LaeA, a regulator of secondary metabolism in Aspergillus spp.

Eukaryotic Cell

Volumn 3, Issue 2, 2004, Pages 527-535

  Bok, Jin Woo ^a   Keller, Nancy P ^a  

^a UNIVERSITY OF WISCONSIN MADISON   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AFLR PROTEIN, ASPERGILLUS; CYCLIC AMP DEPENDENT PROTEIN KINASE; DNA BINDING PROTEIN; FUNGAL PROTEIN; MEVINOLIN; PENICILLIN DERIVATIVE; PROTEIN METHYLTRANSFERASE; RAS PROTEIN; STERIGMATOCYSTIN; TRANSCRIPTION FACTOR;

AMINO ACID SEQUENCE; ARTICLE; ASPERGILLUS; BINDING SITE; BIOSYNTHESIS; ENZYMOLOGY; FUNGUS SPORE; GENE EXPRESSION REGULATION; GENETICS; METABOLISM; MOLECULAR CLONING; MOLECULAR GENETICS; MULTIGENE FAMILY; MYCELIUM; PHYSIOLOGY; PIGMENTATION; PROMOTER REGION; SEQUENCE ALIGNMENT;

AMINO ACID SEQUENCE; ASPERGILLUS; BINDING SITES; CLONING, MOLECULAR; CYCLIC AMP-DEPENDENT PROTEIN KINASES; DNA-BINDING PROTEINS; FUNGAL PROTEINS; GENE EXPRESSION REGULATION, FUNGAL; LOVASTATIN; MOLECULAR SEQUENCE DATA; MULTIGENE FAMILY; MYCELIUM; PENICILLINS; PIGMENTATION; PROMOTER REGIONS (GENETICS); PROTEIN METHYLTRANSFERASES; RAS PROTEINS; SEQUENCE ALIGNMENT; SPORES, FUNGAL; STERIGMATOCYSTIN; TRANSCRIPTION FACTORS;

ASPERGILLUS; BACTERIA (MICROORGANISMS);

EID: 4143090400     PISSN: 15359778     EISSN: None     Source Type: Journal    
DOI: 10.1128/EC.3.2.527-535.2004     Document Type: Article

References (40)

1. Adams, T. H., and J. H. Yu. 1998. Coordinate control of secondary metabolite production and asexual sporulation in Aspergillus nidulans. Curr. Opin. Microbiol. 1:674-677.
2. Adams, T. H., and W. E. Timberlake. 1990. Developmental repression of growth and gene expression in Aspergillus. Proc. Natl. Acad. Sci. USA 87: 5405-5409.
3. Alexander, N. J., T. H. Hohn, and S. P. McCormick. 1998. The TRI11 gene of Fusarium sporotrichioides encodes a cytochrome P-450 monooxygenase required for C-15 hydroxylation in trichothecene biosynthesis. Appl. Environ. Microbiol. 64:221-225.
4. Alspaugh, J. A., J. R. Perfect, and J. Heitman. 1997. Cryptococcus neoformans mating and virulence are regulated by the G-protein alpha subunit GPA1 and cAMP. Genes Dev. 11:3206-3217.
5. Belkacemi, L., R. C. Barton, V. Hopwood, and E. G. V. Evans. 1999. Determination of optimum growth conditions for gliotoxin production by Aspergillus fumigatus and development of a novel method for gliotoxin detection. Med. Mycol. 37:227-233.
6. Brakhage, A. A. 1998. Molecular regulation of beta-lactam biosynthesis in filamentous fungi. Microbiol. Mol. Biol. Rev. 62:547-585.
7. Brown, D. W., J. H. Yu, H. S. Kelkar, M. Fernandes, T. C. Nesbitt, N. P. Keller, T. H. Adams, and T. J. Leonard. 1996. Twenty-five coregulated transcripts define a sterigmatocystin gene cluster in Aspergillus nidulans. Proc. Natl. Acad. Sci. USA 93:1418-1422.
8. Butchko, R. A., T. H. Adams, and N. P. Keller. 1999. Aspergillus nidulans mutants defective in sic gene cluster regulation. Genetics 153:715-720.
9. Calvo, A. M., R. A. Wilson, J. W. Bok, and N. P. Keller. 2002. Relationship between secondary metabolism and fungal development. Microbiol. Mol. Biol. Rev. 66:447-459.
10. Chalfie, M., Y. Tu, G. Euskirchen, W. W. Ward, and D. C. Prasher. 1994. Green fluorescent protein as a marker for gene expression. Science 263:802-805.
11. Demain, A., and A. Fang. 2000. The natural functions of secondary metabolites. Adv. Biochem. Eng. Biotechnol. 69:1-39.
12. Fernandes, M., N. P. Keller, and T. H. Adams. 1998. Sequence-specific binding by Aspergillus nidulans AflR, a C6 zinc cluster protein regulating mycotoxin biosynthesis. Mol. Microbiol. 28:1355-1365.
13. Fernandez-Abalos, J. M., H. Fox, C. Pitt, B. Wells, and J. H. Doonan. 1998. Plant-adapted green fluorescent protein is a versatile vital reporter for gene expression, protein localization and mitosis in the filamentous fungus Aspergillus nidulans. Mol. Microbiol. 27:121-130.
14. Hah, H. 1993. Differential action of cercoran and topsin-M on sensitive and tolerant strains of toxic fungi. Cryptogamie Mycologie 14:61-68.
15. Hamahata, A., Y. Takata, T. Gomi, and M. Fujioka. 1996. Probing the S-adenosylmethionine-binding site of rat guanidinoacetate methyltransferase. Effect of site-directed mutagenesis of residues that are conserved across mammalian non-nucleic acid methyltransferases. Biochem. J. 317: 141-145.
16. Hawksworth, D. L. 2001. The magnitude of fungal diversity: the 1.5 million species estimate revisited. Mycol. Res. 105:1422-1432.
17. Hicks, J. K., K. Shimizu, and N. P. Keller. 2002. Genetics and biosynthesis of aflatoxins and sterigmatocystin, p. 55-69. In F. Kempken and J. W. Bennett (ed.), The mycota, vol. XI. Springer-Verlag, Berlin, Germany.
18. Hicks, J. K., J.-H. Yu, N. P. Keller, and T. H. Adams. 1997. Aspergillus sporulation and mycotoxin production both require inactivation of the FadA G alpha protein-dependent signaling pathway. EMBO J. 16:4916-4923.
19. Hicks, J., R. A. Lockington, J. Strauss, D. Dieringer, C. P. Kubicek, J. Kelly, and N. Keller. 2001. RcoA has pleiotropic effects on Aspergillus nidulans cellular development. Mol. Microbiol. 39:1482-1493.
20. Jin, Y., J. W. Bok, D. Guzman-de-Peña, and N. P. Keller. 2002. Requirement of spermidine for developmental transitions in Aspergillus nidulans. Mol. Microbiol. 46:801-812.
21. Kennedy, J., K. Auclair, S. G. Kendrew, C. Park, J. C. Vederas, and C. R. Hutchinson. 1999. Modulation of polyketide synthase activity by accessory proteins during lovastatin biosynthesis. Science 284:1368-1372.
22. Langfelder, K., M. Streibel, B. Jahn, G. Haase, and A. A. Brakhage. 2003. Biosynthesis of fungal melanins and their importance for human pathogenic fungi. Fungal Genet. Biol. 38:143-158.
23. Lee, B. N., and T. H. Adams. 1994. Overexpression of flbA, an early regulator of Aspergillus asexual sporulation, leads to activation of brlA and premature initiation of development. Mol. Microbiol. 14:323-334.
24. Miller, B. L., K. Y. Miller, and W. E. Timberlake. 1985. Direct and indirect gene replacements in Aspergillus nidulans. Mol. Cell. Biol. 5:1714-1721.
25. Mowen, K. A., J. Tang, W. Zhu, B. T. Schurter, K. Shuai, H. R. Herschman, and M. David. 2001. Arginine methylation of STAT1 modulates IFN alpha/ beta-induced transcription. Cell 104:731-741.
26. Pontecorvo, G., J. A. Roper, L. M. Hemmons, K. P. Macdonald, and A. W. J. Bufton. 1953. The genetics of Aspergillus nidulans. Adv. Genet. 5:141-238.
27. Rosén, S., J.-H. Yu, and T. H. Adams. 1999. The Aspergillus nidulans sfaD gene encodes a G protein beta subunit that is required for normal growth and repression of sporulation. EMBO J. 18:5592-5600.
28. Sambrook, J., E. F. Fritsch, and T. Maniatis. 1989. Molecular cloning: a laboratory manual. Cold Spring Harbor Laboratory Press, Cold Spring Harbor, N.Y.
29. Shimizu, K., and N. P. Keller. 2001. Genetic involvement of a cAMP-dependent protein kinase in a G protein signaling pathway regulating morphological and chemical transitions in Aspergillus nidulans. Genetics 157: 591-600.
30. Shimizu, K., J.-K. Hicks, T.-P. Huang, and N. P. Keller. 2003. Pka, Ras and RGS protein interactions regulate activity of AflR, a Zn(II)2Cys6 transcription factor in Aspergillus nidulans. Genetics 165:1095-1104.
31. Sienko, M., and A. Paszewski. 1999. The metG gene of Aspergillus nidulans encoding cystathionine beta-lyase: cloning and analysis. Curr. Genet. 35:638-646.
32. Skory, C. D., P. K. Chang, J. Cary, and J. E. Linz. 1992. Isolation and characterization of a gene from Aspergillus parasiticus associated with the conversion of versicolorin A to sterigmatocystin in aflatoxin biosynthesis. Appl. Environ. Microbiol. 58:3527-3537.
33. Som, T., and V. S. Kolaparthi. 1994. Developmental decisions in Aspergillus nidulans are modulated by Ras activity. Mol. Cell. Biol. 14:5333-5348.
34. Tag, A., J. Hicks, G. Garifullina, M. Beremand, and N. Keller. 2000. G-protein signalling mediates differential production of toxic secondary metabolites. Mol. Microbiol. 38:658-665.
35. Tamara, H., and E. U. Selker. 2001. A histone H3 methyltransferase controls DNA methylation in Neurospora crassa. Nature 414:277-283.
36. Tilburn, J., S. Sarkar, D. A. Widdick, E. A. Espeso, M. Orejas, J. Mungroo, M. A. Penalva, and H. N. Arst, Jr. 1995. The Aspergillus PacC zinc finger transcription factor mediates regulation of both acid- and alkaline-expressed genes by ambient pH. EMBO J. 14:779-790.
37. Umeyama, T., P. C. Lee, and S. Horinouchi. 2002. Protein serine/threonine kinases in signal transduction for secondary metabolism and morphogenesis in Streptomyces. Appl. Microbiol. Biotechnol. 59:419-425.
38. Wang, L., and L. C. Vining. 2003. Control of growth, secondary metabolism and sporulation in Streptomyces venezuelae ISP5230 by jadW (1), a member of the afsA family of gamma-butyrolactone regulatory genes. Microbiology 149:1991-2004.
39. Wieser, J., and T. H. Adams. 1995. flbD encodes a Myb-like DNA-binding protein that coordinates initiation of Aspergillus nidulans conidiophore development. Genes Dev. 9:491-502.
40. Yu, J.-H., J. Wieser, and T. H. Adams. 1996. The Aspergillus FIbA RGS domain protein antagonizes G protein signaling to block proliferation and allow development. EMBO J. 15:5184-5190.