p53 and Bax activation in 6-hydroxydopamine-induced apoptosis in PC12 cells

Brain Research

Volumn 751, Issue 1, 1997, Pages 139-142

  Blum, David ^a   Wu, Ying ^a   Nissou, Marie France ^a   Arnaud, Séverine ^a   Benabid, Alim Louis ^a   Verna, Jean Marc ^a  

^a HÔPITAL MICHALLON   (France)

Author keywords

6 OHDA; apoptosis; Bax; p53; Parkinson's disease; PC12

Indexed keywords

OXIDOPAMINE; PROTEIN BAX; PROTEIN BCL 2; PROTEIN P53;

ANIMAL CELL; APOPTOSIS; ARTICLE; CELL CULTURE; CONTROLLED STUDY; NONHUMAN; PARKINSON DISEASE; PHEOCHROMOCYTOMA; PRIORITY JOURNAL; RAT;

ANIMALS; APOPTOSIS; BCL-2-ASSOCIATED X PROTEIN; BENZIMIDAZOLES; CELL SURVIVAL; ELECTROPHORESIS; FLUORESCENT DYES; OXIDOPAMINE; PC12 CELLS; PROTO-ONCOGENE PROTEINS; PROTO-ONCOGENE PROTEINS C-BCL-2; RATS; SYMPATHOLYTICS; TUMOR SUPPRESSOR PROTEIN P53;

EID: 0030956532     PISSN: 00068993     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-8993(96)01358-3     Document Type: Article

References (22)

1. Anglade, P., Vvas, S., Javoy-Agid, F., Herrero, M.T., Michel, P.P., Marquez, J., Mouatt-Prigent, A., Ruberg, M., Hirsch, E.C. and Agid, Y., Apoptotic degeneration of nigral dopaminergic neurons in Parkinson's disease, Soc. Neurosci. Abstr., 21 (1995) 489.
2. Davies, A.M., The Bcl-2 family of proteins, and the regulation of neuronal survival, Trends Neurosci., 18 (1995) 355-358 (1995).
3. Eizenberg, O., Faber-Elman, A., Gottlieb, E., Oren, M., Rotter, V. and Schwartz, M., Direct involvement of p53 in programmed cell death of oligodendrocytes, EMBO J., 14 (1995) 1136-1144.
4. Enoch, T. and Norbury, C., Cellular responses to DNA damage: cell-cycle checkpoints, apoptosis and the roles of p53 and ATM, Trends Biochem. Sci., 20 (1995) 426-430.
5. Frankowski, H., Missoten, M., Fernandez, P.A., Martinou, I., Michel, P., Sadoul, R. and Martinou, J.C., Function and expression of the Bcl-x gene in the developing and adult nervous system, NeuroReport, 6 (1995) 1917-1921.
6. Gonzalez-Garcia, M., Garcia, I., Ding, L., O'shea, S., Boise, L.H., Thompson, C.B. and Nunez, G., Bcl-x is expressed in embryonic and postnatal neural tissues and functions to prevent neuronal cell death, Proc. Natl. Acad. Sci. USA, 92 (1995) 4304-4308.
7. Hartley, A., Stone, J.M., Heron, C., Cooper, J.M. and Schapira, A.H.V., Complex I inhibitors induce dose-dependant apoptosis in PC12 cells: relevance to Parkinson's disease, J. Neurochem., 63 (1994) 1987-1990.
8. Jellinger, K., Linert, L., Kienzl, E., Herlinger, E. and Youdim, M.B.H., Chemical evidence for 6-hydroxydopamine to be an endogeneous toxic factor in the pathogenesis of Parkinson's disease, J. Neural Transm., S46 (1995) 297-314.
9. Krajewski, S., Mai, J.K., Krajewska, M., Sikorska, M., Mossakowski, M.J. and Reed, J.C., Upregulation of Bax protein level in neurons following cerebral ischemia, J. Neurosci., 15 (1995) 6364-6376.
10. Mah, S.P., Zhong, L.T., Liu, Y., Roghani, A., Edwards, R.H. and Bredesen, D.E., The proto-oncogene bcl-2 inhibits apoptosis in PC12 cells, J. Neurochem., 60 (1993) 1183-1186.
11. Merry, D.E., Veis, D.J., Hickey, W.F. and Korsmeyer, S.J., Bcl-2 protein expression is widespread in the developing nervous system and retained in the adult PNS, Development, 120 (1994) 301-311.
12. Miyashita, T., Krajewski, S., Krajewska, M., Wang, H.G., Lin, H.K., Liebermann, D.A., Hoffman, B. and Reed, J.C., Tumor suppressor p53 is a regulator of bcl-2 and bax gene expression in vitro and in vivo, Oncogene, 9 (1994) 1799-1805.
13. Miyashita, T. and Reed, J.C., Tumor suppressor p53 is a direct transcriptional activator of human bax gene, Cell, 80 (1995) 293-299.
14. Mosmann, T., Rapic colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assays, J. Immunol. Methods, 65 (1983) 55-63.
15. Oltvai, Z.N., Milliman, C.L. and Korsmeyer, S.J., Bcl-2 heterodimerizes in vivo with a conserved homolog, Bax, that accelerates programmed cell death, Cell, 74 (1993) 609-619.
16. Sakhi, S., Bruce, A., Sun, N., Tocco, G., Baudry, M. and Schreiber, S.S., p53 induction is associated with neuronal damage in the central nervous system, Proc. Natl. Acad. Sci. USA, 91 (1994) 7525-7529.
17. Sakhi, S., Sun, N., Wing, L.L., Mehta, P. and Schreiber, S.S., Nuclear accumulation of p53 protein following kainic acid-induced seizures, NeuroReport, 7 (1996) 493-496.
18. Skaper, S.D., Facci, L. and Leon, A., Inflammatory mediator stimulation of astrocytes and meningeal fibroblasts induces neuronal degeneration via the nitridergic pathway, J. Neurochem., 64 (1995) 266-276.
19. Walkinshaw, G. and Waters, C.M., Neurotoxin-induced cell death in neuronal PC12 cells is mediated by induction of apoptosis, Neuroscience, 63 (1994) 975-987.
20. Wood, K.A. and Youle, R.J., The role of free radicals and p53 in neuron apoptosis in vivo, J. Neurosci., 15 (1995) 5851-5857.
21. Yang, E., Zha, J., Jockel, J., Boise, L.H., Thompson, C.B. and Korsmeyer, S.J., Bad, a heterodimeric partner for Bcl-xL and Bcl-2, displaces Bax and promote cell death, Cell, 80 (1995) 285-291.
22. Zhan, Q., Fan, S., Bae, I., Guillouf, C., Liebermann, D.A., O'Connor, P.M. and Fornace Jr., A.J., Induction of bax by genotoxic stress in human cells correlates with normal p53 status and apoptosis, Oncogene, 9 (1994) 3743-3751.