Evidence for increased microglial priming and macrophage recruitment in the dorsal anterior cingulate white matter of depressed suicides

Brain, Behavior, and Immunity

Volumn 42, Issue , 2014, Pages 50-59

  Torres Platas, Susana G ^a,b   Cruceanu, Cristiana ^a,b   Chen, Gary Gang ^a   Turecki, Gustavo ^a,b,c   Mechawar, Naguib ^a,b,c  

^a MCGILL UNIVERSITY   (Canada)

^b MCGILL UNIVERSITY   (Canada)

^c MCGILL UNIVERSITY   (Canada)

Author keywords

Anterior cingulate cortex; Depression; Human; Microglia; Neuroinflammation; Perivascular macrophages; Suicide

Indexed keywords

ADAPTOR PROTEIN; CD45 ANTIGEN; IONIZED CALCIUM BINDING ADAPTOR MOLECULE 1; MESSENGER RNA; MONOCYTE CHEMOTACTIC PROTEIN 1; UNCLASSIFIED DRUG;

ADULT; ANTERIOR CINGULATE; ARTICLE; ASTROCYTE; CLINICAL ARTICLE; CONTROLLED STUDY; DEPRESSION; DORSAL ANTERIOR CINGULATE CORTEX; FEMALE; GENE EXPRESSION; HUMAN; IMMUNOHISTOCHEMISTRY; MACROPHAGE; MALE; MICROGLIA; MONOCYTE; MOOD DISORDER; NERVOUS SYSTEM INFLAMMATION; PHENOTYPE; STEREOLOGY; SUICIDE; WHITE MATTER; CINGULATE GYRUS; IMMUNOLOGY; MACROPHAGE ACTIVATION; MIDDLE AGED; PATHOLOGY; PSYCHOLOGY;

ADULT; DEPRESSIVE DISORDER; FEMALE; GYRUS CINGULI; HUMANS; MACROPHAGE ACTIVATION; MACROPHAGES; MALE; MICROGLIA; MIDDLE AGED; SUICIDE; WHITE MATTER;

EID: 84908617290     PISSN: 08891591     EISSN: 10902139     Source Type: Journal    
DOI: 10.1016/j.bbi.2014.05.007     Document Type: Article

References (50)

1. Aguliar-Valles A., Kim J., Jung S., Woodside B., Luheshi G.N. Role of brain transmigrating neutrophils in depression-like behavior during systemic infection. Mol. Psychiatry 2013, 19(5):633.
2. Audoy-Remus J., Richard J.F., Soulet D., Zhou H., Kubes P., Vallieres L. Rod-Shaped monocytes patrol the brain vasculature and give rise to perivascular macrophages under the influence of proinflammatory cytokines and angiopoietin-2. J. Neurosci. 2008, 28(41):10187-10199.
3. Bay-Richter C., Janelidze S., Hallberg L., Brundin L. Changes in behaviour and cytokine expression upon a peripheral immune challenge. Behav. Brain Res. 2011, 222(1):193-199.
4. Bessette K.L., Nave A.M., Caprihan A., Stevens M.C. White matter abnormalities in adolescents with major depressive disorder. Brain Imaging Behav. 2013, [Epub ahead of print].
5. Bracht T., Horn H., Strik W., Federspiel A., Schnell S., Hofle O., et al. White matter microstructure alterations of the medial forebrain bundle in melancholic depression. J. Affect. Disord. 2013, 155:186-193.
6. Capuron L., Miller A.H. Cytokines and psychopathology: lessons from interferon-alpha. Biol. Psychiatry 2004, 56(11):819-824.
7. Capuron L., Pagnoni G., Demetrashvili M., Woolwine B.J., Nemeroff C.B., Berns G.S., et al. Anterior cingulate activation and error processing during interferon-alpha treatment. Biol. Psychiatry 2005, 58(3):190-196.
8. Chana G., Landau S., Beasley C., Everall I.P., Cotter D. Two-dimensional assessment of cytoarchitecture in the anterior cingulate cortex in major depressive disorder, bipolar disorder, and schizophrenia: evidence for decreased neuronal somal size and increased neuronal density. Biol. Psychiatry 2003, 53(12):1086-1098.
9. Chen Y.W., Dilsaver S.C. Lifetime rates of suicide attempts among subjects with bipolar and unipolar disorders relative to subjects with other Axis I disorders. Biol. Psychiatry 1996, 39(10):896-899.
10. Dantzer R., O'Connor J.C., Freund G.G., Johnson R.W., Kelley K.W. From inflammation to sickness and depression: when the immune system subjugates the brain. Nat. Rev. Neurosci. 2008, 9(1):46-56.
11. Dean B. Understanding the role of inflammatory-related pathways in the pathophysiology and treatment of psychiatric disorders: evidence from human peripheral studies and CNS studies. Int. J. Neuropsychopharmacol. 2011, 14(7):997-1012.
12. Dibaj P., Steffens H., Nadrigny F., Neusch C., Kirchhoff F., Schomburg E.D. Longlasting post-mortem activity of spinal microglia in situ in mice. J. Neurosci. Res. 2010, 88:2431-2440.
13. Dowlati Y., Herrmann N., Swardfager W., Liu H., Sham L., Reim E.K., et al. A meta-analysis of cytokines in major depression. Biol. Psychiatry 2010, 67(5):446-457.
14. Dumais A., Lesage A.D., Alda M., Rouleau G., Dumont M., Chawky N., et al. Risk factors for suicide completion in major depression: a case-control study of impulsive and aggressive behaviors in men. Am. J. Psychiatry 2005, 162(11):2116-2124.
15. Ebert D., Ebmeier K.P. The role of the cingulate gyrus in depression: from functional anatomy to neurochemistry. Biol. Psychiatry 1996, 39(12):1044-1050.
16. Edgar N., Sibille E. A putative functional role for oligodendrocytes in mood regulation. Transl. Psychiatry 2012, 2:e109.
17. Erhardt S., Lim C.K., Linderholm K.R., Janelidze S., Lindqvist D., Samuelsson M., et al. Connecting inflammation with glutamate agonism in suicidality. Neuropsychopharmacology 2013, 38(5):743-752.
18. Eyo U., Dailey M.E. Effects of oxygen-glucose deprivation on microglial mobility and viability in developing mouse hippocampal tissues. Glia 2012, 60:1747-1760.
19. Frasure-Smith N., Lesperance F. Depression and coronary artery disease. Herz 2006, 31(Suppl. 3):64-68.
20. Gittins R., Harrison P.J. A quantitative morphometric study of the human anterior cingulate cortex. Brain Res. 2004, 1013(2):212-222.
21. Goshen I., Kreisel T., Ben-Menachem-Zidon O., Licht T., Weidenfeld J., Ben-Hur T., et al. Brain interleukin-1 mediates chronic stress-induced depression in mice via adrenocortical activation and hippocampal neurogenesis suppression. Mol. Psychiatry 2008, 13(7):717-728.
22. Guillemin G.J., Brew B.J. Microglia, macrophages, perivascular macrophages, and pericytes: a review of function and identification. J. Leukoc. Biol. 2004, 75(3):388-397.
23. Haroon E., Woolwine B.J., Chen X., Pace T.W., Parekh S., Spivey J.R., et al. IFN-alpha-induced cortical and subcortical glutamate changes assessed by magnetic resonance spectroscopy. Neuropsychopharmacology 2014, 39(7):1777-1785.
24. Hercher C., Parent M., Flores C., Canetti L., Turecki G., Mechawar N. Alcohol dependence-related increase of glial cell density in the anterior cingulate cortex of suicide completers. J. Psychiatry Neurosci. 2009, 34(4):281-288.
25. Imai Y., Kohsaka S. Intracellular signaling in M-CSF-induced microglia activation: role of Iba1. Glia 2002, 40(2):164-174.
26. Karperien A., Ahammer H., Jelinek H.F. Quantitating the subtleties of microglial morphology with fractal analysis. Front. Cell. Neurosci. 2013, 7:3.
27. Kettenmann H., Hanisch U.K., Noda M., Verkhratsky A. Physiology of microglia. Physiol. Rev. 2011, 91(2):461-553.
28. Kim C., Lesage A., Seguin M., Chawky N., Vanier C., Lipp O., et al. Patterns of co-morbidity in male suicide completers. Psychol. Med. 2003, 33(7):1299-1309.
29. Lichtblau N., Schmidt F.M., Schumann R., Kirkby K.C., Himmerich H. Cytokines as biomarkers in depressive disorder: current standing and prospects. Int. Rev. Psychiatry 2013, 25(5):592-603.
30. Maes M., Yirmyia R., Noraberg J., Brene S., Hibbeln J., Perini G., et al. The inflammatory & neurodegenerative (I&ND) hypothesis of depression: leads for future research and new drug developments in depression. Metab. Brain Dis. 2009, 24(1):27-53.
31. Malaguarnera M., Di Fazio I., Restuccia S., Pistone G., Ferlito L., Rampello L. Interferon alpha-induced depression in chronic hepatitis C patients: comparison between different types of interferon alpha. Neuropsychobiology 1998, 37(2):93-97.
32. McNally L., Bhagwagar Z., Hannestad J. Inflammation, glutamate, and glia in depression: a literature review. CNS Spectr. 2008, 13(6):501-510.
33. Merali Z., Brennan K., Brau P., Anisman H. Dissociating anorexia and anhedonia elicited by interleukin-1beta: antidepressant and gender effects on responding for "free chow" and "earned" sucrose intake. Psychopharmacology 2003, 165(4):413-418.
34. Miller A.H., Haroon E., Raison C.L., Felger J.C. Cytokine targets in the brain: impact on neurotransmitters and neurocircuits. Depress. Anxiety 2013, 30(4):297-306.
35. Miller A.H., Maletic V., Raison C.L. Inflammation and its discontents: the role of cytokines in the pathophysiology of major depression. Biol. Psychiatry 2009, 65(9):732-741.
36. Pandey G.N., Rizavi H.S., Ren X., Fareed J., Hoppensteadt D.A., Roberts R.C., et al. Proinflammatory cytokines in the prefrontal cortex of teenage suicide victims. J. Psychiatric Res. 2012, 46(1):57-63.
37. Serrats J., Schiltz J.C., Garcia-Bueno B., van Rooijen N., Reyes T.M., Sawchenko P.E. Dual roles for perivascular macrophages in immune-to-brain signaling. Neuron 2010, 65(1):94-106.
38. Sofroniew M.V., Vinters H.V. Astrocytes: biology and pathology. Acta Neuropathol. 2010, 119(1):7-35.
39. Soltys Z., Ziaja M., Pawlinski R., Setkowicz Z., Janeczko K. Morphology of reactive microglia in the injured cerebral cortex. Fractal analysis and complementary quantitative methods. J. Neurosci. Res. 2001, 63(1):90-97.
40. Steiner J., Bielau H., Brisch R., Danos P., Ullrich O., Mawrin C., et al. Immunological aspects in the neurobiology of suicide: elevated microglial density in schizophrenia and depression is associated with suicide. J. Psychiatric Res. 2008, 42(2):151-157.
41. Steiner J., Walter M., Gos T., Guillemin G.J., Bernstein H.G., Sarnyai Z., et al. Severe depression is associated with increased microglial quinolinic acid in subregions of the anterior cingulate gyrus: evidence for an immune-modulated glutamatergic neurotransmission?. J. Neuroinflammation 2011, 8:94.
42. Stence N., Waite M., Dailey M.E. Dynamics of microglial activation: a confocal time-lapse analysis in hippocampal slices. Glia 2001, 33(3):256-266.
43. Tonelli L.H., Stiller J., Rujescu D., Giegling I., Schneider B., Maurer K., et al. Elevated cytokine expression in the orbitofrontal cortex of victims of suicide. Acta Psychiatr. Scand. 2008, 117(3):198-206.
44. Torres-Platas S.G., Comeau S., Rachalski A., Bo G.D., Cruceanu C., Turecki G., et al. Morphometric characterization of microglial phenotypes in human cerebral cortex. J. Neuroinflammation 2014, 11:12.
45. Torres-Platas S.G., Hercher C., Davoli M.A., Maussion G., Labonte B., Turecki G., et al. Astrocytic hypertrophy in anterior cingulate white matter of depressed suicides. Neuropsychopharmacology 2011, 36(13):2650-2658.
46. Vogt B.A., Nimchinsky E.A., Vogt L.J., Hof P.R. Human cingulate cortex: surface features, flat maps, and cytoarchitecture. J. Comp. Neurol. 1995, 359(3):490-506.
47. Wohleb E.S., Fenn A.M., Pacenta A.M., Powell N.D., Sheridan J.F., Godbout J.P. Peripheral innate immune challenge exaggerated microglia activation, increased the number of inflammatory CNS macrophages, and prolonged social withdrawal in socially defeated mice. Psychoneuroendocrinology 2012, 37(9):1491-1505.
48. Wohleb E.S., Powell N.D., Godbout J.P., Sheridan J.F. Stress-induced recruitment of bone marrow-derived monocytes to the brain promotes anxiety-like behavior. J. Neurosci. 2013, 33(34):13820-13833.
49. World Health Organization (2012). Media Centre Fact Sheet No. 369 . http://www.who.int/mediacentre/factsheets/fs369/en/.
50. World Health Organization (2006). World Mental Health Day 2006: 'Building Awareness - Reducing Risks: Suicide and Mental Illness . http://www.who.int/mediacentre/news/releases/2006/pr53/en/.