Diversity, Application, and Synthetic Biology of Industrially Important Aspergillus Fungi

Advances in Applied Microbiology

Volumn 100, Issue , 2017, Pages 161-202

  Park, Hee Soo ^a   Jun, Sang Cheol ^b   Han, Kap Hoon ^c   Hong, Seung Beom ^d   Yu, Jae Hyuk ^e  

^a Kyungpook National University   (South Korea)

^b Chonbuk National University   (South Korea)

^c Woosuk University   (South Korea)

^d National Institute of Animal Science   (South Korea)

^e UNIVERSITY OF WISCONSIN MADISON   (United States)

Author keywords

Aspergillus; Cell factories; Food fermentation; Genetic engineering; Industry; Synthetic biology

Indexed keywords

ADENOSINE MONOPHOSPHATE DEAMINASE; ALPHA GALACTOSIDASE; AMINOPEPTIDASE; AMYLASE; BETA GLUCAN HYDROLASE; BETA GLUCOSIDASE; CATALASE; CELLULASE; CHYMOSIN; CITRIC ACID; CYCLOSPORIN A; ESTERASE; FUMAGILLIN; FUNGAL PROTEIN; GLUCONIC ACID; GLUCOSE OXIDASE; GLUTAMINASE; INULINASE; ITACONIC ACID; KOJIC ACID; LACTASE; LACTIC ACID; MALIC ACID; MEVINOLIN; OXALIC ACID; PENICILLIN G; SUCCINIC ACID; TERREIN; TRIACYLGLYCEROL LIPASE; XYLAN ENDO 1,3 BETA XYLOSIDASE;

ARTICLE; ASPERGILLUS; ASPERGILLUS ACULEATUS; ASPERGILLUS AWAMORI; ASPERGILLUS CARBONARIUS; ASPERGILLUS FLAVUS; ASPERGILLUS FOETIDUS; ASPERGILLUS FUMIGATUS; ASPERGILLUS NIDULANS; ASPERGILLUS NIGER; ASPERGILLUS ORYZAE; ASPERGILLUS PARASITICUS; ASPERGILLUS RUBER; ASPERGILLUS TAMARII; ASPERGILLUS TERREUS; ASPERGILLUS TUBINGENSIS; ASPERGILLUS WENTII; DNA MODIFICATION; FERMENTATION; FOOD PROCESSING; FUNGAL GENETICS; FUNGUS GROWTH; METABOLITE; MICROBIAL DIVERSITY; NONHUMAN; PHYLOGENY; SECONDARY METABOLISM; SIGNAL TRANSDUCTION; STRAIN IMPROVEMENT; SYNTHETIC BIOLOGY; TAXONOMY; BIODIVERSITY; CLASSIFICATION; ENZYMOLOGY; GENETICS; METABOLISM; MICROBIOLOGY;

ASPERGILLUS; BIODIVERSITY; FERMENTATION; FUNGAL PROTEINS; INDUSTRIAL MICROBIOLOGY; PHYLOGENY; SYNTHETIC BIOLOGY;

EID: 85016008561     PISSN: 00652164     EISSN: None     Source Type: Book Series    
DOI: 10.1016/bs.aambs.2017.03.001     Document Type: Article

References (316)

1. Abarca, M.L., Accensi, F., Bragulat, M.R., Cabanes, F.J., Current importance of ochratoxin A-producing Aspergillus spp. Journal of Food Protection 64 (2001), 903–906.
2. Abd Alla, E.A., Metwally, M.M., Mehriz, A.M., Abu Sree, Y.H., Sterigmatocystin: Incidence, fate and production by Aspergillus versicolor in ras cheese. Nahrung 40 (1996), 310–313.
3. Abe, M., Takaoka, N., Idemoto, Y., Takagi, C., Imai, T., Nakasaki, K., Characteristic fungi observed in the fermentation process for puer tea. International Journal of Food Microbiology 124 (2008), 199–203.
4. Affeldt, K.J., Carrig, J., Amare, M., Keller, N.P., Global survey of canonical Aspergillus flavus G protein-coupled receptors. mBio 5 (2014), e01501–e01514.
5. Ahmed, Y.L., Gerke, J., Park, H.S., Bayram, O., Neumann, P., Ni, M., Ficner, R., The velvet family of fungal regulators contains a DNA-binding domain structurally similar to NF-kappaB. PLoS Biology, 11, 2013, e1001750.
6. Alberts, A.W., Discovery, biochemistry and biology of lovastatin. The American Journal of Cardiology 62 (1988), 10J–15J.
7. Alberts, A.W., Chen, J., Kuron, G., Hunt, V., Huff, J., Hoffman, C., Springer, J., Mevinolin: A highly potent competitive inhibitor of hydroxymethylglutaryl-coenzyme A reductase and a cholesterol-lowering agent. Proceedings of the National Academy of Sciences 77 (1980), 3957–3961.
8. Alkahyyat, F., Ni, M., Kim, S.C., Yu, J.H., The WOPR domain protein OsaA orchestrates development in Aspergillus nidulans. PLoS One, 10, 2015, e0137554.
9. Alkhayyat, F., Chang Kim, S., Yu, J.-H., Genetic control of asexual development in Aspergillus fumigatus. Advances in Applied Microbiology 90 (2015), 93–107.
10. Alkhayyat, F., Yu, J.-H., Upstream regulation of mycotoxin biosynthesis. Advances in Applied Microbiology 86 (2014), 251–278.
11. Amaike, S., Keller, N.P., Aspergillus flavus. Annual Review of Phytopathology 49 (2011), 107–133.
12. Andersen, M.R., Nielsen, J., Current status of systems biology in Aspergilli. Fungal Genetics and Biology 46:Suppl. 1 (2009), S180–S190.
13. Andersen, M.R., Salazar, M.P., Schaap, P.J., van de Vondervoort, P.J., Culley, D., Thykaer, J., Baker, S.E., Comparative genomics of citric-acid-producing Aspergillus niger ATCC 1015 versus enzyme-producing CBS 513.88. Genome Research 21 (2011), 885–897.
14. Ang, S.K., Shaza, E.M., Adibah, Y., Suraini, A.A., Madihah, M.S., Production of cellulases and xylanase by Aspergillus fumigatus SK1 using untreated oil palm trunk through solid state fermentation. Process Biochemistry 48 (2013), 1293–1302.
15. Archer, D.B., Filamentous fungi as microbial cell factories for food use. Current Opinion in Biotechnology 11 (2000), 478–483.
16. Archer, D.B., Turner, G., Genomics of protein secretion and hyphal growth in Aspergillus. 2006, Springer, Berlin Heidelberg.
17. Arnaud, M.B., Cerqueira, G.C., Inglis, D.O., Skrzypek, M.S., Binkley, J., Chibucos, M.C., Wortman, J.R., The Aspergillus Genome Database (AspGD): Recent developments in comprehensive multispecies curation, comparative genomics and community resources. Nucleic Acids Research 40 (2012), D653–D659.
18. Ashu, E., Forsythe, A., Vogan, A.A., Xu, J., Filementous fungi in fermented foods. Montet, D., Ray, R.C., (eds.) Fermented foods, part I: Biochemistry and biotechnology, 2016, CRC Press, Boca Raton, 45–75.
19. Asther, M., Haon, M., Roussos, S., Record, E., Delattre, M., Lesage-Meessen, L., Asther, M., Feruloyl esterase from Aspergillus niger a comparison of the production in solid state and submerged fermentation. Process Biochemistry 38 (2002), 685–691.
20. Bal, J., Yun, S.H., Chun, J., Kim, B.T., Kim, D.H., Taxonomic characterization, evaluation of toxigenicity, and saccharification capability of Aspergillus section flavi isolates from Korean traditional wheat-based fermentation starter nuruk. Mycobiology 44 (2016), 155–161.
21. Balagopalan, C., Cassava utilization in food, feed and industry. Cassava: Biology, Production and Utilization, 2002, 301–318.
22. Battat, E., Peleg, Y., Bercovitz, A., Rokem, J.S., Goldberg, I., Optimization of L-malic acid production by Aspergillus flavus in a stirred fermentor. Biotechnology and Bioengineering 37 (1991), 1108–1116.
23. Bayram, O., Braus, G.H., Coordination of secondary metabolism and development in fungi: The velvet family of regulatory proteins. FEMS Microbiology Reviews 36 (2012), 1–24.
24. Bayram, O., Krappmann, S., Ni, M., Bok, J.W., Helmstaedt, K., Valerius, O., Braus, G.H., VelB/VeA/LaeA complex coordinates light signal with fungal development and secondary metabolism. Science 320 (2008), 1504–1506.
25. Beelik, A., Kojic acid. Advances in Carbohydrate Chemistry 48 (1956), 145–183.
26. Bennett, J.W., An overview of the genus Aspergillus. Aspergillus: Molecular Biology and Genomics, 2010, 1–17.
27. Bennett, J.W., Klich, M., Mycotoxins. Clinical Microbiology Reviews 16 (2003), 497–516.
28. Bentley, R., From miso, sake and shoyu to cosmetics: A century of science for kojic acid. Natural Product Reports 23 (2006), 1046–1062.
29. Bentley, R., Thiessen, C.P., Biosynthesis of itaconic acid in Aspergillus terreus. I. Tracer studies with C14-labeled substrates. Journal of Biological Chemistry 226 (1957), 673–687.
30. Berka, R.M., Dunn-Coleman, N., Ward, M., Industrial enzymes from Aspergillus species. Bennett, J.W., Klich, M.A., (eds.) Aspergillus biology and industrial applications, 1992, Butterworth–Heinemann, Stoneham, MA, 155–202.
31. Berka, R.M., Ward, M., Wilson, L.J., Hayenga, K.J., Kodama, K.H., Carlomagno, L.P., Thompson, S.A., Molecular cloning and deletion of the gene encoding aspergillopepsin A from Aspergillus awamori. Gene 86 (1990), 153–162.
32. Bigelis, R., Arora, D.K., Organic acids of fungi. Arora, D.K., Elander, R.P., Murekji, K.G., (eds.) Handbook of applied mycology Fungal biotechnology, Vol. 4, 1992, Marcel Dekker Inc., New York, 357–376.
33. Bladt, T.T., Frisvad, J.C., Knudsen, P.B., Larsen, T.O., Anticancer and antifungal compounds from Aspergillus, Penicillium and other filamentous fungi. Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry 18 (2013), 11338–11376.
34. Blandino, A., Al-Aseeri, M.E., Pandiella, S.S., Cantero, D., Webb, C., Cereal-based fermented foods and beverages. Food Research International 36 (2003), 527–543.
35. Blumenthal, C.Z., Production of toxic metabolites in Aspergillus niger, Aspergillus oryzae, and Trichoderma reesei: Justification of mycotoxin testing in food grade enzyme preparations derived from the three fungi. Regulatory Toxicology and Pharmacology 39 (2004), 214–228.
36. Bok, J.W., Keller, N.P., LaeA, a regulator of secondary metabolism in Aspergillus spp. Eukaryotic Cell 3 (2004), 527–535.
37. Bonnarme, P., Gillet, B., Sepulchre, A.M., Role, C., Beloeil, J.C., Ducrocq, C., Itaconate biosynthesis in Aspergillus terreus. Journal of Bacteriology 177 (1995), 3573–3578.
38. Brayer, G.D., Luo, Y., Withers, S.G., The structure of human pancreatic alpha-amylase at 1.8 A resolution and comparisons with related enzymes. Protein Science: a Publication of the Protein Society 4 (1995), 1730–1742.
39. Brody, H., Maiyuran, S., RNAi-mediated gene silencing of highly expressed genes in the industrial fungi Trichoderma reesei and Aspergillus niger. Industrial Biotechnology 5 (2009), 53–60.
40. Brooke, A.G., Industrial fermentation and Aspergillus citric acid. Powell, K.A., Renwick, A., Peberdy, R.F., (eds.) The genus Aspergillus: From taxonomy and genetics to industrial application, 1994, Plenum Press, New York, 122–134.
41. Brown, D.W., Yu, J.H., Kelkar, H.S., Fernandes, M., Nesbitt, T.C., Keller, N.P., Leonard, T.J., Twenty-five coregulated transcripts define a sterigmatocystin gene cluster in Aspergillus nidulans. Proceedings of the National Academy of Sciences of The United States Of America 93 (1996), 1418–1422.
42. Brown, S.H., Bashkirova, L., Berka, R., Chandler, T., Doty, T., McCall, K., Metabolic engineering of Aspergillus oryzae NRRL 3488 for increased production of L-malic acid. Applied Microbiology and Biotechnology 97 (2013), 8903–8912.
43. Buchert, J., Oksanen, T., Pere, J., Siika-aho, M., Suurnäkki, A., Viikari, L., Applications of Trichoderma reesei enzymes in the pulp and paper industry. Harman, G.E., Kubicek, C.P., (eds.) Trichoderma and gliocladium, Vol. 2, 1998, Taylor & Francis, London, UK, 343–357.
44. Cabanes, J., Chazarra, S., Garciacarmona, F., Kojic acid, a cosmetic skin whitening agent, is a slow-binding inhibitor of catecholase activity of tyrosinase. The Journal of Pharmacy and Pharmacology 46 (1994), 982–985.
45. Campbell-Platt, G., Cook, P.E., Fungi in the production of foods and food ingredients. Journal of Applied Bacteriology Symposium Supplement, 1989, 117S–131S.
46. Casselton, L., Zolan, M., The art and design of genetic screens: Filamentous fungi. Nature Reviews Genetics 3 (2002), 683–697.
47. Chang, P.K., Matsushima, K., Takahashi, T., Yu, J., Abe, K., Bhatnagar, D., Cleveland, T.E., Understanding nonaflatoxigenicity of Aspergillus sojae: A windfall of aflatoxin biosynthesis research. Applied Microbiology and Biotechnology 76 (2007), 977–984.
48. Chen, A.J., Frisvad, J.C., Sun, B.D., Varga, J., Kocsube, S., Dijksterhuis, J., Samson, R.A., Aspergillus section Nidulantes (formerly Emericella): Polyphasic taxonomy, chemistry and biology. Studies in Mycology 84 (2016), 1–118.
49. Chiang, Y.M., Szewczyk, E., Davidson, A.D., Keller, N., Oakley, B.R., Wang, C.C.C., A gene cluster containing two fungal polyketide synthases encodes the biosynthetic pathway for a polyketide, asperfuranone, in Aspergillus nidulans. Journal of the American Chemical Society 131 (2009), 2965–2970.
50. Chidananda, C., Kumar, C.M., Sattur, A.P., Strain improvement of Aspergillus niger for the enhanced production of asperenone. Indian Journal of Microbiology 48 (2008), 274–278.
51. Cook, P.E., Campbell-Platt, G., Aspergillus and fermented foods. Powell, K.A., Renwick, A., Peberdy, J.F., (eds.) The genus Aspergillus: From taxonomy and genetics to industrial application, 1994, Plenum Press, New York, 171–188.
52. Couto, S.R., Sanroman, M.A., Application of solid-state fermentation to food industry - a review. Journal of Food Engineering 76 (2006), 291–302.
53. Cramer, R.A., Rivera, A., Hohl, T.M., Immune responses against Aspergillus fumigatus: What have we learned?. Current Opinion in Infectious Diseases 24 (2011), 315–322.
54. Cui, C.B., Kakeya, H., Osada, H., Novel mammalian cell cycle inhibitors, spirotryprostatins A and B, produced by Aspergillus fumigatus, which inhibit mammalian cell cycle at G2/M phase. Tetrahedron 52 (1996), 12651–12666.
55. Dagenais, T.R., Keller, N.P., Pathogenesis of Aspergillus fumigatus in invasive aspergillosis. Clinical Microbiology Reviews 22 (2009), 447–465.
56. Dave, K.K., Punekar, N.S., Expression of lactate dehydrogenase in Aspergillus niger for L-lactic acid production. PLoS One, 10, 2015.
57. David, H., Krogh, A.M., Roca, C., Akesson, M., Nielsen, J., CreA influences the metabolic fluxes of Aspergillus nidulans during growth on glucose and xylose. Microbiology 151 (2005), 2209–2221.
58. Dayanandan, A., Rani, S.H., Shanmugavel, M., Gnanamani, A., Rajakumar, G.S., Enhanced production of Aspergillus tamarii lipase for recovery of fat from tannery fleshings. Brazilian Journal of Microbiology 44 (2013), 1089–1095.
59. De Lucca, A.J., Harmful fungi in both agriculture and medicine. Revista iberoamericana de micologÃ-a 24 (2007), 3–13.
60. Demir, H., Tari, C., Bioconversion of wheat bran for polygalacturonase production by Aspergillus sojae in tray type solid-state fermentation. International Biodeterioration and Biodegradation 106 (2016), 60–66.
61. Demir, H., Tari, C., Effect of physicochemical parameters on the polygalacturonase of an Aspergillus sojae mutant using wheat bran, an agro-industrial waste, via solid-state fermentation. Journal of the Science of Food and Agriculture 96 (2016), 3575–3582.
62. Djekrif-Dakhmouche, S., Gheribi-Aoulmi, B., Meraihi, Z., Bennamoun, L., Application of a statistical design to the optimization of culture medium for alpha-amylase production by Aspergillus niger ATCC 16404 grown on orange waste powder. Journal of Food Engineering 73 (2006), 190–197.
63. Dulaney, E.L., Some aspects of penicillin production by Aspergillus nidulans. Mycologia 39 (1947), 570–581.
64. Elgharbi, F., Hmida-Sayari, A., Zaafouri, Y., Bejar, S., Expression of an Aspergillus niger xylanase in yeast: Application in breadmaking and in vitro digestion. International Journal of Biological Macromolecules 79 (2015), 103–109.
65. Ellaiah, P., Adinarayana, K., Bhavani, Y., Padmaja, P., Srinivasulu, B., Optimization of process parameters for glucoamylase production under solid state fermentation by a newly isolated Aspergillus species. Process Biochemistry 38 (2002), 615–620.
66. Fallon, J.P., Reeves, E.P., Kavanagh, K., The Aspergillus fumigatus toxin fumagillin suppresses the immune response of Galleria mellonella larvae by inhibiting the action of haemocytes. Microbiol-Sgm 157 (2011), 1481–1488.
67. Fedorova, N.D., Khaldi, N., Joardar, V.S., Maiti, R., Amedeo, P., Anderson, M.J., Nierman, W.C., Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus. PLoS Genetics, 4, 2008, e1000046.
68. Fernandez, E.Q., Moyer, D.L., Maiyuran, S., Labaro, A., Brody, H., Vector-initiated transitive RNA interference in the filamentous fungus Aspergillus oryzae. Fungal Genetics and Biology 49 (2012), 294–301.
69. Filtenborg, O., Frisvad, J.C., Thrane, U., Moulds in food spoilage. International Journal of Food Microbiology 33 (1996), 85–102.
70. Fisher, M.C., Henk, D.A., Briggs, C.J., Brownstein, J.S., Madoff, L.C., McCraw, S.L., Gurr, S.J., Emerging fungal threats to animal, plant and ecosystem health. Nature 484 (2012), 186–194.
71. Frisvad, J.C., Larsen, T.O., Extrolites of Aspergillus fumigatus and other pathogenic species in Aspergillus section Fumigati. Frontiers in Microbiology, 6, 2015, 1485.
72. Frisvad, J.C., Larsen, T.O., Thrane, U., Meijer, M., Varga, J., Samson, R.A., Nielsen, K.F., Fumonisin and ochratoxin production in industrial Aspergillus niger strains. PLoS One, 6, 2011, e23496.
73. Frisvad, J.C., Smedsgaard, J., Samson, R.A., Larsen, T.O., Thrane, U., Fumonisin B2 production by Aspergillus niger. Journal of Agricultural and Food Chemistry 55 (2007), 9727–9732.
74. Futagami, T., Mori, K., Yamashita, A., Wada, S., Kajiwara, Y., Takashita, H., Goto, M., Genome sequence of the white koji mold Aspergillus kawachii IFO 4308, used for brewing the Japanese distilled spirit shochu. Eukaryotic Cell 10 (2011), 1586–1587.
75. Galagan, J.E., Calvo, S.E., Cuomo, C., Ma, L.J., Wortman, J.R., Batzoglou, S., Birren, B.W., Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae. Nature 438 (2005), 1105–1115.
76. Galante, Y.M., Monteverdi, R., Inama, S., Caldini, C., De Conti, A.V.L., Bonomi, F., New applications of enzymes in wine making and olive oil production. Italian Biochemical Society Transactions, 4, 1993, 34.
77. Gams, W., Christensen, M., Onions, A.H., Pitt, J.I., Samson, R.A., Infrageneric taxa of Aspergillus. Samson, R.A., Pitt, J.I., (eds.) Advances in penicillium and Aspergillus systematics, 1985, Plenum Press, New York, 55–62.
78. Gassem, M.A., Study of the micro-organisms associated with the fermented bread (khamir) produced from sorghum in Gizan region, Saudi Arabia. Journal of Applied Microbiology 86 (1999), 221–225.
79. Gielkens, M.M., Visser, J., de Graaff, L.H., Arabinoxylan degradation by fungi: Characterization of the arabinoxylan-arabinofuranohydrolase encoding genes from Aspergillus niger and Aspergillus tubingensis. Current Genetics 31 (1997), 22–29.
80. Gigras, P., Sahai, V., Gupta, R., Statistical media optimization and production of ITS alpha-amylase from Aspergillus oryzae in a bioreactor. Current Microbiology 45 (2002), 203–208.
81. Giuliani, S., Piana, C., Setti, L., Hochkoeppler, A., Pifferi, P.G., Williamson, G., Faulds, C.B., Synthesis of pentylferulate by a feruloyl esterase from Aspergillus niger using water-in-oil microemulsions. Biotechnology Letters 23 (2001), 325–330.
82. Goetz, M.A., Lopez, M., Monaghan, R.L., Chang, R.S., Lotti, V.J., Chen, T.B., Asperlicin, a novel non-peptidal cholecystokinin antagonist from Aspergillus alliaceus. Fermentation, isolation and biological properties. Journal of Antibiotics (Tokyo) 38 (1985), 1633–1637.
83. Gomez, S., Fernandez, F.J., Vega, M.C., Heterologous expression of proteins in Aspergillus. Gupta, V.G., (eds.) New and future developments in microbial biotechnology and bioengineering, 2016, Elsvier, 55–68.
84. Gomez, S., Lopez-Estepa, M., Fernandez, F.J., Suarez, T., Vega, M.C., Alternative eukaryotic expression systems for the production of proteins and protein complexes. Advances in Experimental Medicine and Biology 896 (2016), 167–184.
85. Grassin, C., Fauquembergue, P., Application of pectinases in beverages. Progress in Biotechnology 14 (1996), 453–462.
86. Gravelat, F.N., Askew, D.S., Sheppard, D.C., Targeted gene deletion in Aspergillus fumigatus using the hygromycin-resistance split-marker approach. Methods in Molecular Biology 845 (2012), 119–130.
87. Gugnani, H.C., Ecology and taxonomy of pathogenic Aspergilli. Frontiers in Bioscience 8 (2003), s346–357.
88. Guo, C.J., Knox, B.P., Chiang, Y.M., Lo, H.C., Sanchez, J.F., Lee, K.H., Wang, C.C., Molecular genetic characterization of a cluster in A. terreus for biosynthesis of the meroterpenoid terretonin. Organic Letters 14 (2012), 5684–5687.
89. Guo, C.J., Wang, C.C., Recent advances in genome mining of secondary metabolites in Aspergillus terreus. Frontiers in Microbiology, 5, 2014, 717.
90. Gupta, R., Gigras, P., Mohapatra, H., Goswami, V.K., Chauhan, B., Microbial alpha-amylases: A biotechnological perspective. Process Biochemistry 38 (2003), 1599–1616.
91. Han, X., Chakrabortti, A., Zhu, J., Liang, Z.X., Li, J., Sequencing and functional annotation of the whole genome of the filamentous fungus Aspergillus westerdijkiae. BMC Genomics, 17, 2016, 633.
92. Hasan, F., Shah, A.A., Hameed, A., Industrial applications of microbial lipases. Enzyme and Microbial Technology 39 (2006), 235–251.
93. Hedayati, M.T., Pasqualotto, A.C., Warn, P.A., Bowyer, P., Denning, D.W., Aspergillus flavus: Human pathogen, allergen and mycotoxin producer. Microbiology 153 (2007), 1677–1692.
94. Hendrickson, L., Davis, C.R., Roach, C., Nguyen, D.K., Aldrich, T., McAda, P.C., Reeves, C.D., Lavastatin biosynthesis in Aspergillus terreus: Characterization of blocked mutants, enzyme activities and a multifunctional polyketide synthase gene. Chemistry & Biology 6 (1999), 429–439.
95. Hernandez, M.S., Rodriguez, M.R., Guerra, N.P., Roses, R.P., Amylase production by Aspergillus niger in submerged cultivation on two wastes from food industries. Journal of Food Engineering 73 (2006), 93–100.
96. Hicks, J.K., Yu, J.-H., Keller, N.P., Adams, T.H., Aspergillus sporulation and mycotoxin production both require inactivation of the FadA G alpha protein-dependent signaling pathway. EMBO J 16 (1997), 4916–4923.
97. Hill, K.J., Kaszuba, M., Creeth, J.E., Jones, M.N., Reactive liposomes encapsulating a glucose oxidase-peroxidase system with antibacterial activity. Biochimica et biophysica acta 1326 (1997), 37–46.
98. Hillocks, R.J., Thresh, J., Bellotti, A., Cassava: Biology, production and utilization (CABI). 2002.
99. Hong, S.B., Kim, D.H., Samson, R.A., Aspergillus associated with meju, a fermented soybean starting material for traditional soy sauce and soybean paste in Korea. Mycobiology 43 (2015), 218–224.
100. Hong, S.B., Lee, M., Kim, D.H., Varga, J., Frisvad, J.C., Perrone, G., Samson, R.A., Aspergillus luchuensis, an industrially important black Aspergillus in East Asia. PLoS One, 8, 2013, e63769.
101. Hong, S.B., Yamada, O., Samson, R.A., Taxonomic re-evaluation of black koji molds. Applied Microbiology and Biotechnology 98 (2014), 555–561.
102. Houbraken, J., Samson, R.A., Phylogeny of Penicillium and the segregation of Trichocomaceae into three families. Studies in Mycology 70 (2011), 1–51.
103. Houbraken, J., Samson, R.A., Yilmaz, N., Taxonomy of Aspergillus, Penicillium and Talaromyces and its significance for biotechnology. de Vries, R.P., Gelber, I.B., Andersen, M.R., (eds.) Aspergillus and Penicillium in the post-genomic era, 2016, Caister Academic Press, U.K, 1–16.
104. Houbraken, J., de Vries, R.P., Samson, R.A., Modern taxonomy of biotechnologically important Aspergillus and Penicillium species. Advances in Applied Microbiology 86 (2014), 199–249.
105. Hu, W., Liu, J., Chen, J.H., Wang, S.Y., Lu, D., Wu, Q.H., Li, W.J., A mutation of Aspergillus niger for hyper-production of citric acid from corn meal hydrolysate in a bioreactor. Journal of Zhejiang University Science B 15 (2014), 1006–1010.
106. Ichishima, E., Development of enzyme technology for Aspergillus oryzae, A. sojae, and A. luchuensis, the national microorganisms of Japan. Bioscience, Biotechnology, and Biochemistry 80 (2016), 1681–1692.
107. Iqbal, S.Z., Jinap, S., Pirouz, A.A., Faizal, A.R.A., Aflatoxin M-1 in milk and dairy products, occurrence and recent challenges: A review. Trends in Food Science & Technology 46 (2015), 110–119.
108. Irwin, D.C., Spezio, M., Walker, L.P., Wilson, D.B., Activity studies of eight purified cellulases: Specificity, synergism, and binding domain effects. Biotechnology and Bioengineering 42 (1993), 1002–1013.
109. Ito, K., Koyama, Y., Hanya, Y., Identification of the glutaminase genes of Aspergillus sojae involved in glutamate production during soy sauce fermentation. Bioscience, Biotechnology, and Biochemistry 77 (2013), 1832–1840.
110. Iwen, P.C., Rupp, M.E., Langnas, A.N., Reed, E.C., Hinrichs, S.H., Invasive pulmonary aspergillosis due to Aspergillus terreus: 12-year experience and review of the literature. Clinical Infectious Diseases: an Official Publication of the Infectious Diseases Society of America 26 (1998), 1092–1097.
111. Jaeger, K.E., Reetz, M.T., Microbial lipases form versatile tools for biotechnology. Trends in Biotechnology 16 (1998), 396–403.
112. Javeda, S., Asghera, M., Sheikha, M.A., Nawazb, H., Strain improvement through UV and chemical mutagenesis for enhanced citric acid production in molasses-based solid state fermentation. Food Biotechnology 24 (2010), 165–179.
113. Jay, J.M., Meats, poultry, and seafoods. Beuchat, L.R., (eds.) Food and beverage mycology, 1987, Springer, New York, 155–173.
114. Jorgensen, T.R., Identification and toxigenic potential of the industrially important fungi, Aspergillus oryzae and Aspergillus sojae. Journal of Food Protection 70 (2007), 2916–2934.
115. Kafer, E., Origins of translocations in Aspergillus nidulans. Genetics 52 (1965), 217–232.
116. Kamei, K., Watanabe, A., Aspergillus mycotoxins and their effect on the host. Medical Mycology 43:Suppl. 1 (2005), S95–S99.
117. Kammoun, R., Naili, B., Bejar, S., Application of a statistical design to the optimization of parameters and culture medium for alpha-amylase production by Aspergillus oryzae CBS 819.72 grown on gruel (wheat grinding by-product). Bioresource Technology 99 (2008), 5602–5609.
118. Kang, C., Yu, X.W., Xu, Y., Cloning and expression of a novel prolyl endopeptidase from Aspergillus oryzae and its application in beer stabilization. Journal of Industrial Microbiology and Biotechnology 42 (2015), 263–272.
119. Kanoh, K., Kohno, S., Asari, T., Harada, T., Katada, J., Muramatsu, M., Uno, I., (-)-phenylahistin: A new mammalian cell cycle inhibitor produced by Aspergillus ustus. Bioorganic & Medicinal Chemistry Letters 7 (1997), 2847–2852.
120. Kanoh, K., Kohno, S., Katada, J., Hayashi, Y., Muramatsu, M., Uno, I., Antitumor activity of phenylahistin in vitro and in vivo. Bioscience, Biotechnology, and Biochemistry 63 (1999), 1130–1133.
121. KarraChaabouni, M., Pulvin, S., Touraud, D., Thomas, D., Enzymatic synthesis of geraniol esters in a solvent-free system by lipases. Biotechnology Letters 18 (1996), 1083–1088.
122. Katayama, T., Tanaka, Y., Okabe, T., Nakamura, H., Fujii, W., Kitamoto, K., Maruyama, J., Development of a genome editing technique using the CRISPR/Cas9 system in the industrial filamentous fungus Aspergillus oryzae. Biotechnology Letters 38 (2016), 637–642.
123. Kato, N., Brooks, W., Calvo, A.M., The expression of sterigmatocystin and penicillin genes in Aspergillus nidulans is controlled by veA, a gene required for sexual development. Eukaryotic Cell 2 (2003), 1178–1186.
124. Kensler, T.W., Roebuck, B.D., Wogan, G.N., Groopman, J.D., Aflatoxin: A 50-year odyssey of mechanistic and translational toxicology. Toxicological Sciences: an Official Journal of the Society of Toxicology 120:Suppl. 1 (2011), S28–S48.
125. Kim, D.H., Kim, S.H., Kwon, S.W., Lee, J.K., Hong, S.B., The mycobiota of air inside and outside the meju fermentation room and the origin of meju fungi. Mycobiology 43 (2015), 258–265.
126. Kim, H., Han, K., Kim, K., Han, D., Jahng, K., Chae, K., The veA gene activates sexual development in Aspergillus nidulans. Fungal Genetics and Biology 37 (2002), 72–80.
127. Kim, K.M., Lim, J., Lee, J.J., Hurh, B.S., Lee, I., Characterization of Aspergillus sojae isolated from meju, Korean traditional fermented soybean bricks. Journal of Microbiology and Biotechnology, 2016.
128. Kimura, S., Maruyama, J., Takeuchi, M., Kitamoto, K., Monitoring global gene expression of proteases and improvement of human lysozyme production in the nptB gene disruptant of Aspergillus oryzae. Bioscience, Biotechnology, and Biochemistry 72 (2008), 499–505.
129. Kis-Papo, T., Oren, A., Wasser, S.P., Nevo, E., Survival of filamentous fungi in hypersaline Dead Sea water. Microbial Ecology 45 (2003), 183–190.
130. Kitagaki, H., Kitamoto, K., Breeding research on sake yeasts in Japan: History, recent technological advances, and future perspectives. Annual Review of Food Science and Technology 4 (2013), 215–235.
131. Kitahara, K., Kurushima, M., Is Aspergillus kawachii really a mutant of black Aspergillus?. Journal of Fermentation Technology 27 (1949), 182–183.
132. Kitahara, K., Yoshida, M., On the so-called awamori white mold part III. (1) Morphological and several physiological characteristics. Journal of Fermentation Technology 27 (1949), 162–166.
133. Kitamoto, K., Molecular biology of the Koji molds. Advances in Applied Microbiology 51 (2002), 129–153.
134. Kitamoto, K., Cell biology of the Koji mold Aspergillus oryzae. Bioscience, Biotechnology, and Biochemistry 79 (2015), 863–869.
135. Kleppe, K., The effect of hydrogen peroxide on glucose oxidase from Aspergillus niger. Biochemistry 5 (1966), 139–143.
136. Klich, M.A., Aspergillus flavus: The major producer of aflatoxin. Molecular Plant Pathology 8 (2007), 713–722.
137. Knuf, C., Nielsen, J., Aspergilli: Systems biology and industrial applications. Biotechnology Journal 7 (2012), 1147–1155.
138. Knuf, C., Nookaew, I., Brown, S.H., McCulloch, M., Berry, A., Nielsen, J., Investigation of malic acid production in Aspergillus oryzae under nitrogen starvation conditions. Applied and Environmental Microbiology 79 (2013), 6050–6058.
139. Kobayashi, K., Hattori, T., Honda, Y., Kirimura, K., Oxalic acid production by citric acid-producing Aspergillus niger overexpressing the oxaloacetate hydrolase gene oahA. Journal of Industrial Microbiology & Biotechnology 41 (2014), 749–756.
140. Koo, H., Ueda, M., Wakida, T., Yoshimura, Y., Igarashi, T., Cellulase treatment of cotton fabrics. Textile Research Journal 64 (1994), 70–74.
141. Krishnan, S., Manavathu, E.K., Chandrasekar, P.H., Aspergillus flavus: An emerging non-fumigatus Aspergillus species of significance. Mycoses 52 (2009), 206–222.
142. Kum, S.J., Yang, S.O., Lee, S.M., Chang, P.S., Choi, Y.H., Lee, J.J., Kim, Y.S., Effects of Aspergillus species inoculation and their enzymatic activities on the formation of volatile components in fermented soybean paste (doenjang). Journal of Agricultural and Food Chemistry 63 (2015), 1401–1418.
143. Kumar, A., Dutt, D., Gautam, A., Production of crude enzyme from Aspergillus nidulans AKB-25 using black gram residue as the substrate and its industrial applications. Journal of Genetic Engineering and Biotechnology 14 (2016), 107–118.
144. Kumar, P., Mahato, D.K., Kamle, M., Mohanta, T.K., Kang, S.G., Aflatoxins: A global concern for food safety, human health and their management. Frontiers in Microbiology, 7, 2016, 2170.
145. Kurtzman, C.P., Horn, B.W., Hesseltine, C.W., Aspergillus nomius, a new aflatoxin-producing species related to Aspergillus flavus and Aspergillus tamarii. Antonie van Leeuwenhoek 53 (1987), 147–158.
146. Kwon, N.J., Shin, K.S., Yu, J.H., Characterization of the developmental regulator FlbE in Aspergillus fumigatus and Aspergillus nidulans. Fungal Genetics and Biology 47 (2010), 981–993.
147. Labuza, T.P., Breene, W.M., Applications of “Active packaging”for improvement of shelf-life and nutritional quality of fresh and extended shelf-life foods 1. Journal of Food Processing and Preservation 13 (1989), 1–69.
148. Lamboni, Y., Nielsen, K.F., Linnemann, A.R., Gezgin, Y., Hell, K., Nout, M.J., Frisvad, J.C., Diversity in secondary metabolites including mycotoxins from strains of Aspergillus section nigri isolated from raw cashew nuts from benin, west Africa. PLoS One, 11, 2016, e0164310.
149. Lane, K.S., Aflatoxin, tobacco, ammonia and the p53 tumor-suppressor gene: Cancer's missing link?. Medscape General Medicin, E10, 1999.
150. Latarullo, M.B., Tavares, E.Q., Maldonado, G.P., Leite, D.C., Buckeridge, M.S., Pectins, endopolygalacturonases, and bioenergy. Frontiers in Plant Science, 7, 2016, 1401.
151. Latge, J.P., Aspergillus fumigatus and aspergillosis. Clinical Microbiology Reviews 12 (1999), 310–350.
152. Latge, J.P., The pathobiology of Aspergillus fumigatus. Trends in Microbiology 9 (2001), 382–389.
153. Lee, M.K., Kwon, N.J., Choi, J.M., Lee, I.S., Jung, S., Yu, J.H., NsdD is a key repressor of asexual development in Aspergillus nidulans. Genetics 197 (2014), 159–173.
154. Lee, M.K., Kwon, N.J., Lee, I.S., Jung, S., Kim, S.C., Yu, J.H., Negative regulation and developmental competence in Aspergillus. Scientific Reports, 6, 2016, 28874.
155. Lei, X.G., Stahl, C.H., Biotechnological development of effective phytases for mineral nutrition and environmental protection. Applied Microbiology and Biotechnology 57 (2001), 474–481.
156. Leiter, E., Marx, F., Pusztahelyi, T., Haas, H., Pocsi, I., Penicillium chrysogenum glucose oxidase – a study on its antifungal effects. Journal of Applied Microbiology 97 (2004), 1201–1209.
157. Leonard, C.A., Brown, S.D., Hayman, J.R., Random mutagenesis of the Aspergillus oryzae genome results in fungal antibacterial activity. International Journal of Microbiology, 2013, 2013, 901697.
158. Letunic, I., Bork, P., Interactive tree of life (iTOL): An online tool for phylogenetic tree display and annotation. Bioinformatics 23 (2007), 127–128.
159. Liaud, N., Rosso, M.N., Fabre, N., Crapart, S., Herpoel-Gimbert, I., Sigoillot, J.C., Levasseur, A., L-lactic acid production by Aspergillus brasiliensis overexpressing the heterologous ldha gene from Rhizopus oryzae. Microbial Cell Factories, 14, 2015, 66.
160. Lin, C., Shen, Z., Qin, W., Characterization of xylanase and cellulase produced by a newly isolated Aspergillus fumigatus N2 and its efficient saccharification of barley straw. Applied Biochemistry and Biotechnology, 2016.
161. Lin, H.C., Chooi, Y.H., Dhingra, S., Xu, W., Calvo, A.M., Tang, Y., Fumagillin biosynthesis in Aspergillus fumigatus: A cryptic terpene cyclase gene is involved in the formation of beta-trans-bergamotene. Planta Medica, 79, 2013, 825.
162. Lowe, D.A., Fungal enzymes. Arora, D.K., Elander, R.P., Murekji, K.G., (eds.) Handbook of applied mycology Fungal biotechnology, Vol. 4, 1992, Marcel Dekker Inc, New York, 681–706.
163. Lv, A., Li, Z.L., Du, F.S., Li, Z.C., Synthesis, functionalization, and controlled degradation of high molecular weight polyester from itaconic acid via ADMET polymerization. Macromolecules 47 (2014), 7707–7716.
164. MacCabe, A.P., Orejas, M., Tamayo, E.N., Villanueva, A., Ramon, D., Improving extracellular production of food-use enzymes from Aspergillus nidulans. Journal of Biotechnology 96 (2002), 43–54.
165. Machida, M., Asai, K., Sano, M., Tanaka, T., Kumagai, T., Terai, G., Kikuchi, H., Genome sequencing and analysis of Aspergillus oryzae. Nature 438 (2005), 1157–1161.
166. Machida, M., Yamada, O., Gomi, K., Genomics of Aspergillus oryzae: Learning from the history of Koji mold and exploration of its future. DNA Research: an International Journal for Rapid Publication of Reports on Genes and Genomes 15 (2008), 173–183.
167. Macios, M., Caddick, M.X., Weglenski, P., Scazzocchio, C., Dzikowska, A., The GATA factors AREA and AREB together with the co-repressor NMRA, negatively regulate arginine catabolism in Aspergillus nidulans in response to nitrogen and carbon source. Fungal Genetics and Biology 49 (2012), 189–198.
168. Mah, J.H., Yu, J.H., Upstream and downstream regulation of asexual development in Aspergillus fumigatus. Eukaryotic Cell 5 (2006), 1585–1595.
169. Martinez, F.A.C., Balciunas, E.M., Salgado, J.M., Gonzalez, J.M.D., Converti, A., Oliveira, R.P.D., Lactic acid properties, applications and production: A review. Trends in Food Science & Technology 30 (2013), 70–83.
170. Marui, J., Ohashi-Kunihiro, S., Ando, T., Nishimura, M., Koike, H., Machidal, M., Penicillin biosynthesis in Aspergillus oryzae and its overproduction by genetic engineering. Journal of Bioscience and Bioengineering 110 (2010), 8–11.
171. Marui, J., Yamane, N., Ohashi-Kunihiro, S., Ando, T., Terabayashi, Y., Sano, M., Machida, M., Kojic acid biosynthesis in Aspergillus oryzae is regulated by a Zn(II)(2)Cys(6) transcriptional activator and induced by kojic acid at the transcriptional level. Journal of Bioscience and Bioengineering 112 (2011), 40–43.
172. Mathlouthi, N., Juin, H., Larbier, M., Effect of xylanase and beta-glucanase supplementation of wheat- or wheat- and barley-based diets on the performance of male turkeys. British Poultry Science 44 (2003), 291–298.
173. Metwally, M., El-Sayed, A.A., Mehriz, A., Abu Sree, Y., Sterigmatocystin - incidence, fate and production by A. versicolor in ras cheese. Mycotoxin Research 13 (1997), 61–66.
174. Meyer, V., Genetic engineering of filamentous fungi–progress, obstacles and future trends. Biotechnology Advances 26 (2008), 177–185.
175. Meyer, V., Wu, B., Ram, A.F., Aspergillus as a multi-purpose cell factory: Current status and perspectives. Biotechnology Letters 33 (2011), 469–476.
176. Michielse, C.B., Hooykaas, P.J., van den Hondel, C.A., Ram, A.F., Agrobacterium-mediated transformation as a tool for functional genomics in fungi. Current Genetics 48 (2005), 1–17.
177. Mitidieri, S., Martinelli, A.H.S., Schrank, A., Vainstein, M.H., Enzymatic detergent formulation containing amylase from Aspergillus niger: A comparative study with commercial detergent formulations. Bioresource Technology 97 (2006), 1217–1224.
178. Mo, H.Z., Xu, X.Q., Yan, M.C., Zhu, Y., Microbiological analysis and antibacterial effects of the indigenous fermented Puer tea. Agro Food Industry Hi Tech 16 (2005), 16–18.
179. Mogensen, J.M., Varga, J., Thrane, U., Frisvad, J.C., Aspergillus acidus from puerh tea and black tea does not produce ochratoxin A and fumonisin B2. International Journal of Food Microbiology 132 (2009), 141–144.
180. Montella, I.R., Schama, R., Valle, D., The classification of esterases: An important gene family involved in insecticide resistance–a review. Memã³rias Do Instituto Oswaldo Cruz 107 (2012), 437–449.
181. Mooney, J.L., Hassett, D.E., Yager, L.N., Genetic analysis of suppressors of the veA1 mutation in Aspergillus nidulans. Genetics 126 (1990), 869–874.
182. Mooney, J.L., Yager, L.N., Light is required for conidiation in Aspergillus nidulans. Genes & Development 4 (1990), 1473–1482.
183. Moore, D., Chiu, S.W., Fungal products as food. Pointing, S.B., Hyde, K.D., (eds.) Bio-exploitation of filamentous fungi, 2001, Fungal Diversity Press, Hong Kong, 223–251.
184. Moralejo, F.J., Cardoza, R.E., Gutierrez, S., Lombrana, M., Fierro, F., Martin, J.F., Silencing of the aspergillopepsin B (pepB) gene of Aspergillus awamori by antisense RNA expression or protease removal by gene disruption results in a large increase in thaumatin production. Applied and Environmental Microbiology 68 (2002), 3550–3559.
185. Mora-Lugo, R., Madrigal, M., Yelemane, V., Fernandez-Lahore, M., Improved biomass and protein production in solid-state cultures of an Aspergillus sojae strain harboring the Vitreoscilla hemoglobin. Applied Microbiology and Biotechnology 99 (2015), 9699–9708.
186. Mukherjee, R., Chakraborty, R., Dutta, A., Role of fermentation in improving nutritional quality of soybean meal - a review. Asian Australasian Journal of Animal Sciences 29 (2016), 1523–1529.
187. Murakami, H., Classification system of the black Aspergilli. Taxonomic studies on Japanese industrial strains of the Aspergillus (Part 32). Journal of the Brewing Society of Japan 74 (1979), 849–853.
188. Nayak, T., Szewczyk, E., Oakley, C.E., Osmani, A., Ukil, L., Murray, S.L., Oakley, B.R., A versatile and efficient gene-targeting system for Aspergillus nidulans. Genetics 172 (2006), 1557–1566.
189. Nevalainen, K.M., Te'o, V.S., Bergquist, P.L., Heterologous protein expression in filamentous fungi. Trends in Biotechnology 23 (2005), 468–474.
190. Ni, M., Yu, J.-H., A novel regulator couples sporogenesis and trehalose biogenesis in Aspergillus nidulans. PLoS One, 2, 2007, e970.
191. Nidetzky, B., Steiner, W., Hayn, M., Claeyssens, M., Cellulose hydrolysis by the cellulases from Trichoderma reesei: A new model for synergistic interaction. The Biochemical Journal 298:Pt 3 (1994), 705–710.
192. Nielsen, J.B., Nielsen, M.L., Mortensen, U.H., Transient disruption of non-homologous end-joining facilitates targeted genome manipulations in the filamentous fungus Aspergillus nidulans. Fungal Genetics and Biology 45 (2008), 165–170.
193. Nielsen, J.E., Borchert, T.V., Protein engineering of bacterial alpha-amylases. Biochimica et Biophysica Acta (BBA) - Protein Structure and Molecular Enzymology 1543 (2000), 253–274.
194. Nierman, W.C., Pain, A., Anderson, M.J., Wortman, J.R., Kim, H.S., Arroyo, J., Denning, D.W., Genomic sequence of the pathogenic and allergenic filamentous fungus Aspergillus fumigatus. Nature 438 (2005), 1151–1156.
195. Nodvig, C.S., Nielsen, J.B., Kogle, M.E., Mortensen, U.H., A CRISPR-Cas9 system for genetic engineering of filamentous fungi. PLoS One, 10, 2015, e0133085.
196. Nohynek, G.J., Kirkland, D., Marzin, D., Toutain, H., Leclerc-Ribaud, C., Jinnai, H., An assessment of the genotoxicity and human health risk of topical use of kojic acid [5-hydroxy-2-(hydroxymethyl)-4H-pyran-4-one]. Food and Chemical Toxicology 42 (2004), 93–105.
197. Nout, M.J., Rich nutrition from the poorest - cereal fermentations in Africa and Asia. Food Microbiology 26 (2009), 685–692.
198. Nout, M.J., Kiers, J.L., Tempe fermentation, innovation and functionality: Update into the third millenium. Journal of Applied Microbiology 98 (2005), 789–805.
199. O'Callaghan, J., Caddick, M.X., Dobson, A.D.W., A polyketide synthase gene required for ochratoxin A biosynthesis in Aspergillus ochraceus. Microbiol-Sgm 149 (2003), 3485–3491.
200. Ohta, K., Hamada, S., Nakamura, T., Production of high concentrations of ethanol from inulin by simultaneous saccharification and fermentation using Aspergillus niger and Saccharomyces cerevisiae. Applied and Environmental Microbiology 59 (1993), 729–733.
201. Okado, N., Sugi, M., Ueda, M., Mizuhashi, F., Lynch, B.S., Vo, T.D., Roberts, A.S., Safety evaluation of AMP deaminase from Aspergillus oryzae. Food and Chemical Toxicology 86 (2015), 342–350.
202. Pandey, A., Nigam, P., Soccol, C.R., Soccol, V.T., Singh, D., Mohan, R., Advances in microbial amylases. Biotechnology and Applied Biochemistry 31:Pt 2 (2000), 135–152.
203. Pandey, A., Selvakumar, P., Soccol, C.R., Nigam, P., Solid state fermentation for the production of industrial enzymes. Current Science India 77 (1999), 149–162.
204. Parenicova, L., Benen, J.A., Kester, H.C., Visser, J., pgaA and pgaB encode two constitutively expressed endopolygalacturonases of Aspergillus niger. The Biochemical Journal 345:Pt 3 (2000), 637–644.
205. Pariza, M.W., Johnson, E.A., Evaluating the safety of microbial enzyme preparations used in food processing: Update for a new century. Regulatory Toxicology and Pharmacology: RTP 33 (2001), 173–186.
206. Park, H.-S., Nam, T.Y., Han, K.H., Kim, S.C., Yu, J.-H., VelC positively controls sexual development in Aspergillus nidulans. PLoS One, 9, 2014, e89883.
207. Park, H.-S., Ni, M., Jeong, K.C., Kim, Y.H., Yu, J.-H., The role, interaction and regulation of the velvet regulator VelB in Aspergillus nidulans. PLoS One, 7, 2012, e45935.
208. Park, H.-S., Yu, J.-H., Genetic control of asexual sporulation in filamentous fungi. Current Opinion in Microbiology 15 (2012), 669–677.
209. Park, H.-S., Yu, J.-H., Developmental regulators in Aspergillus fumigatus. The Journal of Microbiology 54 (2016), 223–231.
210. Park, H.-S., Yu, J.-H., Velvet regulators in Aspergillus spp. Microbiology Biotechnology Letters 44 (2016), 409–419.
211. Park, H.-S., Yu, Y.M., Lee, M.K., Maeng, P.J., Kim, S.C., Yu, J.-H., Velvet-mediated repression of beta-glucan synthesis in Aspergillus nidulans spores. Scientific Reports, 5, 2015, 10199.
212. Park, S.H., Kim, D.S., Kim, W.G., Ryoo, I.J., Lee, D.H., Huh, C.H., Park, K.C., Terrein: A new melanogenesis inhibitor and its mechanism. Cellular and Molecular Life Sciences: CMLS 61 (2004), 2878–2885.
213. Pastor, F.J., Guarro, J., Treatment of Aspergillus terreus infections: A clinical problem not yet resolved. International Journal of Antimicrobial Agents 44 (2014), 281–289.
214. Patil, A.G., Kote, N.V., Mulimani, V., Enzymatic removal of flatulence-inducing sugars in chickpea milk using free and polyvinyl alcohol immobilized alpha-galactosidase from Aspergillus oryzae. Journal of Industrial Microbiology & Biotechnology 36 (2009), 29–33.
215. Payne, G.A., Nierman, W.C., Wortman, J.R., Pritchard, B.L., Brown, D., Dean, R.A., Yu, J., Whole genome comparison of Aspergillus flavus and A. oryzae. Medical Mycology 44 (2006), 9–11.
216. Payne, G.A., Yu, J., Nierman, W.C., Machida, M., Bhatnagar, D., Cleveland, T.E., Dean, R.A., A first glance into the genome sequence of Aspergillus flavus. Osmani, S., Goldman, G., (eds.) The Aspergilli: Genomics, medical aspects, biotechnology and research methods, 2007, CRC Press, Boca Ratan, FL, 15–23.
217. Pelaez, F., Biological activities of fungal metabolites. An, Z., (eds.) Handbook of industrial mycology, 2004, CRC Press, New York, 49–92.
218. Pel, H.J., de Winde, J.H., Archer, D.B., Dyer, P.S., Hofmann, G., Schaap, P.J., Stam, H., Genome sequencing and analysis of the versatile cell factory Aspergillus niger CBS 513.88. Nature Biotechnology 25 (2007), 221–231.
219. Peleg, Y., Stieglitz, B., Goldberg, I., Malic acid accumulation by Aspergillus flavus - I. Biochemical aspects of acid biosynthesis. Applied Microbiology and Biotechnology 28 (1988), 69–75.
220. Peterson, S.W., Phylogenetic analysis of Aspergillus species using DNA sequences from four loci. Mycologia 100 (2008), 205–226.
221. Peterson, S.W., Varga, J., Frisvad, J.C., Samson, R.A., Phylogeny and subgeneric taxonomy of Aspergillus. Varga, J., Samson, R.A., (eds.) Aspergillus in the genomic era, 2008, Wageningen Academic Publishers, Wageningen, 33–56.
222. Pi, B., Yu, D., Dai, F., Song, X., Zhu, C., Li, H., Yu, Y., A genomics based discovery of secondary metabolite biosynthetic gene clusters in Aspergillus ustus. PLoS One, 10, 2015, e0116089.
223. Pitt, J.I., Aspergillus and related teleomorphs. Pitt, J.I., Hocking, A.D., (eds.) Fungi and food spoilage, 2009, Springer, New York, 275–337.
224. Poutanen, K., Enzymes: An important tool in the improvement of the quality of cereal foods. Trends in Food Science & Technology 8 (1997), 300–306.
225. Punt, P.J., van Biezen, N., Conesa, A., Albers, A., Mangnus, J., van den Hondel, C., Filamentous fungi as cell factories for heterologous protein production. Trends in Biotechnology 20 (2002), 200–206.
226. Qian-Cutrone, J.F., Huang, S., Shu, Y.Z., Vyas, D., Fairchild, C., Menendez, A., Gao, Q., Stephacidin A and B: Two structurally novel, selective inhibitors of the testosterone-dependent prostate LNCaP cells. Journal of the American Chemical Society 124 (2002), 14556–14557.
227. Rabie, C.J., Lubben, A., Steyn, M., Production of sterigmatocystin by Aspergillus versicolor and Bipolaris sorokiniana on semisynthetic liquid and solid media. Applied and Environmental Microbiology 32 (1976), 206–208.
228. Rabindran, S.K., He, H.Y., Singh, M., Brown, E., Collins, K.I., Annable, T., Greenberger, L.M., Reversal of a novel multidrug resistance mechanism in human colon carcinoma cells by fumitremorgin C. Cancer Research 58 (1998), 5850–5858.
229. Rana, V., Eckard, A.D., Teller, P., Ahring, B.K., On-site enzymes produced from Trichoderma reesei RUT-C30 and Aspergillus saccharolyticus for hydrolysis of wet exploded corn stover and loblolly pine. Bioresource Technology 154 (2014), 282–289.
230. Rank, C., Larsen, T.O., Frisvad, J.C., Functional systems biology of Aspergillus. Machida, M., Gomi, K., (eds.) Aspergillus: Molecular biology and genomics, 2010, Caister Academic Press, Wymondham, Norfolk, UK, 173–198.
231. Raper, K.B., Fennell, D.I., The genus Aspergillus. 1965, Williams and Wilkins, Baltimore.
232. Rasiah, I.A., Sutton, K.H., Low, F.L., Lin, H.M., Gerrard, J.A., Crosslinking of wheat dough proteins by glucose oxidase and the resulting effects on bread and croissants. Food Chemistry 89 (2005), 325–332.
233. Reddy, D.S., Duncan, S., Shimizu, G.K., A family of supramolecular inclusion solids based upon second-sphere interactions. Angewandte Chemie International Edition 42 (2003), 1360–1364.
234. Richard, J., Significant features in the history of aflatoxins. Phytopathology, 98, 2008, S182.
235. Rosen, S., Yu, J.H., Adams, T.H., The Aspergillus nidulans sfaD gene encodes a G protein beta subunit that is required for normal growth and repression of sporulation. EMBO Journal 18 (1999), 5592–5600.
236. Ruijter, G.J., Panneman, H., Xu, D., Visser, J., Properties of Aspergillus niger citrate synthase and effects of citA overexpression on citric acid production. FEMS Microbiology Letters 184 (2000), 35–40.
237. Ruijter, G.J., van de Vondervoort, P.J., Visser, J., Oxalic acid production by Aspergillus niger: An oxalate-non-producing mutant produces citric acid at pH 5 and in the presence of manganese. Microbiology 145:Pt 9 (1999), 2569–2576.
238. Ruiz-Diez, B., Strategies for the transformation of filamentous fungi. Journal of Applied Microbiology 92 (2002), 189–195.
239. Saito, K., Über die Säurebinding von Aspergillus oryzae. Botanical Magazine 21 (1907), 7–11.
240. Sallam, L.A., El-Refai, A.M., Hamdy, A.H., El-Minofi, H.A., Abdel-Salam, I.S., Role of some fermentation parameters on cyclosporin A production by a new isolate of Aspergillus terreus. The Journal of General and Applied Microbiology 49 (2003), 321–328.
241. Samson, R.A., Peterson, S.W., Frisvad, J.C., Varga, J., New species in Aspergillus section Terrei. Studies in Mycology 69 (2011), 39–55.
242. Samson, R.A., Visagie, C.M., Houbraken, J., Hong, S.B., Hubka, V., Klaassen, C.H., Frisvad, J.C., Phylogeny, identification and nomenclature of the genus Aspergillus. Studies in Mycology 78 (2014), 141–173.
243. Sanchez, J.F., Somoza, A.D., Keller, N.P., Wang, C.C., Advances in Aspergillus secondary metabolite research in the post-genomic era. Natural Product Reports 29 (2012), 351–371.
244. Sanchez, O.J., Cardona, C.A., Trends in biotechnological production of fuel ethanol from different feedstocks. Bioresource Technology 99 (2008), 5270–5295.
245. Sarkar, N., Aikat, K., Aspergillus fumigatus NITDGPKA3 provides for increased cellulase production. International Journal of Chemical Engineering 5 (2014), 1–9.
246. Saruno, R., Kato, F., Ikeno, T., Kojic acid, a tyrosinase inhibitor from Aspergillus albus. Agricultural and Biological Chemistry 43 (1979), 1337–1338.
247. Sato, A., Oshima, K., Noguchi, H., Ogawa, M., Takahashi, T., Oguma, T., Hanya, Y., Draft genome sequencing and comparative analysis of Aspergillus sojae NBRC4239. DNA Research: an International Journal for Rapid Publication of Reports on Genes and Genomes 18 (2011), 165–176.
248. Scharf, D.H., Brakhage, A.A., Mukherjee, P.K., Gliotoxin - bane or boon?. Environmental Microbiology 18 (2016), 1096–1109.
249. Scharf, D.H., Heinekamp, T., Remme, N., Hortschansky, P., Brakhage, A.A., Hertweck, C., Biosynthesis and function of gliotoxin in Aspergillus fumigatus. Applied Microbiology and Biotechnology 93 (2012), 467–472.
250. Schmid, A., Dordick, J.S., Hauer, B., Kiener, A., Wubbolts, M., Witholt, B., Industrial biocatalysis today and tomorrow. Nature 409 (2001), 258–268.
251. Schuster, E., Dunn-Coleman, N., Frisvad, J.C., Van Dijck, P.W., On the safety of Aspergillus niger–a review. Applied Microbiology and Biotechnology 59 (2002), 426–435.
252. Seifu, E., Buys, E.M., Donkin, E.F., Significance of the lactoperoxidase system in the dairy industry and its potential applications: A review. Trends in Food Science & Technology 16 (2005), 137–154.
253. Seo, J.A., Han, K.H., Yu, J.H., Multiple roles of a heterotrimeric G-protein gamma-subunit in governing growth and development of Aspergillus nidulans. Genetics 171 (2005), 81–89.
254. Sheikh-Ali, S.I., Ahmad, A., Mohd-Setapar, S.H., Zakaria, Z.A., Abdul-Talib, N., Khamis, A.K., Hoque, M.E., The potential hazards of Aspergillus sp. in foods and feeds, and the role of biological treatment: A review. The Journal of Microbiology 52 (2014), 807–818.
255. Shin, K.S., Park, H.S., Kim, Y.H., Yu, J.H., Comparative proteomic analyses reveal that FlbA down-regulates gliT expression and SOD activity in Aspergillus fumigatus. Journal of Proteomics 87 (2013), 40–52.
256. Shraddha, Shekher, R., Sehgal, S., Kamthania, M., Kumar, A., Laccase: Microbial sources, production, purification, and potential biotechnological applications. Enzyme Research, 2011, 2011, 217861.
257. da Silva, C.R., Silva, M.L., Kamida, H.M., Goes-Neto, A., Koblitz, M.G., Lytic enzyme production optimization using low-cost substrates and its application in the clarification of xanthan gum culture broth. Food Sciences and Nutrition 2 (2014), 299–307.
258. Singh, A.K., Mukhopadhyay, M., Overview of fungal lipase: A review. Applied Biochemistry and Biotechnology 166 (2012), 486–520.
259. Sisak, C., Csanadi, Z., Ronay, E., Szajani, B., Elimination of glucose in egg white using immobilized glucose oxidase. Enzyme and Microbial Technology 39 (2006), 1002–1007.
260. Song, J., Imanaka, H., Imamura, K., Kajitani, K., Nakanishi, K., Development of a highly efficient indigo dyeing method using indican with an immobilized beta-glucosidase from Aspergillus niger. Journal of Bioscience and Bioengineering 110 (2010), 281–287.
261. Sorensen, A., Lubeck, P.S., Lubeck, M., Nielsen, K.F., Ahring, B.K., Teller, P.J., Frisvad, J.C., Aspergillus saccharolyticus sp. nov., a black Aspergillus species isolated in Denmark. International Journal of Systematic and Evolutionary Microbiology 61 (2011), 3077–3083.
262. de Souza, P.M., Bittencourt, M.L., Caprara, C.C., de Freitas, M., de Almeida, R.P., Silveira, D., Magalhaes, P.O., A biotechnology perspective of fungal proteases. Brazilian Journal of Microbiology 46 (2015), 337–346.
263. van der Straat, L., Vernooij, M., Lammers, M., van den Berg, W., Schonewille, T., Cordewener, J., de Graaff, L.H., Expression of the Aspergillus terreus itaconic acid biosynthesis cluster in Aspergillus niger. Microbial Cell Factories, 13, 2014, 11.
264. Suganuma, T., Fujita, K., Kitahara, K., Some distinguishable properties between acid-stable and neutral types of alpha-amylases from acid-producing koji. Journal of Bioscience and Bioengineering 104 (2007), 353–362.
265. Sugawara, E., Fermented soybean pastes miso and shoyu with reference to aroma. Tamang, J.P., Kailasapathy, K., (eds.) Fermented foods and beverages of the world, 2010, CRC Press, New York, 225–245.
266. Sullivan, G.A., Calkins, C.R., Application of exogenous enzymes to beef muscle of high and low-connective tissue. Meat Science 85 (2010), 730–734.
267. Su, X., Schmitz, G., Zhang, M., Mackie, R.I., Cann, I.K., Heterologous gene expression in filamentous fungi. Advances in Applied Microbiology 81 (2012), 1–61.
268. Szewczyk, E., Nayak, T., Oakley, C.E., Edgerton, H., Xiong, Y., Taheri-Talesh, N., Oakley, B.R., Fusion PCR and gene targeting in Aspergillus nidulans. Nature Protocols Other Titles: Protocols 1 (2006), 3111–3120.
269. Takahashi, T., Masuda, T., Koyama, Y., Enhanced gene targeting frequency in ku70 and ku80 disruption mutants of Aspergillus sojae and Aspergillus oryzae. Molecular Genetics and Genomics: MGG 275 (2006), 460–470.
270. Takahashi, T., Masuda, T., Koyama, Y., Identification and analysis of Ku70 and Ku80 homologs in the koji molds Aspergillus sojae and Aspergillus oryzae. Bioscience, Biotechnology, and Biochemistry 70 (2006), 135–143.
271. Tamang, J.P., Plant-based fermented foods and beverages of Asia. Hui, Y.H., (eds.) Handbook of plant-based fermented food and beverage technology, 2nd ed., 2012, CRC Press, Boca Raton, 49–91.
272. Tamang, J.P., Watanabe, K., Holzapfel, W.H., Review: Diversity of microorganisms in global fermented foods and beverages. Frontiers in Microbiology, 7, 2016, 377.
273. Tanyildizi, M.S., Ozer, D., Elibol, M., Optimization of alpha-amylase production by Bacillus sp using response surface methodology. Process Biochemistry 40 (2005), 2291–2296.
274. Taylor, J.W., Bowman, B.H., Berbee, M.L., White, T.J., Fungal model organisms - phylogenetics of Saccharomyces, Aspergillus, and Neurospora. Systematic Biology 42 (1993), 440–457.
275. Taylor, M.J., Richardson, T., Applications of microbial enzymes in food systems and in biotechnology. Advances in Applied Microbiology 25 (1979), 7–35.
276. Teotia, P., Kumar, M., Varma, A., Kumar, V., Molecular tools for strain improvement in Aspergillus. Gupta, V.G., (eds.) New and future developments in microbial biotechnology and bioengineering, 2016, Elsvier, 119–124.
277. Terabayashi, Y., Sano, M., Yamane, N., Marui, J., Tamano, K., Sagara, J., Machida, M., Identification and characterization of genes responsible for biosynthesis of kojic acid, an industrially important compound from Aspergillus oryzae. Fungal Genetics and Biology 47 (2010), 953–961.
278. Thakur, N., Savitri, Saris, P.E.J., Bhalla, T.C., Microorganisms associated with amylolytic starters and traditional fermented alcoholic beverages of North Western Himalayas in India. Food Bioscience 11 (2015), 92–96.
279. Thrane, U., Fungal protein for food. Dijksterhuis, J., Samson, R.A., (eds.) Food mycology: A multifaceted approach to fungi and food, 2007, CRC Press, Boca Raton, 353–360.
280. Tobert, J.A., Lovastatin and beyond: The history of the HMG-CoA reductase inhibitors. Nature Reviews Drug Discovery 2 (2003), 517–526.
281. Tomoda, H., Kim, Y.K., Nishida, H., Masuma, R., Omura, S., Pyripyropenes, novel inhibitors of acyl-CoA:cholesterol acyltransferase produced by Aspergillus fumigatus. I. Production, isolation, and biological properties. Journal of Antibiotics (Tokyo) 47 (1994), 148–153.
282. Tosa, T., Shibatani, T., Industrial application of immobilized biocatalysts in Japan. Annals of the New York Academy of Sciences 750 (1995), 364–375.
283. Vandenberghe, L.P.S., Soccol, C.R., Pandey, A., Lebeault, J.M., Microbial production of citric acid. Brazilian Archives of Biology and Technology 42 (1999), 263–276.
284. Varga, J., Frisvad, J.C., Kocsube, S., Brankovics, B., Toth, B., Szigeti, G., Samson, R.A., New and revisited species in Aspergillus section Nigri. Studies in Mycology 69 (2011), 1–17.
285. Varga, J., Kocsube, S., Toth, B., Frisvad, J.C., Perrone, G., Susca, A., Samson, R.A., Aspergillus brasiliensis sp. nov., a biseriate black Aspergillus species with world-wide distribution. International Journal of Systematic and Evolutionary Microbiology 57 (2007), 1925–1932.
286. Viikari, L., Kantelinen, A., Sundquist, J., Linko, M., Xylanases in bleaching - from an idea to the industry. FEMS Microbiology Review 13 (1994), 335–350.
287. Villena, G.K., Gutierrez-Correa, M., Production of cellulase by Aspergillus niger biofilms developed on polyester cloth. Letters in Applied Microbiology 43 (2006), 262–268.
288. Vishwanatha, K.S., Rao, A.G.A., Singh, S.A., Production and characterization of a milk-clotting enzyme from Aspergillus oryzae MTCC 5341. Applied Microbiology and Biotechnology 85 (2010), 1849–1859.
289. de Vries, R.P., Riley, R., Wiebenga, A., Aguilar-Osorio, G., Amillis, S., Uchima, C.A., Grigoriev, I.V., Comparative genomics reveals high biological diversity and specific adaptations in the industrially and medically important fungal genus Aspergillus. Genome Biology, 18, 2017, 28.
290. Wadham, M., Bio-polishing of cellulosic fabrics. Journal of the Society of Dyers 110 (1994), 367–368.
291. Walsh, G.A., Power, R.F., Headon, D.R., Enzymes in the animal-feed industry. Trends in Biotechnology 11 (1993), 424–430.
292. Walsh, T.J., Groll, A.H., Overview: Non-fumigatus species of Aspergillus: Perspectives on emerging pathogens in immunocompromised hosts. Current Opinion in Investigational Drugs 2 (2001), 1366–1367.
293. Wang, C.C.C., Chiang, Y.M., Praseuth, M.B., Kuo, P.L., Liang, H.L., Hsu, Y.L., Asperfuranone from Aspergillus nidulans inhibits proliferation of human non-small cell lung cancer A549 cells via blocking cell cycle progression and inducing apoptosis. Basic and Clinical Pharmacology and Toxicology 107 (2010), 583–589.
294. Ward, M., Lin, C., Victoria, D.C., Fox, B.P., Fox, J.A., Wong, D.L., Wang, H., Characterization of humanized antibodies secreted by Aspergillus niger. Applied and Environmental Microbiology 70 (2004), 2567–2576.
295. Weld, R.J., Plummer, K.M., Carpenter, M.A., Ridgway, H.J., Approaches to functional genomics in filamentous fungi. Cell Research 16 (2006), 31–44.
296. Wiebe, M.G., Myco-protein from Fusarium venenatum: A well-established product for human consumption. Applied Microbiology and Biotechnology 58 (2002), 421–427.
297. Witteveen, F.B., van de Vondervoort, P.J., van den Broeck, H.C., van Engelenburg, A.C., de Graaff, L.H., Hillebrand, M.H., Visser, J., Induction of glucose oxidase, catalase, and lactonase in Aspergillus niger. Current Genetics 24 (1993), 408–416.
298. Woloshuk, C.P., Foutz, K.R., Brewer, J.F., Bhatnagar, D., Cleveland, T.E., Payne, G.A., Molecular characterization of aflr, a regulatory locus for aflatoxin biosynthesis. Applied and Environmental Microbiology 60 (1994), 2408–2414.
299. Wong, C.M., Wong, K.H., Chen, X.D., Glucose oxidase: Natural occurrence, function, properties and industrial applications. Applied Microbiology and Biotechnology 78 (2008), 927–938.
300. Yakushiji, F., Tanaka, H., Muguruma, K., Iwahashi, T., Yamazaki, Y., Hayashi, Y., Water-soluble prodrug of antimicrotubule agent plinabulin: Effective strategy with click chemistry. Chemistry: A European Journal 17 (2011), 12587–12590.
301. Yamada, O., Machida, M., Hosoyama, A., Goto, M., Takahashi, T., Futagami, T., Gomi, K., Genome sequence of Aspergillus luchuensis NBRC 4314. DNA Research: an International Journal for Rapid Publication of Reports on Genes and Genomes 23 (2016), 507–515.
302. Yamada, R., Yoshie, T., Wakai, S., Asai-Nakashima, N., Okazaki, F., Ogino, C., Kondo, A., Aspergillus oryzae-based cell factory for direct kojic acid production from cellulose. Microbial Cell Factories, 13, 2014, 71.
303. Yang, L., Lübeck, M., Ahring, B.K., Lübeck, P.S., Enhanced succinic acid production in Aspergillus saccharolyticus by heterologous expression of fumarate reductase from Trypanosoma brucei. Applied Microbiology and Biotechnology 100 (2016), 1799–1809.
304. Yang, L., Lübeck, M., Lübeck, P.S., Aspergillus as a versatile cell factory for organic acid production. Fungal Biology Reviews, 2016, 1–17.
305. Yan, S., Tang, H., Wang, S., Xu, L., Liu, H., Guo, Y., Yao, J., Improvement of kojic acid production in Aspergillus oryzae B008 mutant strain and its uses in fermentation of concentrated corn stalk hydrolysate. Bioprocess and Biosystems Engineering 37 (2014), 1095–1103.
306. Yin, Y., Cai, M., Zhou, X., Li, Z., Zhang, Y., Polyketides in Aspergillus terreus: Biosynthesis pathway discovery and application. Applied Microbiology and Biotechnology 100 (2016), 7787–7798.
307. Yoder, W.T., Christianson, L.M., Species-specific primers resolve members of Fusarium section Fusarium. Taxonomic status of the edible “Quorn” fungus reevaluated. Fungal Genetics and Biology 23 (1998), 68–80.
308. Yokotsuka, T., Soy sauce biochemistry. Advances in Food Research 30 (1986), 195–329.
309. Yu, J.-H., Heterotrimeric G protein signaling and RGSs in Aspergillus nidulans. The Journal of Microbiology 44 (2006), 145–154.
310. Yu, J.H., Regulation of development in Aspergillus nidulans and Aspergillus fumigatus. Mycobiology 38 (2010), 229–237.
311. Yu, J.-H., Hamari, Z., Han, K.H., Seo, J.A., Reyes-Dominguez, Y., Scazzocchio, C., Double-joint PCR: A PCR-based molecular tool for gene manipulations in filamentous fungi. Fungal Genetics and Biology 41 (2004), 973–981.
312. Yu, J.-H., Keller, N., Regulation of secondary metabolism in filamentous fungi. Annual Review of Phytopathology 43 (2005), 437–458.
313. Yu, J.-H., Leonard, T.J., Sterigmatocystin biosynthesis in Aspergillus nidulans requires a novel type I polyketide synthase. Journal of Bacteriology 177 (1995), 4792–4800.
314. Yu, J.H., Wieser, J., Adams, T.H., The Aspergillus FlbA RGS domain protein antagonizes G protein signaling to block proliferation and allow development. EMBO Journal 15 (1996), 5184–5190.
315. Zhou, Q., Liao, J.K., Statins and cardiovascular diseases: From cholesterol lowering to pleiotropy. Current Pharmaceutical Design 15 (2009), 467–478.
316. Znad, H., Markos, J., Bales, V., Production of gluconic acid from glucose by Aspergillus niger: Growth and non-growth conditions. Process Biochemistry 39 (2004), 1341–1345.