Parkinson’s disease iron deposition caused by nitric oxide- induced loss of β-amyloid precursor protein

Journal of Neuroscience

Volumn 35, Issue 8, 2015, Pages 3591-3597

  Ayton, Scott ^a   Lei, Peng ^a   Hare, Dominic J ^a,e,f   Duce, James A ^a,b   George, Jessica L ^a   Adlard, Paul A ^a   McLean, Catriona ^a,c   Rogers, Jack T ^d   Cherny, Robert A ^a   Finkelstein, David I ^a   Bush, Ashley I ^a  

^a UNIVERSITY OF MELBOURNE   (Australia)

^b UNIVERSITY OF LEEDS   (United Kingdom)

^c ALFRED HOSPITAL   (Australia)

^d MASSACHUSETTS GENERAL HOSPITAL   (United States)

^e UNIVERSITY OF TECHNOLOGY SYDNEY   (Australia)

^f MOUNT SINAI SCHOOL OF MEDICINE   (United States)

Author keywords

APP; Iron; Nitric oxide

Indexed keywords

EID: 84923347844     PISSN: 02706474     EISSN: 15292401     Source Type: Journal    
DOI: 10.1523/JNEUROSCI.3439-14.2015     Document Type: Article

References (22)

1. Arkadir D, Bergman H, Fahn S (2014) Redundant dopaminergic activity may enable compensatory axonal sprouting in Parkinson disease. Neurology 82:1093-1098. CrossRef Medline
2. Austin SA, Santhanam AV, Katusic ZS (2010) Endothelial nitric oxide modulates expression and processing of amyloid precursor protein. Circ Res 107:1498 -1502. Medline
3. Ayton S, Lei P, Duce JA, Wong BX, Sedjahtera A, Adlard PA, Bush AI, Finkelstein DI (2013) Ceruloplasmin dysfunction and therapeutic potential for parkinson disease. Ann Neurol 73:554 -559. Medline
4. Chung CY, Khurana V, Auluck PK, Tardiff DF, Mazzulli JR, Soldner F, Baru V, Lou Y, Freyzon Y, Cho S, Mungenast AE, Muffat J, Mitalipova M, Pluth MD, Jui NT, Schüle B, Lippard SJ, Tsai LH, Krainc D, Buchwald SL, Jaenisch R, Lindquist S (2013) Identification and rescue of alpha-synuclein toxicity in Parkinson patient-derived neurons. Science 342:983-987. CrossRef Medline
5. Devos D, Moreau C, Devedjian JC, Kluza J, Petrault M, Laloux C, Jonneaux A, Ryckewaert G, Garçon G, Rouaix N, Duhamel A, Jissendi P, Dujardin K, Auger F, Ravasi L, Hopes L, Grolez G, Firdaus W, Sablonnière B, Strubi-Vuillaume I, Zahr N, Destée A, Corvol JC, Pöltl D, Leist M, Rose C, Defebvre L, Marchetti P, Cabantchik ZI, Bordet R (2014) Targeting chelatable iron as a therapeutic modality in Parkinson's disease. Antioxid Redox Signal 21:195-210. CrossRef Medline
6. Di Monte DA, Royland JE, Anderson A, Castagnoli K, Castagnoli N Jr, Langston JW (1997) Inhibition of monoamine oxidase contributes to the protective effect of 7-nitroindazole againstMPTPneurotoxicity. J Neurochem 69:1771- 1773. Medline
7. Duce JA, Tsatsanis A, Cater MA, James SA, Robb E, Wikhe K, Leong SL, Perez K, Johanssen T, Greenough MA, Cho HH, Galatis D, Moir RD, Masters CL, McLean C, Tanzi RE, Cappai R, Barnham KJ, Ciccotosto GD, Rogers JT, Bush AI (2010) Iron-export ferroxidase activity of beta-amyloid precursor protein is inhibited by zinc in Alzheimer's disease. Cell 142:857- 867. CrossRef Medline
8. Duce JA, Ayton S, Miller AA, Tsatsanis A, Lam LQ, Leone L, Corbin JE, Butzkueven H, Kilpatrick TJ, Rogers JT, Barnham KJ, Finkelstein DI, Bush AI (2013) Amine oxidase activity of beta-amyloid precursor protein modulates systemic and local catecholamine levels. Mol Psychiatry 18:245-254. Medline
9. Guérin D, Sacquet J, Mandairon N, Jourdan F, Didier A (2009) Early locus coeruleus degeneration and olfactory dysfunctions in Tg2576 mice. Neurobiol Aging 30:272-283. Medline
10. Hare DJ, Lei P, Ayton S, Roberts BR, Grimm R, George JL, Bishop D, Beavis A, Donovan SJ, McColl G, Volitakis I, Masters CL, Adlard PA, Cherny RA, Bush AI, Finkelstein DI, Doble P (2014) An iron-dopamine index predicts risk of parkinsonian neurodegeneration in the substantia nigra pars compacta. Chem Sci 5:2160 -2169. CrossRef
11. Hung LW, Villemagne VL, Cheng L, Sherratt NA, Ayton S, White AR, Crouch PJ, Lim S, Leong SL, Wilkins S, George J, Roberts BR, Pham CL, Liu X, Chiu FC, Shackleford DM, Powell AK, Masters CL, Bush AI, O'Keefe G, Culvenor JG, Cappai R, Cherny RA, Donnelly PS, Hill AF, Finkelstein DI, Barnham KJ (2012) The hypoxia imaging agent CuII(atsm) is neuroprotective and improves motor and cognitive functions in multiple animal models of Parkinson's disease. J Exp Med 209:837- 854. Medline
12. Jaffrey SR, Cohen NA, Rouault TA, Klausner RD, Snyder SH (1994) The iron-responsive element binding protein: a target for synaptic actions of nitric oxide. Proc Natl Acad Sci USA 91:12994 -12998. CrossRef Medline
13. Lei P, Ayton S, Finkelstein DI, Spoerri L, Ciccotosto GD, Wright DK, Wong BX, Adlard PA, Cherny RA, Lam LQ, Roberts BR, Volitakis I, Egan GF, McLean CA, Cappai R, Duce JA, Bush AI (2012) Tau deficiency induces parkinsonism with dementia by impairing APP-mediated iron export. Nat Med 18:291-295. Medline
14. McCarthy RC, Park YH, Kosman DJ (2014) sAPP modulates iron efflux from brain microvascular endothelial cells by stabilizing the ferrous iron exporter ferroportin. EMBO Rep 15:809-815. CrossRef Medline
15. Morris CM, Candy JM, Omar S, Bloxham CA, Edwardson JA (1994) Transferrin receptors in the parkinsonian midbrain. Neuropathol Appl Neurobiol 20:468-472. Medline
16. Oakley AE, Collingwood JF, Dobson J, Love G, Perrott HR, Edwardson JA, Elstner M, Morris CM (2007) Individual dopaminergic neurons show raised iron levels in Parkinson disease. Neurology 68:1820-1825. CrossRef Medline
17. Przedborski S, Jackson-Lewis V, Yokoyama R, Shibata T, Dawson VL, Dawson TM (1996) Role of neuronal nitric oxide in 1-methyl-4-phenyl-1,2,3,6- tetrahydropyridine (MPTP)-induced dopaminergic neurotoxicity. Proc Natl Acad Sci USA 93:4565-4571. CrossRef Medline
18. Rogers JT, Randall JD, Cahill CM, Eder PS, Huang X, Gunshin H, Leiter L, McPhee J, Sarang SS, Utsuki T, Greig NH, Lahiri DK, Tanzi RE, Bush AI, Giordano T, Gullans SR (2002) An iron-responsive element type II in the 5ʹ-untranslated region of the Alzheimer's amyloid precursor protein transcript. J Biol Chem 277:45518-45528. Medline
19. Ryan SD, Dolatabadi N, Chan SF, Zhang X, Akhtar MW, Parker J, Soldner F, Sunico CR, Nagar S, Talantova M, Lee B, Lopez K, Nutter A, Shan B, Molokanova E, Zhang Y, Han X, Nakamura T, Masliah E, Yates JR 3rd, Nakanishi N, Andreyev AY, Okamoto S, Jaenisch R, Ambasudhan R, Lipton SA (2013) Isogenic human iPSC Parkinson's model shows nitrosative stress-induced dysfunction in MEF2-PGC1alpha transcription. Cell 155:1351-1364. CrossRef Medline
20. Salazar J, Mena N, Hunot S, Prigent A, Alvarez-Fischer D, Arredondo M, Duyckaerts C, Sazdovitch V, Zhao L, Garrick LM, Nuñez MT, Garrick MD, Raisman-Vozari R, Hirsch EC (2008) Divalent metal transporter 1 (DMT1) contributes to neurodegeneration in animal models of Parkinson's disease. Proc Natl Acad Sci USA 105:18578 -18583. CrossRef Medline
21. Weiss G, Goossen B, Doppler W, Fuchs D, Pantopoulos K, Werner-Felmayer G, Wachter H, Hentze MW (1993) Translational regulation via ironresponsive elements by the nitric oxide/NO-synthase pathway. EMBO J 12:3651-3657. Medline
22. Zheng H, Jiang M, Trumbauer ME, Sirinathsinghji DJ, Hopkins R, Smith DW, Heavens RP, Dawson GR, Boyce S, Conner MW, Stevens KA, Slunt HH, Sisoda SS, Chen HY, Van der Ploeg LH (1995) beta-Amyloid precursor protein-deficient mice show reactive gliosis and decreased locomotor activity. Cell 81:525-531. CrossRef Medline