Autophagy in microglia degrades extracellular β-amyloid fibrils and regulates the NLRP3 inflammasome

Autophagy

Volumn 10, Issue 10, 2014, Pages 1761-1775

  Cho, Mi Hyang ^a   Cho, Kwangmin ^a   Kang, Hoe Jin ^a   Jeon, Eun Young ^a   Kim, Hun Sik ^a   Kwon, Hyung Joon ^a   Kim, Hong Mi ^a   Kim, Dong Hou ^a   Yoon, Seung Yong ^a  

^a University of Ulsan College of Medicine   (South Korea)

Author keywords

Alzheimer disease; Autophagy; Microglia; NLRP3; amyloid

Indexed keywords

AMYLOID BETA PROTEIN; CRYOPYRIN; INFLAMMASOME; OPTINEURIN; ATG7 PROTEIN, MOUSE; CARRIER PROTEIN; CIAS1 PROTEIN, MOUSE; CRE RECOMBINASE; EYE PROTEIN; HEAT SHOCK PROTEIN; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE KINASE; INTEGRASE; MICROTUBULE ASSOCIATED PROTEIN; OPTN PROTEIN, HUMAN; OPTN PROTEIN, MOUSE; SIGNAL TRANSDUCING ADAPTOR PROTEIN; SQSTM1 PROTEIN, HUMAN; SQSTM1 PROTEIN, MOUSE; TRANSCRIPTION FACTOR IIIA;

ALZHEIMER DISEASE; ANIMAL CELL; ARTICLE; AUTOPHAGY; BRAIN NERVE CELL; CELL SURVIVAL; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME REGULATION; FEMALE; IMMUNOCOMPETENT CELL; LYSOSOME; MALE; MICROGLIA; MICROGLIAL CELL CULTURE; MOUSE; NONHUMAN; PROTEIN DEGRADATION; AGED; ANIMAL; BIOLOGICAL MODEL; CELL LINE; EXTRACELLULAR SPACE; HUMAN; INFLAMMATION; METABOLISM; NERVE CELL; PATHOLOGY; VERY ELDERLY;

ADAPTOR PROTEINS, SIGNAL TRANSDUCING; AGED; AGED, 80 AND OVER; ALZHEIMER DISEASE; AMP-ACTIVATED PROTEIN KINASES; AMYLOID BETA-PEPTIDES; ANIMALS; AUTOPHAGY; CARRIER PROTEINS; CELL LINE; EXTRACELLULAR SPACE; EYE PROTEINS; FEMALE; HEAT-SHOCK PROTEINS; HUMANS; INFLAMMASOMES; INFLAMMATION; INTEGRASES; MALE; MICE; MICROGLIA; MICROTUBULE-ASSOCIATED PROTEINS; MODELS, BIOLOGICAL; NEURONS; PROTEOLYSIS; TRANSCRIPTION FACTOR TFIIIA;

EID: 84907898151     PISSN: 15548627     EISSN: 15548635     Source Type: Journal    
DOI: 10.4161/auto.29647     Document Type: Article

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