Genetic control of asexual sporulation in filamentous fungi

Current Opinion in Microbiology

Volumn 15, Issue 6, 2012, Pages 669-677

  Park, Hee Soo ^a   Yu, Jae Hyuk ^a  

^a UNIVERSITY OF WISCONSIN MADISON   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

TRANSCRIPTION FACTOR;

ASEXUAL REPRODUCTION; ASPERGILLUS NIDULANS; CELL DIFFERENTIATION; FUNGUS GROWTH; GENE TARGETING; GENETIC REGULATION; NEUROSPORA CRASSA; NONHUMAN; REGULATOR GENE; REGULATORY MECHANISM; REVIEW; SEXUAL DEVELOPMENT; SPOROGENESIS;

ASPERGILLUS NIDULANS; GENE EXPRESSION REGULATION, FUNGAL; NEUROSPORA CRASSA; SIGNAL TRANSDUCTION; SPORES, FUNGAL;

EMERICELLA NIDULANS; FUNGI; NEUROSPORA CRASSA;

EID: 84872262471     PISSN: 13695274     EISSN: 18790364     Source Type: Journal    
DOI: 10.1016/j.mib.2012.09.006     Document Type: Review

References (89)

1. Adams T.H., Wieser J.K., Yu J.-H. Asexual sporulation in Aspergillus nidulans. Microbiol Mol Biol Rev 1998, 62:35-54.
2. Ni M., Gao N., Kwon N.-J., Shin K.-S., Yu J.-H. Regulation of Aspergillus conidiation. Cellular and Molecular Biology of Filamentous Fungi 2010, 559-576. ASM press. K.A. Borkovich, D.J. Ebbole (Eds.).
3. Ebbole D.J. The conidium. Cellular and Molecular Biology of Filamentous Fungi 2010, 577-590. ASM press. K.A. Borkovich, D.J. Ebbole (Eds.).
4. Bahn Y.-S., Xue C., Idnurm A., Rutherford J.C., Heitman J., Cardenas M.E. Sensing the environment: lessons from fungi. Nat Rev Microbiol 2007, 5:57-69.
5. Corrochano L.M., Avalos J. Light sensing. Cellular and Molecular Biology of Filamentous Fungi 2010, 417-441. ASM press. K.A. Borkovich, D.J. Ebbole (Eds.).
6. Yu J.-H. Regulation of development in Aspergillus nidulans and Aspergillus fumigatus. Mycobiology 2010, 38:229-237.
7. Etxebeste O., Garzia A., Espeso E.A., Ugalde U. Aspergillus nidulans asexual development: making the most of cellular modules. Trends Microbiol 2010, 18:569-576.
8. Adams T.H., Boylan M.T., Timberlake W.E. brlA is necessary and sufficient to direct conidiophore development in Aspergillus nidulans. Cell 1988, 54:353-362.
9. Clutterbuck A.J. A mutational analysis of conidial development in Aspergillus nidulans. Genetics 1969, 63:317-327.
10. Boylan M.T., Mirabito P.M., Willett C.E., Zimmerman C.R., Timberlake W.E. Isolation and physical characterization of three essential conidiation genes from Aspergillus nidulans. Mol Cell Biol 1987, 7:3113-3118.
11. Chang Y.C., Timberlake W.E. Identification of Aspergillus brlA response elements (BREs) by genetic selection in yeast. Genetics 1993, 133:29-38.
12. Prade R.A., Timberlake W.E. The Aspergillus nidulans brlA regulatory locus consists of overlapping transcription units that are individually required for conidiophore development. EMBO J 1993, 12:2439-2447.
13. Han S., Navarro J., Greve R.A., Adams T.H. Translational repression of brlA expression prevents premature development in Aspergillus. EMBO J 1993, 12:2449-2457.
14. Timberlake W.E., Clutterbuck A.J. Genetic regulation of conidiation. Prog Ind Microbiol 1994, 29:383-427.
15. Sewall T.C., Mims C.W., Timberlake W.E. abaA controls phialide differentiation in Aspergillus nidulans. Plant Cell 1990, 2:731-739.
16. Andrianopoulos A., Timberlake W.E. The Aspergillus nidulans abaA gene encodes a transcriptional activator that acts as a genetic switch to control development. Mol Cell Biol 1994, 14:2503-2515.
17. Mirabito P.M., Adams T.H., Timberlake W.E. Interactions of three sequentially expressed genes control temporal and spatial specificity in Aspergillus development. Cell 1989, 57:859-868.
18. Aramayo R., Timberlake W.E. The Aspergillus nidulans yA gene is regulated by abaA. EMBO J 1993, 12:2039-2048.
19. Sewall T.C., Mims C.W., Timberlake W.E. Conidium differentiation in Aspergillus nidulans wild-type and wet-white (wetA) mutant strains. Dev Biol 1990, 138:499-508.
20. Marshall M.A., Timberlake W.E. Aspergillus nidulans wetA activates spore-specific gene expression. Mol Cell Biol 1991, 11:55-62.
21. Wieser J., Lee B.N., Fondon J., Adams T.H. Genetic requirements for initiating asexual development in Aspergillus nidulans. Curr Genet 1994, 27:62-69.
22. Lee B.N., Adams T.H. The Aspergillus nidulans fluG gene is required for production of an extracellular developmental signal and is related to prokaryotic glutamine synthetase I. Genes Dev 1994, 8:641-651.
23. Rodriguez-Urra A.B., Jimenez C., Nieto M.I., Rodriguez J., Hayashi H., Ugalde U. Signaling the induction of sporulation involves the interaction of two secondary metabolites in Aspergillus nidulans. ACS Chem Biol 2012, 7:599-606.
24. Yu J.-H., Wieser J., Adams T.H. The Aspergillus FlbA RGS domain protein antagonizes G protein signaling to block proliferation and allow development. EMBO J 1996, 15:5184-5190.
25. Rosen S., Yu J.-H., Adams T.H. The Aspergillus nidulans sfaD gene encodes a G protein beta subunit that is required for normal growth and repression of sporulation. EMBO J 1999, 18:5592-5600.
26. Seo J.-A., Han K.-H., Yu J.-H. Multiple roles of a heterotrimeric G-protein gamma-subunit in governing growth and development of Aspergillus nidulans. Genetics 2005, 171:81-89.
27. Wieser J., Adams T.H. flbD encodes a Myb-like DNA-binding protein that coordinates initiation of Aspergillus nidulans conidiophore development. Genes Dev 1995, 9:491-502.
28. Lee B.N., Adams T.H. FluG and flbA function interdependently to initiate conidiophore development in Aspergillus nidulans through brlA beta activation. EMBO J 1996, 15:299-309.
29. Seo J.-A., Guan Y., Yu J.-H. FluG-dependent asexual development in Aspergillus nidulans occurs via derepression. Genetics 2006, 172:1535-1544.
30. 2 transcription factor regulating development in Aspergillus nidulans. Mol Microbiol 2010, 77:1203-1219.
31. Garzia A., Etxebeste O., Herrero-Garcia E., Fischer R., Espeso E.A., Ugalde U. Aspergillus nidulans FlbE is an upstream developmental activator of conidiation functionally associated with the putative transcription factor FlbB. Mol Microbiol 2009, 71:172-184.
32. Kwon N.-J., Shin K.-S., Yu J.-H. Characterization of the developmental regulator FlbE in Aspergillus fumigatus and Aspergillus nidulans. Fungal Genet Biol 2010, 47:981-993.
33. Garzia A., Etxebeste O., Herrero-Garcia E., Ugalde U., Espeso E.A. The concerted action of bZip and cMyb transcription factors FlbB and FlbD induces brlA expression and asexual development in Aspergillus nidulans. Mol Microbiol 2010, 75:1314-1324.
34. Ni M., Yu J.-H. A novel regulator couples sporogenesis and trehalose biogenesis in Aspergillus nidulans. PLoS ONE 2007, 2:e970.
35. Yu J.-H. Heterotrimeric G protein signaling and RGSs in Aspergillus nidulans. J Microbiol 2006, 44:145-154.
36. Hicks J.K., Yu J.-H., Keller N.P., Adams T.H. Aspergillus sporulation and mycotoxin production both require inactivation of the FadA G alpha protein-dependent signaling pathway. EMBO J 1997, 16:4916-4923.
37. Chang M.H., Chae K.-S., Han D.M., Jahng K.Y. The GanB Galpha-protein negatively regulates asexual sporulation and plays a positive role in conidial germination in Aspergillus nidulans. Genetics 2004, 167:1305-1315.
38. Lafon A., Seo J.A., Han K.H., Yu J.H., d'Enfert C. The heterotrimeric G-protein GanB(alpha)-SfaD(beta)-GpgA(gamma) is a carbon source sensor involved in early cAMP-dependent germination in Aspergillus nidulans. Genetics 2005, 171:71-80.
39. Han K.-H., Seo J.-A., Yu J.-H. Regulators of G-protein signalling in Aspergillus nidulans: RgsA downregulates stress response and stimulates asexual sporulation through attenuation of GanB (Galpha) signalling. Mol Microbiol 2004, 53:529-540.
40. Kwon N.-J., Park H.-S., Jung S., Kim S.C., Yu J.-H. The putative GEF RicA mediates upstream signaling for growth and development in Aspergillus. Eukaryot Cell 2012, 10.1128/EC.00255-12.
41. Hoffmann B., Wanke C., Lapaglia S.K., Braus G.H. c-Jun and RACK1 homologues regulate a control point for sexual development in Aspergillus nidulans. Mol Microbiol 2000, 37:28-41.
42. Han K.-H., Han K.-Y., Yu J.-H., Chae K.-S., Jahng K.-Y., Han D.-M. The nsdD gene encodes a putative GATA-type transcription factor necessary for sexual development of Aspergillus nidulans. Mol Microbiol 2001, 41:299-309.
43. 2-type transcription factor is a key activator of sexual development in Aspergillus nidulans. Genetics 2009, 182:771-783.
44. Bayram O., Braus G.H. Coordination of secondary metabolism and development in fungi: the velvet family of regulatory proteins. FEMS Microbiol Rev 2012, 36:1-24.
45. Park H.-S., Ni M., Jeong K.C., Kim Y.H., Yu J.-H. The role, interaction and regulation of the velvet regulator VelB in Aspergillus nidulans. PLoS ONE 2012, 7:e45935.
46. Bayram O., Krappmann S., Ni M., Bok J.W., Helmstaedt K., Valerius O., Braus-Stromeyer S., Kwon N.-J., Keller N.P., Yu J.-H., et al. VelB/VeA/LaeA complex coordinates light signal with fungal development and secondary metabolism. Science 2008, 320:1504-1506.
47. Sarikaya Bayram O., Bayram O., Valerius O., Park H.S., Irniger S., Gerke J., Ni M., Han K.H., Yu J.H., Braus G.H. LaeA control of velvet family regulatory proteins for light-dependent development and fungal cell-type specificity. PLoS Genet 2010, 6:e1001226.
48. Kim H., Han K., Kim K., Han D., Jahng K., Chae K. The veA gene activates sexual development in Aspergillus nidulans. Fungal Genet Biol 2002, 37:72-80.
49. Park H.-S., Bayram O., Braus G.H., Kim S.C., Yu J.-H. Characterization of the velvet regulators in Aspergillus fumigatus. Mol Microbiol 2012, 10.1111/mmi.12032.
50. Mooney J.L., Yager L.N. Light is required for conidiation in Aspergillus nidulans. Genes Dev 1990, 4:1473-1482.
51. Bayram O., Braus G.H., Fischer R., Rodriguez-Romero J. Spotlight on Aspergillus nidulans photosensory systems. Fungal Genet Biol 2010, 47:900-908.
52. Ruger-Herreros C., Rodriguez-Romero J., Fernandez-Barranco R., Olmedo M., Fischer R., Corrochano L.M., Canovas D. Regulation of conidiation by light in Aspergillus nidulans. Genetics 2011, 188:809-822.
53. Blumenstein A., Vienken K., Tasler R., Purschwitz J., Veith D., Frankenberg-Dinkel N., Fischer R. The Aspergillus nidulans phytochrome FphA represses sexual development in red light. Curr Biol 2005, 15:1833-1838.
54. Purschwitz J., Muller S., Kastner C., Schoser M., Haas H., Espeso E.A., Atoui A., Calvo A.M., Fischer R. Functional and physical interaction of blue- and red-light sensors in Aspergillus nidulans. Curr Biol 2008, 18:255-259.
55. Bayram O., Biesemann C., Krappmann S., Galland P., Braus G.H. More than a repair enzyme: Aspergillus nidulans photolyase-like CryA is a regulator of sexual development. Mol Biol Cell 2008, 19:3254-3262.
56. Springer M.L., Yanofsky C. A morphological and genetic analysis of conidiophore development in Neurospora crassa. Genes Dev 1989, 3:559-571.
57. Springer M.L. Genetic control of fungal differentiation: the three sporulation pathways of Neurospora crassa. Bioessays 1993, 15:365-374.
58. Matsuyama S.S., Nelson R.E., Siegel R.W. Mutations specifically blocking differentiation of macroconidia Neurospora crassa. Dev Biol 1974, 41:278-287.
59. Selitrennikoff C.P., Nelson R.E., Siegel R.W. Phase-specific genes for macroconidiation in Neurospora crassa. Genetics 1974, 78:679-690.
60. Beever R.E., Dempsey G.P. Function of rodlets on surface of fungal spores. Nature 1978, 272:608-610.
61. 6 zinc cluster protein required for conidial development. Genetics 1998, 148:1813-1820.
62. Berlin V., Yanofsky C. Isolation and characterization of genes differentially expressed during conidiation of Neurospora crassa. Mol Cell Biol 1985, 5:849-855.
63. Bailey-Shrode L., Ebbole D.J. The fluffy gene of Neurospora crassa is necessary and sufficient to induce conidiophore development. Genetics 2004, 166:1741-1749.
64. Rerngsamran P., Murphy M.B., Doyle S.A., Ebbole D.J. Fluffy, the major regulator of conidiation in Neurospora crassa, directly activates a developmentally regulated hydrophobin gene. Mol Microbiol 2005, 56:282-297.
65. Greenwald C.J., Kasuga T., Glass N.L., Shaw B.D., Ebbole D.J., Wilkinson H.H. Temporal and spatial regulation of gene expression during asexual development of Neurospora crassa. Genetics 2010, 186:1217-1230.
66. Li L., Wright S.J., Krystofova S., Park G., Borkovich K.A. Heterotrimeric G protein signaling in filamentous fungi. Annu Rev Microbiol 2007, 61:423-452.
67. Turner G.E., Borkovich K.A. Identification of a G protein alpha subunit from Neurospora crassa that is a member of the Gi family. J Biol Chem 1993, 268:14805-14811.
68. Ivey F.D., Hodge P.N., Turner G.E., Borkovich K.A. The G alpha i homologue gna-1 controls multiple differentiation pathways in Neurospora crassa. Mol Biol Cell 1996, 7:1283-1297.
69. Ivey F.D., Kays A.M., Borkovich K.A. Shared and independent roles for a Galpha(i) protein and adenylyl cyclase in regulating development and stress responses in Neurospora crassa. Eukaryot Cell 2002, 1:634-642.
70. Li L., Borkovich K.A. GPR-4 is a predicted G-protein-coupled receptor required for carbon source-dependent asexual growth and development in Neurospora crassa. Eukaryot Cell 2006, 5:1287-1300.
71. Kays A.M., Borkovich K.A. Severe impairment of growth and differentiation in a Neurospora crassa mutant lacking all heterotrimeric G alpha proteins. Genetics 2004, 166:1229-1240.
72. Kays A.M., Rowley P.S., Baasiri R.A., Borkovich K.A. Regulation of conidiation and adenylyl cyclase levels by the Galpha protein GNA-3 in Neurospora crassa. Mol Cell Biol 2000, 20:7693-7705.
73. Yang Q., Poole S.I., Borkovich K.A. A G-protein beta subunit required for sexual and vegetative development and maintenance of normal G alpha protein levels in Neurospora crassa. Eukaryot Cell 2002, 1:378-390.
74. Krystofova S., Borkovich K.A. The heterotrimeric G-protein subunits GNG-1 and GNB-1 form a Gbetagamma dimer required for normal female fertility, asexual development, and galpha protein levels in Neurospora crassa. Eukaryot Cell 2005, 4:365-378.
75. Wright S.J., Inchausti R., Eaton C.J., Krystofova S., Borkovich K.A. RIC8 is a guanine-nucleotide exchange factor for Galpha subunits that regulates growth and development in Neurospora crassa. Genetics 2011, 189:165-176.
76. Lauter F.R., Yamashiro C.T., Yanofsky C. Light stimulation of conidiation in Neurospora crassa: studies with the wild-type strain and mutants wc-1, wc-2 and acon-2. J Photochem Photobiol 1997, 37:203-211.
77. Olmedo M., Ruger-Herreros C., Luque E.M., Corrochano L.M. A complex photoreceptor system mediates the regulation by light of the conidiation genes con-10 and con-6 in Neurospora crassa. Fungal Genet Biol 2010, 47:352-363.
78. Olmedo M., Ruger-Herreros C., Corrochano L.M. Regulation by blue light of the fluffy gene encoding a major regulator of conidiation in Neurospora crassa. Genetics 2010, 184:651-658.
79. Corrochano L.M., Lauter F.R., Ebbole D.J., Yanofsky C. Light and developmental regulation of the gene con-10 of Neurospora crassa. Dev Biol 1995, 167:190-200.
80. Lambreghts R., Shi M., Belden W.J., Decaprio D., Park D., Henn M.R., Galagan J.E., Basturkmen M., Birren B.W., Sachs M.S., et al. A high-density single nucleotide polymorphism map for Neurospora crassa. Genetics 2009, 181:767-781.
81. Lauter F.R., Russo V.E.A. Blue-light induction of conidiation-specific genes in Neurospora crassa. Nucleic Acids Res 1991, 19:6883-6886.
82. Lauter F.R., Yanofsky C. Day/night and circadian rhythm control of con gene expression in Neurospora. Proc Natl Acad Sci USA 1993, 90:8249-8253.
83. Ballario P., Vittorioso P., Magrelli A., Talora C., Cabibbo A., Macino G. White collar-1, a central regulator of blue light responses in Neurospora, is a zinc finger protein. EMBO J 1996, 15:1650-1657.
84. Linden H., Macino G. White collar 2, a partner in blue-light signal transduction, controlling expression of light-regulated genes in Neurospora crassa. EMBO J 1997, 16:98-109.
85. He Q., Cheng P., Yang Y., Wang L., Gardner K.H., Liu Y. White collar-1, a DNA binding transcription factor and a light sensor. Science 2002, 297:840-843.
86. Heintzen C., Loros J.J., Dunlap J.C. The PAS protein VIVID defines a clock-associated feedback loop that represses light input, modulates gating, and regulates clock resetting. Cell 2001, 104:453-464.
87. Shrode L.B., Lewis Z.A., White L.D., Bell-Pedersen D., Ebbole D.J. vvd is required for light adaptation of conidiation-specific genes of Neurospora crassa, but not circadian conidiation. Fungal Genet Biol 2001, 32:169-181.
88. Olmedo M., Navarro-Sampedro L., Ruger-Herreros C., Kim S.R., Jeong B.K., Lee B.U., Corrochano L.M. A role in the regulation of transcription by light for RCO-1 and RCM-1, the Neurospora homologs of the yeast Tup1-Ssn6 repressor. Fungal Genet Biol 2010, 47:939-952.
89. Bayram O., Krappmann S., Seiler S., Vogt N., Braus G.H. Neurospora crassa ve-1 affects asexual conidiation. Fungal Genet Biol 2008, 45:127-138.