Genetic Control of Asexual Development in Aspergillus fumigatus

Advances in Applied Microbiology

Volumn 90, Issue , 2015, Pages 93-107

  Alkhayyat, Fahad ^a   Chang Kim, Sun ^b   Yu, Jae Hyuk ^a  

^a UNIVERSITY OF WISCONSIN MADISON   (United States)

^b Korea Advanced Institute of Science and Technology (KAIST)   (South Korea)

Author keywords

Asexual development; Aspergillus fumigatus; Conidia; Gliotoxin; Regulation

Indexed keywords

GLIOTOXIN; GUANINE NUCLEOTIDE BINDING PROTEIN; PROTEIN FLB; UNCLASSIFIED DRUG; FUNGAL PROTEIN;

ARTICLE; ASEXUAL REPRODUCTION; ASEXUAL SPORE; ASPERGILLUS FUMIGATUS; CONIDIUM; FUNGAL GENE; GENETIC REGULATION; HOST PATHOGEN INTERACTION; IMMUNOCOMPROMISED PATIENT; LUNG ASPERGILLOSIS; MORTALITY; NONHUMAN; REGULATORY MECHANISM; SIGNAL TRANSDUCTION; TOXIN SYNTHESIS; VELVET GENE; FUNGUS SPORE; GENE EXPRESSION REGULATION; GENETICS; GROWTH, DEVELOPMENT AND AGING; METABOLISM; PHYSIOLOGY;

ASPERGILLUS FUMIGATUS; FUNGI;

ASPERGILLUS FUMIGATUS; FUNGAL PROTEINS; GENE EXPRESSION REGULATION, FUNGAL; REPRODUCTION, ASEXUAL; SPORES, FUNGAL;

EID: 84920934875     PISSN: 00652164     EISSN: None     Source Type: Book Series    
DOI: 10.1016/bs.aambs.2014.09.004     Document Type: Article

References (48)

1. Adams T.H., Boylan M.T., Timberlake W.E. brlA is necessary and sufficient to direct conidiophore development in Aspergillus nidulans. Cell 1988, 54:353-362.
2. Adams T.H., Wieser J.K., Yu J.H. Asexual sporulation in Aspergillus nidulans. Microbiology and Molecular Biology Reviews 1998, 62:35-54.
3. Ahmed Y.L., Gerke J., Park H.S., Bayram O., Neumann P., Ni M., et al. The velvet family of fungal regulators contains a DNA-binding domain structurally similar to NF-kappaB. PLoS Biology 2013, 11:e1001750.
4. Andrianopoulos A., Timberlake W.E. The Aspergillus nidulans abaA gene encodes a transcriptional activator that acts as a genetic switch to control development. Molecular and Cellular Biology 1994, 14:2503-2515.
5. Aramayo R., Timberlake W.E. The Aspergillus nidulans yA gene is regulated by abaA. The EMBO Journal 1993, 12:2039-2048.
6. Bayram O., Braus G.H. Coordination of secondary metabolism and development in fungi: the velvet family of regulatory proteins. FEMS Microbiology Reviews 2012, 36:1-24.
7. Bayram O., Krappmann S., Ni M., Bok J.W., Helmstaedt K., Valerius O., et al. VelB/VeA/LaeA complex coordinates light signal with fungal development and secondary metabolism. Science 2008, 320:1504-1506.
8. Bayram O., Krappmann S., Seiler S., Vogt N., Braus G.H. Neurospora crassa ve-1 affects asexual conidiation. Fungal Genetics and Biology 2008, 45:127-138.
9. Blumenstein A., Vienken K., Tasler R., Purschwitz J., Veith D., Frankenberg-Dinkel N., et al. The Aspergillus nidulans phytochrome FphA represses sexual development in red light. Current Biology 2005, 15:1833-1838.
10. Calvo A.M. The VeA regulatory system and its role in morphological and chemical development in fungi. Fungal Genetics and Biology 2008, 45:1053-1061.
11. Chang Y.C., Timberlake W.E. Identification of Aspergillus brlA response elements (BREs) by genetic selection in yeast. Genetics 1993, 133:29-38.
12. Clutterbuck A.J. A mutational analysis of conidial development in Aspergillus nidulans. Genetics 1969, 63:317-327.
13. Denning D.W., Follansbee S.E., Scolaro M., Norris S., Edelstein H., Stevens D.A. Pulmonary aspergillosis in the acquired immunodeficiency syndrome. The New England Journal of Medicine 1991, 324:654-662.
14. Dhingra S., Andes D., Calvo A.M. VeA regulates conidiation, gliotoxin production, and protease activity in the opportunistic human pathogen Aspergillus fumigatus. Eukaryotic Cell 2012, 11:1531-1543.
15. Fillinger S., Chaveroche M.K., van Dijck P., de Vries R., Ruijter G., Thevelein J., et al. Trehalose is required for the acquisition of tolerance to a variety of stresses in the filamentous fungus Aspergillus nidulans. Microbiology 2001, 147:1851-1862.
16. Fuller K.K., Ringelberg C.S., Loros J.J., Dunlap J.C. The fungal pathogen Aspergillus fumigatus regulates growth, metabolism, and stress resistance in response to light. mBio 2013, 4.
17. Kim H., Han K., Kim K., Han D., Jahng K., Chae K. The veA gene activates sexual development in Aspergillus nidulans. Fungal Genetics and Biology 2002, 37:72-80.
18. Kong Q., Wang L., Liu Z., Kwon N.J., Kim S.C., Yu J.H. Gbeta-like CpcB plays a crucial role for growth and development of Aspergillus nidulans and Aspergillus fumigatus. PloS One 2013, 8:e70355.
19. Kwon-Chung K.J., Sugui J.A. Aspergillus fumigatus - what makes the species a ubiquitous human fungal pathogen?. PLoS Pathogens 2013, 9:e1003743.
20. Kwon N.J., Park H.S., Jung S., Kim S.C., Yu J.H. The putative guanine nucleotide exchange factor RicA mediates upstream signaling for growth and development in Aspergillus. Eukaryotic Cell 2012, 11:1399-1412.
21. Kwon N.J., Shin K.S., Yu J.H. Characterization of the developmental regulator FlbE in Aspergillus fumigatus and Aspergillus nidulans. Fungal Genetics and Biology: FG & B 2010, 47:981-993.
22. Latge J.P. Aspergillus fumigatus and aspergillosis. Clinical Microbiology Review 1999, 12:310-350.
23. Liebmann B., Gattung S., Jahn B., Brakhage A.A. cAMP signaling in Aspergillus fumigatus is involved in the regulation of the virulence gene pksP and in defense against killing by macrophages. Molecular Genetics and Genomics 2003, 269:420-435.
24. Li L., Wright S.J., Krystofova S., Park G., Borkovich K.A. Heterotrimeric G protein signaling in filamentous fungi. Annual Review of Microbiology 2007, 61:423-452.
25. Mah J.H., Yu J.H. Upstream and downstream regulation of asexual development in Aspergillus fumigatus. Eukaryotic Cell 2006, 5:1585-1595.
26. Mirabito P.M., Adams T.H., Timberlake W.E. Interactions of three sequentially expressed genes control temporal and spatial specificity in Aspergillus development. Cell 1989, 57:859-868.
27. Mooney J.L., Yager L.N. Light is required for conidiation in Aspergillus nidulans. Genes & Development 1990, 4:1473-1482.
28. Mullins J., Harvey R., Seaton A. Sources and incidence of airborne Aspergillus fumigatus (Fres). Clinical Allergy 1976, 6:209-217.
29. Mullins J., Hutcheson P.S., Slavin R.G. Aspergillus fumigatus spore concentration in outside air: Cardiff and St Louis compared. Clinical Allergy 1984, 14:351-354.
30. Neves S.R., Ram P.T., Iyengar R. G protein pathways. Science 2002, 296:1636-1639.
31. Ni M., Gao N., Kwon N.J., Shin K.S., Yu J.H. Regulation of aspergillus conidiation. Cellular and Molecular Biology of Filamentous Fungi 2010, 559-576.
32. Ni M., Yu J.H. A novel regulator couples sporogenesis and trehalose biogenesis in Aspergillus nidulans. PloS One 2007, 2:e970.
33. Park H.S., Bayram O., Braus G.H., Kim S.C., Yu J.H. Characterization of the velvet regulators in Aspergillus fumigatus. Molecular Microbiology 2012, 86:937-953.
34. Park H.S., Ni M., Jeong K.C., Kim Y.H., Yu J.H. The role, interaction and regulation of the velvet regulator VelB in Aspergillus nidulans. PloS One 2012, 7:e45935.
35. Purschwitz J., Muller S., Kastner C., Schoser M., Haas H., Espeso E.A., et al. Functional and physical interaction of blue- and red-light sensors in Aspergillus nidulans. Current Biology 2008, 18:255-259.
36. Rhodes J.C., Askew D.S. Aspergillus fumigatus. Cellular and Molecular Biology of Filamentous Fungi 2010, 697-716.
37. Ross E.M., Wilkie T.M. GTPase-activating proteins for heterotrimeric G proteins: Regulators of G protein signaling (RGS) and RGS-like proteins. Annual Review of Biochemistry 2000, 69:795-827.
38. Ruger-Herreros C., Rodriguez-Romero J., Fernandez-Barranco R., Olmedo M., Fischer R., Corrochano L.M., et al. Regulation of conidiation by light in Aspergillus nidulans. Genetics 2011, 188:809-822.
39. Shin K.S., Kwon N.J., Yu J.H. Gbetagamma-mediated growth and developmental control in Aspergillus fumigatus. Current Genetics 2009, 55:631-641.
40. Smith G.R. Aspergillus fumigatus: A possible relationship between spore size and virulence for mice. Journal of General Microbiology 1977, 102:413-415.
41. Tao L., Yu J.H. AbaA and WetA govern distinct stages of Aspergillus fumigatus development. Microbiology 2011, 157:313-326.
42. Thau N., Monod M., Crestani B., Rolland C., Tronchin G., Latge J.P., et al. Rodletless mutants of Aspergillus fumigatus. Infection Immunology 1994, 62:4380-4388.
43. Tomlinson J.R., Sahn S.A. Aspergilloma in sarcoid and tuberculosis. Chest 1987, 92:505-508.
44. Wiemann P., Brown D.W., Kleigrewe K., Bok J.W., Keller N.P., Humpf H.U., et al. FfVel1 and FfLae1, components of a velvet-like complex in Fusarium fujikuroi, affect differentiation, secondary metabolism and virulence. Molecular Microbiology 2010, 77:972-977.
45. Wieser J., Lee B.N., Fondon J., Adams T.H. Genetic requirements for initiating asexual development in Aspergillus nidulans. Current Genetics 1994, 27:62-69.
46. Xiao P., Shin K.S., Wang T., Yu J.H. Aspergillus fumigatus flbB encodes two basic leucine zipper domain (bZIP) proteins required for proper asexual development and gliotoxin production. Eukaryotic Cell 2010, 9:1711-1723.
47. Yu J.H. Heterotrimeric G protein signaling and RGSs in Aspergillus nidulans. Journal of Microbiology 2006, 44:145-154.
48. Yu J.H., Keller N. Regulation of secondary metabolism in filamentous fungi. Annual Review of Phytopathology 2005, 43:437-458.