메뉴 건너뛰기




Volumn 111, Issue 25, 2014, Pages 9289-9294

Abrogation of α-synuclein -mediated dopaminergic neurodegeneration in LRRK2-deficient rats

Author keywords

CD68; NACP; PARK8; Rat knockout; SNCA

Indexed keywords

ALPHA SYNUCLEIN; INDUCIBLE NITRIC OXIDE SYNTHASE; LEUCINE RICH REPEAT KINASE 2; LIPOPOLYSACCHARIDE;

EID: 84903435402     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1403215111     Document Type: Article
Times cited : (179)

References (23)
  • 1
    • 48849092336 scopus 로고    scopus 로고
    • LRRK2 Gly2019Ser penetrance in Arab-Berber patients from Tunisia: A case-control genetic study
    • Hulihan MM, et al. (2008) LRRK2 Gly2019Ser penetrance in Arab-Berber patients from Tunisia: A case-control genetic study. Lancet Neurol 7(7):591-594.
    • (2008) Lancet Neurol , vol.7 , Issue.7 , pp. 591-594
    • Hulihan, M.M.1
  • 3
    • 79959851714 scopus 로고    scopus 로고
    • A two-stage meta-analysis identifies several new loci for Parkinson's disease
    • International Parkinson's Disease Genomics Consortium (IPDGC); Wellcome Trust Case Control Consortium 2 (WTCCC2)
    • International Parkinson's Disease Genomics Consortium (IPDGC); Wellcome Trust Case Control Consortium 2 (WTCCC2) (2011) A two-stage meta-analysis identifies several new loci for Parkinson's disease. PLoS Genet 7(6):e1002142.
    • (2011) PLoS Genet , vol.7 , Issue.6
  • 4
    • 79951811351 scopus 로고    scopus 로고
    • Imputation of sequence variants for identification of genetic risks for Parkinson's disease: A meta-analysis of genome-wide association studies
    • International Parkinson Disease Genomics Consortium
    • Nalls MA, et al.; International Parkinson Disease Genomics Consortium (2011) Imputation of sequence variants for identification of genetic risks for Parkinson's disease: A meta-analysis of genome-wide association studies. Lancet 377(9766):641-649.
    • (2011) Lancet , vol.377 , Issue.9766 , pp. 641-649
    • Nalls, M.A.1
  • 5
    • 78650711124 scopus 로고    scopus 로고
    • Association of variants at 1q32 and STAT3 with ankylosing spondylitis suggests genetic overlap with Crohn's disease
    • Australo-Anglo-American Spondyloarthritis Consortium; Spondyloarthritis Research Consortium of Canada
    • Danoy P, et al.; Australo-Anglo-American Spondyloarthritis Consortium; Spondyloarthritis Research Consortium of Canada (2010) Association of variants at 1q32 and STAT3 with ankylosing spondylitis suggests genetic overlap with Crohn's disease. PLoS Genet 6(12):e1001195.
    • (2010) PLoS Genet , vol.6 , Issue.12
    • Danoy, P.1
  • 6
    • 74049127960 scopus 로고    scopus 로고
    • Genomewide association study of leprosy
    • Zhang FR, et al. (2009) Genomewide association study of leprosy. N Engl J Med 361(27):2609-2618.
    • (2009) N Engl J Med , vol.361 , Issue.27 , pp. 2609-2618
    • Zhang, F.R.1
  • 7
    • 72149087091 scopus 로고    scopus 로고
    • Leucine-rich repeat kinase 2 regulates the progression of neuropathology induced by Parkinson's-disease-related mutant alpha-synuclein
    • Lin X, et al. (2009) Leucine-rich repeat kinase 2 regulates the progression of neuropathology induced by Parkinson's-disease-related mutant alpha-synuclein. Neuron 64(6):807-827.
    • (2009) Neuron , vol.64 , Issue.6 , pp. 807-827
    • Lin, X.1
  • 8
    • 84861162180 scopus 로고    scopus 로고
    • Neurodegenerative phenotypes in an A53T α-synuclein transgenic mouse model are independent of LRRK2
    • Daher JP, et al. (2012) Neurodegenerative phenotypes in an A53T α-synuclein transgenic mouse model are independent of LRRK2. Hum Mol Genet 21(11):2420-2431.
    • (2012) Hum Mol Genet , vol.21 , Issue.11 , pp. 2420-2431
    • Daher, J.P.1
  • 9
    • 84866145895 scopus 로고    scopus 로고
    • High LRRK2 levels fail to induce or exacerbate neuronal alpha-synucleinopathy in mouse brain
    • Herzig MC, et al. (2012) High LRRK2 levels fail to induce or exacerbate neuronal alpha-synucleinopathy in mouse brain. PLoS ONE 7(5):e36581.
    • (2012) PLoS ONE , vol.7 , Issue.5
    • Herzig, M.C.1
  • 10
    • 84856632181 scopus 로고    scopus 로고
    • LRRK2 inhibition attenuates microglial inflammatory responses
    • Moehle MS, et al. (2012) LRRK2 inhibition attenuates microglial inflammatory responses. J Neurosci 32(5):1602-1611.
    • (2012) J Neurosci , vol.32 , Issue.5 , pp. 1602-1611
    • Moehle, M.S.1
  • 13
    • 0031881687 scopus 로고    scopus 로고
    • Lipopolysaccharide intranigral injection induces inflammatory reaction and damage in nigrostriatal dopaminergic system
    • Castaño A, Herrera AJ, Cano J, Machado A (1998) Lipopolysaccharide intranigral injection induces inflammatory reaction and damage in nigrostriatal dopaminergic system. J Neurochem 70(4):1584- 1592.
    • (1998) J Neurochem , vol.70 , Issue.4 , pp. 1584-1592
    • Castaño, A.1    Herrera, A.J.2    Cano, J.3    Machado, A.4
  • 14
    • 84878508881 scopus 로고    scopus 로고
    • MHCII is required for α-synuclein-induced activation of microglia, CD4 T cell proliferation, and dopaminergic neurodegeneration
    • Harms AS, et al. (2013) MHCII is required for α-synuclein-induced activation of microglia, CD4 T cell proliferation, and dopaminergic neurodegeneration. J Neurosci 33(23):9592-9600.
    • (2013) J Neurosci , vol.33 , Issue.23 , pp. 9592-9600
    • Harms, A.S.1
  • 15
    • 78149435065 scopus 로고    scopus 로고
    • The myeloid cells of the central nervous system parenchyma
    • Ransohoff RM, Cardona AE (2010) The myeloid cells of the central nervous system parenchyma. Nature 468(7321):253-262.
    • (2010) Nature , vol.468 , Issue.7321 , pp. 253-262
    • Ransohoff, R.M.1    Cardona, A.E.2
  • 16
    • 84872595532 scopus 로고    scopus 로고
    • Toll-like receptor 4 is required for α-synuclein dependent activation of microglia and astroglia
    • Fellner L, et al. (2013) Toll-like receptor 4 is required for α-synuclein dependent activation of microglia and astroglia. Glia 61(3):349-360.
    • (2013) Glia , vol.61 , Issue.3 , pp. 349-360
    • Fellner, L.1
  • 17
    • 77649294300 scopus 로고    scopus 로고
    • Microglia acquire distinct activation profiles depending on the degree of alpha-synuclein neuropathology in a rAAV based model of Parkinson's disease
    • Sanchez-Guajardo V, Febbraro F, Kirik D, Romero-Ramos M (2010) Microglia acquire distinct activation profiles depending on the degree of alpha-synuclein neuropathology in a rAAV based model of Parkinson's disease. PLoS ONE 5(1):e8784.
    • (2010) PLoS ONE , vol.5 , Issue.1
    • Sanchez-Guajardo, V.1    Febbraro, F.2    Kirik, D.3    Romero-Ramos, M.4
  • 18
    • 84879024830 scopus 로고    scopus 로고
    • Comprehensive characterization and optimization of anti-LRRK2 (leucine-rich repeat kinase 2) monoclonal antibodies
    • Davies P, et al. (2013) Comprehensive characterization and optimization of anti-LRRK2 (leucine-rich repeat kinase 2) monoclonal antibodies. Biochem J 453(1):101-113.
    • (2013) Biochem J , vol.453 , Issue.1 , pp. 101-113
    • Davies, P.1
  • 19
    • 84901648685 scopus 로고    scopus 로고
    • Differential LRRK2 expression in the cortex, striatum, and substantia nigra in transgenic and nontransgenic rodents
    • 10.1002/cne.23583
    • West AB, et al. (2014) Differential LRRK2 expression in the cortex, striatum, and substantia nigra in transgenic and nontransgenic rodents. J Comp Neurol, 10.1002/cne.23583.
    • (2014) J Comp Neurol
    • West, A.B.1
  • 20
    • 84869109864 scopus 로고    scopus 로고
    • Pathological α-synuclein transmission initiates Parkinson-like neurodegeneration in nontransgenic mice
    • Luk KC, et al. (2012) Pathological α-synuclein transmission initiates Parkinson-like neurodegeneration in nontransgenic mice. Science 338(6109):949-953.
    • (2012) Science , vol.338 , Issue.6109 , pp. 949-953
    • Luk, K.C.1
  • 21
    • 78649389313 scopus 로고    scopus 로고
    • The role of leucine-rich repeat kinase 2 (LRRK2) in Parkinson's disease
    • Cookson MR (2010) The role of leucine-rich repeat kinase 2 (LRRK2) in Parkinson's disease. Nat Rev Neurosci 11(12):791-797.
    • (2010) Nat Rev Neurosci , vol.11 , Issue.12 , pp. 791-797
    • Cookson, M.R.1
  • 22
    • 0034651575 scopus 로고    scopus 로고
    • A panel of epitope-specific antibodies detects protein domains distributed throughout human alpha-synuclein in Lewy bodies of Parkinson's disease
    • DOI 10.1002/(SICI)1097-4547(20000215)59:4<528::AID-
    • Giasson BI, et al. (2000) A panel of epitope-specific antibodies detects protein domains distributed throughout human alpha-synuclein in Lewy bodies of Parkinson's disease. J Neurosci Res 59(4):528-533. (Pubitemid 30090580)
    • (2000) Journal of Neuroscience Research , vol.59 , Issue.4 , pp. 528-533
    • Giasson, B.I.1    Jakes, R.2    Goedert, M.3    Duda, J.E.4    Leight, S.5    Trojanowski, J.Q.6    Lee, V.M.Y.7
  • 23
    • 47749139266 scopus 로고    scopus 로고
    • Characterization of antibodies that selectively detect alpha-synuclein in pathological inclusions
    • Waxman EA, Duda JE, Giasson BI (2008) Characterization of antibodies that selectively detect alpha-synuclein in pathological inclusions. Acta Neuropathol 116(1):37-46. Neurological Disorders and Stroke
    • (2008) Acta Neuropathol , vol.116 , Issue.1 , pp. 37-46
    • Waxman, E.A.1    Duda, J.E.2    Giasson, B.I.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.