(-)-phenylahistin: A new mammalian cell cycle inhibitor produced by Aspergillus ustus

Bioorganic and Medicinal Chemistry Letters

Volumn 7, Issue 22, 1997, Pages 2847-2852

  Kanoh, Kaneo ^a   Kohno, Shinkichi ^a   Asari, Tohru ^a   Harada, Takeo ^a   Katada, Jun ^a   Muramatsu, Michiko ^a   Kawashima, Hiroshi ^a   Sekiya, Hirokatsu ^a   Uno, Isao ^a  

^a NIPPON STEEL CORPORATION   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

PHENYLALANINE DERIVATIVE; PIPERAZINEDIONE;

ARTICLE; ASPERGILLUS; CARBON NUCLEAR MAGNETIC RESONANCE; CELL CYCLE; CELL CYCLE G2 PHASE; CYTOSTASIS; CYTOTOXICITY; DRUG STRUCTURE; STEREOCHEMISTRY;

ASPERGILLUS; ASPERGILLUS USTUS; MAMMALIA;

EID: 0030697347     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0960-894X(97)10104-4     Document Type: Article

References (12)

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3. The agar medium contained glucose (0.5%), glycerol (2%), yeast extract (0.2%), Pharmamedia® (Traders Protein) (2%), NaCl (0.25%) and agar (1.5%), adjusted to pH 6.5 before sterilization.
4. -1; HR-FAB-MS (m/z) 350.1741 (M calcd. for C20H22N4O2: 350.1743)
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7. HPLC conditions: column; Crownpak CR(+) φ4.0 × 150 mm (Daicel Chemical Industries, Ltd.), mobile phase; H2O (pH 2, adjusted with perchloric acid), flow rate; 0.8 ml/min, detector; UV λ 200 nm.
8. + : 166.2 ].
9. HPLC conditions: column; Chiracel OD φ4.6 × 250 mm (Daicel Chemical Industries, LTD), mobile phase; n-hexane/ ethanol = 75/25, flow rate; 1.0 ml/min, temperature; 25 °C. Absolute configuration was determined by analysis of phenylalanine obtained from (+)-phenylahistin using chiral HPLC.
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