60
    • 84886775282 scopus 로고    scopus 로고
    • A review of the role of female gender in autism spectrum disorders
    • Kirkovski M, Enticott PG, Fitzgerald PB. A review of the role of female gender in autism spectrum disorders. J Autism Dev Disord 2013; 43: 2584-2603.
    • (2013) J Autism Dev Disord , vol.43 , pp. 2584-2603
    • Kirkovski, M.1    Enticott, P.G.2    Fitzgerald, P.B.3
  • 61
    • 84860741138 scopus 로고    scopus 로고
    • Sporadic autism exomes reveal a highly interconnected protein network of de novo mutations
    • O'Roak BJ, Vives L, Girirajan S, Karakoc E, Krumm N, Coe BP et al. Sporadic autism exomes reveal a highly interconnected protein network of de novo mutations. Nature 2012; 485: 246-250.
    • (2012) Nature , vol.485 , pp. 246-250
    • O'Roak, B.J.1    Vives, L.2    Girirajan, S.3    Karakoc, E.4    Krumm, N.5    Coe, B.P.6
  • 62
    • 84871448593 scopus 로고    scopus 로고
    • Multiplex targeted sequencing identifies recurrently mutated genes in autism spectrum disorders
    • O'Roak BJ, Vives L, Fu W, Egertson JD, Stanaway IB, Phelps IG et al. Multiplex targeted sequencing identifies recurrently mutated genes in autism spectrum disorders. Science 2012; 338: 1619-1622.
    • (2012) Science , vol.338 , pp. 1619-1622
    • O'Roak, B.J.1    Vives, L.2    Fu, W.3    Egertson, J.D.4    Stanaway, I.B.5    Phelps, I.G.6
  • 64
    • 84954561845 scopus 로고    scopus 로고
    • Sexual divergence in microtubule function: The novel intranasal microtubule targeting SKIP normalizes axonal transport and enhances memory
    • e-pub ahead of print 19 January
    • Amram N, Hacohen-Kleiman G, Sragovich S, Malishkevich A, Katz J, Touloumi O et al. Sexual divergence in microtubule function: the novel intranasal microtubule targeting SKIP normalizes axonal transport and enhances memory. Mol Psychiatry (e-pub ahead of print 19 January 2016; doi:10.1038/mp.2015.208).
    • (2016) Mol Psychiatry
    • Amram, N.1    Hacohen-Kleiman, G.2    Sragovich, S.3    Malishkevich, A.4    Katz, J.5    Touloumi, O.6
  • 65
    • 84927754004 scopus 로고    scopus 로고
    • Activity-dependent neuroprotective protein (ADNP) exhibits striking sexual dichotomy impacting on autistic and Alzheimer's pathologies
    • Malishkevich A, Amram N, Hacohen-Kleiman G, Magen I, Giladi E, Gozes I. Activity-dependent neuroprotective protein (ADNP) exhibits striking sexual dichotomy impacting on autistic and Alzheimer's pathologies. Transl Psychiatry 2015; 5: e501.
    • (2015) Transl Psychiatry , vol.5 , pp. e501
    • Malishkevich, A.1    Amram, N.2    Hacohen-Kleiman, G.3    Magen, I.4    Giladi, E.5    Gozes, I.6
  • 66
    • 20844438514 scopus 로고    scopus 로고
    • The expression of activity-dependent neuroprotective protein (ADNP) is regulated by brain damage and treatment of mice with the ADNP derived peptide, NAP, reduces the severity of traumatic head injury
    • Gozes I, Zaltzman R, Hauser J, Brenneman DE, Shohami E, Hill JM. The expression of activity-dependent neuroprotective protein (ADNP) is regulated by brain damage and treatment of mice with the ADNP derived peptide, NAP, reduces the severity of traumatic head injury. Curr Alzheimer Res 2005; 2: 149-153.
    • (2005) Curr Alzheimer Res , vol.2 , pp. 149-153
    • Gozes, I.1    Zaltzman, R.2    Hauser, J.3    Brenneman, D.E.4    Shohami, E.5    Hill, J.M.6
  • 67
    • 84857917135 scopus 로고    scopus 로고
    • Sex differences in microglial colonization of the developing rat brain
    • Schwarz JM, Sholar PW, Bilbo SD. Sex differences in microglial colonization of the developing rat brain. J Neurochem 2012; 120: 948-963.
    • (2012) J Neurochem , vol.120 , pp. 948-963
    • Schwarz, J.M.1    Sholar, P.W.2    Bilbo, S.D.3
  • 68
    • 84930342622 scopus 로고    scopus 로고
    • A starring role for microglia in brain sex differences
    • Lenz KM, McCarthy MM. A starring role for microglia in brain sex differences. Neuroscientist 2015; 21: 306-321.
    • (2015) Neuroscientist , vol.21 , pp. 306-321
    • Lenz, K.M.1    McCarthy, M.M.2
  • 69
    • 84873693906 scopus 로고    scopus 로고
    • Microglia are essential to masculinization of brain and behavior
    • Lenz KM, Nugent BM, Haliyur R, McCarthy MM. Microglia are essential to masculinization of brain and behavior. J Neurosci 2013; 33: 2761-2772.
    • (2013) J Neurosci , vol.33 , pp. 2761-2772
    • Lenz, K.M.1    Nugent, B.M.2    Haliyur, R.3    McCarthy, M.M.4
  • 70
    • 3042555347 scopus 로고    scopus 로고
    • Autism and learning disability
    • O'Brien G, Pearson J. Autism and learning disability. Autism 2004; 8: 125-140.
    • (2004) Autism , vol.8 , pp. 125-140
    • O'Brien, G.1    Pearson, J.2
  • 71
    • 73149102059 scopus 로고    scopus 로고
    • Prevalence of autism spectrum disorders-autism and developmental disabilities monitoring network, United States, 2006
    • Investigators. AaDDMNSYP, (CDC). CfDCaP
    • Investigators. AaDDMNSYP, (CDC). CfDCaP. Prevalence of autism spectrum disorders-Autism and Developmental Disabilities Monitoring Network, United States, 2006. MMWR Surveill Summ 2009; 58: 1-20.
    • (2009) MMWR Surveill Summ , vol.58 , pp. 1-20
  • 72
    • 84975687993 scopus 로고    scopus 로고
    • Identification of segregated regions in the functional brain connectome of autistic patients by a combination of fuzzy spectral clustering and entropy analysis
    • Sato JR, Balardin J, Vidal MC, Fujita A. Identification of segregated regions in the functional brain connectome of autistic patients by a combination of fuzzy spectral clustering and entropy analysis. J Psychiatry Neurosci 2015; 41: 140364.
    • (2015) J Psychiatry Neurosci , vol.41 , pp. 140364
    • Sato, J.R.1    Balardin, J.2    Vidal, M.C.3    Fujita, A.4
  • 73
    • 84952875612 scopus 로고    scopus 로고
    • Abnormal wiring of the connectome in adults with high-functioning autism spectrum disorder
    • Roine U, Roine T, Salmi J, Nieminen-von Wendt T, Tani P, Leppamaki S et al. Abnormal wiring of the connectome in adults with high-functioning autism spectrum disorder. Mol Autism 2015; 6: 65.
    • (2015) Mol Autism , vol.6 , pp. 65
    • Roine, U.1    Roine, T.2    Salmi, J.3    Nieminen-Von Wendt, T.4    Tani, P.5    Leppamaki, S.6
  • 74
    • 84923174333 scopus 로고    scopus 로고
    • The idiosyncratic brain: Distortion of spontaneous connectivity patterns in autism spectrum disorder
    • Hahamy A, Behrmann M, Malach R. The idiosyncratic brain: distortion of spontaneous connectivity patterns in autism spectrum disorder. Nat Neurosci 2015; 18: 302-309.
    • (2015) Nat Neurosci , vol.18 , pp. 302-309
    • Hahamy, A.1    Behrmann, M.2    Malach, R.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.