Cutting edge: TREM-2 attenuates macrophage activation

Journal of Immunology

Volumn 177, Issue 6, 2006, Pages 3520-3524

  Turnbull, Isaiah R ^a   Gilfillan, Susan ^a   Cella, Marina ^a   Aoshi, Taiki ^a   Miller, Mark ^a   Piccio, Laura ^a   Hernandez, Maristela ^a   Colonna, Marco ^a  

^a WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADAPTOR PROTEIN; CELL RECEPTOR; CYTOKINE; GAMMA INTERFERON; INTERLEUKIN 4; KILLER CELL ACTIVATING RECEPTOR ASSOCIATED PROTEIN; LIPOPOLYSACCHARIDE; TRIGGERING RECEPTOR EXPRESSED ON MYELOID CELLS 2; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; BONE MARROW CELL; CELL DIFFERENTIATION; CELL FUNCTION; CELL INFILTRATION; CELL MATURATION; CONTROLLED STUDY; CYTOKINE PRODUCTION; IMMUNE SYSTEM; IN VIVO STUDY; MACROPHAGE ACTIVATION; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN INDUCTION; SIGNAL TRANSDUCTION;

EID: 33748517428     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: 10.4049/jimmunol.177.6.3520     Document Type: Article

References (18)

1. Bouchon, A., C. Hernandez-Munain, M. Cella, and M. Colonna. 2001. A DAP12-mediated pathway regulates expression of CC chemokine receptor 7 and maturation of human dendritic cells. J. Exp. Med. 194: 1111-1122.
2. Daws, M. R., L. L. Lanier, W. E. Seaman, and J. C. Ryan. 2001. Cloning and characterization of a novel mouse myeloid DAP 12-associated receptor family. Eur. J. Immunol. 31: 783-791.
3. Paloneva, J., T. Manninen, G. Christman, K. Hovanes, J. Mandelin, R. Adolfsson, M. Bianchin, T. Bird, R. Miranda, A. Salmaggi, et al. 2002. Mutations in two genes encoding different subunits of a receptor signaling complex result in an identical disease phenotype. Am. J. Hum. Genet. 71: 656-662.
4. Humphrey, M. B., M. R. Daws, S. C. Spusta, E. C. Niemi, J. A. Torchia, L. L. Lanier, W. E. Seaman, and M. C. Nakamura. 2006. TREM2, a DAP12-associated receptor, regulates osteoclast differentiation and function. J. Bone Miner. Res. 21: 237-245.
5. Aoki, N., A. Zganiacz, P. Margetts, and Z. Xing. 2004. Diffetential regulation of DAP12 and molecules associated with DAP12 during host responses to mycobacterial infection. Infect. Immun. 72: 2477-2483.
6. Vivier, E., J. A. Nunes, and F. Vely. 2004. Natural killer cell signaling pathways. Science 306: 1517-1519.
7. McVicar, D. W. and D. N. Burshtyn. 2001. Intracellular signaling by the killer immunoglobulin-like receptors and Ly49. Sci. STKE. 2001: RE1.
8. Hamerman, J. A., N. K. Tchao, C. A. Lowell, and L. L. Lanier. 2005. Enhanced Toll-like receptor responses in the absence of signaling adaptor DAP12. Nat. Immunol. 6: 579-586.
9. Hamerman, J. A. and L. L. Lanier. 2006. Inhibition of immune responses by ITAM-bearing receptors. Sci. STKE. 2006: RE1.
10. Terme, M., E. Tomasello, K. Maruyama, F. Crepineau, N. Chaput, C. Flament, J. P. Marolleau, E. Angevin, E. F. Wagner, B. Salomon, et al. 2004. IL-4 confers NK stimulatory capacity to murine dendritic cells: a signaling pathway involving KARAP/DAP12-triggering receptor expressed on myeloid cell 2 molecules. J Immunol. 172: 5957-5966.
11. Takahashi, K., C. D. Rochford, and H. Neumann. 2005. Clearance of apoptotic neurons without inflammation by microglial triggering receptor expressed on myeloid cells-2. J. Exp. Med. 201: 647-657.
12. Kaifu, T., J. Nakahara, M. Inui, K. Mishima, T. Momiyama, M. Kaji, A. Sugahara, H. Koito, A. Ujike-Asai, A. Nakamura, et al. 2003. Osteopetrosis and thalamic hypomyelinosis with synaptic degeneration in DAP12-deficient mice. J. Clin. Invest. 111: 323-332.
13. Julia, V., E. M. Hessel, L. Malherbe, N. Glaichenhaus, A. O'Garra, and R. L. Coffman. 2002. A restricted subset of dendritic cells captures airborne antigens and remains able to activate specific T cells long after antigen exposure. Immunity 16: 271-283.
14. Hershey, G. K. 2003. IL-13 receptors and signaling pathways: an evolving web. J. Allergy Clin. Immunol. 111: 677-690.
15. Gordon, S. 2003. Alternative activation of macrophages. Nat. Rev. Immunol. 3: 23-35.
16. Takeda, K., T. Kaisho, and S. Akira. 2003. Toll-like receptors. Annu. Rev. Immunol. 21: 335-376.
17. Fukao, T., and S. Koyasu. 2003- PI3K and negative regulation of TLR signaling. Trends Immunol. 24: 358-363.
18. Randolph, G. J., S. Beaulieu, S. Lebecque, R. M. Steinman, and W, A. Muller. 1998. Differentiation of monocytes into dendritic cells in a model of transendothelial trafficking. Science 282: 480-483.