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Volumn 4, Issue 2, 2013, Pages 385-401

A neurodegeneration-specific gene-expression signature of acutely isolated microglia from an amyotrophic lateral sclerosis mouse model

Author keywords

[No Author keywords available]

Indexed keywords

LIPOPOLYSACCHARIDE; MESSENGER RNA; TRANSCRIPTOME;

EID: 84880802569     PISSN: None     EISSN: 22111247     Source Type: Journal    
DOI: 10.1016/j.celrep.2013.06.018     Document Type: Article
Times cited : (503)

References (79)
  • 1
    • 36448994709 scopus 로고    scopus 로고
    • Local self-renewal can sustain CNS microglia maintenance and function throughout adult life
    • Ajami B., Bennett J.L., Krieger C., Tetzlaff W., Rossi F.M. Local self-renewal can sustain CNS microglia maintenance and function throughout adult life. Nat. Neurosci. 2007, 10:1538-1543.
    • (2007) Nat. Neurosci. , vol.10 , pp. 1538-1543
    • Ajami, B.1    Bennett, J.L.2    Krieger, C.3    Tetzlaff, W.4    Rossi, F.M.5
  • 2
    • 0026034802 scopus 로고
    • Microglial progenitors with a high proliferative potential in the embryonic and adult mouse brain
    • Alliot F., Lecain E., Grima B., Pessac B. Microglial progenitors with a high proliferative potential in the embryonic and adult mouse brain. Proc. Natl. Acad. Sci. USA 1991, 88:1541-1545.
    • (1991) Proc. Natl. Acad. Sci. USA , vol.88 , pp. 1541-1545
    • Alliot, F.1    Lecain, E.2    Grima, B.3    Pessac, B.4
  • 5
    • 55749110043 scopus 로고    scopus 로고
    • CD4+ Tcells support glial neuroprotection, slow disease progression, and modify glial morphology in an animal model of inherited ALS
    • Beers D.R., Henkel J.S., Zhao W., Wang J., Appel S.H. CD4+ Tcells support glial neuroprotection, slow disease progression, and modify glial morphology in an animal model of inherited ALS. Proc. Natl. Acad. Sci. USA 2008, 105:15558-15563.
    • (2008) Proc. Natl. Acad. Sci. USA , vol.105 , pp. 15558-15563
    • Beers, D.R.1    Henkel, J.S.2    Zhao, W.3    Wang, J.4    Appel, S.H.5
  • 6
    • 79957528028 scopus 로고    scopus 로고
    • Endogenous regulatory T lymphocytes ameliorate amyotrophic lateral sclerosis in mice and correlate with disease progression in patients with amyotrophic lateral sclerosis
    • Beers D.R., Henkel J.S., Zhao W., Wang J., Huang A., Wen S., Liao B., Appel S.H. Endogenous regulatory T lymphocytes ameliorate amyotrophic lateral sclerosis in mice and correlate with disease progression in patients with amyotrophic lateral sclerosis. Brain 2011, 134:1293-1314.
    • (2011) Brain , vol.134 , pp. 1293-1314
    • Beers, D.R.1    Henkel, J.S.2    Zhao, W.3    Wang, J.4    Huang, A.5    Wen, S.6    Liao, B.7    Appel, S.H.8
  • 9
    • 17444419749 scopus 로고    scopus 로고
    • Beta-amyloid 42 accumulation in the lumbar spinal cord motor neurons of amyotrophic lateral sclerosis patients
    • Calingasan N.Y., Chen J., Kiaei M., Beal M.F. Beta-amyloid 42 accumulation in the lumbar spinal cord motor neurons of amyotrophic lateral sclerosis patients. Neurobiol. Dis. 2005, 19:340-347.
    • (2005) Neurobiol. Dis. , vol.19 , pp. 340-347
    • Calingasan, N.Y.1    Chen, J.2    Kiaei, M.3    Beal, M.F.4
  • 10
    • 34248673126 scopus 로고    scopus 로고
    • Isolation of murine microglial cells for RNA analysis or flow cytometry
    • Cardona A.E., Huang D., Sasse M.E., Ransohoff R.M. Isolation of murine microglial cells for RNA analysis or flow cytometry. Nat. Protoc. 2006, 1:1947-1951.
    • (2006) Nat. Protoc. , vol.1 , pp. 1947-1951
    • Cardona, A.E.1    Huang, D.2    Sasse, M.E.3    Ransohoff, R.M.4
  • 17
    • 80054829298 scopus 로고    scopus 로고
    • Ubiquitin-mediated regulation of CD86 protein expression by the ubiquitin ligase membrane-associated RING-CH-1 (MARCH1)
    • Corcoran K., Jabbour M., Bhagwandin C., Deymier M.J., Theisen D.L., Lybarger L. Ubiquitin-mediated regulation of CD86 protein expression by the ubiquitin ligase membrane-associated RING-CH-1 (MARCH1). J.Biol. Chem. 2011, 286:37168-37180.
    • (2011) J.Biol. Chem. , vol.286 , pp. 37168-37180
    • Corcoran, K.1    Jabbour, M.2    Bhagwandin, C.3    Deymier, M.J.4    Theisen, D.L.5    Lybarger, L.6
  • 19
    • 0031690332 scopus 로고    scopus 로고
    • The origin and differentiation of microglial cells during development
    • Cuadros M.A., Navascués J. The origin and differentiation of microglial cells during development. Prog. Neurobiol. 1998, 56:173-189.
    • (1998) Prog. Neurobiol. , vol.56 , pp. 173-189
    • Cuadros, M.A.1    Navascués, J.2
  • 22
    • 79952792761 scopus 로고    scopus 로고
    • InVivo imaging reveals distinct inflammatory activity of CNS microglia versus PNS macrophages in a mouse model for ALS
    • Dibaj P., Steffens H., Zschüntzsch J., Nadrigny F., Schomburg E.D., Kirchhoff F., Neusch C. InVivo imaging reveals distinct inflammatory activity of CNS microglia versus PNS macrophages in a mouse model for ALS. PLoS ONE 2011, 6:e17910.
    • (2011) PLoS ONE , vol.6
    • Dibaj, P.1    Steffens, H.2    Zschüntzsch, J.3    Nadrigny, F.4    Schomburg, E.D.5    Kirchhoff, F.6    Neusch, C.7
  • 23
    • 35348955882 scopus 로고    scopus 로고
    • A universal framework for regulatory element discovery across all genomes and data types
    • Elemento O., Slonim N., Tavazoie S. A universal framework for regulatory element discovery across all genomes and data types. Mol. Cell 2007, 28:337-350.
    • (2007) Mol. Cell , vol.28 , pp. 337-350
    • Elemento, O.1    Slonim, N.2    Tavazoie, S.3
  • 26
    • 84867740805 scopus 로고    scopus 로고
    • Gene-expression profiles and transcriptional regulatory pathways that underlie the identity and diversity of mouse tissue macrophages
    • Immunological Genome Consortium
    • Gautier E.L., Shay T., Miller J., Greter M., Jakubzick C., Ivanov S., Helft J., Chow A., Elpek K.G., Gordonov S., et al. Gene-expression profiles and transcriptional regulatory pathways that underlie the identity and diversity of mouse tissue macrophages. Nat. Immunol. 2012, 13:1118-1128. Immunological Genome Consortium.
    • (2012) Nat. Immunol. , vol.13 , pp. 1118-1128
    • Gautier, E.L.1    Shay, T.2    Miller, J.3    Greter, M.4    Jakubzick, C.5    Ivanov, S.6    Helft, J.7    Chow, A.8    Elpek, K.G.9    Gordonov, S.10
  • 28
    • 71149084382 scopus 로고    scopus 로고
    • Revealing global regulatory perturbations across human cancers
    • Goodarzi H., Elemento O., Tavazoie S. Revealing global regulatory perturbations across human cancers. Mol. Cell 2009, 36:900-911.
    • (2009) Mol. Cell , vol.36 , pp. 900-911
    • Goodarzi, H.1    Elemento, O.2    Tavazoie, S.3
  • 29
    • 0037265240 scopus 로고    scopus 로고
    • Alternative activation of macrophages
    • Gordon S. Alternative activation of macrophages. Nat. Rev. Immunol. 2003, 3:23-35.
    • (2003) Nat. Rev. Immunol. , vol.3 , pp. 23-35
    • Gordon, S.1
  • 31
    • 55049120934 scopus 로고    scopus 로고
    • Ablation of proliferating microglia does not affect motor neuron degeneration in amyotrophic lateral sclerosis caused by mutant superoxide dismutase
    • Gowing G., Philips T., Van Wijmeersch B., Audet J.N., Dewil M., Van Den Bosch L., Billiau A.D., Robberecht W., Julien J.P. Ablation of proliferating microglia does not affect motor neuron degeneration in amyotrophic lateral sclerosis caused by mutant superoxide dismutase. J.Neurosci. 2008, 28:10234-10244.
    • (2008) J.Neurosci. , vol.28 , pp. 10234-10244
    • Gowing, G.1    Philips, T.2    Van Wijmeersch, B.3    Audet, J.N.4    Dewil, M.5    Van Den Bosch, L.6    Billiau, A.D.7    Robberecht, W.8    Julien, J.P.9
  • 32
    • 77349114038 scopus 로고    scopus 로고
    • Progressive changes in microglia and macrophages in spinal cord and peripheral nerve in the transgenic rat model of amyotrophic lateral sclerosis
    • Graber D.J., Hickey W.F., Harris B.T. Progressive changes in microglia and macrophages in spinal cord and peripheral nerve in the transgenic rat model of amyotrophic lateral sclerosis. J. Neuroinflammation 2010, 7:8.
    • (2010) J. Neuroinflammation , vol.7 , pp. 8
    • Graber, D.J.1    Hickey, W.F.2    Harris, B.T.3
  • 36
    • 0032125587 scopus 로고    scopus 로고
    • Relationship of microglial and astrocytic activation to disease onset and progression in a transgenic model of familial ALS
    • Hall E.D., Oostveen J.A., Gurney M.E. Relationship of microglial and astrocytic activation to disease onset and progression in a transgenic model of familial ALS. Glia 1998, 23:249-256.
    • (1998) Glia , vol.23 , pp. 249-256
    • Hall, E.D.1    Oostveen, J.A.2    Gurney, M.E.3
  • 38
    • 34047160451 scopus 로고    scopus 로고
    • Osteopontin-deficient mice exhibit less inflammation, greater tissue damage, and impaired locomotor recovery from spinal cord injury compared with wild-type controls
    • Hashimoto M., Sun D., Rittling S.R., Denhardt D.T., Young W. Osteopontin-deficient mice exhibit less inflammation, greater tissue damage, and impaired locomotor recovery from spinal cord injury compared with wild-type controls. J.Neurosci. 2007, 27:3603-3611.
    • (2007) J.Neurosci. , vol.27 , pp. 3603-3611
    • Hashimoto, M.1    Sun, D.2    Rittling, S.R.3    Denhardt, D.T.4    Young, W.5
  • 39
    • 52649097448 scopus 로고    scopus 로고
    • The Immunological Genome Project: networks of gene expression in immune cells
    • Immunological Genome Project Consortium
    • Heng T.S., Painter M.W. The Immunological Genome Project: networks of gene expression in immune cells. Nat. Immunol. 2008, 9:1091-1094. Immunological Genome Project Consortium.
    • (2008) Nat. Immunol. , vol.9 , pp. 1091-1094
    • Heng, T.S.1    Painter, M.W.2
  • 41
    • 51149120624 scopus 로고    scopus 로고
    • Microglial dysfunction and defective beta-amyloid clearance pathways in aging Alzheimer's disease mice
    • Hickman S.E., Allison E.K., El Khoury J. Microglial dysfunction and defective beta-amyloid clearance pathways in aging Alzheimer's disease mice. J.Neurosci. 2008, 28:8354-8360.
    • (2008) J.Neurosci. , vol.28 , pp. 8354-8360
    • Hickman, S.E.1    Allison, E.K.2    El Khoury, J.3
  • 42
    • 0042528664 scopus 로고    scopus 로고
    • Retrograde viral delivery of IGF-1 prolongs survival in a mouse ALS model
    • Kaspar B.K., Lladó J., Sherkat N., Rothstein J.D., Gage F.H. Retrograde viral delivery of IGF-1 prolongs survival in a mouse ALS model. Science 2003, 301:839-842.
    • (2003) Science , vol.301 , pp. 839-842
    • Kaspar, B.K.1    Lladó, J.2    Sherkat, N.3    Rothstein, J.D.4    Gage, F.H.5
  • 47
    • 33746072956 scopus 로고    scopus 로고
    • The matrix metalloproteinases inhibitor Ro 28-2653 [correction of Ro 26-2853] extends survival in transgenic ALS mice
    • Lorenzl S., Narr S., Angele B., Krell H.W., Gregorio J., Kiaei M., Pfister H.W., Beal M.F. The matrix metalloproteinases inhibitor Ro 28-2653 [correction of Ro 26-2853] extends survival in transgenic ALS mice. Exp. Neurol. 2006, 200:166-171.
    • (2006) Exp. Neurol. , vol.200 , pp. 166-171
    • Lorenzl, S.1    Narr, S.2    Angele, B.3    Krell, H.W.4    Gregorio, J.5    Kiaei, M.6    Pfister, H.W.7    Beal, M.F.8
  • 48
    • 83755173163 scopus 로고    scopus 로고
    • Antigen targeting to plasmacytoid dendritic cells via Siglec-H inhibits Th cell-dependent autoimmunity
    • Loschko J., Heink S., Hackl D., Dudziak D., Reindl W., Korn T., Krug A.B. Antigen targeting to plasmacytoid dendritic cells via Siglec-H inhibits Th cell-dependent autoimmunity. J.Immunol. 2011, 187:6346-6356.
    • (2011) J.Immunol. , vol.187 , pp. 6346-6356
    • Loschko, J.1    Heink, S.2    Hackl, D.3    Dudziak, D.4    Reindl, W.5    Korn, T.6    Krug, A.B.7
  • 49
    • 84864249514 scopus 로고    scopus 로고
    • Mechanisms underlying the rapid peroxisome proliferator-activated receptor-gamma-mediated amyloid clearance and reversal of cognitive deficits in a murine model of Alzheimer's disease
    • Mandrekar-Colucci S., Karlo J.C., Landreth G.E. Mechanisms underlying the rapid peroxisome proliferator-activated receptor-gamma-mediated amyloid clearance and reversal of cognitive deficits in a murine model of Alzheimer's disease. J.Neurosci. 2012, 32:10117-10128.
    • (2012) J.Neurosci. , vol.32 , pp. 10117-10128
    • Mandrekar-Colucci, S.1    Karlo, J.C.2    Landreth, G.E.3
  • 51
    • 0036787810 scopus 로고    scopus 로고
    • Inflammatory processes in amyotrophic lateral sclerosis
    • McGeer P.L., McGeer E.G. Inflammatory processes in amyotrophic lateral sclerosis. Muscle Nerve 2002, 26:459-470.
    • (2002) Muscle Nerve , vol.26 , pp. 459-470
    • McGeer, P.L.1    McGeer, E.G.2
  • 52
    • 77956238665 scopus 로고    scopus 로고
    • Dual induction of TREM2 and tolerance-related transcript, Tmem176b, in amyloid transgenic mice: implications for vaccine-based therapies for Alzheimer's disease
    • Melchior B., Garcia A.E., Hsiung B.K., Lo K.M., Doose J.M., Thrash J.C., Stalder A.K., Staufenbiel M., Neumann H., Carson M.J. Dual induction of TREM2 and tolerance-related transcript, Tmem176b, in amyloid transgenic mice: implications for vaccine-based therapies for Alzheimer's disease. ASN Neuro 2010, 2:e00037.
    • (2010) ASN Neuro , vol.2
    • Melchior, B.1    Garcia, A.E.2    Hsiung, B.K.3    Lo, K.M.4    Doose, J.M.5    Thrash, J.C.6    Stalder, A.K.7    Staufenbiel, M.8    Neumann, H.9    Carson, M.J.10
  • 53
    • 67349251479 scopus 로고    scopus 로고
    • Characterization of the microglial phenotype under specific pro-inflammatory and anti-inflammatory conditions: Effects of oligomeric and fibrillar amyloid-beta
    • Michelucci A., Heurtaux T., Grandbarbe L., Morga E., Heuschling P. Characterization of the microglial phenotype under specific pro-inflammatory and anti-inflammatory conditions: Effects of oligomeric and fibrillar amyloid-beta. J.Neuroimmunol. 2009, 210:3-12.
    • (2009) J.Neuroimmunol. , vol.210 , pp. 3-12
    • Michelucci, A.1    Heurtaux, T.2    Grandbarbe, L.3    Morga, E.4    Heuschling, P.5
  • 55
    • 84855384345 scopus 로고    scopus 로고
    • The fractalkine receptor but not CCR2 is present on microglia from embryonic development throughout adulthood
    • Mizutani M., Pino P.A., Saederup N., Charo I.F., Ransohoff R.M., Cardona A.E. The fractalkine receptor but not CCR2 is present on microglia from embryonic development throughout adulthood. J.Immunol. 2012, 188:29-36.
    • (2012) J.Immunol. , vol.188 , pp. 29-36
    • Mizutani, M.1    Pino, P.A.2    Saederup, N.3    Charo, I.F.4    Ransohoff, R.M.5    Cardona, A.E.6
  • 56
    • 27644537011 scopus 로고    scopus 로고
    • Prevention of spinal motor neuron death by insulin-like growth factor-1 associating with the signal transduction systems in SODG93A transgenic mice
    • Narai H., Nagano I., Ilieva H., Shiote M., Nagata T., Hayashi T., Shoji M., Abe K. Prevention of spinal motor neuron death by insulin-like growth factor-1 associating with the signal transduction systems in SODG93A transgenic mice. J.Neurosci. Res. 2005, 82:452-457.
    • (2005) J.Neurosci. Res. , vol.82 , pp. 452-457
    • Narai, H.1    Nagano, I.2    Ilieva, H.3    Shiote, M.4    Nagata, T.5    Hayashi, T.6    Shoji, M.7    Abe, K.8
  • 57
    • 19744380563 scopus 로고    scopus 로고
    • Resting microglial cells are highly dynamic surveillants of brain parenchyma invivo
    • Nimmerjahn A., Kirchhoff F., Helmchen F. Resting microglial cells are highly dynamic surveillants of brain parenchyma invivo. Science 2005, 308:1314-1318.
    • (2005) Science , vol.308 , pp. 1314-1318
    • Nimmerjahn, A.1    Kirchhoff, F.2    Helmchen, F.3
  • 59
    • 79952775180 scopus 로고    scopus 로고
    • Transcriptomes of the B and T lineages compared by multiplatform microarray profiling
    • Immunological Genome Project Consortium
    • Painter M.W., Davis S., Hardy R.R., Mathis D., Benoist C. Transcriptomes of the B and T lineages compared by multiplatform microarray profiling. J.Immunol. 2011, 186:3047-3057. Immunological Genome Project Consortium.
    • (2011) J.Immunol. , vol.186 , pp. 3047-3057
    • Painter, M.W.1    Davis, S.2    Hardy, R.R.3    Mathis, D.4    Benoist, C.5
  • 60
    • 3242703300 scopus 로고    scopus 로고
    • Amyotrophic lateral sclerosis-associated SOD1 mutant proteins bind and aggregate with Bcl-2 in spinal cord mitochondria
    • Pasinelli P., Belford M.E., Lennon N., Bacskai B.J., Hyman B.T., Trotti D., Brown R.H. Amyotrophic lateral sclerosis-associated SOD1 mutant proteins bind and aggregate with Bcl-2 in spinal cord mitochondria. Neuron 2004, 43:19-30.
    • (2004) Neuron , vol.43 , pp. 19-30
    • Pasinelli, P.1    Belford, M.E.2    Lennon, N.3    Bacskai, B.J.4    Hyman, B.T.5    Trotti, D.6    Brown, R.H.7
  • 62
    • 79960303432 scopus 로고    scopus 로고
    • APOE ε4 allele is associated with an increased risk of bulbar-onset amyotrophic lateral sclerosis in men
    • French ALS Study Group
    • Praline J., Blasco H., Vourc'h P., Garrigue M.A., Gordon P.H., Camu W., Corcia P., Andres C.R. APOE ε4 allele is associated with an increased risk of bulbar-onset amyotrophic lateral sclerosis in men. Eur. J. Neurol. 2011, 18:1046-1052. French ALS Study Group.
    • (2011) Eur. J. Neurol. , vol.18 , pp. 1046-1052
    • Praline, J.1    Blasco, H.2    Vourc'h, P.3    Garrigue, M.A.4    Gordon, P.H.5    Camu, W.6    Corcia, P.7    Andres, C.R.8
  • 63
    • 67650966680 scopus 로고    scopus 로고
    • Microglial physiology: unique stimuli, specialized responses
    • Ransohoff R.M., Perry V.H. Microglial physiology: unique stimuli, specialized responses. Annu. Rev. Immunol. 2009, 27:119-145.
    • (2009) Annu. Rev. Immunol. , vol.27 , pp. 119-145
    • Ransohoff, R.M.1    Perry, V.H.2
  • 66
    • 83555165957 scopus 로고    scopus 로고
    • Optineurin with amyotrophic lateral sclerosis-related mutations abrogates inhibition of interferon regulatory factor-3 activation
    • Sakaguchi T., Irie T., Kawabata R., Yoshida A., Maruyama H., Kawakami H. Optineurin with amyotrophic lateral sclerosis-related mutations abrogates inhibition of interferon regulatory factor-3 activation. Neurosci. Lett. 2011, 505:279-281.
    • (2011) Neurosci. Lett. , vol.505 , pp. 279-281
    • Sakaguchi, T.1    Irie, T.2    Kawabata, R.3    Yoshida, A.4    Maruyama, H.5    Kawakami, H.6
  • 68
    • 80053174167 scopus 로고    scopus 로고
    • A comparison of invitro properties of resting SOD1 transgenic microglia reveals evidence of reduced neuroprotective function
    • Sargsyan S.A., Blackburn D.J., Barber S.C., Grosskreutz J., De Vos K.J., Monk P.N., Shaw P.J. A comparison of invitro properties of resting SOD1 transgenic microglia reveals evidence of reduced neuroprotective function. BMC Neurosci. 2011, 12:91.
    • (2011) BMC Neurosci. , vol.12 , pp. 91
    • Sargsyan, S.A.1    Blackburn, D.J.2    Barber, S.C.3    Grosskreutz, J.4    De Vos, K.J.5    Monk, P.N.6    Shaw, P.J.7
  • 71
    • 0025900245 scopus 로고
    • Isolation and direct characterization of resident microglial cells from the normal and inflamed central nervous system
    • Sedgwick J.D., Schwender S., Imrich H., Dörries R., Butcher G.W., ter Meulen V. Isolation and direct characterization of resident microglial cells from the normal and inflamed central nervous system. Proc. Natl. Acad. Sci. USA 1991, 88:7438-7442.
    • (1991) Proc. Natl. Acad. Sci. USA , vol.88 , pp. 7438-7442
    • Sedgwick, J.D.1    Schwender, S.2    Imrich, H.3    Dörries, R.4    Butcher, G.W.5    ter Meulen, V.6
  • 72
    • 28844469794 scopus 로고    scopus 로고
    • Elevated levels of the 64-kDa cleavage stimulatory factor (CstF-64) in lipopolysaccharide-stimulated macrophages influence gene expression and induce alternative poly(A) site selection
    • Shell S.A., Hesse C., Morris S.M., Milcarek C. Elevated levels of the 64-kDa cleavage stimulatory factor (CstF-64) in lipopolysaccharide-stimulated macrophages influence gene expression and induce alternative poly(A) site selection. J.Biol. Chem. 2005, 280:39950-39961.
    • (2005) J.Biol. Chem. , vol.280 , pp. 39950-39961
    • Shell, S.A.1    Hesse, C.2    Morris, S.M.3    Milcarek, C.4
  • 73
    • 69549086231 scopus 로고    scopus 로고
    • Concentrations of beta-amyloid precursor protein processing products in cerebrospinal fluid of patients with amyotrophic lateral sclerosis and frontotemporal lobar degeneration
    • Steinacker P., Hendrich C., Sperfeld A.D., Jesse S., Lehnert S., Pabst A., von Arnim C.A., Mottaghy F.M., Uttner I., Tumani H., et al. Concentrations of beta-amyloid precursor protein processing products in cerebrospinal fluid of patients with amyotrophic lateral sclerosis and frontotemporal lobar degeneration. J. Neural Transm. 2009, 116:1169-1178.
    • (2009) J. Neural Transm. , vol.116 , pp. 1169-1178
    • Steinacker, P.1    Hendrich, C.2    Sperfeld, A.D.3    Jesse, S.4    Lehnert, S.5    Pabst, A.6    von Arnim, C.A.7    Mottaghy, F.M.8    Uttner, I.9    Tumani, H.10
  • 74
    • 53849106834 scopus 로고    scopus 로고
    • Cystatin C-cathepsin B axis regulates amyloid beta levels and associated neuronal deficits in an animal model of Alzheimer's disease
    • Sun B., Zhou Y., Halabisky B., Lo I., Cho S.H., Mueller-Steiner S., Devidze N., Wang X., Grubb A., Gan L. Cystatin C-cathepsin B axis regulates amyloid beta levels and associated neuronal deficits in an animal model of Alzheimer's disease. Neuron 2008, 60:247-257.
    • (2008) Neuron , vol.60 , pp. 247-257
    • Sun, B.1    Zhou, Y.2    Halabisky, B.3    Lo, I.4    Cho, S.H.5    Mueller-Steiner, S.6    Devidze, N.7    Wang, X.8    Grubb, A.9    Gan, L.10
  • 75
    • 78649388701 scopus 로고    scopus 로고
    • STAT6 transcription factor is a facilitator of the nuclear receptor PPARγ-regulated gene expression in macrophages and dendritic cells
    • Szanto A., Balint B.L., Nagy Z.S., Barta E., Dezso B., Pap A., Szeles L., Poliska S., Oros M., Evans R.M., et al. STAT6 transcription factor is a facilitator of the nuclear receptor PPARγ-regulated gene expression in macrophages and dendritic cells. Immunity 2010, 33:699-712.
    • (2010) Immunity , vol.33 , pp. 699-712
    • Szanto, A.1    Balint, B.L.2    Nagy, Z.S.3    Barta, E.4    Dezso, B.5    Pap, A.6    Szeles, L.7    Poliska, S.8    Oros, M.9    Evans, R.M.10
  • 76
    • 58149459143 scopus 로고    scopus 로고
    • Developmental regulation of TREM2 and DAP12 expression in the murine CNS: implications for Nasu-Hakola disease
    • Thrash J.C., Torbett B.E., Carson M.J. Developmental regulation of TREM2 and DAP12 expression in the murine CNS: implications for Nasu-Hakola disease. Neurochem. Res. 2009, 34:38-45.
    • (2009) Neurochem. Res. , vol.34 , pp. 38-45
    • Thrash, J.C.1    Torbett, B.E.2    Carson, M.J.3
  • 77
    • 80455125893 scopus 로고    scopus 로고
    • Excess circulating alternatively activated myeloid (M2) cells accelerate ALS progression while inhibiting experimental autoimmune encephalomyelitis
    • Vaknin I., Kunis G., Miller O., Butovsky O., Bukshpan S., Beers D.R., Henkel J.S., Yoles E., Appel S.H., Schwartz M. Excess circulating alternatively activated myeloid (M2) cells accelerate ALS progression while inhibiting experimental autoimmune encephalomyelitis. PLoS ONE 2011, 6:e26921.
    • (2011) PLoS ONE , vol.6
    • Vaknin, I.1    Kunis, G.2    Miller, O.3    Butovsky, O.4    Bukshpan, S.5    Beers, D.R.6    Henkel, J.S.7    Yoles, E.8    Appel, S.H.9    Schwartz, M.10
  • 78
    • 50849096059 scopus 로고    scopus 로고
    • Upregulation of cathepsin S in the aging and pathological nervous system of mice
    • Wendt W., Lübbert H., Stichel C.C. Upregulation of cathepsin S in the aging and pathological nervous system of mice. Brain Res. 2008, 1232:7-20.
    • (2008) Brain Res. , vol.1232 , pp. 7-20
    • Wendt, W.1    Lübbert, H.2    Stichel, C.C.3
  • 79
    • 34548233140 scopus 로고    scopus 로고
    • Mutant SOD1(G93A) microglia are more neurotoxic relative to wild-type microglia
    • Xiao Q., Zhao W., Beers D.R., Yen A.A., Xie W., Henkel J.S., Appel S.H. Mutant SOD1(G93A) microglia are more neurotoxic relative to wild-type microglia. J.Neurochem. 2007, 102:2008-2019.
    • (2007) J.Neurochem. , vol.102 , pp. 2008-2019
    • Xiao, Q.1    Zhao, W.2    Beers, D.R.3    Yen, A.A.4    Xie, W.5    Henkel, J.S.6    Appel, S.H.7


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.