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Volumn 104, Issue , 2017, Pages 34-48

Ferroptosis and cell death mechanisms in Parkinson's disease

Author keywords

Alpha synuclein; Cell death; Ferroptosis; Parkinson's disease

Indexed keywords

ALPHA SYNUCLEIN; CASPASE; GLUTATHIONE; IRON;

EID: 85009738319     PISSN: 01970186     EISSN: 18729754     Source Type: Journal    
DOI: 10.1016/j.neuint.2017.01.004     Document Type: Review
Times cited : (291)

References (241)
  • 1
    • 0035353725 scopus 로고    scopus 로고
    • Frequency of levodopa-related dyskinesias and motor fluctuations as estimated from the cumulative literature
    • Ahlskog, J.E., Muenter, M.D., Frequency of levodopa-related dyskinesias and motor fluctuations as estimated from the cumulative literature. Mov. Disord. Official J. Mov. Disord. Soc. 16 (2001), 448–458.
    • (2001) Mov. Disord. Official J. Mov. Disord. Soc. , vol.16 , pp. 448-458
    • Ahlskog, J.E.1    Muenter, M.D.2
  • 5
    • 0035809182 scopus 로고    scopus 로고
    • Matrix attachment regulates Fas-induced apoptosis in endothelial cells: a role for c-flip and implications for anoikis
    • Aoudjit, F., Vuori, K., Matrix attachment regulates Fas-induced apoptosis in endothelial cells: a role for c-flip and implications for anoikis. J. Cell Biol. 152 (2001), 633–643.
    • (2001) J. Cell Biol. , vol.152 , pp. 633-643
    • Aoudjit, F.1    Vuori, K.2
  • 7
    • 85011549354 scopus 로고    scopus 로고
    • Parkinson's Disease Iron Deposition Caused by Nitric Oxide-induced Loss of APP
    • Ayton, S., Parkinson's Disease Iron Deposition Caused by Nitric Oxide-induced Loss of APP. 2015.
    • (2015)
    • Ayton, S.1
  • 8
    • 84930225631 scopus 로고    scopus 로고
    • Ferritin levels in the cerebrospinal fluid predict Alzheimer's disease outcomes and are regulated by APOE
    • Ayton, S., Faux, N.G., Bush, A.I., Ferritin levels in the cerebrospinal fluid predict Alzheimer's disease outcomes and are regulated by APOE. Nat. Commun., 6, 2015, 6760.
    • (2015) Nat. Commun. , vol.6 , pp. 6760
    • Ayton, S.1    Faux, N.G.2    Bush, A.I.3
  • 9
    • 84893774898 scopus 로고    scopus 로고
    • Nigral iron elevation is an invariable feature of Parkinson's disease and is a sufficient cause of neurodegeneration
    • Ayton, S., Lei, P., Nigral iron elevation is an invariable feature of Parkinson's disease and is a sufficient cause of neurodegeneration. Biomed. Res. Int., 2014, 2014, 581256.
    • (2014) Biomed. Res. Int. , vol.2014 , pp. 581256
    • Ayton, S.1    Lei, P.2
  • 10
    • 84903870684 scopus 로고    scopus 로고
    • Iron accumulation confers neurotoxicity to a vulnerable population of nigral neurons: implications for Parkinson's disease
    • Ayton, S., Lei, P., Adlard, P.A., Volitakis, I., Cherny, R.A., Bush, A.I., Finkelstein, D.I., Iron accumulation confers neurotoxicity to a vulnerable population of nigral neurons: implications for Parkinson's disease. Mol. Neurodegener., 9, 2014, 27.
    • (2014) Mol. Neurodegener. , vol.9 , pp. 27
    • Ayton, S.1    Lei, P.2    Adlard, P.A.3    Volitakis, I.4    Cherny, R.A.5    Bush, A.I.6    Finkelstein, D.I.7
  • 13
    • 0031941058 scopus 로고    scopus 로고
    • Aggregation of alpha-synuclein in Lewy bodies of sporadic Parkinson's disease and dementia with Lewy bodies
    • Baba, M., Nakajo, S., Tu, P.H., Tomita, T., Nakaya, K., Lee, V.M., Trojanowski, J.Q., Iwatsubo, T., Aggregation of alpha-synuclein in Lewy bodies of sporadic Parkinson's disease and dementia with Lewy bodies. Am. J. Pathol. 152 (1998), 879–884.
    • (1998) Am. J. Pathol. , vol.152 , pp. 879-884
    • Baba, M.1    Nakajo, S.2    Tu, P.H.3    Tomita, T.4    Nakaya, K.5    Lee, V.M.6    Trojanowski, J.Q.7    Iwatsubo, T.8
  • 14
    • 0031930771 scopus 로고    scopus 로고
    • Glial pathology but absence of apoptotic nigral neurons in long-standing Parkinson's disease
    • Banati, R.B., Daniel, S.E., Blunt, S.B., Glial pathology but absence of apoptotic nigral neurons in long-standing Parkinson's disease. Mov. Disord. Official J. Mov. Disord. Soc. 13 (1998), 221–227.
    • (1998) Mov. Disord. Official J. Mov. Disord. Soc. , vol.13 , pp. 221-227
    • Banati, R.B.1    Daniel, S.E.2    Blunt, S.B.3
  • 15
    • 0022969399 scopus 로고
    • Exchange of cystine and glutamate across plasma membrane of human fibroblasts
    • Bannai, S., Exchange of cystine and glutamate across plasma membrane of human fibroblasts. J. Biol. Chem. 261 (1986), 2256–2263.
    • (1986) J. Biol. Chem. , vol.261 , pp. 2256-2263
    • Bannai, S.1
  • 17
    • 0031711224 scopus 로고    scopus 로고
    • Excitotoxicity and nitric oxide in Parkinson's disease pathogenesis
    • Beal, M.F., Excitotoxicity and nitric oxide in Parkinson's disease pathogenesis. Ann. Neurol. 44 (1998), S110–S114.
    • (1998) Ann. Neurol. , vol.44 , pp. S110-S114
    • Beal, M.F.1
  • 20
    • 0029417080 scopus 로고
    • Interleukin-1 beta and interleukin-6 are elevated in the cerebrospinal fluid of Alzheimer's and de novo Parkinson's disease patients
    • Blum-Degen, D., Muller, T., Kuhn, W., Gerlach, M., Przuntek, H., Riederer, P., Interleukin-1 beta and interleukin-6 are elevated in the cerebrospinal fluid of Alzheimer's and de novo Parkinson's disease patients. Neurosci. Lett. 202 (1995), 17–20.
    • (1995) Neurosci. Lett. , vol.202 , pp. 17-20
    • Blum-Degen, D.1    Muller, T.2    Kuhn, W.3    Gerlach, M.4    Przuntek, H.5    Riederer, P.6
  • 21
    • 0030956532 scopus 로고    scopus 로고
    • p53 and Bax activation in 6-hydroxydopamine-induced apoptosis in PC12 cells
    • Blum, D., Wu, Y., Nissou, M.F., Arnaud, S., Alim Louis, B., Verna, J.M., p53 and Bax activation in 6-hydroxydopamine-induced apoptosis in PC12 cells. Brain Res. 751 (1997), 139–142.
    • (1997) Brain Res. , vol.751 , pp. 139-142
    • Blum, D.1    Wu, Y.2    Nissou, M.F.3    Arnaud, S.4    Alim Louis, B.5    Verna, J.M.6
  • 22
    • 49049096562 scopus 로고    scopus 로고
    • Autophagy induction and autophagosome clearance in neurons: relationship to autophagic pathology in Alzheimer's disease
    • Boland, B., Kumar, A., Lee, S., Platt, F.M., Wegiel, J., Yu, W.H., Nixon, R.A., Autophagy induction and autophagosome clearance in neurons: relationship to autophagic pathology in Alzheimer's disease. J. Neurosci. Official J. Soc. Neurosci. 28 (2008), 6926–6937.
    • (2008) J. Neurosci. Official J. Soc. Neurosci. , vol.28 , pp. 6926-6937
    • Boland, B.1    Kumar, A.2    Lee, S.3    Platt, F.M.4    Wegiel, J.5    Yu, W.H.6    Nixon, R.A.7
  • 27
    • 84938717912 scopus 로고    scopus 로고
    • Glitazone treatment and incidence of Parkinson's disease among people with diabetes: a retrospective cohort study
    • Brauer, R., Bhaskaran, K., Chaturvedi, N., Dexter, D.T., Smeeth, L., Douglas, I., Glitazone treatment and incidence of Parkinson's disease among people with diabetes: a retrospective cohort study. PLoS Med., 12, 2015, e1001854.
    • (2015) PLoS Med. , vol.12 , pp. e1001854
    • Brauer, R.1    Bhaskaran, K.2    Chaturvedi, N.3    Dexter, D.T.4    Smeeth, L.5    Douglas, I.6
  • 28
    • 0033815330 scopus 로고    scopus 로고
    • Salmonella induces macrophage death by caspase-1-dependent necrosis
    • Brennan, M.A., Cookson, B.T., Salmonella induces macrophage death by caspase-1-dependent necrosis. Mol. Microbiol. 38 (2000), 31–40.
    • (2000) Mol. Microbiol. , vol.38 , pp. 31-40
    • Brennan, M.A.1    Cookson, B.T.2
  • 31
    • 79952104480 scopus 로고    scopus 로고
    • The accumulation of neurotoxic proteins, induced by proteasome inhibition, is reverted by trehalose, an enhancer of autophagy, in human neuroblastoma cells
    • Casarejos, M.J., Solano, R.M., Gomez, A., Perucho, J., de Yebenes, J.G., Mena, M.A., The accumulation of neurotoxic proteins, induced by proteasome inhibition, is reverted by trehalose, an enhancer of autophagy, in human neuroblastoma cells. Neurochem. Int. 58 (2011), 512–520.
    • (2011) Neurochem. Int. , vol.58 , pp. 512-520
    • Casarejos, M.J.1    Solano, R.M.2    Gomez, A.3    Perucho, J.4    de Yebenes, J.G.5    Mena, M.A.6
  • 33
    • 78049383132 scopus 로고    scopus 로고
    • Mitochondrial alpha-synuclein accumulation impairs complex I function in dopaminergic neurons and results in increased mitophagy in vivo
    • Chinta, S.J., Mallajosyula, J.K., Rane, A., Andersen, J.K., Mitochondrial alpha-synuclein accumulation impairs complex I function in dopaminergic neurons and results in increased mitophagy in vivo. Neurosci. Lett. 486 (2010), 235–239.
    • (2010) Neurosci. Lett. , vol.486 , pp. 235-239
    • Chinta, S.J.1    Mallajosyula, J.K.2    Rane, A.3    Andersen, J.K.4
  • 35
    • 68149123529 scopus 로고    scopus 로고
    • Alterations in lysosomal and proteasomal markers in Parkinson's disease: relationship to alpha-synuclein inclusions
    • Chu, Y., Dodiya, H., Aebischer, P., Olanow, C.W., Kordower, J.H., Alterations in lysosomal and proteasomal markers in Parkinson's disease: relationship to alpha-synuclein inclusions. Neurobiol. Dis. 35 (2009), 385–398.
    • (2009) Neurobiol. Dis. , vol.35 , pp. 385-398
    • Chu, Y.1    Dodiya, H.2    Aebischer, P.3    Olanow, C.W.4    Kordower, J.H.5
  • 36
    • 84873123076 scopus 로고    scopus 로고
    • Triggering of inflammasome by aggregated alpha-synuclein, an inflammatory response in synucleinopathies
    • Codolo, G., Plotegher, N., Pozzobon, T., Brucale, M., Tessari, I., Bubacco, L., de Bernard, M., Triggering of inflammasome by aggregated alpha-synuclein, an inflammatory response in synucleinopathies. PLoS One, 8, 2013, e55375.
    • (2013) PLoS One , vol.8 , pp. e55375
    • Codolo, G.1    Plotegher, N.2    Pozzobon, T.3    Brucale, M.4    Tessari, I.5    Bubacco, L.6    de Bernard, M.7
  • 38
    • 0030581308 scopus 로고    scopus 로고
    • Poly(ADP-ribose) polymerase inhibitors protect against MPTP-induced depletions of striatal dopamine and cortical noradrenaline in C57B1/6 mice
    • Cosi, C., Colpaert, F., Koek, W., Degryse, A., Marien, M., Poly(ADP-ribose) polymerase inhibitors protect against MPTP-induced depletions of striatal dopamine and cortical noradrenaline in C57B1/6 mice. Brain Res. 729 (1996), 264–269.
    • (1996) Brain Res. , vol.729 , pp. 264-269
    • Cosi, C.1    Colpaert, F.2    Koek, W.3    Degryse, A.4    Marien, M.5
  • 39
    • 0033389550 scopus 로고    scopus 로고
    • Implication of poly (ADP-ribose) polymerase (PARP) in neurodegeneration and brain energy metabolism. Decreases in mouse brain NAD+ and ATP caused by MPTP are prevented by the PARP inhibitor benzamide
    • Cosi, C., Marien, M., Implication of poly (ADP-ribose) polymerase (PARP) in neurodegeneration and brain energy metabolism. Decreases in mouse brain NAD+ and ATP caused by MPTP are prevented by the PARP inhibitor benzamide. Ann. N. Y. Acad. Sci. 890 (1999), 227–239.
    • (1999) Ann. N. Y. Acad. Sci. , vol.890 , pp. 227-239
    • Cosi, C.1    Marien, M.2
  • 40
    • 1642564597 scopus 로고    scopus 로고
    • Concurrent hereditary haemochromatosis and idiopathic Parkinson's disease: a case report series
    • Costello, D.J., Walsh, S.L., Harrington, H.J., Walsh, C.H., Concurrent hereditary haemochromatosis and idiopathic Parkinson's disease: a case report series. J. Neurol. Neurosurg. Psychiatry 75 (2004), 631–633.
    • (2004) J. Neurol. Neurosurg. Psychiatry , vol.75 , pp. 631-633
    • Costello, D.J.1    Walsh, S.L.2    Harrington, H.J.3    Walsh, C.H.4
  • 41
    • 84895920556 scopus 로고    scopus 로고
    • Over-expression of an inactive mutant cathepsin D increases endogenous alpha-synuclein and cathepsin B activity in SH-SY5Y cells
    • Crabtree, D., Dodson, M., Ouyang, X., Boyer-Guittaut, M., Liang, Q., Ballestas, M.E., Fineberg, N., Zhang, J., Over-expression of an inactive mutant cathepsin D increases endogenous alpha-synuclein and cathepsin B activity in SH-SY5Y cells. J. Neurochem. 128 (2014), 950–961.
    • (2014) J. Neurochem. , vol.128 , pp. 950-961
    • Crabtree, D.1    Dodson, M.2    Ouyang, X.3    Boyer-Guittaut, M.4    Liang, Q.5    Ballestas, M.E.6    Fineberg, N.7    Zhang, J.8
  • 42
    • 4344659685 scopus 로고    scopus 로고
    • Impaired degradation of mutant alpha-synuclein by chaperone-mediated autophagy
    • Cuervo, A.M., Stefanis, L., Fredenburg, R., Lansbury, P.T., Sulzer, D., Impaired degradation of mutant alpha-synuclein by chaperone-mediated autophagy. Science 305 (2004), 1292–1295.
    • (2004) Science , vol.305 , pp. 1292-1295
    • Cuervo, A.M.1    Stefanis, L.2    Fredenburg, R.3    Lansbury, P.T.4    Sulzer, D.5
  • 43
    • 84995460774 scopus 로고    scopus 로고
    • Ferroptosis: oxidized PEs trigger death
    • D'Herde, K., Krysko, D.V., Ferroptosis: oxidized PEs trigger death. Nat. Chem. Biol. 13 (2017), 4–5.
    • (2017) Nat. Chem. Biol. , vol.13 , pp. 4-5
    • D'Herde, K.1    Krysko, D.V.2
  • 44
    • 84873741905 scopus 로고    scopus 로고
    • Curcumin protects against iron induced neurotoxicity in primary cortical neurons by attenuating necroptosis
    • Dai, M.C., Zhong, Z.H., Sun, Y.H., Sun, Q.F., Wang, Y.T., Yang, G.Y., Bian, L.G., Curcumin protects against iron induced neurotoxicity in primary cortical neurons by attenuating necroptosis. Neurosci. Lett. 536 (2013), 41–46.
    • (2013) Neurosci. Lett. , vol.536 , pp. 41-46
    • Dai, M.C.1    Zhong, Z.H.2    Sun, Y.H.3    Sun, Q.F.4    Wang, Y.T.5    Yang, G.Y.6    Bian, L.G.7
  • 45
    • 0032816549 scopus 로고    scopus 로고
    • The substantia nigra of the human brain. II. Patterns of loss of dopamine-containing neurons in Parkinson's disease
    • Damier, P., Hirsch, E.C., Agid, Y., Graybiel, A.M., The substantia nigra of the human brain. II. Patterns of loss of dopamine-containing neurons in Parkinson's disease. Brain J. Neurol. 122:Pt 8 (1999), 1437–1448.
    • (1999) Brain J. Neurol. , vol.122 , pp. 1437-1448
    • Damier, P.1    Hirsch, E.C.2    Agid, Y.3    Graybiel, A.M.4
  • 47
    • 79251572323 scopus 로고    scopus 로고
    • Alpha-synuclein is a cellular ferrireductase
    • Davies, P., Moualla, D., Brown, D.R., Alpha-synuclein is a cellular ferrireductase. PLos One, 6, 2011, e15814.
    • (2011) PLos One , vol.6 , pp. e15814
    • Davies, P.1    Moualla, D.2    Brown, D.R.3
  • 54
    • 0022475372 scopus 로고
    • Lipid peroxidation as cause of nigral cell death in Parkinson's disease
    • Dexter, D., Carter, C., Agid, F., Agid, Y., Lees, A.J., Jenner, P., Marsden, C.D., Lipid peroxidation as cause of nigral cell death in Parkinson's disease. Lancet 2 (1986), 639–640.
    • (1986) Lancet , vol.2 , pp. 639-640
    • Dexter, D.1    Carter, C.2    Agid, F.3    Agid, Y.4    Lees, A.J.5    Jenner, P.6    Marsden, C.D.7
  • 55
    • 0025821265 scopus 로고
    • Alterations in the levels of iron, ferritin and other trace metals in Parkinson's disease and other neurodegenerative diseases affecting the basal ganglia
    • Dexter, D.T., Carayon, A., Javoy-Agid, F., Agid, Y., Wells, F.R., Daniel, S.E., Lees, A.J., Jenner, P., Marsden, C.D., Alterations in the levels of iron, ferritin and other trace metals in Parkinson's disease and other neurodegenerative diseases affecting the basal ganglia. Brain J. Neurol. 114:Pt 4 (1991), 1953–1975.
    • (1991) Brain J. Neurol. , vol.114 , pp. 1953-1975
    • Dexter, D.T.1    Carayon, A.2    Javoy-Agid, F.3    Agid, Y.4    Wells, F.R.5    Daniel, S.E.6    Lees, A.J.7    Jenner, P.8    Marsden, C.D.9
  • 57
    • 0024356620 scopus 로고
    • Increased nigral iron content and alterations in other metal ions occurring in brain in Parkinson's disease
    • Dexter, D.T., Wells, F.R., Lees, A.J., Agid, F., Agid, Y., Jenner, P., Marsden, C.D., Increased nigral iron content and alterations in other metal ions occurring in brain in Parkinson's disease. J. Neurochem. 52 (1989), 1830–1836.
    • (1989) J. Neurochem. , vol.52 , pp. 1830-1836
    • Dexter, D.T.1    Wells, F.R.2    Lees, A.J.3    Agid, F.4    Agid, Y.5    Jenner, P.6    Marsden, C.D.7
  • 67
    • 0025954066 scopus 로고
    • Ageing and Parkinson's disease: substantia nigra regional selectivity
    • Fearnley, J.M., Lees, A.J., Ageing and Parkinson's disease: substantia nigra regional selectivity. Brain J. Neurol. 114:Pt 5 (1991), 2283–2301.
    • (1991) Brain J. Neurol. , vol.114 , pp. 2283-2301
    • Fearnley, J.M.1    Lees, A.J.2
  • 68
    • 84861453955 scopus 로고    scopus 로고
    • alpha-Synuclein expression is modulated at the translational level by iron
    • Febbraro, F., Giorgi, M., Caldarola, S., Loreni, F., Romero-Ramos, M., alpha-Synuclein expression is modulated at the translational level by iron. Neuroreport 23 (2012), 576–580.
    • (2012) Neuroreport , vol.23 , pp. 576-580
    • Febbraro, F.1    Giorgi, M.2    Caldarola, S.3    Loreni, F.4    Romero-Ramos, M.5
  • 69
    • 33748973074 scopus 로고    scopus 로고
    • Progressive neurodegeneration and motor disabilities induced by chronic expression of IL-1beta in the substantia nigra
    • Ferrari, C.C., Pott Godoy, M.C., Tarelli, R., Chertoff, M., Depino, A.M., Pitossi, F.J., Progressive neurodegeneration and motor disabilities induced by chronic expression of IL-1beta in the substantia nigra. Neurobiol. Dis. 24 (2006), 183–193.
    • (2006) Neurobiol. Dis. , vol.24 , pp. 183-193
    • Ferrari, C.C.1    Pott Godoy, M.C.2    Tarelli, R.3    Chertoff, M.4    Depino, A.M.5    Pitossi, F.J.6
  • 70
    • 41949127121 scopus 로고    scopus 로고
    • Anthrax lethal toxin and Salmonella elicit the common cell death pathway of caspase-1-dependent pyroptosis via distinct mechanisms
    • Fink, S.L., Bergsbaken, T., Cookson, B.T., Anthrax lethal toxin and Salmonella elicit the common cell death pathway of caspase-1-dependent pyroptosis via distinct mechanisms. Proc. Natl. Acad. Sci. U. S. A. 105 (2008), 4312–4317.
    • (2008) Proc. Natl. Acad. Sci. U. S. A. , vol.105 , pp. 4312-4317
    • Fink, S.L.1    Bergsbaken, T.2    Cookson, B.T.3
  • 71
    • 33847320669 scopus 로고    scopus 로고
    • The 5'-untranslated region of Parkinson's disease alpha-synuclein messengerRNA contains a predicted iron responsive element
    • Friedlich, A.L., Tanzi, R.E., Rogers, J.T., The 5'-untranslated region of Parkinson's disease alpha-synuclein messengerRNA contains a predicted iron responsive element. Mol. Psychiatry 12 (2007), 222–223.
    • (2007) Mol. Psychiatry , vol.12 , pp. 222-223
    • Friedlich, A.L.1    Tanzi, R.E.2    Rogers, J.T.3
  • 73
    • 0028057613 scopus 로고
    • Disruption of epithelial cell-matrix interactions induces apoptosis
    • Frisch, S.M., Francis, H., Disruption of epithelial cell-matrix interactions induces apoptosis. J. Cell Biol. 124 (1994), 619–626.
    • (1994) J. Cell Biol. , vol.124 , pp. 619-626
    • Frisch, S.M.1    Francis, H.2
  • 74
    • 0030458602 scopus 로고    scopus 로고
    • A role for Jun-N-terminal kinase in anoikis; suppression by bcl-2 and crmA
    • Frisch, S.M., Vuori, K., Kelaita, D., Sicks, S., A role for Jun-N-terminal kinase in anoikis; suppression by bcl-2 and crmA. J. Cell Biol. 135 (1996), 1377–1382.
    • (1996) J. Cell Biol. , vol.135 , pp. 1377-1382
    • Frisch, S.M.1    Vuori, K.2    Kelaita, D.3    Sicks, S.4
  • 76
    • 0023149198 scopus 로고
    • Cellular euthanasia mediated by a nuclear enzyme: a central role for nuclear ADP-ribosylation in cellular metabolism
    • Gaal, J.C., Smith, Kevin R., Pearson, Colin K., Cellular euthanasia mediated by a nuclear enzyme: a central role for nuclear ADP-ribosylation in cellular metabolism. Trends Biochem. Sci. 12 (1987), 129–130.
    • (1987) Trends Biochem. Sci. , vol.12 , pp. 129-130
    • Gaal, J.C.1    Smith, K.R.2    Pearson, C.K.3
  • 77
    • 0026545073 scopus 로고
    • Cyclin B2 undergoes cell cycle-dependent nuclear translocation and, when expressed as a non-destructible mutant, causes mitotic arrest in HeLa cells
    • Gallant, P., Nigg, E.A., Cyclin B2 undergoes cell cycle-dependent nuclear translocation and, when expressed as a non-destructible mutant, causes mitotic arrest in HeLa cells. J. Cell Biol. 117 (1992), 213–224.
    • (1992) J. Cell Biol. , vol.117 , pp. 213-224
    • Gallant, P.1    Nigg, E.A.2
  • 80
    • 0035094532 scopus 로고    scopus 로고
    • Integrin signaling via the PI3-kinase-Akt pathway increases neuronal resistance to glutamate-induced apoptosis
    • Gary, D.S., Mattson, M.P., Integrin signaling via the PI3-kinase-Akt pathway increases neuronal resistance to glutamate-induced apoptosis. J. Neurochem. 76 (2001), 1485–1496.
    • (2001) J. Neurochem. , vol.76 , pp. 1485-1496
    • Gary, D.S.1    Mattson, M.P.2
  • 81
    • 0035951869 scopus 로고    scopus 로고
    • A hydrophobic stretch of 12 amino acid residues in the middle of alpha-synuclein is essential for filament assembly
    • Giasson, B.I., Murray, I.V., Trojanowski, J.Q., Lee, V.M., A hydrophobic stretch of 12 amino acid residues in the middle of alpha-synuclein is essential for filament assembly. J. Biol. Chem. 276 (2001), 2380–2386.
    • (2001) J. Biol. Chem. , vol.276 , pp. 2380-2386
    • Giasson, B.I.1    Murray, I.V.2    Trojanowski, J.Q.3    Lee, V.M.4
  • 82
    • 0023898945 scopus 로고
    • The relevance of the Lewy body to the pathogenesis of idiopathic Parkinson's disease
    • Gibb, W.R., Lees, A.J., The relevance of the Lewy body to the pathogenesis of idiopathic Parkinson's disease. J. Neurol. Neurosurg. Psychiatry 51 (1988), 745–752.
    • (1988) J. Neurol. Neurosurg. Psychiatry , vol.51 , pp. 745-752
    • Gibb, W.R.1    Lees, A.J.2
  • 83
    • 0033781027 scopus 로고    scopus 로고
    • The coordinate release of cytochrome c during apoptosis is rapid, complete and kinetically invariant
    • Goldstein, J.C., Waterhouse, N.J., Juin, P., Evan, G.I., Green, D.R., The coordinate release of cytochrome c during apoptosis is rapid, complete and kinetically invariant. Nat. Cell Biol. 2 (2000), 156–162.
    • (2000) Nat. Cell Biol. , vol.2 , pp. 156-162
    • Goldstein, J.C.1    Waterhouse, N.J.2    Juin, P.3    Evan, G.I.4    Green, D.R.5
  • 84
    • 33846018602 scopus 로고    scopus 로고
    • Cell death by necrosis: towards a molecular definition
    • Golstein, P., Kroemer, G., Cell death by necrosis: towards a molecular definition. Trends Biochem. Sci. 32 (2007), 37–43.
    • (2007) Trends Biochem. Sci. , vol.32 , pp. 37-43
    • Golstein, P.1    Kroemer, G.2
  • 85
    • 0037013194 scopus 로고    scopus 로고
    • Magnesium inhibits spontaneous and iron-induced aggregation of alpha-synuclein
    • Golts, N., Snyder, H., Frasier, M., Theisler, C., Choi, P., Wolozin, B., Magnesium inhibits spontaneous and iron-induced aggregation of alpha-synuclein. J. Biol. Chem. 277 (2002), 16116–16123.
    • (2002) J. Biol. Chem. , vol.277 , pp. 16116-16123
    • Golts, N.1    Snyder, H.2    Frasier, M.3    Theisler, C.4    Choi, P.5    Wolozin, B.6
  • 86
    • 0026746512 scopus 로고
    • Neuromelanin-containing neurons of the substantia nigra accumulate iron and aluminum in Parkinson's disease: a LAMMA study
    • Good, P.F., Olanow, C.W., Perl, D.P., Neuromelanin-containing neurons of the substantia nigra accumulate iron and aluminum in Parkinson's disease: a LAMMA study. Brain Res. 593 (1992), 343–346.
    • (1992) Brain Res. , vol.593 , pp. 343-346
    • Good, P.F.1    Olanow, C.W.2    Perl, D.P.3
  • 87
    • 19444362951 scopus 로고    scopus 로고
    • Clinical perspectives of PARP inhibitors
    • Graziani, G., Szabo, C., Clinical perspectives of PARP inhibitors. Pharmacol. Res. 52 (2005), 109–118.
    • (2005) Pharmacol. Res. , vol.52 , pp. 109-118
    • Graziani, G.1    Szabo, C.2
  • 88
    • 84856578855 scopus 로고    scopus 로고
    • ATP13A2 regulates mitochondrial bioenergetics through macroautophagy
    • Gusdon, A.M., Zhu, J., Van Houten, B., Chu, C.T., ATP13A2 regulates mitochondrial bioenergetics through macroautophagy. Neurobiol. Dis. 45 (2012), 962–972.
    • (2012) Neurobiol. Dis. , vol.45 , pp. 962-972
    • Gusdon, A.M.1    Zhu, J.2    Van Houten, B.3    Chu, C.T.4
  • 89
    • 0030950055 scopus 로고    scopus 로고
    • Further evidence for an association between a mutation in the APP gene and Lewy body formation
    • Halliday, G., Brooks, W., Arthur, H., Creasey, H., Broe, G.A., Further evidence for an association between a mutation in the APP gene and Lewy body formation. Neurosci. Lett. 227 (1997), 49–52.
    • (1997) Neurosci. Lett. , vol.227 , pp. 49-52
    • Halliday, G.1    Brooks, W.2    Arthur, H.3    Creasey, H.4    Broe, G.A.5
  • 93
    • 0033577159 scopus 로고    scopus 로고
    • Oxidative stress induces amyloid-like aggregate formation of NACP/alpha-synuclein in vitro
    • Hashimoto, M., Hsu, L.J., Xia, Y., Takeda, A., Sisk, A., Sundsmo, M., Masliah, E., Oxidative stress induces amyloid-like aggregate formation of NACP/alpha-synuclein in vitro. Neuroreport 10 (1999), 717–721.
    • (1999) Neuroreport , vol.10 , pp. 717-721
    • Hashimoto, M.1    Hsu, L.J.2    Xia, Y.3    Takeda, A.4    Sisk, A.5    Sundsmo, M.6    Masliah, E.7
  • 94
    • 0000056069 scopus 로고
    • Zur Pathologie der Paralysis agitans und des postenzephalitischen Parkinsonismus
    • Hassler, R., Zur Pathologie der Paralysis agitans und des postenzephalitischen Parkinsonismus. J. Psychol. Neurol. 48 (1938), 387–476.
    • (1938) J. Psychol. Neurol. , vol.48 , pp. 387-476
    • Hassler, R.1
  • 95
    • 0036337748 scopus 로고    scopus 로고
    • A20 inhibits tumor necrosis factor (TNF) alpha-induced apoptosis by disrupting recruitment of TRADD and RIP to the TNF receptor 1 complex in Jurkat T cells
    • He, K.L., Ting, A.T., A20 inhibits tumor necrosis factor (TNF) alpha-induced apoptosis by disrupting recruitment of TRADD and RIP to the TNF receptor 1 complex in Jurkat T cells. Mol. Cell. Biol. 22 (2002), 6034–6045.
    • (2002) Mol. Cell. Biol. , vol.22 , pp. 6034-6045
    • He, K.L.1    Ting, A.T.2
  • 96
    • 0033955925 scopus 로고    scopus 로고
    • 6-Hydroxydopamine induced apoptosis of dopaminergic cells in the rat substantia nigra
    • He, Y., Lee, T., Leong, S.K., 6-Hydroxydopamine induced apoptosis of dopaminergic cells in the rat substantia nigra. Brain Res. 858 (2000), 163–166.
    • (2000) Brain Res. , vol.858 , pp. 163-166
    • He, Y.1    Lee, T.2    Leong, S.K.3
  • 98
    • 0023740954 scopus 로고
    • Melanized dopaminergic neurons are differentially susceptible to degeneration in Parkinson's disease
    • Hirsch, E., Graybiel, A.M., Agid, Y.A., Melanized dopaminergic neurons are differentially susceptible to degeneration in Parkinson's disease. Nature 334 (1988), 345–348.
    • (1988) Nature , vol.334 , pp. 345-348
    • Hirsch, E.1    Graybiel, A.M.2    Agid, Y.A.3
  • 99
    • 0026034279 scopus 로고
    • Iron and aluminum increase in the substantia nigra of patients with Parkinson's disease: an X-ray microanalysis
    • Hirsch, E.C., Brandel, J.P., Galle, P., Javoy-Agid, F., Agid, Y., Iron and aluminum increase in the substantia nigra of patients with Parkinson's disease: an X-ray microanalysis. J. Neurochem. 56 (1991), 446–451.
    • (1991) J. Neurochem. , vol.56 , pp. 446-451
    • Hirsch, E.C.1    Brandel, J.P.2    Galle, P.3    Javoy-Agid, F.4    Agid, Y.5
  • 104
    • 0029949257 scopus 로고    scopus 로고
    • TNF-dependent recruitment of the protein kinase RIP to the TNF receptor-1 signaling complex
    • Hsu, H., Huang, J., Shu, H.B., Baichwal, V., Goeddel, D.V., TNF-dependent recruitment of the protein kinase RIP to the TNF receptor-1 signaling complex. Immunity 4 (1996), 387–396.
    • (1996) Immunity , vol.4 , pp. 387-396
    • Hsu, H.1    Huang, J.2    Shu, H.B.3    Baichwal, V.4    Goeddel, D.V.5
  • 105
    • 0030032106 scopus 로고    scopus 로고
    • TRADD-TRAF2 and TRADD-FADD interactions define two distinct TNF receptor 1 signal transduction pathways
    • Hsu, H., Shu, H.B., Pan, M.G., Goeddel, D.V., TRADD-TRAF2 and TRADD-FADD interactions define two distinct TNF receptor 1 signal transduction pathways. Cell 84 (1996), 299–308.
    • (1996) Cell , vol.84 , pp. 299-308
    • Hsu, H.1    Shu, H.B.2    Pan, M.G.3    Goeddel, D.V.4
  • 106
    • 0029007855 scopus 로고
    • The TNF receptor 1-associated protein TRADD signals cell death and NF-kappa B activation
    • Hsu, H., Xiong, J., Goeddel, D.V., The TNF receptor 1-associated protein TRADD signals cell death and NF-kappa B activation. Cell 81 (1995), 495–504.
    • (1995) Cell , vol.81 , pp. 495-504
    • Hsu, H.1    Xiong, J.2    Goeddel, D.V.3
  • 107
    • 0026514953 scopus 로고
    • Accuracy of clinical diagnosis of idiopathic Parkinson's disease: a clinico-pathological study of 100 cases
    • Hughes, A.J., Daniel, S.E., Kilford, L., Lees, A.J., Accuracy of clinical diagnosis of idiopathic Parkinson's disease: a clinico-pathological study of 100 cases. J. Neurol. Neurosurg. Psychiatry 55 (1992), 181–184.
    • (1992) J. Neurol. Neurosurg. Psychiatry , vol.55 , pp. 181-184
    • Hughes, A.J.1    Daniel, S.E.2    Kilford, L.3    Lees, A.J.4
  • 111
    • 0026635461 scopus 로고
    • Oxidative stress as a cause of nigral cell death in Parkinson's disease and incidental Lewy body disease
    • The Royal Kings and Queens Parkinson's Disease Research Group Suppl:S82–87
    • Jenner, P., Dexter, D.T., Sian, J., Schapira, A.H., Marsden, C.D., Oxidative stress as a cause of nigral cell death in Parkinson's disease and incidental Lewy body disease. The Royal Kings and Queens Parkinson's Disease Research Group Ann. Neurol., 32, 1992 Suppl:S82–87.
    • (1992) Ann. Neurol. , vol.32
    • Jenner, P.1    Dexter, D.T.2    Sian, J.3    Schapira, A.H.4    Marsden, C.D.5
  • 114
    • 2442494278 scopus 로고    scopus 로고
    • Alpha-synuclein up-regulation and aggregation during MPP+-induced apoptosis in neuroblastoma cells: intermediacy of transferrin receptor iron and hydrogen peroxide
    • Kalivendi, S.V., Cunningham, S., Kotamraju, S., Joseph, J., Hillard, C.J., Kalyanaraman, B., Alpha-synuclein up-regulation and aggregation during MPP+-induced apoptosis in neuroblastoma cells: intermediacy of transferrin receptor iron and hydrogen peroxide. J. Biol. Chem. 279 (2004), 15240–15247.
    • (2004) J. Biol. Chem. , vol.279 , pp. 15240-15247
    • Kalivendi, S.V.1    Cunningham, S.2    Kotamraju, S.3    Joseph, J.4    Hillard, C.J.5    Kalyanaraman, B.6
  • 115
    • 59249090537 scopus 로고    scopus 로고
    • Glutathione depletion in immortalized midbrain-derived dopaminergic neurons results in increases in the labile iron pool: implications for Parkinson's disease
    • Kaur, D., Lee, D., Ragapolan, S., Andersen, J.K., Glutathione depletion in immortalized midbrain-derived dopaminergic neurons results in increases in the labile iron pool: implications for Parkinson's disease. Free Radic. Biol. Med. 46 (2009), 593–598.
    • (2009) Free Radic. Biol. Med. , vol.46 , pp. 593-598
    • Kaur, D.1    Lee, D.2    Ragapolan, S.3    Andersen, J.K.4
  • 116
    • 0032033132 scopus 로고    scopus 로고
    • The death domain kinase RIP mediates the TNF-induced NF-kappaB signal
    • Kelliher, M.A., Grimm, S., Ishida, Y., Kuo, F., Stanger, B.Z., Leder, P., The death domain kinase RIP mediates the TNF-induced NF-kappaB signal. Immunity 8 (1998), 297–303.
    • (1998) Immunity , vol.8 , pp. 297-303
    • Kelliher, M.A.1    Grimm, S.2    Ishida, Y.3    Kuo, F.4    Stanger, B.Z.5    Leder, P.6
  • 117
    • 0030913673 scopus 로고    scopus 로고
    • Matrix adhesion and Ras transformation both activate a phosphoinositide 3-OH kinase and protein kinase B/Akt cellular survival pathway
    • Khwaja, A., Rodriguez-Viciana, P., Wennstrom, S., Warne, P.H., Downward, J., Matrix adhesion and Ras transformation both activate a phosphoinositide 3-OH kinase and protein kinase B/Akt cellular survival pathway. EMBO J. 16 (1997), 2783–2793.
    • (1997) EMBO J. , vol.16 , pp. 2783-2793
    • Khwaja, A.1    Rodriguez-Viciana, P.2    Wennstrom, S.3    Warne, P.H.4    Downward, J.5
  • 118
    • 0035816590 scopus 로고    scopus 로고
    • Expression and characterization of recombinant rat Acyl-CoA synthetases 1, 4, and 5. Selective inhibition by triacsin C and thiazolidinediones
    • Kim, J.H., Lewin, T.M., Coleman, R.A., Expression and characterization of recombinant rat Acyl-CoA synthetases 1, 4, and 5. Selective inhibition by triacsin C and thiazolidinediones. J. Biol. Chem. 276 (2001), 24667–24673.
    • (2001) J. Biol. Chem. , vol.276 , pp. 24667-24673
    • Kim, J.H.1    Lewin, T.M.2    Coleman, R.A.3
  • 119
    • 0036661699 scopus 로고    scopus 로고
    • The ceruloplasmin and hydrogen peroxide system induces alpha-synuclein aggregation in vitro
    • Kim, K.S., Choi, S.Y., Kwon, H.Y., Won, M.H., Kang, T.C., Kang, J.H., The ceruloplasmin and hydrogen peroxide system induces alpha-synuclein aggregation in vitro. Biochimie 84 (2002), 625–631.
    • (2002) Biochimie , vol.84 , pp. 625-631
    • Kim, K.S.1    Choi, S.Y.2    Kwon, H.Y.3    Won, M.H.4    Kang, T.C.5    Kang, J.H.6
  • 120
    • 0034537290 scopus 로고    scopus 로고
    • Autophagy as a regulated pathway of cellular degradation
    • Klionsky, D.J., Emr, S.D., Autophagy as a regulated pathway of cellular degradation. Science 290 (2000), 1717–1721.
    • (2000) Science , vol.290 , pp. 1717-1721
    • Klionsky, D.J.1    Emr, S.D.2
  • 122
    • 0034081056 scopus 로고    scopus 로고
    • Aceruloplasminemia with a novel mutation associated with parkinsonism
    • Kohno, S., Miyajima, H., Takahashi, Y., Inoue, Y., Aceruloplasminemia with a novel mutation associated with parkinsonism. Neurogenetics 2 (2000), 237–238.
    • (2000) Neurogenetics , vol.2 , pp. 237-238
    • Kohno, S.1    Miyajima, H.2    Takahashi, Y.3    Inoue, Y.4
  • 124
    • 42249115877 scopus 로고    scopus 로고
    • Neuroinflammation mediated by IL-1beta increases susceptibility of dopamine neurons to degeneration in an animal model of Parkinson's disease
    • Koprich, J.B., Reske-Nielsen, C., Mithal, P., Isacson, O., Neuroinflammation mediated by IL-1beta increases susceptibility of dopamine neurons to degeneration in an animal model of Parkinson's disease. J. Neuroinflammation, 5, 2008, 8.
    • (2008) J. Neuroinflammation , vol.5 , pp. 8
    • Koprich, J.B.1    Reske-Nielsen, C.2    Mithal, P.3    Isacson, O.4
  • 128
    • 33845977959 scopus 로고    scopus 로고
    • Mitochondrial membrane permeabilization in cell death
    • Kroemer, G., Galluzzi, L., Brenner, C., Mitochondrial membrane permeabilization in cell death. Physiol. Rev. 87 (2007), 99–163.
    • (2007) Physiol. Rev. , vol.87 , pp. 99-163
    • Kroemer, G.1    Galluzzi, L.2    Brenner, C.3
  • 132
    • 84866650630 scopus 로고    scopus 로고
    • Bax activation initiates the assembly of a multimeric catalyst that facilitates Bax pore formation in mitochondrial outer membranes
    • Kushnareva, Y., Andreyev, A.Y., Kuwana, T., Newmeyer, D.D., Bax activation initiates the assembly of a multimeric catalyst that facilitates Bax pore formation in mitochondrial outer membranes. PLoS Biol., 10, 2012, e1001394.
    • (2012) PLoS Biol. , vol.10 , pp. e1001394
    • Kushnareva, Y.1    Andreyev, A.Y.2    Kuwana, T.3    Newmeyer, D.D.4
  • 134
    • 0035066885 scopus 로고    scopus 로고
    • Direct binding and functional coupling of alpha-synuclein to the dopamine transporters accelerate dopamine-induced apoptosis
    • Lee, F.J., Liu, F., Pristupa, Z.B., Niznik, H.B., Direct binding and functional coupling of alpha-synuclein to the dopamine transporters accelerate dopamine-induced apoptosis. FASEB J. Official Publ. Fed. Am. Soc. Exp. Biol. 15 (2001), 916–926.
    • (2001) FASEB J. Official Publ. Fed. Am. Soc. Exp. Biol. , vol.15 , pp. 916-926
    • Lee, F.J.1    Liu, F.2    Pristupa, Z.B.3    Niznik, H.B.4
  • 140
    • 2342553892 scopus 로고    scopus 로고
    • Mitochondrial p53 activates Bak and causes disruption of a Bak-Mcl1 complex
    • Leu, J.I., Dumont, P., Hafey, M., Murphy, M.E., George, D.L., Mitochondrial p53 activates Bak and causes disruption of a Bak-Mcl1 complex. Nat. Cell Biol. 6 (2004), 443–450.
    • (2004) Nat. Cell Biol. , vol.6 , pp. 443-450
    • Leu, J.I.1    Dumont, P.2    Hafey, M.3    Murphy, M.E.4    George, D.L.5
  • 142
    • 0032555697 scopus 로고    scopus 로고
    • Cleavage of BID by caspase 8 mediates the mitochondrial damage in the Fas pathway of apoptosis
    • Li, H., Zhu, H., Xu, C.J., Yuan, J., Cleavage of BID by caspase 8 mediates the mitochondrial damage in the Fas pathway of apoptosis. Cell 94 (1998), 491–501.
    • (1998) Cell , vol.94 , pp. 491-501
    • Li, H.1    Zhu, H.2    Xu, C.J.3    Yuan, J.4
  • 143
    • 0035811496 scopus 로고    scopus 로고
    • Endonuclease G is an apoptotic DNase when released from mitochondria
    • Li, L.Y., Luo, X., Wang, X., Endonuclease G is an apoptotic DNase when released from mitochondria. Nature 412 (2001), 95–99.
    • (2001) Nature , vol.412 , pp. 95-99
    • Li, L.Y.1    Luo, X.2    Wang, X.3
  • 144
    • 84954358195 scopus 로고    scopus 로고
    • Necroptosis contributes to the NMDA-induced excitotoxicity in rat's cultured cortical neurons
    • Li, Y., Yang, X., Ma, C., Qiao, J., Zhang, C., Necroptosis contributes to the NMDA-induced excitotoxicity in rat's cultured cortical neurons. Neurosci. Lett. 447 (2008), 120–123.
    • (2008) Neurosci. Lett. , vol.447 , pp. 120-123
    • Li, Y.1    Yang, X.2    Ma, C.3    Qiao, J.4    Zhang, C.5
  • 145
    • 0030598917 scopus 로고    scopus 로고
    • Dopamine, 6-hydroxydopamine, iron, and dioxygen–their mutual interactions and possible implication in the development of Parkinson's disease
    • Linert, W., Herlinger, E., Jameson, R.F., Kienzl, E., Jellinger, K., Youdim, M.B., Dopamine, 6-hydroxydopamine, iron, and dioxygen–their mutual interactions and possible implication in the development of Parkinson's disease. Biochim. Biophys. Acta 1316 (1996), 160–168.
    • (1996) Biochim. Biophys. Acta , vol.1316 , pp. 160-168
    • Linert, W.1    Herlinger, E.2    Jameson, R.F.3    Kienzl, E.4    Jellinger, K.5    Youdim, M.B.6
  • 146
    • 84869109864 scopus 로고    scopus 로고
    • Pathological alpha-synuclein transmission initiates Parkinson-like neurodegeneration in nontransgenic mice
    • Luk, K.C., Kehm, V., Carroll, J., Zhang, B., O'Brien, P., Trojanowski, J.Q., Lee, V.M., Pathological alpha-synuclein transmission initiates Parkinson-like neurodegeneration in nontransgenic mice. Science 338 (2012), 949–953.
    • (2012) Science , vol.338 , pp. 949-953
    • Luk, K.C.1    Kehm, V.2    Carroll, J.3    Zhang, B.4    O'Brien, P.5    Trojanowski, J.Q.6    Lee, V.M.7
  • 148
    • 0017344150 scopus 로고
    • Success and problems of long-term levodopa therapy in Parkinson's disease
    • Marsden, C.D., Parkes, J.D., Success and problems of long-term levodopa therapy in Parkinson's disease. Lancet 1 (1977), 345–349.
    • (1977) Lancet , vol.1 , pp. 345-349
    • Marsden, C.D.1    Parkes, J.D.2
  • 152
    • 0036671894 scopus 로고    scopus 로고
    • The inflammasome: a molecular platform triggering activation of inflammatory caspases and processing of proIL-beta
    • Martinon, F., Burns, K., Tschopp, J., The inflammasome: a molecular platform triggering activation of inflammatory caspases and processing of proIL-beta. Mol. Cell 10 (2002), 417–426.
    • (2002) Mol. Cell , vol.10 , pp. 417-426
    • Martinon, F.1    Burns, K.2    Tschopp, J.3
  • 159
    • 0028266425 scopus 로고
    • Iron accumulation in the substantia nigra of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced hemiparkinsonian monkeys
    • Mochizuki, H., Imai, H., Endo, K., Yokomizo, K., Murata, Y., Hattori, N., Mizuno, Y., Iron accumulation in the substantia nigra of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced hemiparkinsonian monkeys. Neurosci. Lett. 168 (1994), 251–253.
    • (1994) Neurosci. Lett. , vol.168 , pp. 251-253
    • Mochizuki, H.1    Imai, H.2    Endo, K.3    Yokomizo, K.4    Murata, Y.5    Hattori, N.6    Mizuno, Y.7
  • 160
    • 0028178281 scopus 로고
    • Tumor necrosis factor-alpha (TNF-alpha) increases both in the brain and in the cerebrospinal fluid from parkinsonian patients
    • Mogi, M., Harada, M., Riederer, P., Narabayashi, H., Fujita, K., Nagatsu, T., Tumor necrosis factor-alpha (TNF-alpha) increases both in the brain and in the cerebrospinal fluid from parkinsonian patients. Neurosci. Lett. 165 (1994), 208–210.
    • (1994) Neurosci. Lett. , vol.165 , pp. 208-210
    • Mogi, M.1    Harada, M.2    Riederer, P.3    Narabayashi, H.4    Fujita, K.5    Nagatsu, T.6
  • 162
    • 15844407874 scopus 로고    scopus 로고
    • Cyclophilin D-dependent mitochondrial permeability transition regulates some necrotic but not apoptotic cell death
    • Nakagawa, T., Shimizu, S., Watanabe, T., Yamaguchi, O., Otsu, K., Yamagata, H., Inohara, H., Kubo, T., Tsujimoto, Y., Cyclophilin D-dependent mitochondrial permeability transition regulates some necrotic but not apoptotic cell death. Nature 434 (2005), 652–658.
    • (2005) Nature , vol.434 , pp. 652-658
    • Nakagawa, T.1    Shimizu, S.2    Watanabe, T.3    Yamaguchi, O.4    Otsu, K.5    Yamagata, H.6    Inohara, H.7    Kubo, T.8    Tsujimoto, Y.9
  • 163
    • 0021328595 scopus 로고
    • Parkinson's disease: neuron loss in the nucleus basalis without concomitant Alzheimer's disease
    • Nakano, I., Hirano, A., Parkinson's disease: neuron loss in the nucleus basalis without concomitant Alzheimer's disease. Ann. Neurol. 15 (1984), 415–418.
    • (1984) Ann. Neurol. , vol.15 , pp. 415-418
    • Nakano, I.1    Hirano, A.2
  • 164
    • 0029086742 scopus 로고
    • Hereditary haemochromatosis: a case of iron accumulation in the basal ganglia associated with a parkinsonian syndrome
    • Nielsen, J.E., Jensen, L.N., Krabbe, K., Hereditary haemochromatosis: a case of iron accumulation in the basal ganglia associated with a parkinsonian syndrome. J. Neurol. Neurosurg. Psychiatry 59 (1995), 318–321.
    • (1995) J. Neurol. Neurosurg. Psychiatry , vol.59 , pp. 318-321
    • Nielsen, J.E.1    Jensen, L.N.2    Krabbe, K.3
  • 165
    • 84894279534 scopus 로고    scopus 로고
    • Accumulation of cytosolic calcium induces necroptotic cell death in human neuroblastoma
    • Nomura, M., Ueno, A., Saga, K., Fukuzawa, M., Kaneda, Y., Accumulation of cytosolic calcium induces necroptotic cell death in human neuroblastoma. Cancer Res. 74 (2014), 1056–1066.
    • (2014) Cancer Res. , vol.74 , pp. 1056-1066
    • Nomura, M.1    Ueno, A.2    Saga, K.3    Fukuzawa, M.4    Kaneda, Y.5
  • 167
    • 0027166048 scopus 로고
    • Bcl-2 heterodimerizes in vivo with a conserved homolog, Bax, that accelerates programmed cell death
    • Oltvai, Z.N., Milliman, C.L., Korsmeyer, S.J., Bcl-2 heterodimerizes in vivo with a conserved homolog, Bax, that accelerates programmed cell death. Cell 74 (1993), 609–619.
    • (1993) Cell , vol.74 , pp. 609-619
    • Oltvai, Z.N.1    Milliman, C.L.2    Korsmeyer, S.J.3
  • 168
    • 0014027719 scopus 로고
    • The possible significance of the ferrous oxidase activity of ceruloplasmin in normal human serum
    • Osaki, S., Johnson, D.A., Frieden, E., The possible significance of the ferrous oxidase activity of ceruloplasmin in normal human serum. J. Biol. Chem. 241 (1966), 2746–2751.
    • (1966) J. Biol. Chem. , vol.241 , pp. 2746-2751
    • Osaki, S.1    Johnson, D.A.2    Frieden, E.3
  • 171
    • 0034660568 scopus 로고    scopus 로고
    • Metal-catalyzed oxidation of alpha-synuclein in the presence of Copper(II) and hydrogen peroxide
    • Paik, S.R., Shin, H.J., Lee, J.H., Metal-catalyzed oxidation of alpha-synuclein in the presence of Copper(II) and hydrogen peroxide. Arch. Biochem. Biophys. 378 (2000), 269–277.
    • (2000) Arch. Biochem. Biophys. , vol.378 , pp. 269-277
    • Paik, S.R.1    Shin, H.J.2    Lee, J.H.3
  • 175
    • 77049084488 scopus 로고    scopus 로고
    • Binding of alpha-synuclein with Fe(III) and with Fe(II) and biological implications of the resultant complexes
    • Peng, Y., Wang, C., Xu, H.H., Liu, Y.N., Zhou, F., Binding of alpha-synuclein with Fe(III) and with Fe(II) and biological implications of the resultant complexes. J. Inorg. Biochem. 104 (2010), 365–370.
    • (2010) J. Inorg. Biochem. , vol.104 , pp. 365-370
    • Peng, Y.1    Wang, C.2    Xu, H.H.3    Liu, Y.N.4    Zhou, F.5
  • 176
    • 0022400573 scopus 로고
    • Partial protection from the dopaminergic neurotoxin N-methyl-4-phenyl-1,2,3,6-tetrahydropyridine by four different antioxidants in the mouse
    • Perry, T.L., Yong, V.W., Clavier, R.M., Jones, K., Wright, J.M., Foulks, J.G., Wall, R.A., Partial protection from the dopaminergic neurotoxin N-methyl-4-phenyl-1,2,3,6-tetrahydropyridine by four different antioxidants in the mouse. Neurosci. Lett. 60 (1985), 109–114.
    • (1985) Neurosci. Lett. , vol.60 , pp. 109-114
    • Perry, T.L.1    Yong, V.W.2    Clavier, R.M.3    Jones, K.4    Wright, J.M.5    Foulks, J.G.6    Wall, R.A.7
  • 183
    • 0024395281 scopus 로고
    • Dementia in Parkinson's disease is related to neuronal loss in the medial substantia nigra
    • Rinne, J.O., Rummukainen, J., Paljarvi, L., Rinne, U.K., Dementia in Parkinson's disease is related to neuronal loss in the medial substantia nigra. Ann. Neurol. 26 (1989), 47–50.
    • (1989) Ann. Neurol. , vol.26 , pp. 47-50
    • Rinne, J.O.1    Rummukainen, J.2    Paljarvi, L.3    Rinne, U.K.4
  • 184
    • 0024809382 scopus 로고
    • Neuronal loss in the substantia nigra in patients with Alzheimer's disease and Parkinson's disease in relation to extrapyramidal symptoms and dementia
    • Rinne, J.O., Rummukainen, J., Paljarvi, L., Sako, E., Molsa, P., Rinne, U.K., Neuronal loss in the substantia nigra in patients with Alzheimer's disease and Parkinson's disease in relation to extrapyramidal symptoms and dementia. Prog. Clin. Biol. Res. 317 (1989), 325–332.
    • (1989) Prog. Clin. Biol. Res. , vol.317 , pp. 325-332
    • Rinne, J.O.1    Rummukainen, J.2    Paljarvi, L.3    Sako, E.4    Molsa, P.5    Rinne, U.K.6
  • 190
    • 5544229693 scopus 로고    scopus 로고
    • Classic toxin-induced animal models of Parkinson's disease: 6-OHDA and MPTP
    • Schober, A., Classic toxin-induced animal models of Parkinson's disease: 6-OHDA and MPTP. Cell Tissue Res. 318 (2004), 215–224.
    • (2004) Cell Tissue Res. , vol.318 , pp. 215-224
    • Schober, A.1
  • 192
    • 0038512499 scopus 로고    scopus 로고
    • The PI3-kinase-Akt pathway promotes mesangial cell survival and inhibits apoptosis in vitro via NF-kappa B and Bad
    • Shimamura, H., Terada, Y., Okado, T., Tanaka, H., Inoshita, S., Sasaki, S., The PI3-kinase-Akt pathway promotes mesangial cell survival and inhibits apoptosis in vitro via NF-kappa B and Bad. J. Am. Soc. Nephrol. JASN 14 (2003), 1427–1434.
    • (2003) J. Am. Soc. Nephrol. JASN , vol.14 , pp. 1427-1434
    • Shimamura, H.1    Terada, Y.2    Okado, T.3    Tanaka, H.4    Inoshita, S.5    Sasaki, S.6
  • 194
    • 0028075410 scopus 로고
    • Alterations in glutathione levels in Parkinson's disease and other neurodegenerative disorders affecting basal ganglia
    • Sian, J., Dexter, D.T., Lees, A.J., Daniel, S., Agid, Y., Javoy-Agid, F., Jenner, P., Marsden, C.D., Alterations in glutathione levels in Parkinson's disease and other neurodegenerative disorders affecting basal ganglia. Ann. Neurol. 36 (1994), 348–355.
    • (1994) Ann. Neurol. , vol.36 , pp. 348-355
    • Sian, J.1    Dexter, D.T.2    Lees, A.J.3    Daniel, S.4    Agid, Y.5    Javoy-Agid, F.6    Jenner, P.7    Marsden, C.D.8
  • 198
    • 0035831473 scopus 로고    scopus 로고
    • Executioner caspase-3, -6, and -7 perform distinct, non-redundant roles during the demolition phase of apoptosis
    • Slee, E.A., Adrain, C., Martin, S.J., Executioner caspase-3, -6, and -7 perform distinct, non-redundant roles during the demolition phase of apoptosis. J. Biol. Chem. 276 (2001), 7320–7326.
    • (2001) J. Biol. Chem. , vol.276 , pp. 7320-7326
    • Slee, E.A.1    Adrain, C.2    Martin, S.J.3
  • 199
    • 29644434199 scopus 로고    scopus 로고
    • Endoplasmic reticulum stress and mitochondrial cell death pathways mediate A53T mutant alpha-synuclein-induced toxicity
    • Smith, W.W., Jiang, H., Pei, Z., Tanaka, Y., Morita, H., Sawa, A., Dawson, V.L., Dawson, T.M., Ross, C.A., Endoplasmic reticulum stress and mitochondrial cell death pathways mediate A53T mutant alpha-synuclein-induced toxicity. Hum. Mol. Genet. 14 (2005), 3801–3811.
    • (2005) Hum. Mol. Genet. , vol.14 , pp. 3801-3811
    • Smith, W.W.1    Jiang, H.2    Pei, Z.3    Tanaka, Y.4    Morita, H.5    Sawa, A.6    Dawson, V.L.7    Dawson, T.M.8    Ross, C.A.9
  • 200
    • 0026644192 scopus 로고
    • Reduced and oxidized glutathione in the substantia nigra of patients with Parkinson's disease
    • Sofic, E., Lange, K.W., Jellinger, K., Riederer, P., Reduced and oxidized glutathione in the substantia nigra of patients with Parkinson's disease. Neurosci. Lett. 142 (1992), 128–130.
    • (1992) Neurosci. Lett. , vol.142 , pp. 128-130
    • Sofic, E.1    Lange, K.W.2    Jellinger, K.3    Riederer, P.4
  • 201
    • 0025963530 scopus 로고
    • Selective increase of iron in substantia nigra zona compacta of parkinsonian brains
    • Sofic, E., Paulus, W., Jellinger, K., Riederer, P., Youdim, M.B., Selective increase of iron in substantia nigra zona compacta of parkinsonian brains. J. Neurochem. 56 (1991), 978–982.
    • (1991) J. Neurochem. , vol.56 , pp. 978-982
    • Sofic, E.1    Paulus, W.2    Jellinger, K.3    Riederer, P.4    Youdim, M.B.5
  • 203
    • 84894350781 scopus 로고    scopus 로고
    • HMGB1 is involved in autophagy inhibition caused by SNCA/alpha-synuclein overexpression: a process modulated by the natural autophagy inducer corynoxine B
    • Song, J.X., Lu, J.H., Liu, L.F., Chen, L.L., Durairajan, S.S., Yue, Z., Zhang, H.Q., Li, M., HMGB1 is involved in autophagy inhibition caused by SNCA/alpha-synuclein overexpression: a process modulated by the natural autophagy inducer corynoxine B. Autophagy 10 (2014), 144–154.
    • (2014) Autophagy , vol.10 , pp. 144-154
    • Song, J.X.1    Lu, J.H.2    Liu, L.F.3    Chen, L.L.4    Durairajan, S.S.5    Yue, Z.6    Zhang, H.Q.7    Li, M.8
  • 204
    • 0037716926 scopus 로고    scopus 로고
    • Ca2+-induced oxidative stress in brain mitochondria treated with the respiratory chain inhibitor rotenone
    • Sousa, S.C., Maciel, E.N., Vercesi, A.E., Castilho, R.F., Ca2+-induced oxidative stress in brain mitochondria treated with the respiratory chain inhibitor rotenone. FEBS Lett. 543 (2003), 179–183.
    • (2003) FEBS Lett. , vol.543 , pp. 179-183
    • Sousa, S.C.1    Maciel, E.N.2    Vercesi, A.E.3    Castilho, R.F.4
  • 207
    • 0031036391 scopus 로고    scopus 로고
    • Evidence for generation of oxidative stress in brain by MPTP: in vitro and in vivo studies in mice
    • Sriram, K., Pai, K.S., Boyd, M.R., Ravindranath, V., Evidence for generation of oxidative stress in brain by MPTP: in vitro and in vivo studies in mice. Brain Res. 749 (1997), 44–52.
    • (1997) Brain Res. , vol.749 , pp. 44-52
    • Sriram, K.1    Pai, K.S.2    Boyd, M.R.3    Ravindranath, V.4
  • 208
    • 70349917814 scopus 로고    scopus 로고
    • Mutant alpha-synuclein overexpression mediates early proinflammatory activity
    • Su, X., Federoff, H.J., Maguire-Zeiss, K.A., Mutant alpha-synuclein overexpression mediates early proinflammatory activity. Neurotox. Res. 16 (2009), 238–254.
    • (2009) Neurotox. Res. , vol.16 , pp. 238-254
    • Su, X.1    Federoff, H.J.2    Maguire-Zeiss, K.A.3
  • 211
    • 84906877508 scopus 로고    scopus 로고
    • Amyloid-beta induces NLRP1-dependent neuronal pyroptosis in models of Alzheimer's disease
    • Tan, M.S., Tan, L., Jiang, T., Zhu, X.C., Wang, H.F., Jia, C.D., Yu, J.T., Amyloid-beta induces NLRP1-dependent neuronal pyroptosis in models of Alzheimer's disease. Cell Death Dis., 5, 2014, e1382.
    • (2014) Cell Death Dis. , vol.5 , pp. e1382
    • Tan, M.S.1    Tan, L.2    Jiang, T.3    Zhu, X.C.4    Wang, H.F.5    Jia, C.D.6    Yu, J.T.7
  • 212
    • 0035870881 scopus 로고    scopus 로고
    • Inducible expression of mutant alpha-synuclein decreases proteasome activity and increases sensitivity to mitochondria-dependent apoptosis
    • Tanaka, Y., Engelender, S., Igarashi, S., Rao, R.K., Wanner, T., Tanzi, R.E., Sawa, A., Dawson, V.L., Dawson, T.M., Ross, C.A., Inducible expression of mutant alpha-synuclein decreases proteasome activity and increases sensitivity to mitochondria-dependent apoptosis. Hum. Mol. Genet. 10 (2001), 919–926.
    • (2001) Hum. Mol. Genet. , vol.10 , pp. 919-926
    • Tanaka, Y.1    Engelender, S.2    Igarashi, S.3    Rao, R.K.4    Wanner, T.5    Tanzi, R.E.6    Sawa, A.7    Dawson, V.L.8    Dawson, T.M.9    Ross, C.A.10
  • 214
    • 0033756901 scopus 로고    scopus 로고
    • Increased caspase 3 and Bax immunoreactivity accompany nuclear GAPDH translocation and neuronal apoptosis in Parkinson's disease
    • Tatton, N.A., Increased caspase 3 and Bax immunoreactivity accompany nuclear GAPDH translocation and neuronal apoptosis in Parkinson's disease. Exp. Neurol. 166 (2000), 29–43.
    • (2000) Exp. Neurol. , vol.166 , pp. 29-43
    • Tatton, N.A.1
  • 215
    • 84863229879 scopus 로고    scopus 로고
    • Mitochondrial permeability transition pore component cyclophilin D distinguishes nigrostriatal dopaminergic death paradigms in the MPTP mouse model of Parkinson's disease
    • Thomas, B., Banerjee, R., Starkova, N.N., Zhang, S.F., Calingasan, N.Y., Yang, L., Wille, E., Lorenzo, B.J., Ho, D.J., Beal, M.F., Starkov, A., Mitochondrial permeability transition pore component cyclophilin D distinguishes nigrostriatal dopaminergic death paradigms in the MPTP mouse model of Parkinson's disease. Antioxid. Redox Signal. 16 (2012), 855–868.
    • (2012) Antioxid. Redox Signal. , vol.16 , pp. 855-868
    • Thomas, B.1    Banerjee, R.2    Starkova, N.N.3    Zhang, S.F.4    Calingasan, N.Y.5    Yang, L.6    Wille, E.7    Lorenzo, B.J.8    Ho, D.J.9    Beal, M.F.10    Starkov, A.11
  • 217
    • 0023242350 scopus 로고
    • The role of selenium peroxidases in the protection against oxidative damage of membranes
    • Ursini, F., Bindoli, A., The role of selenium peroxidases in the protection against oxidative damage of membranes. Chem. Phys. Lipids 44 (1987), 255–276.
    • (1987) Chem. Phys. Lipids , vol.44 , pp. 255-276
    • Ursini, F.1    Bindoli, A.2
  • 218
    • 0020065662 scopus 로고
    • Purification from pig liver of a protein which protects liposomes and biomembranes from peroxidative degradation and exhibits glutathione peroxidase activity on phosphatidylcholine hydroperoxides
    • Ursini, F., Maiorino, M., Valente, M., Ferri, L., Gregolin, C., Purification from pig liver of a protein which protects liposomes and biomembranes from peroxidative degradation and exhibits glutathione peroxidase activity on phosphatidylcholine hydroperoxides. Biochim. Biophys. Acta 710 (1982), 197–211.
    • (1982) Biochim. Biophys. Acta , vol.710 , pp. 197-211
    • Ursini, F.1    Maiorino, M.2    Valente, M.3    Ferri, L.4    Gregolin, C.5
  • 219
    • 0035941201 scopus 로고    scopus 로고
    • Metal-triggered structural transformations, aggregation, and fibrillation of human alpha-synuclein. A possible molecular NK between Parkinson's disease and heavy metal exposure
    • Uversky, V.N., Li, J., Fink, A.L., Metal-triggered structural transformations, aggregation, and fibrillation of human alpha-synuclein. A possible molecular NK between Parkinson's disease and heavy metal exposure. J. Biol. Chem. 276 (2001), 44284–44296.
    • (2001) J. Biol. Chem. , vol.276 , pp. 44284-44296
    • Uversky, V.N.1    Li, J.2    Fink, A.L.3
  • 223
    • 43049152912 scopus 로고    scopus 로고
    • TNF-alpha induces two distinct caspase-8 activation pathways
    • Wang, L., Du, F., Wang, X., TNF-alpha induces two distinct caspase-8 activation pathways. Cell 133 (2008), 693–703.
    • (2008) Cell , vol.133 , pp. 693-703
    • Wang, L.1    Du, F.2    Wang, X.3
  • 224
    • 79953840957 scopus 로고    scopus 로고
    • Poly(ADP-ribose) (PAR) binding to apoptosis-inducing factor is critical for PAR polymerase-1-dependent cell death (parthanatos)
    • Wang, Y., Kim, N.S., Haince, J.F., Kang, H.C., David, K.K., Andrabi, S.A., Poirier, G.G., Dawson, V.L., Dawson, T.M., Poly(ADP-ribose) (PAR) binding to apoptosis-inducing factor is critical for PAR polymerase-1-dependent cell death (parthanatos). Sci. Signal., 4, 2011, ra20.
    • (2011) Sci. Signal. , vol.4 , pp. ra20
    • Wang, Y.1    Kim, N.S.2    Haince, J.F.3    Kang, H.C.4    David, K.K.5    Andrabi, S.A.6    Poirier, G.G.7    Dawson, V.L.8    Dawson, T.M.9
  • 230
    • 65849127844 scopus 로고    scopus 로고
    • Abberant alpha-synuclein confers toxicity to neurons in part through inhibition of chaperone-mediated autophagy
    • Xilouri, M., Vogiatzi, T., Vekrellis, K., Park, D., Stefanis, L., Abberant alpha-synuclein confers toxicity to neurons in part through inhibition of chaperone-mediated autophagy. PLoS One, 4, 2009, e5515.
    • (2009) PLoS One , vol.4 , pp. e5515
    • Xilouri, M.1    Vogiatzi, T.2    Vekrellis, K.3    Park, D.4    Stefanis, L.5
  • 231
    • 5144225191 scopus 로고    scopus 로고
    • A novel systemically active caspase inhibitor attenuates the toxicities of MPTP, malonate, and 3NP in vivo
    • Yang, L., Sugama, S., Mischak, R.P., Kiaei, M., Bizat, N., Brouillet, E., Joh, T.H., Beal, M.F., A novel systemically active caspase inhibitor attenuates the toxicities of MPTP, malonate, and 3NP in vivo. Neurobiol. Dis. 17 (2004), 250–259.
    • (2004) Neurobiol. Dis. , vol.17 , pp. 250-259
    • Yang, L.1    Sugama, S.2    Mischak, R.P.3    Kiaei, M.4    Bizat, N.5    Brouillet, E.6    Joh, T.H.7    Beal, M.F.8
  • 233
    • 40849085503 scopus 로고    scopus 로고
    • Synthetic lethal screening identifies compounds activating iron-dependent, nonapoptotic cell death in oncogenic-RAS-harboring cancer cells
    • Yang, W.S., Stockwell, B.R., Synthetic lethal screening identifies compounds activating iron-dependent, nonapoptotic cell death in oncogenic-RAS-harboring cancer cells. Chem. Biol. 15 (2008), 234–245.
    • (2008) Chem. Biol. , vol.15 , pp. 234-245
    • Yang, W.S.1    Stockwell, B.R.2
  • 234
    • 0031038137 scopus 로고    scopus 로고
    • Bax suppresses tumorigenesis and stimulates apoptosis in vivo
    • Yin, C., Knudson, C.M., Korsmeyer, S.J., Van Dyke, T., Bax suppresses tumorigenesis and stimulates apoptosis in vivo. Nature 385 (1997), 637–640.
    • (1997) Nature , vol.385 , pp. 637-640
    • Yin, C.1    Knudson, C.M.2    Korsmeyer, S.J.3    Van Dyke, T.4
  • 236
    • 84861899099 scopus 로고    scopus 로고
    • Trehalose inhibits fibrillation of A53T mutant alpha-synuclein and disaggregates existing fibrils
    • Yu, W.B., Jiang, T., Lan, D.M., Lu, J.H., Yue, Z.Y., Wang, J., Zhou, P., Trehalose inhibits fibrillation of A53T mutant alpha-synuclein and disaggregates existing fibrils. Arch. Biochem. Biophys. 523 (2012), 144–150.
    • (2012) Arch. Biochem. Biophys. , vol.523 , pp. 144-150
    • Yu, W.B.1    Jiang, T.2    Lan, D.M.3    Lu, J.H.4    Yue, Z.Y.5    Wang, J.6    Zhou, P.7
  • 237
    • 0037337815 scopus 로고    scopus 로고
    • Neuronal loss is greater in the locus coeruleus than nucleus basalis and substantia nigra in Alzheimer and Parkinson diseases
    • Zarow, C., Lyness, S.A., Mortimer, J.A., Chui, H.C., Neuronal loss is greater in the locus coeruleus than nucleus basalis and substantia nigra in Alzheimer and Parkinson diseases. Arch. Neurol. 60 (2003), 337–341.
    • (2003) Arch. Neurol. , vol.60 , pp. 337-341
    • Zarow, C.1    Lyness, S.A.2    Mortimer, J.A.3    Chui, H.C.4
  • 241
    • 0033596980 scopus 로고    scopus 로고
    • An APAF-1.cytochrome c multimeric complex is a functional apoptosome that activates procaspase-9
    • Zou, H., Li, Y., Liu, X., Wang, X., An APAF-1.cytochrome c multimeric complex is a functional apoptosome that activates procaspase-9. J. Biol. Chem. 274 (1999), 11549–11556.
    • (1999) J. Biol. Chem. , vol.274 , pp. 11549-11556
    • Zou, H.1    Li, Y.2    Liu, X.3    Wang, X.4


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