α-Synuclein Locus Triplication Causes Parkinson's Disease

Science

Volumn 302, Issue 5646, 2003, Pages 841-

  Singleton, A B ^a   Farrer, M ^d   Johnson, J ^a   Singleton, A ^b   Hague, S ^a   Kachergus, J ^d   Hulihan, M ^d   Peuralinna, T ^a   Dutra, A ^c   Nussbaum, R ^b   Lincoln, S ^d   Crawley, A ^b   Hanson, M ^a   Maraganore, D ^e   Adler, C ^f   Cookson, M R ^a   Muenter, M ^f   Baptista, M ^a   Miller, D ^a   Blancato, J ^g   Hardy, J ^a   Gwinn Hardy, K ^b   more..

^a NATIONAL INSTITUTE ON AGING   (United States)

^b NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE   (United States)

^c NATIONAL HUMAN GENOME RESEARCH INSTITUTE   (United States)

^d MAYO CLINIC   (United States)

^e MAYO CLINIC   (United States)

^f MAYO CLINIC   (United States)

^g GEORGETOWN UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA SYNUCLEIN;

ARTICLE; CHROMOSOME; DNA FLANKING REGION; GENE LOCUS; GENE MUTATION; GENETIC ANALYSIS; HUMAN; INTERPHASE; METAPHASE; PARKINSON DISEASE; PATHOGENESIS; PRIORITY JOURNAL; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION;

ALLELES; ALPHA-SYNUCLEIN; EXONS; FAMILY; FEMALE; GENE DOSAGE; HAPLOTYPES; HUMANS; IN SITU HYBRIDIZATION, FLUORESCENCE; LINKAGE (GENETICS); MALE; MUTATION; NERVE TISSUE PROTEINS; PARKINSON DISEASE; PEDIGREE; POLYMORPHISM, SINGLE NUCLEOTIDE; PROMOTER REGIONS (GENETICS); REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; SYNUCLEINS;

EID: 0242300619     PISSN: 00368075     EISSN: None     Source Type: Journal    
DOI: 10.1126/science.1090278     Document Type: Article

References (6)

1. M. H. Polymeropoulos et al. Science 276, 2045 (1997).
2. P. H. Tu et al., Ann. Neurology 44, 415 (1998).
3. M. D. Muenter et al., Ann. Neurology 43, 768 (1998).
4. M. Farrer et al., Human Molec. Genet. 8, 81 (1999).
5. M. Farrer et al., Human Molec. Genet. 10, 1847 (2001).
6. We thank the family and the NINDS Genetics Repository at Coriell laboratories. This work was funded in part by a Morris K. Udall Center of Excellence grant (M.F.).