Stephacidin A and B: Two structurally novel, selective inhibitors of the testosterone-dependent prostate LNCaP cells

Journal of the American Chemical Society

Volumn 124, Issue 49, 2002, Pages 14556-14557

  Qian Cutrone, Jingfang ^a   Huang, Stella ^a   Shu, Yue Zhong ^a   Vyas, Dolatrai ^a   Fairchild, Craig ^a   Menendez, Ana ^a   Krampitz, Kimberly ^a   Dalterio, Richard ^a   Klohr, Steven E ^a   Gaot, Qi ^a  

^a BRISTOL MYERS SQUIBB PHARMACEUTICAL RESEARCH INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALKALOID DERIVATIVE; STEPHACIDIN A; STEPHACIDIN B; UNCLASSIFIED DRUG;

ARTICLE; CANCER CELL CULTURE; CONTROLLED STUDY; DRUG CYTOTOXICITY; DRUG ISOLATION; DRUG POTENCY; DRUG SYNTHESIS; HUMAN; HUMAN CELL; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PROTON NUCLEAR MAGNETIC RESONANCE; X RAY CRYSTALLOGRAPHY;

ANTINEOPLASTIC AGENTS; ASPERGILLUS OCHRACEUS; CRYSTALLOGRAPHY, X-RAY; DRUG SCREENING ASSAYS, ANTITUMOR; HUMANS; INDOLES; MALE; MOLECULAR STRUCTURE; NEOPLASMS, HORMONE-DEPENDENT; NUCLEAR MAGNETIC RESONANCE, BIOMOLECULAR; PROSTATIC NEOPLASMS; TESTOSTERONE; TUMOR CELLS, CULTURED;

EID: 0037065301     PISSN: 00027863     EISSN: None     Source Type: Journal    
DOI: 10.1021/ja028538n     Document Type: Article

References (5)

1. Dreyfuss, M. M.; Chapela, I. H. Biotechnol. Ser. 1994, 26, 49-80.
2. Qian-Cutrone, J.; Krampitz, K. D.; Shu, Y. Z.; Chang, L. P. Stephacidin Antitumor Antibiotics. U.S. Patent 6,291,461, 2001.
3. Fenical, W.; Jensen, P.; Cheng, X. C. Avrainvillamide, a Cytotoxic Marine Natural Product, and the Derivatives thereof. U.S. Patent 6,066,635, 2000.
4. Sugie, Y.; Hirai, H.; Inagaki, T.; Ishiguro, M.; Kim, Y.-J.; Kojima, Y.; Sakakibara, T.; Sakemi, S.; Sugiura, A.; Suzuki, Y.; Brennan, L.; Duignan, J.; Huang, L.; Sutcliffe, J.; Kojima, N. J. Antibiot. 2001, 54, 911-916.
5. 2) = 0.092; S = 1.103.